Deficiency of T cell CD40L has minor beneficial effects on obesity-induced metabolic dysfunction by Lisa Willemsen, Myrthe den Toom, Myrthe E Reiche, Marion J J Gijbels, Esther Lutgens, Bram van Os, Norbert Gerdes, Suzanne A B M Aarts

“…Our data indicate that other CD40L-expressing cell types are more relevant in the pathogenesis of obesity-associated metabolic dysfunction.…”
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Engineering adoptive T cell therapy to co-opt Fas ligand-mediated death signaling in ovarian cancer enhances therapeutic efficacy by Philip D Greenberg, Kristin G Anderson, Shannon K Oda, Breanna M Bates, Madison G Burnett, Magdalia Rodgers Suarez, Susan L Ruskin

“…Background In the USA, more than 50% of patients with ovarian cancer die within 5 years of diagnosis, highlighting the need for therapeutic innovations. …”
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Strong Hsp90α/β Protein Expression in Advanced Primary CRC Indicates Short Survival and Predicts Response to the Hsp90α/β-Specific Inhibitor Pimitespib by Sebastian B. M. Schmitz, Jakob Gülden, Marlene Niederreiter, Cassandra Eichner, Jens Werner, Barbara Mayer

“…The anti-cancer effect and chemosensitization of Pim-based therapy were prospectively confirmed in PDCS directly generated from Hsp90α/β > 40% pCRCs. Protein profiling combined with functional drug testing stratifies Hsp90α/β > 40% pCRC patients diagnosed with UICC IIb-IV for effective Pim-based therapy.…”
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A Monocyte-Driven Prognostic Model for Multiple Myeloma: Multi-Omics and Machine Learning Insights by Xie L, Gao M, Tan S, Zhou Y, Liu J, Wang L, Li X

“…Results indicated that low-risk patients are more likely to benefit from immunotherapy, while a high MGPS score reflects cellular functional impairment.Conclusion: Our findings reveal a complex interplay between immune cells and MM. …”
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Construction and characterization of chimeric FcγR T cells for universal T cell therapy by Juanjuan Zhao, Manling Chen, Xudong Li, Zhaoqi Chen, Wei Li, Rongqun Guo, Min Wang, Zhongxing Jiang, Yongping Song, Jianxiang Wang, Delong Liu

“…Methods Chimeric FcγR (CFR) constructs were generated using three distinct forms of FcγR, namely CD16A, CD32A, and CD64. …”
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The sensor histidine kinase PhcS participates in the regulation of quorum sensing-dependent virulence genes in Ralstonia pseudosolanacearum strain OE1-1 by Wakana Senuma, Masayuki Tsuzuki, Chika Takemura, Yuki Terazawa, Akinori Kiba, Kouhei Ohnishi, Kenji Kai, Yasufumi Hikichi

“…It is thus thought that PhcS participates in not only the 3-OH MAME sensing-independently PhcK-mediated regulation of phcA but also the PhcA activation following 3-OH MAME sensing. Both functions of PhcS are significantly influenced by the autophosphorylation of H230-PhcS.IMPORTANCEThe soil-borne Ralstonia solanacearum species complex (RSSC) infects more than 300 plant species in over 50 families, including solanaceous plants, causing the devastating wilt disease that substantially decreases agricultural production worldwide. …”
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Stochastic blockmodeling of the modules and core of the Caenorhabditis elegans connectome. by Dragana M Pavlovic, Petra E Vértes, Edward T Bullmore, William R Schafer, Thomas E Nichols

“…We also show that the blockmodel can be used both to generate stochastic realisations (simulations) of the biological connectome, and to compress network into a small number of super-nodes and their connectivity. …”
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Disputed aspects of the reputation management implementation by Vitaliy Shkromyda

“…The recognition of the company and its products, its positive perception among stakeholders are important drivers of sustainable development, which together generate constant sales, provide high margins and strengthen competitive positions in the relevant market. …”
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High-throughput site-directed mutagenesis using oligonucleotides synthesized on DNA chips by Didier Saboulard, Vincent Dugas, Mehdi Jaber, Jérôme Broutin, Eliane Souteyrand, Julien Sylvestre, Marc Delcourt

