Preclinical Positron Emission Tomographic Imaging of Acute Hyperoxia Therapy of Chronic Hypoxia during Pregnancy by Alexander Zheleznyak, Joel R. Garbow, Michal Neeman, Suzanne E. Lapi

“…Herein we report first-in-mouse PET imaging of fetuses employing both tracers [ 18 F]FDG (metabolism) and 64 Cu-ATSM (hypoxia). [ 18 F]FDG PET/CT imaging allowed clear visualization of placental-fetal structures and supported quantification of tracer uptake, making this a sensitive tool for monitoring placental function in preclinical rodent models. These measurements illustrate the potentially irreversible damage generated by chronic exposure to hypoxia, which cannot be corrected by acute exposure to hyperoxia.…”
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Designing a Multistage Supply Chain in Cross-Stage Reverse Logistics Environments: Application of Particle Swarm Optimization Algorithms by Tzu-An Chiang, Z. H. Che, Zhihua Cui

“…Regarding system execution time, the GA consumed more time than the other three PSOs did. Regarding objective function value, the GA, PSOA_IWM, and PSOA_CFM could obtain a lower convergence value than PSOA_VMM could. …”
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Sharing and Specificity of Co-expression Networks across 35 Human Tissues. by Emma Pierson, GTEx Consortium, Daphne Koller, Alexis Battle, Sara Mostafavi, Kristin G Ardlie, Gad Getz, Fred A Wright, Manolis Kellis, Simona Volpi, Emmanouil T Dermitzakis

“…To understand the regulation of tissue-specific gene expression, the GTEx Consortium generated RNA-seq expression data for more than thirty distinct human tissues. …”
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Mechanical Behavior and Energy Evolution of Sandstone considering Slenderness Ratio Effect by Bibo Dai, Xingdong Zhao, Shuwen Zhang, Qian Kang, Zhonghua Zhu

“…When the slenderness ratio, D, is lower than 1.5, complex failures and multiple shear planes are formed, while simple failures and single shear planes are generated at D larger than 1.5. Besides, the AE ringing counts are more obvious with a higher slenderness ratio, D, at the initial compression stage due to the greater body volume and more defects in the sandstone. …”
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A 3D Most Vulnerable Path Search Method for Physical Protection Systems Based on the EASI Model by Aiguo Li, Yanfeng Deng

“…The search efficiency is improved by restricting the intermediate points and the angle between the start and target points and improving the heuristic function. The improved algorithms are simulated and compared, and the results show that the paths generated by the improved algorithms are more reasonable, and the algorithms consume less time and have shorter path lengths.…”
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Systematic Analysis and Modelling of Profit Maximization on Carsharing by Giulio Giorgione, Dzmitry Kliazovich, Luca Bolzani, Francesco Ciari, Francesco Viti

“…Using agent-based modeling to generate realistic scenarios, we analyze pricing as a function of the potential demand (i.e., number of members) and supply (hours of booking supplied). …”
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Coordinated Multimodal Transportation Infrastructure Planning in Megacities: An Agent-AI-Discrete Network Design Problem Approach Based on Chat-GPT by Jin Guo, Chenyang Wang, Linxiu Wang

“…AA-DNDP extends the traditional DNDP by incorporating mode-choice functionality. In each simulation iteration, the Agent-AI calls Chat-GPT via API, using the attributes of the origin and destination as prompts to generate a mode choice. …”
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The genomic landscape of compensatory evolution. by Béla Szamecz, Gábor Boross, Dorottya Kalapis, Károly Kovács, Gergely Fekete, Zoltán Farkas, Viktória Lázár, Mónika Hrtyan, Patrick Kemmeren, Marian J A Groot Koerkamp, Edit Rutkai, Frank C P Holstege, Balázs Papp, Csaba Pál

“…However, as deleterious mutations are common in natural populations, they generate a strong selection pressure to mitigate their detrimental effects through compensatory genetic changes. …”
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Investigating the Impact of Mental Stress on Electrocardiological Signals through the Use of Virtual Reality by Penio Lebamovski, Evgeniya Gospodinova

“…The results show that the application of immersive VR generates higher mental stress levels than non-immersive VR, but in both cases, HRV changes (decreases), but more significantly in immersive VR. …”
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Neutrosophic Wald Distribution with Applications to Reliability Analysis by Afrah Al Bossly, Adnan Amin

“…To make it even more applicable, we propose an approach to generate random samples from neutrosophic Wald distribution using quantile function so that neutrosophic Wald distribution can be simulated and empirically validated. …”
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FADA-SMOTE-Ms: Fuzzy Adaptative Smote-Based Methods by Roudani Mohammed, El Moutaouakil Karim

