Lysosomal NKG7 restrains mTORC1 activity to promote CD8+ T cell durability and tumor control by Hyoungjun Ham, Jacob B. Hirdler, Daniel T. Bihnam, Zhiming Mao, Joanina K. Gicobi, Bruna Gois Macedo, Maria F. Rodriguez-Quevedo, Destiny F. Schultz, Cristina Correia, Jun Zhong, Kodi E. Martinez, Alma Banuelos, Dallin S. Ashton, Anthony B. Lagnado, Ruifeng Guo, Rodrigo Pessoa, Akhilesh Pandey, Hu Li, Fabrice Lucien, Henrique Borges da Silva, Haidong Dong, Daniel D. Billadeau

“…Human and mouse CD8+ T cells lacking NKG7 show more acidic lysosomes and increased activation of mTORC1 signaling, which could be reversed by inhibition of v-ATPase activity. …”
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An Overview of Heavy Metal Contamination of Water and Its Effect on Human Health by Danjuma, M.S., Abdulkadir, B.

“…The continuous industrial activities that generate metals have led to their wide distribution in the environment which raised a concern over the effects of such metals on human health and the environment itself. …”
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A Refined Terrace Extraction Method Based on a Local Optimization Model Using GF-2 Images by Guobin Kan, Jie Gong, Bao Wang, Xia Li, Jing Shi, Yutao Ma, Wei Wei, Jun Zhang

“…The model structure and loss function were adjusted accordingly to achieve high-quality terrace mapping results. …”
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A Label Correction Learning Framework for Gully Erosion Extraction Using High-Resolution Remote Sensing Images and Noisy Labels by Chunhui Zhao, Yi Shen, Nan Su, Yiming Yan, Shou Feng, Wei Xiang, Yong Liu, Tianhao Zhao

“…To achieve this, we introduce three key components in the framework, including an adaptive correction loss function, a multitree refinement module, and a noise correction module. …”
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Mobile Robot Path Planning Based on Fused Multi-Strategy White Shark Optimisation Algorithm by Dazhang You, Junjie Yu, Zhiyuan Jia, Yepeng Zhang, Zhiyuan Yang

“…Path length and path smoothness are used as fitness evaluation metrics, and an evaluation function is established in conjunction with a non-complete model that reflects actual motion to assess the effectiveness of path planning. …”
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Crude Radix Aconiti Lateralis Preparata (Fuzi) with Glycyrrhiza Reduces Inflammation and Ventricular Remodeling in Mice through the TLR4/NF-κB Pathway by Ping Yan, Wen Mao, Lushuai Jin, Mingsun Fang, Xia Liu, Jiali Lang, Lu Jin, Beibei Cao, Qiyang Shou, Huiying Fu

“…CFZ+GC was more effective than CFZ and PFZ, whereas CFZ had higher toxicity than CFZ+GC and PFZ. …”
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Geometrical constraints dictate assembly and phenotype of human iPSC-derived motoneuronal spheroids by Eleonora Mello, Stefano Sorrentino, Alessio Bucciarelli, Ermanno Cordelli, Elisa De Luca, Haakon Nygaard, Stefan Wendt, Alberto Rainer, Giuseppe Gigli, Lorenzo Moroni, Alessandro Polini, Pamela Mozetic

“…Conventional approaches to generate spheroids lack accurate size control, scalability, and customizability. …”
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Deep sequencing reveals distinct microRNA-mRNA signatures that differentiate pancreatic neuroendocrine tumor from non-diseased pancreas tissue by N Matyasovska, N Valkova, M Gala, S Bendikova, A Abdulhamed, V. Palicka, Neil Renwick, Pavol Čekan, Evan Paul

“…Then we crossed a list of differentially expressed mRNAs with a list of in silico predicted mRNA targets of the most and least abundant miRs to generate high probability miR-mRNA interaction networks. …”
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Skeletal muscle reprogramming enhances reinnervation after peripheral nerve injury by Pihu Mehrotra, James Jablonski, John Toftegaard, Yali Zhang, Shahryar Shahini, Jianmin Wang, Carey W. Hung, Reilly Ellis, Gabriella Kayal, Nika Rajabian, Song Liu, Kelly C. S. Roballo, Susan B. Udin, Stelios T. Andreadis, Kirkwood E. Personius

