Cell type-specific driver lines targeting the Drosophila central complex and their use to investigate neuropeptide expression and sleep regulation by Tanya Wolff, Mark Eddison, Nan Chen, Aljoscha Nern, Preeti Sundaramurthi, Divya Sitaraman, Gerald M Rubin

“…Genetic tools for manipulating individual cell types, and knowledge of what neurotransmitters and neuromodulators they express, will be required to gain mechanistic understanding of how these functions are implemented. We generated and characterized split-GAL4 driver lines that express in individual or small subsets of about half of CX cell types. …”
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Synthesis and analysis of an integrated suspension energy harvesting system for continuous half-width speed bumps by Min-Chie Chiu, Ho-Chih Cheng, Ming-Guo Her, Mansour Karkoub

“…The focus is on the effect of harvesters’ parameters and speed bump’s physical characteristics on the power generation performance of the harvesters. The main objective is to maximize electricity and minimize the ride comfort efficiency index using a multi-objective optimization function in conjunction with a genetic algorithm. …”
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Improved YOLOv5s With Coordinate Attention for Small and Dense Object Detection From Optical Remote Sensing Images by Qinggang Wu, Yonglei Wu, Yang Li, Wei Huang

“…Third, we replace the commonly used complete intersection over union (IoU) loss function in YOLOv5s with the AW-IoU loss function based on both α-IoU and wise-IoU. …”
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Cisplatin-Induced Stria Vascularis Damage Is Associated with Inflammation and Fibrosis by Na Zhang, Jing Cai, Lei Xu, Haibo Wang, Wenwen Liu

“…The stria vascularis (SV) generates the endocochlear potential (EP) in the inner ear and is necessary for proper hair cell (HC) mechanotransduction and hearing. …”
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Induction of tissue resident memory T cells by measles vaccine vector by Heidy Vera-Peralta, Claude Ruffié, Valérie Najburg, Matthias Brione, Chantal Combredet, Phanramphoei Frantz, Jean-Nicolas Tournier, Frédéric Tangy, Marie Mura

“…The intranasal route induced more Trm in the lungs than other routes, confirming the potential of intranasal vaccine administration of replicative viral vectors to generate a strong pulmonary immune response. …”
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Compositional editing of extracellular matrices by CRISPR/Cas9 engineering of human mesenchymal stem cell lines by Sujeethkumar Prithiviraj, Alejandro Garcia Garcia, Karin Linderfalk, Bai Yiguang, Sonia Ferveur, Ludvig Nilsén Falck, Agatheeswaran Subramaniam, Sofie Mohlin, David Hidalgo Gil, Steven J Dupard, Dimitra Zacharaki, Deepak Bushan Raina, Paul E Bourgine

“…In this study, we demonstrated the exploitation of CRISPR/Cas9 as a high precision system for editing the composition and function of eECMs. Human mesenchymal stromal/stem cell (hMSC) lines were modified to knock out vascular endothelial growth factor (VEGF) and Runt-related transcription factor 2 (RUNX2) and assessed for their capacity to generate osteoinductive cartilage matrices. …”
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CPT1C deficiency in SF1 neurons impairs early metabolic adaptation to dietary fats, leading to obesity by A. Fosch, D.S. Pizarro, S. Zagmutt, A.C. Reguera, G. Batallé, M. Rodríguez-García, J. García-Chica, O. Freire-Agulleiro, C. Miralpeix, P. Zizzari, D. Serra, L. Herrero, M. López, D. Cota, R. Rodríguez-Rodríguez, N. Casals

“…Methods: Mice deficient in CPT1C within SF1 neurons were generated, and their response to a HFD was investigated. …”
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Mitochondrial Dysfunction in Glycogen Storage Disorders (GSDs) by Kumudesh Mishra, Or Kakhlon

“…Deficiencies in enzymes responsible for glycogen breakdown and synthesis can impair mitochondrial function. For instance, in GSD type II (Pompe disease), acid alpha-glucosidase deficiency leads to lysosomal glycogen accumulation, which secondarily impacts mitochondrial function through dysfunctional mitophagy, which disrupts mitochondrial quality control, generating oxidative stress. …”
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High resolution genome wide binding event finding and motif discovery reveals transcription factor spatial binding constraints. by Yuchun Guo, Shaun Mahony, David K Gifford

“…An essential component of genome function is the syntax of genomic regulatory elements that determine how diverse transcription factors interact to orchestrate a program of regulatory control. …”
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Insulin Secretion Defect in Children and Adolescents with Obesity: Clinical and Molecular Genetic Characterization by Helena Enders-Seidlitz, Klemens Raile, Maolian Gong, Angela Galler, Peter Kuehnen, Susanna Wiegand

