Differences in neuronal ciliation rate and ciliary content revealed by systematic imaging-based analysis of hiPSC-derived models across protocols by Walther Haenseler, Melanie Eschment, Melanie Eschment, Beth Evans, Marta Brasili, Marta Brasili, Joana Figueiro-Silva, Fee Roethlisberger, Fee Roethlisberger, Affef Abidi, Affef Abidi, Darcie Jackson, Martin Müller, Martin Müller, Sally A. Cowley, Ruxandra Bachmann-Gagescu, Ruxandra Bachmann-Gagescu, Ruxandra Bachmann-Gagescu, Ruxandra Bachmann-Gagescu

“…Interestingly, we found that while GPR161 signal almost completely disappeared from cilia upon Sonic hedgehog (SHH) stimulation in NSCs and immature neurons, this was not the case in more mature neurons, suggesting a possible developmental time window for cilia-dependent SHH signaling.ConclusionTaken together, our results provide a systematic description of cilia in hiPSC-derived neuronal cells generated with different protocols, underscoring the importance of selecting the optimal model system and controls for investigating primary cilia in hiPSC-derived neuronal cells.…”
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Energy Recovery Ventilation: What Is Needed to Fill the Research Gaps Related to Its Effects on Exposure to Indoor Bio-Aerosols, Nanoparticulate, and Gaseous Indoor Air Pollution by Yevgen Nazarenko, Chitra Narayanan

“…Filling the research gaps identified herein is urgently needed to alert and inform the industry about how to optimize ERVs to help prevent air pollutant generation and recirculation from these systems and enhance their function of pollutant removal from residential and commercial buildings. …”
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Satellite Altimetry-based Extension of global-scale in situ river discharge Measurements (SAEM) by P. Saemian, O. Elmi, M. Stroud, R. Riggs, B. M. Kitambo, F. Papa, G. H. Allen, M. J. Tourian

“…These water level time series are sourced from both existing Level-3 water level time series and newly generated ones within this study. The Level-3 data are gathered from pre-existing data sets, including Hydroweb.Next (formerly Hydroweb), the Database of Hydrological Time Series of Inland Waters (DAHITI), the Global River Radar Altimetry Time Series (GRRATS), and HydroSat. (3) SAEM's third product is rating curves for the defined VSs, which map water level values into discharge values, derived using a nonparametric stochastic quantile mapping function approach. …”
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Long-Term Management and Monitoring of the Bladder After Spinal Cord Injury in a Rodent Model by Michael Kleindorfer, Elena Esra Keller, Karin Roider, Evelyn Beyerer, Patrick Heimel, David Hercher, Martha Georgina Brandtner, Lukas Lusuardi, Ludwig Aigner, Sophina Bauer

“…To our knowledge, this is the first study that obtained a clinically relevant urodynamic dataset seamlessly from the acute to the chronic phase in rats with SCI. The ability to generate a complete data set from one single individual, rather than requiring multiple subjects, has the potential to markedly reduce the number of experimental animals, eliminate group differences, and give more flexibility for therapeutic intervention. …”
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Perspectives and Experiences With Large Language Models in Health Care: Survey Study by Jennifer Sumner, Yuchen Wang, Si Ying Tan, Emily Hwee Hoon Chew, Alexander Wenjun Yip

“…While 75% (470/624) agreed that the user experience was positive, 46% (294/624) found the generated content unhelpful. Regression analysis showed that the experience with LLMs is more likely to be positive if the user is male (odds ratio [OR] 1.62, CI 1.06-2.48), and increasing age was associated with a reduced likelihood of reporting LLM output as useful (OR 0.98, CI 0.96-0.99). …”
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Lightweight Multi-Head MambaOut with CosTaylorFormer for Hyperspectral Image Classification by Yi Liu, Yanjun Zhang, Jianhong Zhang

“…Following this, one branch employs a linear transformer, CosTaylorFormer, to extract global spectral information. More specifically, we propose CosTaylorFormer with a cosine function, adjusting the weights based on the spectral curve distribution, which is more conducive to establishing long-distance spectral dependencies. …”
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Influence of Rib Cage on Static Characteristics of Scoliotic Spine by Liying Lin, Shaowei Jia, Hufei Yang, Ye Li, Shunxin Zhang, Jie Fan, Li Han

“…Under the common postures, intervertebral discs of scoliotic segments are more susceptible to generate stress concentrations compared with the normal spine. …”
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Downregulation of autophagy is associated with severe ischemia-reperfusion-induced acute kidney injury in overexpressing C-reactive protein mice. by Ao Bian, Mingjun Shi, Brianna Flores, Nancy Gillings, Peng Li, Shirley Xiao Yan, Beth Levine, Changying Xing, Ming Chang Hu

“…C-reactive protein (CRP), was recently reported to be closely associated with poor renal function in patients with acute kidney injury (AKI), but whether CRP is pathogenic or a mere biomarker in AKI remains largely unclear. …”
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Least Absolute Value-Based Temperature-Dependent Robust State Estimation by Yohan Park, Jeuk Kang, Gyeong-Hun Kim, Yun-Su Kim