“…Abstract Peripheral Nerve Injuries (PNI) affect more than 20 million Americans and severely impact quality of life by causing long-term disability. …”
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Hepatocyte Rho-associated kinase signaling is required for mice to survive experimental porphyria-associated liver injury by Jessica M. Herrera, Yun Weng, Tyler J. Lieberthal, Marcus Paoletti, Tammy T. Chang

“…Rho-associated kinases 1 and 2 (ROCK1 and ROCK2) regulate critical cell functions, including actomyosin contractility, apoptosis, and proliferation. …”
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Flavones enrich rhizosphere Pseudomonas to enhance nitrogen utilization and secondary root growth in Populus by Jiadong Wu, Sijia Liu, Haoyu Zhang, Sisi Chen, Jingna Si, Lin Liu, Yue Wang, Shuxian Tan, Yuxin Du, Zhelun Jin, Jianbo Xie, Deqiang Zhang

“…Abstract Plant growth behavior is a function of genetic network architecture. The importance of root microbiome variation driving plant functional traits is increasingly recognized, but the genetic mechanisms governing this variation are less studied. …”
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Blurring the lines: an empirical examination of the interrelationships among acceptability, appropriateness, and feasibility by Zoe Fehlberg, Zornitza Stark, Marlena Klaic, Stephanie Best

“…Further, in the interest of reducing research waste, more research is needed to determine if the outcomes could serve as proxies for each other.…”
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Prostruc: an open-source tool for 3D structure prediction using homology modeling by Shivani V. Pawar, Wilson Sena Kwaku Banini, Musa Muhammad Shamsuddeen, Toheeb A. Jumah, Nigel N. O. Dolling, Abdulwasiu Tiamiyu, Olaitan I. Awe

“…IntroductionHomology modeling is a widely used computational technique for predicting the three-dimensional (3D) structures of proteins based on known templates,evolutionary relationships to provide structural insights critical for understanding protein function, interactions, and potential therapeutic targets. …”
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Interpréter dans la grosseur du trait by François-Joseph Daniel

“…Their recurrent mobilisation in newly established industrial facilities brings to the fore issues regarding their use in specific scientific, economic and institutional contexts. More particularly, these issues raise the following questions: how is trust developed in these models? …”
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A Parameter-tunable Triangular Norm with Monotonic Genes by WU Lunhua, ZHAO Hui, WANG Yue

“… In order to study the optimization of Zadeh operator, a definition of parameter-tunable triangular norm with monotonic genes is given.First, we defined a kind of triangular norm Fλin the general sense generated by monotone functions using elementary operations, and then a definition of triangular conorm Gλin the general sense is given by using duality.This type of definition unifies the optimal Zadeh operator proposed by some authors.Next, this definition is applied to generate a new pair of triangular norms. …”
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Effects of Land Fragmentation on Productivity in Northwestern Ethiopia by Gashaw Tenna Alemu, Zewdu Berhanie Ayele, Assefa Abelieneh Berhanu

“…Hence, the government should come up with land use policy and population growth controlling program, which enables determining minimum economic farmland size, improving land productivity, and finding ways to strengthen off-farm activities and livestock sector to absorb more labor and enhance means of generating more income so as to decrease minimum farmland size required.…”
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Protein Glycosylation in Aspergillus fumigatus Is Essential for Cell Wall Synthesis and Serves as a Promising Model of Multicellular Eukaryotic Development by Cheng Jin

“…Glycosylation is a conserved posttranslational modification that is found in all eukaryotes, which helps generate proteins with multiple functions. Our knowledge of glycosylation mainly comes from the investigation of the yeast Saccharomyces cerevisiae and mammalian cells. …”
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Calibrated muscle models improve tracking simulations without enhancing gait predictions. by Filippo Maceratesi, Míriam Febrer-Nafría, Josep M Font-Llagunes

“…<h4>Objectives</h4>This study presents two main aims: (i) to assess functionally-calibrated musculoskeletal models (FCMs) in both tracking and predictive simulations of human motion, against non-linearly scaled models (NSMs), and (ii) to examine the effects of three different variations of our baseline functional calibration approach on the results of tracking and predictive simulations.…”
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Orbit simulations with Maxima software by Ednilton S. de Oliveira

“…Abstract The computational algebra system Maxima is used together with the fourth order Runge-Kutta method to generate simulations of orbits caused by the newtonian gravitational interaction. …”
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Silence after narratives by patients in psychodynamic psychotherapy: a conversation analytic study by Carolina Fenner

“…However, when patients remain silent, it can serve various functions, such as reflecting more deeply or hesitating to elaborate on a topic. …”
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