Gut Microbiota: A New Challenge in Mood Disorder Research by Giuseppe Marano, Sara Rossi, Greta Sfratta, Gianandrea Traversi, Francesco Maria Lisci, Maria Benedetta Anesini, Roberto Pola, Antonio Gasbarrini, Eleonora Gaetani, Marianna Mazza

“…This review examines the latest findings on the gut–microbiota–brain axis and elucidates how alterations in gut microbiota composition can influence this axis, leading to changes in brain function and behavior. Although dietary interventions, prebiotics, probiotics, and fecal microbiota transplantation have yielded encouraging results, significant advances are needed to establish next-generation approaches that precisely target the neurobiological mechanisms of mood disorders. …”
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Artificial intelligence analysis of thermal energy for convectively heated ternary nanofluid flow in radiated channel considering viscous dissipations aspects by Hamid Qureshi, Amjad Ali Pasha, Muhammad Asif Zahoor Raja, Zahoor Shah, Salem Algarni, Talal Alqahtani, Waqar Azeem Khan, Moinul Haq

“…This research works to establish the convective heat transfer coefficient (CHTC) of new improved ternary hybrid functionalized nanofluids with CuO, Fe2O3, and SiO2 nanoparticles in polymeric fluid. …”
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Shotgun metagenomic sequencing reveals the influence of artisanal dairy environments on the microbiomes, quality, and safety of Idiazabal, a raw ewe milk PDO cheese by Gorka Santamarina-García, Min Yap, Fiona Crispie, Gustavo Amores, Cathy Lordan, Mailo Virto, Paul D. Cotter

“…Results The results revealed diverse microbial ecosystems across sample types, comprising more than 1300 bacterial genera and 3400 species. …”
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Structure-dependent degradation of milk oligosaccharides by newly isolated intestinal commensal bacterial strains from suckling piglets and rabbits by Mathilde Rumeau, Sead Chadi, Frederic Pepke, Martin Beaumont, Cláudia M. Vicente, Agathe Juppeau, Céline Vandecasteele, Laurent Cauquil, Géraldine Pascal, Philippe Langella, Christelle Knudsen, Sylvie Combes, Rebeca Martín

“…Milk oligosaccharide fermentation generated a more diverse metabolome compared to glucose. …”
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Amniotic fluid-derived stem cells: potential factories of natural and mimetic strategies for congenital malformations by Cristiane S. R. Fonteles, Julia Enterria-Rosales, Ying Lin, John W. Steele, Ramiro A. Villarreal-Leal, Jing Xiao, Daniel I. Idowu, Beck Burgelin, Bogdan J. Wlodarczyk, Richard H. Finnell, Bruna Corradetti

“…These nanovesicles present a minimally invasive therapeutic option, addressing the limitations of MSC-based treatments while retaining therapeutic efficacy. Methods: MIMs were generated from AF-MSCs by combining sequential filtration steps through filter membranes with different porosity and size exclusion chromatography columns. …”
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Acridocarpus smeathmannii root extracts inhibit human prostate and bladder smooth muscle contraction, porcine arterial vasoconstriction, and cytotoxicity of prostate stromal cells by Oluwafemi Ezekiel Kale, Sheng Hu, Claudia Huber, Felix Schierholz, Anna Ciotkowska, Alexander Tamalunas, Christian G. Stief, Wolfgang Eisenreich, Martin Hennenberg

“…In addition, assays were conducted to evaluate cell proliferation and viability, providing complementary insights into functional and cellular-level effects. The bioactive compounds in the extract were characterized using gas chromatography–mass spectrometry (GC-MS) and nuclear magnetic resonance spectroscopy and were subsequently evaluated in silico for their interaction with the α1-adrenergic receptor.ResultsProstate tissue contractions induced by α1-adrenergic agonists (0.1–100 µM) were reduced by 50% or more with A. smeathmannii at concentrations of 0.25 and 0.50 mg/mL. …”
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Deficiency of T cell CD40L has minor beneficial effects on obesity-induced metabolic dysfunction by Lisa Willemsen, Myrthe den Toom, Myrthe E Reiche, Marion J J Gijbels, Esther Lutgens, Bram van Os, Norbert Gerdes, Suzanne A B M Aarts

“…Our data indicate that other CD40L-expressing cell types are more relevant in the pathogenesis of obesity-associated metabolic dysfunction.…”
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Engineering adoptive T cell therapy to co-opt Fas ligand-mediated death signaling in ovarian cancer enhances therapeutic efficacy by Philip D Greenberg, Kristin G Anderson, Shannon K Oda, Breanna M Bates, Madison G Burnett, Magdalia Rodgers Suarez, Susan L Ruskin

“…Background In the USA, more than 50% of patients with ovarian cancer die within 5 years of diagnosis, highlighting the need for therapeutic innovations. …”
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Strong Hsp90α/β Protein Expression in Advanced Primary CRC Indicates Short Survival and Predicts Response to the Hsp90α/β-Specific Inhibitor Pimitespib by Sebastian B. M. Schmitz, Jakob Gülden, Marlene Niederreiter, Cassandra Eichner, Jens Werner, Barbara Mayer

“…The anti-cancer effect and chemosensitization of Pim-based therapy were prospectively confirmed in PDCS directly generated from Hsp90α/β > 40% pCRCs. Protein profiling combined with functional drug testing stratifies Hsp90α/β > 40% pCRC patients diagnosed with UICC IIb-IV for effective Pim-based therapy.…”
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A Monocyte-Driven Prognostic Model for Multiple Myeloma: Multi-Omics and Machine Learning Insights by Xie L, Gao M, Tan S, Zhou Y, Liu J, Wang L, Li X

