Reflections and trajectories for interdisciplinary research on the energy transition by Cesare Sposito, Francesca Scalisi

“…The goals of climate neutrality by 2050 and the reduction of CO2 emissions by 55% (compared to the 1990 level) by 2030 (European Commission, 2019, 2021) pose the European Union, and even more so the rest of the world, with several complex issues, including a significant increase in ‘clean’ energy production from alternative and renewable sources, the reduction of energy poverty, greater security of energy supply and a drastic decrease in dependence on energy imports; at the same time, the aim is to foster modern economic growth decoupled from the use of non-renewable resources, the creation of new jobs, and to generate environmental and health benefits, objectives with inevitable cultural, political, economic, production, technological and social implications to be addressed both within one’s borders and in foreign policy. …”
Get full text

The SARS-CoV-2 main protease causes mitochondrial dysfunction in a yeast model by Wojciech Grabiński, Anna Kicińska, Karolina Funtowicz, Tomasz Skrzypczak, Andonis Karachitos

“…Yeasts are easy to culture and manipulate genetically, which allows rapid generation of mutant strains and detailed dissection of mitochondrial pathways. …”
Get full text

Modeling of lifetime scenarios with non-monotonic failure rates. by Amani Abdullah Alahmadi, Olayan Albalawi, Rana H Khashab, Arne Johannssen, Suleman Nasiru, Sanaa Mohammed Almarzouki, Mohammed Elgarhy

“…We analyze the statistical features of the MKWD, such as the quantile function, median, moments, mean, variance, skewness, kurtosis, coefficient of variation, index of dispersion, moment generating function, incomplete moments, conditional moments, Bonferroni, Lorenz, and Zenga curves, and order statistics. …”
Get full text

The Decision Making Process of an Electricity Retailer Under Medium and Long Term Restriction in Spot Market by Yun XU

“…The paper establishes the cost and income model of electricity procurement and selling by a retailer, and generates a series of scenarios with different spot price based on lognormal distribution, and quantifies the risk in all scenarios with CVaR mode, and finally establishes the profit-risk objective function. …”
Get full text

Sources of uncertainty in DNA metabarcoding of whole communities: Implications for its use in biomonitoring by J. Iwan Jones, Amanda Arnold, Dominik Buchner, John F. Murphy, Jasmine N. Childress, Pedro Beja, Florian Altermatt, Kristian Meissner, Ian Adams, Meri Anderson, Yaisel J. Borrell, Andrew G. Briscoe, Kat Bruce, Cátia Chaves, Chris Conyers, Kristy Deiner, Vasco Elbrecht, Álvaro Fueyo, Tim Goodall, Javier Granero‐Castro, Cristina Hartmann‐Fatu, Eleanor Jones, Elvira Mächler, Filipa M. S. Martins, Sam McGreig, Lyndall Pereira‐da‐Conceicoa, James L. Pretty, Daniel S. Read, Ben Price, Florian Leese, Rosetta C. Blackman

Get full text

Chain entanglement enhanced strong and tough wool keratin/albumin fibers for bioabsorbable and immunocompatible surgical sutures by Haonan He, Xianchi Zhou, Yuxian Lai, Rouye Wang, Hongye Hao, Xintian Shen, Peng Zhang, Jian Ji

Get full text

CD137 and PD-L1 targeting with immunovirotherapy induces a potent and durable antitumor immune response in glioblastoma models by Hong Jiang, Sandra Hervás-Stubbs, Sara Labiano, Candelaria Gomez-Manzano, Juan Fueyo, Marta Alonso, Zhihong Chen, Montserrat Puigdelloses, Marc Garcia-Moure, Virginia Laspidea, Marisol Gonzalez-Huarriz, Marta Zalacain, Lucia Marrodan, Naiara Martinez-Velez, Daniel De la Nava, Iker Ausejo, Guillermo Herrador, Dolores Hambardzumyan, Ana Patino Garcia, Jaime Gállego Pérez-Larraya

“…Moreover, Delta-24-ACT expressed functional 4-1BBL that was able to costimulate T lymphocytes in vitro and in vivo. …”
Get full text

Characterization and quantification of proteins secreted by single human embryos prior to implantation by Maurizio Poli, Alessandro Ori, Tim Child, Souraya Jaroudi, Katharina Spath, Martin Beck, Dagan Wells

“…Our work paves the way for the development of “next‐generation” embryo competence assessment strategies, based on functional proteomics.…”
Get full text

Butterfat recovery from waste ice cream via churning and clarification – Proof of concept by Rafael A. Garcia, Lorelie P. Bumanlag, Faith Olszewski, Farah Huynh, Changhoon Lee, Benjamin M. Plumier, John A. Renye, Peggy M. Tomasula

Get full text

Weightage Identified Network of Keywords Technique: A Structured Approach in Identifying Keywords for Systematic Reviews by Sasidharan Sivakumar, Gowardhan Sivakumar

“…Objectives The objective of this study was to develop the weightage identified network of keywords (WINK) technique for selecting and utilizing keywords to perform systematic reviews more efficiently. This technique aims to improve the thoroughness and precision of evidence synthesis by employing a more rigorous approach to keyword selection. …”
Get full text