“…Today's demands for more complete functional cartographies of proteins and advances in selection and screening technologies require that site-directed mutagenesis be adapted for high-throughput applications. …”
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Hardware Obfuscation Based Watermarking Technique for IPR Ownership Identification by Priyanka Bagul, Vandana Inamdar

“…Furthermore, an encrypted functionality is set as the signature generator module for generating owner’s signature. …”
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Partial Cell Fate Transitions to Promote Cardiac Regeneration by Jianchang Yang

“…Heart disease, including myocardial infarction (MI), remains a leading cause of morbidity and mortality worldwide, necessitating the development of more effective regenerative therapies. Direct reprogramming of cardiomyocyte-like cells from resident fibroblasts offers a promising avenue for myocardial regeneration, but its efficiency and consistency in generating functional cardiomyocytes remain limited. …”
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A Finite-Interval Uniqueness Theorem for Bilateral Laplace Transforms by Patrick Chareka

“…Two or more bilateral Laplace transforms with a complex argument “s” may be equal in a finite vertical interval when, in fact, the transforms correspond to different functions. …”
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TestAnaAPP: An interactive R-shiny application for various test analysis methods by Youxiang Jiang, Qing Zeng, Hongbo Wen

“…As demonstrated in this paper, TestAnaAPP empowers researchers and practitioners from diverse fields with an interest in applying psychometric methods to seamlessly perform analyses, access comprehensive data analysis results, generate visualizations, obtain detailed analysis reports, and more.…”
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A new Maxwell-Log logistic distribution and its applications for mortality rate data by Uthumporn Panitanarak, Aliyu Ismail Ishaq, Alfred Adewole Abiodun, Hanita Daud, Ahmad Abubakar Suleiman

“…We discussed some essential properties of the Max-LL distribution, including moments, moment generating function, probability weighted moments, stress-strength, and order statistics. …”
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Ultrahigh-field animal MRI system with advanced technological update by Yaohui Wang, Guyue Zhou, Haoran Chen, Pengfei Wu, Wenhui Yang, Feng Liu, Qiuliang Wang

“…Further research investigation will be performed to promote more scientific outputs with enhanced functional capabilities.…”
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YOLO Network-Based Extraction of Target Geometry From Time-Frequency Representation by Jingyuan Han, Kunyi Guo, Xinqing Sheng

“…Experimental results, including metric functions and data on reconstructed geometric structures, demonstrate good consistency between the extracted and actual geometric parameters, and the trained network model has a good generalization ability for more complicated structural targets. …”
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Penerapan Algoritma Kunang-Kunang pada Open Vehicle Routing Problem (OVRP) by Ihda Septiyafi, Herry Suprajitno, Asri Bekti Pratiwi

“…The results obtained from the program output indicate that the more the number of iterations and the number of fireflies, then the results of the objective function (total mileage) obtained tend to be better so that these parameters affect the value of the objective function. …”
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RESEARCH OF EFFECT OF PLATELET RICH FIBRIN, PRF ON PARADONTOSIS TISSUES REGENERATION DURING THE EXPERIMENT by О. S. Barylo, Т. М. Kanishyna, А.V. Biloshytska

“…The main function of macrophages is absorption and resorption of foreign structures. …”
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Long Term Optimal DG Placement Considering Transmission System Reliability and Load Uncertainty by Ali Badri, Mahdy Norouzi

“…This paper presents an optimization method to determine long term optimal DG placement in distribution systems in which system reliability and operational constraints as well as environmental constraints are taken into account. In order to get more realistic results impact of load uncertainty is modeled using normal distribution function. …”
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Solar Spectrum Simulation Algorithms Considering AM0G and AM1.5G by Junjie Yang, Guoyu Zhang, Bin Zhao, Dongpeng Yang, Ke Zhang, Yu Zhang, Jian Zhang, Zhengwei Ren, Jingrui Sun, Lu Wang, Xiaoxu Mo, Taiyang Ren, Dianwu Ren, Zeng Peng, Songzhou Yang, Jiabo Lv

“…This strategy integrates a multi-objective genetic algorithm to generate training datasets and a neural network for solar spectrum simulation. …”
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