Two-stream spatio-temporal GCN-transformer networks for skeleton-based action recognition by Dong Chen, Mingdong Chen, Peisong Wu, Mengtao Wu, Tao Zhang, Chuanqi Li

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Nonlinear behavior of dispersive solitary wave solutions for the propagation of shock waves in the nonlinear coupled system of equations by Mujahid Iqbal, Waqas Ali Faridi, Huda Daefallh Alrashdi, Abeer Aljohani, Muhammad Amin S. Murad, Nazar Mohammad, Abdullah S. Alsubaie

“…Consequently, various solutions in solitons and solitary waves are generated in rational, trigonometric, and hyperbolic functions and displayed within contour, two–dimension and three–dimension plotting by using the numerical simulation. …”
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Sculpting molecules in text-3D space: a flexible substructure aware framework for text-oriented molecular optimization by Kaiwei Zhang, Yange Lin, Guangcheng Wu, Yuxiang Ren, Xuecang Zhang, Bo Wang, Xiao-Yu Zhang, Weitao Du

“…This work not only holds general significance for the advancement of deep learning methodologies but also paves the way for a transformative shift in molecular design strategies. 3DToMolo creates opportunities for a more nuanced and effective exploration of the vast chemical space, opening new frontiers in the development of molecular entities with tailored properties and functionalities.…”
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Quantifying conformational heterogeneity of 3D genome organization in fruit fly. by Samira Mali, Igor S Tolokh, Erik Cross, Alexey V Onufriev

“…Within our computational approach, depletion of nuclear lamins leads to increased structural heterogeneity at nearly all genomic separations, with the potential implication that cell functions that depend on chromatin structure might be more variable within lamins depleted nuclei compared to the wild type.…”
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Novel resistance to Cydia pomonella granulovirus (CpGV) in codling moth shows autosomal and dominant inheritance and confers cross-resistance to different CpGV genome groups. by Annette J Sauer, Eva Fritsch, Karin Undorf-Spahn, Petr Nguyen, Frantisek Marec, David G Heckel, Johannes A Jehle

“…To further analyze type II resistance, two CM strains, termed CpR5M and CpR5S, were generated from parental NRW-WE by repeated mass crosses and selection using the two isolates CpGV-M and CpGV-S, respectively. …”
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A Qualitative Study Examining the Unintended Consequences from Implementing a Case Management Team to Reduce Avoidable Hospital Readmission in Singapore by Shilpa Surendran, Stephen So, Toon Wei Lim, David Bruce Matchar

“…As a result, the intervention team functioned more as a consulting service, providing recommendations to the primary team, which retained decision-making authority. …”
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Prediction and design of thermostable proteins with a desired melting temperature by Purva Tijare, Nishant Kumar, Gajendra P. S. Raghava

“…Abstract The stability of proteins at higher temperatures is crucial for their functionality, which is measured by their melting temperature (Tm). …”
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Cost-effectiveness of percutaneous mitral repair for patients with severe secondary mitral regurgitation: an updated evaluation using a modelling approach based on COAPT final data... by Xavier Armoiry, Peter Auguste, Martin Connock, Jean-Francois Obadia

“…After discounting, the model generated life-years of 3.843 years and 3.055 years for PR+GDMT and GDMT, respectively. …”
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ALDH^High Breast Cancer Stem Cells Exhibit a Mesenchymal–Senescent Hybrid Phenotype, with Elevated Metabolic and Migratory Activities by Luis Larrea Murillo, Conor J. Sugden, Bela Ozsvari, Zahra Moftakhar, Ghada S. Hassan, Federica Sotgia, Michael P. Lisanti

“…Cancer stem cells (CSCs) account for 0.01 to 2% of the total tumor mass; however, they play a key role in tumor progression, metastasis and resistance to current cancer therapies. The generation and maintenance of CSCs are usually linked to the epithelial–mesenchymal transition (EMT), a dynamic process involved in reprogramming cancer cells towards a more aggressive and motile phenotype with increased stemness potential. …”
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Morphologic Pattern Differences in Reconstructive Tissue Repair of Bone Defects Mediated by Bioactive Ceramics and Hydrogels: A Microscopic Follow-Up Evaluation of Re-Ossification by Róbert Boda, Viktória Hegedűs, Sándor Manó, Andrea Keczánné-Üveges, Balázs Dezső, Csaba Hegedűs

“…However, both βTCP-containing bone substituents generated larger amounts and more mature new bones inside the defects. …”
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A mesoscale numerical approach to predict damage behavior in concrete basing on phase field method by Nguyen Hoang Quan, Tran Bao Viet, Nguyen Thanh Tung

“…Some factors that affect the numerical result (type of crack density function and type of split decomposition of strain energy) are accounted to make the predictions more accurate for the case of concrete material. …”
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A fluorescence probe for monitoring toxic hypochlorous acid in biosystems and environmental waters with a broad pH adaptation by Junyan Ma, Zilin Jiao, Mingtao Zhao, Xiangtao Kong, Hua Xie, Zhenxing Zhang