“…In this regard, the <inline-formula> <tex-math notation="LaTeX">$\alpha $ </tex-math></inline-formula>-SMOTE is chosen in such a way that the synthetic data is as far as possible from the two closest majority data. More precisely, this method processes into six steps: (a) clustering minority class into <italic>k</italic> groups (b) selecting a safe region (c) selecting random two minority data, (d) finding the M closest majority data to these minority data using original membership functions based on Fuzzy mean and flirting results, (e) finding the <inline-formula> <tex-math notation="LaTeX">$\alpha $ </tex-math></inline-formula>-SMOTE producing a synthetic data as close as possible to the minority class and as far as possible from the M majority data by solving a very simple multi-objective mathematical optimization model, and (f) using SMOTE to generate synthetic samples using optimal <inline-formula> <tex-math notation="LaTeX">$\alpha $ </tex-math></inline-formula>-SMOTE. …”
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Tremor and its duration‐amplitude distribution at Popocatépetl volcano, Mexico by R. Arámbula‐Mendoza, C. Valdés‐González, N. Varley, T. A. Reyes‐Pimentel, B. Juárez‐García

“…Abstract The duration‐amplitude distribution was calculated for the tremor observed at Popocatépetl volcano during episodes of activity in 2000 and 2012–2014. An exponential function was used to obtain a good fit for the duration‐amplitude distribution, and the source of volcanic tremor is probably generated by the transportation of magmatic fluids and its coupling with the host rock within the volcanic conduit. …”
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Sensing the Cultural Significance with AI for Social Inclusion by Nan Bai

“…This thesis explores the use of AI in a methodological framework to include the contribution of a larger and more diverse group of participants with user-generated data. …”
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Identification of Ecological Security Pattern and Ecological Restoration Zoning Strategy in the Shandong Section of the Beijing-Hangzhou Grand Canal by Chizhou Xu, Yande Jing, Yiwen Zhang, Yingchun Liu, Wenyang Yin, Shiping Zhao

“…Additionally, 40 ecological corridors, 48 ecological pinch points, and 75 ecological barrier points were generated, densely distributed in the east. The area was divided into five core functional zones. (4) Conclusions: Establishing ecological function zones and considering landscape changes from high-frequency human activities in spatial planning can lead to a more reasonable division of ecological restoration areas. …”
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TRF1 and TRF2 form distinct shelterin subcomplexes at telomeres by Tomáš Janovič, Gloria I. Perez, Greta Boelting, Jens C. Schmidt

“…To quantitatively analyze shelterin function, we generated a panel of human cancer cell lines expressing HaloTagged shelterin proteins from their endogenous loci. …”
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Knockdown of Hsc70-5/mortalin induces loss of synaptic mitochondria in a Drosophila Parkinson's disease model. by Jun-Yi Zhu, Natalia Vereshchagina, Vrinda Sreekumar, Lena F Burbulla, Ana C Costa, Katharina J Daub, Dirk Woitalla, L Miguel Martins, Rejko Krüger, Tobias M Rasse

“…We generated the first loss-of-Hsc70-5/mortalin-function Drosophila model. …”
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Multipotent Mesenchymal Stem Cell Treatment for Discogenic Low Back Pain and Disc Degeneration by Jeffrey Zeckser, Michael Wolff, Jason Tucker, Josh Goodwin

“…Low back pain with resultant loss of function, decreased productivity, and high economic costs is burdensome for both the individual and the society. …”
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ROLE OF FLUID ON THE CONTACT DEFORMATION RESPONSE OF BIOLOGICAL TISSUE by Michael V. Swain

“…All natural biological materials contain fluid and function in a fluidic environment, which plays a critical role in responding to loading events as well as tissue nutrition. …”
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A Historical Approach to the Mirror Neuron System by Palacios-Sánchez, Leonardo, Botía, Inés, Palacios-Espinosa, Ximena

“…The initial enthusiasm manifested with the discovery of MN has been progressively nuanced, giving rise to a functional, neuroscientific perspective that requires more evidence on its therapeutic utility and applicability in areas of knowledge beyond health sciences.…”
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The vascular endothelium as decision maker in lung injury by Diana Klein

“…The vascular endothelium is the largest organ in the human body, capable of performing a wide range of cellular signaling and synthetic functions. It is also subjected to considerable mechanical stress due to the shear forces generated by blood flow, which amounts to approximately 10,000 L per day. …”
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