“…Inaccuracies in both measurements and parameter determination can generate biased results in state estimation. The change in branch temperature precipitates fluctuations in resistance and branch flow measurements. …”
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CAR-T cells and TRUCKs that recognize an EBNA-3C-derived epitope presented on HLA-B*35 control Epstein-Barr virus-associated lymphoproliferation by Michael Hudecek, Anna Christina Dragon, Katharina Zimmermann, Thomas Nerreter, Deborah Sandfort, Julia Lahrberg, Stephan Klöß, Christina Kloth, Caroline Mangare, Agnes Bonifacius, Sabine Tischer-Zimmermann, Rainer Blasczyk, Britta Maecker-Kolhoff, Barbara Uchanska-Ziegler, Hinrich Abken, Axel Schambach, Britta Eiz-Vesper

“…In order to attract additional immune cells to proximity of PTLD cells, based on the TÜ165 CAR, we moreover generated T cells redirected for universal cytokine-mediated killing (TRUCKs), which induce interleukin (IL)-12 release on target contact.Methods TÜ165-based CAR-T cells (CAR-Ts) and TRUCKs with inducible IL-12 expression in an all-in-one construct were generated. …”
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Enhanced Hybrid Artificial Fish Swarm Algorithm for Three-Dimensional Path Planning Applied to Robotic Systems by Ilias Chouridis, Gabriel Mansour, Vasileios Papageorgiou, Michel Theodor Mansour, Apostolos Tsagaris

“…The improved AFSA incorporates a 3D model of 24 possible movement points to more realistically simulate real-world robot movement capabilities. …”
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MAPPING RAYLEIGH WAVE GROUP VELOCITIES FROM AMBIENT NOISE IN THE WAY RATAI GEOTHERMAL FIELD USING PIGRAF SEISMOGRAPH PROTOTYPES by Karyanto Karyanto, Haidar Prida Mazzaluna, I Gede Boy Darmawan, Rahmat Catur Wibowo, Ahmad Zaenudin, Maman Hermana

“…However, the clarity of the cross-correlogram of the Green’s function group was identified as a topic for further investigation, suggesting adding more stations and longer measurement times.…”
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Cdkn1c Boosts the Development of Brown Adipose Tissue in a Murine Model of Silver Russell Syndrome. by Matthew Van De Pette, Simon J Tunster, Grainne I McNamara, Tatyana Shelkovnikova, Steven Millership, Lindsay Benson, Stuart Peirson, Mark Christian, Antonio Vidal-Puig, Rosalind M John

“…Conversely, loss-of-function of Cdkn1c resulted in the complete developmental failure of the brown adipocyte lineage with a loss of markers of both brown adipose fate and function. …”
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Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations. by Katherine R Bull, Andrew J Rimmer, Owen M Siggs, Lisa A Miosge, Carla M Roots, Anselm Enders, Edward M Bertram, Tanya L Crockford, Belinda Whittle, Paul K Potter, Michelle M Simon, Ann-Marie Mallon, Steve D M Brown, Bruce Beutler, Christopher C Goodnow, Gerton Lunter, Richard J Cornall

“…Forward genetics screens with N-ethyl-N-nitrosourea (ENU) provide a powerful way to illuminate gene function and generate mouse models of human disease; however, the identification of causative mutations remains a limiting step. …”
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External debt-growth nexus: Empirical evidence from Ethiopian economy by Wondatir Atinafu

“…Hence, this study recommended the government of Ethiopia and local policy makers to improve the existing policies on public external debt management such as to invest in productive activities and sectors, to implement structural change, public sector reform and tax reform, should try to minimize the dependence on external borrowing through diversifying the economy so as to generate more revenue in the domestic.…”
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Policy Options for Contributory Health Insurance Schemes in Low and Lower-Middle Income Countries to Enable Progress Towards Universal Health Coverage by Agnes Gatome-Munyua, Joseph Kutzin, Cheryl Cashin

“…The promise of contributory health insurance to generate additional, self-sustaining funding for the health sector has not been achieved in many low- and lower-middle-income countries. …”
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Femtosecond laser ablation of nitrocellulose for spatio-temporal flow control in µPADs by Esteban Builes Münden, Andreas Dietzel

“…Microfluidic paper-based analytical devices (μPADs) are gaining popularity due to their low cost and ease of use, but controlling fluid flow for more complex biochemical assays within these devices remains challenging. …”
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DIAGNOSTIC COMPLEX FOR IDENTIFING FAULTS OF MODERN CARS ENGINES by G. G. Musayelyants, E. A. Pavlenko, D. K. Sysoyev

“…Diagnostic practice shows that every year in order to improve environmental safety becomes more complicated engine design and its systems, and in particular the electronic control systems. …”
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Genome-wide association studies are enriched for interacting genes by Peter T. Nguyen, Simon G. Coetzee, Irina Silacheva, Dennis J. Hazelett

“…Results We used genetic algorithms to measure fitness of gene-cell set proposals against a series of objective functions that capture data and annotations. The highest information objective function captured protein-protein interactions. …”
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Computational approach in obtaining analytic solutions of a generalized nonlinear breaking soliton equation with applications in engineering and physics by Oke Davies Adeyemo, Chaudry Masood Khalique

“…Moreover, in conjunction with the theory, the direct integration technique is engaged to secure an analytic solution of the equation and as a result, a general analytic solution with regard to the second-kind elliptic-integral function is furnished. Moreover, we engage the novel simplest equation technique to gain more general solutions to the equation. …”
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