“…Results indicated that low-risk patients are more likely to benefit from immunotherapy, while a high MGPS score reflects cellular functional impairment.Conclusion: Our findings reveal a complex interplay between immune cells and MM. …”
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Construction and characterization of chimeric FcγR T cells for universal T cell therapy by Juanjuan Zhao, Manling Chen, Xudong Li, Zhaoqi Chen, Wei Li, Rongqun Guo, Min Wang, Zhongxing Jiang, Yongping Song, Jianxiang Wang, Delong Liu

“…Methods Chimeric FcγR (CFR) constructs were generated using three distinct forms of FcγR, namely CD16A, CD32A, and CD64. …”
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The sensor histidine kinase PhcS participates in the regulation of quorum sensing-dependent virulence genes in Ralstonia pseudosolanacearum strain OE1-1 by Wakana Senuma, Masayuki Tsuzuki, Chika Takemura, Yuki Terazawa, Akinori Kiba, Kouhei Ohnishi, Kenji Kai, Yasufumi Hikichi

“…It is thus thought that PhcS participates in not only the 3-OH MAME sensing-independently PhcK-mediated regulation of phcA but also the PhcA activation following 3-OH MAME sensing. Both functions of PhcS are significantly influenced by the autophosphorylation of H230-PhcS.IMPORTANCEThe soil-borne Ralstonia solanacearum species complex (RSSC) infects more than 300 plant species in over 50 families, including solanaceous plants, causing the devastating wilt disease that substantially decreases agricultural production worldwide. …”
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Antimicrobial Smart Dressings for Combating Antibiotic Resistance in Wound Care by Alina-Georgiana Cristea (Hohotă), Elena-Lăcrămioara Lisă, Simona Iacob (Ciobotaru), Ionut Dragostin, Claudia Simona Ștefan, Iuliu Fulga, Andra Monica Anghel (Ștefan), Maria Dragan, Ionela Daniela Morariu, Oana-Maria Dragostin

“…These innovations enable early detection of adverse events such as bacterial infections and inflammation, facilitating more effective, on-demand treatment. This review highlights the current state of antibiotic-embedded wound dressings, discusses their limitations, and explores the potential of next-generation wound dressings incorporating microelectronic sensors for real-time monitoring and adaptive therapeutic responses to support healing and combat antimicrobial resistance.…”
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DCLTV: An Improved Dual-Condition Diffusion Model for Laser-Visible Image Translation by Xiaoyu Zhang, Laixian Zhang, Huichao Guo, Haijing Zheng, Houpeng Sun, Yingchun Li, Rong Li, Chenglong Luan, Xiaoyun Tong

“…In recent studies, diffusion models have demonstrated superior image generation and translation abilities and been shown to be capable of generating high-quality images. …”
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Single-cell sequencing on PBMCs from patients with HA and HB with inhibitors reveals different immune responses to FVIII and FIX by Enhao Li, Zekun Li, Jinzeng Wang, Haoyang Wu, Yilun Xue, Can Lou, Zhenping Chen, Feng Liu, Wenman Wu, Qiulan Ding, Runhui Wu, Xuefeng Wang, Jing Dai

“…HA group exhibited a relatively higher proportion of B cells and more active B cells, whereas HB group demonstrated a higher proportion of T cells, with more active CD4+ T helper cells. …”
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Desain Layanan E-Surat untuk Desa Waru Barat, Pamekasan, Madura menggunakan QR-Code by Wahyudi Agustiono, Intan Rofika Putri, Devie Rosa Anamisa

“…Therefore, this research attempted to design and develop e-certificate for Waru Barat Village using QR Code. The functionality testing showed the application successfully generated e-certificate along with the unique QR Code to secure and maintain the validity of the document. …”
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Simultaneously acquired rSUV and rCBF of 18F-FDG/MRI in peritumoral brain zone can help to differentiate the grade of gliomas by Hong Qu, Yuping Zeng, Lifeng Hang, Jin Fang, Hui Sun, Hong Li, Guihua Jiang

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Characteristics of Soil Nutrients Accumulation and Nitrogen and Phosphorus Loss of Greenhouse Vegetable Field by YANG Tao, CHEN Yuanhua, CHEN Feng, XU Changxu, ZHUANG Yanhua, TU Xiangming, CHEN Jingrui

“…Due to the degenerated function of regulation, storage and purification of ditches and ponds, the generation of short-term, high-flow and low-concentration runoff water from greenhouse vegetable is difficult to be consumed in farmland ecosystem locally in at present. …”
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Towards non-virtual inertia control of renewable energy for frequency regulation: Modeling, analysis and new control scheme by Haishu Gao, Feng Zhang, Lei Ding, Gang Zhang, Libin Yang, Athuman Salimu

“…Currently, when renewable generation participates in frequency regulation, the traditional control method is to emulate synchronous generators through virtual inertia control. …”
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A glyco-engineering approach for site-specific conjugation to Fab glycans by Maria L. Jaramillo, Traian Sulea, Yves Durocher, Mauro Acchione, Melissa J. Schur, Anna Robotham, John F. Kelly, Marie-France Goneau, Alma Robert, Yuneivy Cepero-Donates, Michel Gilbert

“…In conventional ADCs, the drug molecules are chemically attached randomly to antibody surface residues (typically Lys or Cys), which can interfere with epitope binding and targeting, and lead to overall product heterogeneity, long-term colloidal instability and unfavorable pharmacokinetics. Here, we present a more controlled process for generating ADCs where drug is specifically conjugated to only Fab N-linked glycans in a narrow ratio range through functionalized sialic acids. …”
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