“…This probe exhibits rapid and sensitive response, with a detection limit as low as 35 nM. More importantly, the probe is capable of functioning under highly acidic or basic conditions, exhibiting a wide pH range adaptability from pH 2–11. …”
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Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote. by Jonathan A Eisen, Robert S Coyne, Martin Wu, Dongying Wu, Mathangi Thiagarajan, Jennifer R Wortman, Jonathan H Badger, Qinghu Ren, Paolo Amedeo, Kristie M Jones, Luke J Tallon, Arthur L Delcher, Steven L Salzberg, Joana C Silva, Brian J Haas, William H Majoros, Maryam Farzad, Jane M Carlton, Roger K Smith, Jyoti Garg, Ronald E Pearlman, Kathleen M Karrer, Lei Sun, Gerard Manning, Nels C Elde, Aaron P Turkewitz, David J Asai, David E Wilkes, Yufeng Wang, Hong Cai, Kathleen Collins, B Andrew Stewart, Suzanne R Lee, Katarzyna Wilamowska, Zasha Weinberg, Walter L Ruzzo, Dorota Wloga, Jacek Gaertig, Joseph Frankel, Che-Chia Tsao, Martin A Gorovsky, Patrick J Keeling, Ross F Waller, Nicola J Patron, J Michael Cherry, Nicholas A Stover, Cynthia J Krieger, Christina del Toro, Hilary F Ryder, Sondra C Williamson, Rebecca A Barbeau, Eileen P Hamilton, Eduardo Orias

“…Like other ciliates, this species has separate germline and soma functions that are embodied by distinct nuclei within a single cell. …”
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Modulating the serine metabolism in human differentiated astrocytes: an integrated multi omics approach by Farida Tripodi, Elisa Maffioli, Silvia Sacchi, Valentina Rabattoni, Zoraide Motta, Claudia Bearzi, Gabriella Tedeschi, Gabriella Tedeschi, Loredano Pollegioni, Paola Coccetti

“…IntroductionAstrocytes are the major source of L-serine (L-Ser) in the brain: the glycolytic intermediate D-3-phosphoglycerate is converted into L-Ser through the phosphorylated pathway (PP) made up of three enzymes, phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase (PSAT) and phosphoserine phosphatase (PSP), recently proposed to generate a metabolic assembly named serinosome. In the central nervous system, L-Ser is used for a number of functions, including the synthesis of glycine (Gly) and D-serine (D-Ser), the two key NMDAR co-agonists.MethodsHere, we used iPSC-derived human astrocytes as a cellular model to evaluate the impact on cell metabolism of the overexpression of each of the three enzymes of the PP as GFP-tagged proteins.ResultsThe subcellular cytosolic localization of PP enzymes remains unchanged compared to endogenous proteins, while the complex formation is increased in all cases. …”
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Association of microtubule destabilization with platelet yields in terminally differentiating hiPSC-derived megakaryocyte lines. by Emiri Nakamura, Yasuo Harada, Trevor Bingham, Christian Skorik, Anjali Jha, John Atwater, Natsumi Higashi, Kosuke Fujio, Mariko Ishiguro, Haruki Okamoto, Leonard I Zon, George Q Daley, Andrew L Frelinger, Koji Eto, Thorsten M Schlaeger

“…These challenges could be overcome with universal donor platelets generated from human induced pluripotent stem cell (hiPSC)-derived megakaryocytes (MKs). …”
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Surface microlayer-mediated virome dissemination in the Central Arctic by Janina Rahlff, George Westmeijer, Julia Weissenbach, Alfred Antson, Karin Holmfeldt

“…., the latter having a relatively small genome size of 1.2 Mb and the metabolic potential to generate ATP using the phosphate acetyltransferase-acetate kinase pathway. …”
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Descriptive epidemiology of gynecologic and breast cancers between 1988 and 2018 in Burkina Faso, West Africa by Smaila Ouedraogo, Nayi Zongo, Adeline Djiguemde, Hyacinthe Zaman, Aimé Sosthène Ouedraogo, Blandine Thieba

“…However, there are no data on its full extent in Burkina Faso given the lack of functioning national registry of cancer. This study aims to determine the incidence of gynecologic and breast cancers. …”
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Mental health disorders among children with special health needs: A population-based cohort study using linked administrative data from Manitoba, Canada. by Jennifer E Enns, Caroline Reid-Westoby, Gilles R Detillieux, Marni Brownell, Nathan C Nickel, Anne Gadermann, Astrid Guttmann, Teresa Bennett, Eric Duku, Barry Forer, Monique Gagné Petteni, Katholiki Georgiades, Martin Guhn, Ana Hanlon-Dearman, Brenda T Poon, Magdalena Janus

“…<h4>Objective</h4>An estimated 15-22% of Canadian kindergarten-age children have a special health need (SHN), defined as a clinical diagnosis, a functional need requiring special accommodation at school, or a health condition leading to increased needs. …”
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Innovative gene delivery systems for retinal disease therapy by Hongguang Wu, Ling Dong, Shibo Jin, Yongwang Zhao, Lili Zhu

“…The human retina, a complex and highly specialized structure, includes multiple cell types that work synergistically to generate and transmit visual signals. However, genetic predisposition or age-related degeneration can lead to retinal damage that severely impairs vision or causes blindness. …”
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VANTAGE: An open‐source application for visualisation, navigation and analysis of video and ancillary time‐series data in bio‐logging studies by Stefan Schoombie, Tagen deWet, Stefan Britz, Andrew D. Lowther, W. Chris Oosthuizen

“…However, such deployments generate large amounts of data that are often not synchronised and may be difficult to analyse because open‐source software tools facilitating simultaneous visualisation of multiple data channels along with video streams are lacking. …”
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