Direct coupling analysis and the attention mechanism by Francesco Caredda, Andrea Pagnani

“…Abstract Proteins are involved in nearly all cellular functions, encompassing roles in transport, signaling, enzymatic activity, and more. …”
Get full text

A Perspective on Robotic Assistance for Knee Arthroplasty by Nathan A. Netravali, Feimo Shen, Youngbae Park, William L. Bargar

“…Therefore, a lot of effort has gone into improving surgical technique including the use of computer-aided surgery. The latest generation of orthopedic surgical tools involves the use of robotics to enhance the surgeons’ abilities to install implants more precisely and consistently. …”
Get full text

Review of Different Types of Neural Network Architectures by T. L. Makosso, A. Almaktoof, K. Abo-Al-Ez

“… Innovative technologies come with such a huge amount of data that can only computerize with fast and more complex software. As time went by, more complicated problems arose such as pattern recognition, machine learning and prediction and unfortunately the conventional computer system was unable to carry out such tasks. …”
Get full text

Semantic Motivation of Nominative Relatives as a Problem of Modern Lexicograph by N. A. Aksarina, L. V. Basova

“…The analysis of dictionary entries and materials of the National Corpus of the Russian allows us to conclude that denominative relatives have a more complexly organized lexical part of the meaning than homonymous adverbs with the same generating base. …”
Get full text

Study protocol for a randomized double-blinded placebo-controlled trial on ASA therapy for patients with chronic rhinosinusitis with nasal polyps, NSAID-exacerbated respiratory dis... by Sanna Toppila-Salmi, Sanna Toppila-Salmi, Sanna Toppila-Salmi, Annina Lyly, Annina Lyly, Viljami Salmi, Viljami Salmi, Mikko Nuutinen, Mikko Nuutinen, Michael Kilpiö, Michael Kilpiö, Tanzeela Hanif, Tanzeela Hanif, Tanzeela Hanif, Mikko Niemi, Mikko Niemi, Mikko Niemi, Anu Laulajainen-Hongisto, Lena Hafrén, Mika Mäkelä, Paula Kauppi, Paula Virkkula, Alma Helevä, Alma Helevä

“…Secondary measures include variations in nasal polyp scores, CRS symptom control, general HRQoL, work productivity loss, peak nasal inspiratory flow (PNIF) with or without acoustic rhinometry (ARM), olfactory function assessed by the Sniffin' Sticks identification test, spirometry, peak expiratory flow (PEF), and histopathological findings at the 12-month follow-up.DiscussionThe AirGOs Medical trial is expected to generate data on the therapeutic value and safety profile of ATAD in patients with coexisting severe CRSwNP, N-ERD, and asthma, potentially informing future clinical practice. …”
Get full text

Revisiting the Middle Molecule Hypothesis of Uremic Toxicity: A Systematic Review of Beta 2 Microglobulin Population Kinetics and Large Scale Modeling of Hemodialysis Trials In Sil... by Maria Eleni Roumelioti, Thomas Nolin, Mark L Unruh, Christos Argyropoulos

“…A quantitative description of the relative importance of factors determining β2M concentrations among patients with impaired kidney function is currently lacking.<h4>Methods</h4>Herein we undertook a systematic review of existing studies reporting patient level data concerning generation, elimination and distribution of β2M in order to develop a population model of β2M kinetics. …”
Get full text

RECURRENT DEPRESSIVE DISORDER,TYPE 2 DIABETES MELLITUSAND OXIDATIVE STRESS by P. Marinov, Y. Petkov

“…Because ROS is an essential mediator for the activation of pro-inflammatory signalling pathways, obesity and hyperglycaemia-induced ROS production may favour the induction of M1-like pro-inflammatory macrophages during the onset and progression of diabetes. By generating more reactive oxygen species (ROS) and upregulating markers of chronic inflammation, hyperglycaemia can lead to vascular dysfunction. …”
Get full text

User Experiences of and Preferences for Self-Guided Digital Interventions for the Treatment of Mild to Moderate Eating Disorders: Systematic Review and Metasynthesis by Lauryn Gar-Mun Cheung, Pamela Carien Thomas, Eva Brvar, Sarah Rowe

“… BackgroundDigital interventions typically involve using smartphones or PCs to access online or downloadable self-help and may offer a more accessible and convenient option than face-to-face interventions for some people with mild to moderate eating disorders. …”
Get full text

A novel economic load dispatch method of microgrid based on hybrid slime mould and genetic algorithm by Wei Ba, Wei Sun, Chunjiang Zhao, Qi Li

“…Objective function models and their constraints based on wind, photovoltaic, energy storage and fuel power generation are presented. …”
Get full text

Properties and Applications of Neutrosophic Burr XII Distribution by Laila A. Al-Essa, Farrukh Jamal, Shakaiba Shafiq, Sadaf Khan, Qamer Abbas, Rehan Ahmad Khan Sherwani, Muhammad Aslam

“…The primary objective is to study the statistical properties of the proposed model by providing explicit expressions of reliability properties, the expression of moments and generating function, expression of order statistics, mean residual life, mean inactivity time, stochastic ordering, income inequality measures, and entropy in neutrosophic realm. …”
Get full text