“…We calculated Matsuda index, the area under the curve (AUC (Ins/Glu)), and an oral disposition index (ISSI-2) to estimate insulin resistance and beta-cell function. We identified patients with IGR and low insulin secretion (maximum insulin during OGTT<200 mU/l) and tested a subgroup using next generation sequencing to identify possible mutations in 103 candidate genes. …”
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A Comparative Analysis of Attitudes Toward Sexual Orientation and Gender Identity Minority People by B. J. Rye, Rebecca Goldszmidt

“…Attitudes toward sexual and gender minority people is a generative field of study leading to theoretical and practical advances. …”
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Approximate Bayesian Computation for a Dual-Failure-Modes Models and Its Application to Failure Times Data by Mustapha Muhammad, Badamasi Abba, Jinsen Xiao

“…We practically demonstrate approximate Bayesian computation (ABC)-Gibbs scheme using Kolmogorov-Smirnov as distance function; this method is a simulation-based scheme, which the explicit formulation of the likelihood function is not required, hence, suitable for a complex model or big data, where the &#x201C;accept-reject&#x201D; mechanism is required for the posterior computation. …”
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Optimal Bidding Strategies for the Participation of Aggregators in Energy Flexibility Markets by Gian Giuseppe Soma, Giuseppe Marco Tina, Stefania Conti

“…It is evident that quantitatively more significant results can be obtained when larger aggregations (more participants) are considered.…”
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An Original Socialist Realist Novelist in the Context of the Approach to Religion in Modern Turkish Literature: Kemal Tahir by Muhammed Hüküm, Muhammet Fatih Kanter, Bedirhan Ünlü

“…Kemal Tahir, who occupies a significant role in the realm of Turkish socialist novels, offers insights into the position and function of faith within society, as he transitioned from the classical Marxist paradigm towards a more original understanding. …”
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Integration biometrics in web application: Security for web apps by Wulandari Kusuma Herdanu, Rabab Alayham Abbas Helmi, Mariana Syamsudin

“…First, two performance metrics privacy, determined by the biometric measurements' normalized equivocation rate, and security, determined by the biometric measurements' key generation rate are specified. Then, it is decided that there is a fundamental tradeoff between these two measurements. …”
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The Sensitivity Analysis of Whitecapping Dissipation Term for Calibration of SWAN Model Forced with ERA5 Winds in the Gulf of Oman by Amir Siahsarani, Majid Azadi, Behzad Layeghi, Davoud Babazadeh

“…In the present study, the sensitivity of the simulations of the significant wave height to the terms of the wind input and whitecapping dissipation in a third generation wave model has been investigated. For this purpose, 36 different configurations of the wave model have been used. the results of this study allow us to see the response of the SWAN model as a function of physical parameters. …”
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Environmental Levels and Degradation Behavior of Pharmaceuticals and Personal Care Products (PPCPs) in the Water Environment by Zhaohe ZHANG, Dian CHEN, Wei ZHAO, Guoli YUAN, Jun LI, Xingchun JIAO

“…In general, photodegradation and biodegradation are more common than hydrolysis. In surface water, many PPCPs have avoided the strict biodegradation environment of wastewater treatment, and photochemistry may have a greater effect than the biodegradation under sunlight, in which antibiotics are mainly photodegraded in the water environment; ibuprofen, iopromide and caffeine are more prone to biodegradation; esters and amides are the most common functional groups that are easily hydrolyzed in PPCPs[63], and tetracycline can undergo hydrolysis reactions due to adsorption into sediments. …”
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Deletion of <i>ddx4</i> Ovary-Specific Transcript Causes Dysfunction of Meiosis and Derepress of DNA Transposons in Zebrafish Ovaries by Yuanyuan Chen, Xing Lin, Jing Dai, Yifan Bai, Fei Liu, Daji Luo

“…Alternative splicing of <i>ddx4</i> (DEAD-box helicase 4), a key germline marker gene, has been reported to generate sex-specific transcripts in zebrafish gonads. …”
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BRAF inhibitor resistance of melanoma cells triggers increased susceptibility to natural killer cell-mediated lysis by Antoine Toubert, Eric Pasmant, Alexandra Frazao, Louise Rethacker, Géraldine Jeudy, Marina Colombo, Marie-Françoise Avril, Helene Moins-Teisserenc, Marie Roelens, Sophie Dalac, Eve Maubec, Anne Caignard

“…Soluble NKG2D ligands known to regulate the receptor function have been associated to cancer progression. …”
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Statistical inference of constant-stress partially accelerated life tests under type II generalized hybrid censored data from Burr III distribution by Hassan Amal S., Alsadat Najwan, Kayid Mohamed, Elgarhy Mohammed, Balogun Oluwafemi Samson, Almetwally Ehab M.

“…Bayesian estimators are generated using symmetric and asymmetric loss functions through the Monte Carlo Markov Chain approach. …”
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