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5341
A reappraisal of cell cycle phase enrichment in synchronized estrogen receptor-positive cell models derived from breast adenocarcinomas
Published 2025-02-01“…Abstract 17β-estradiol (E2), the main circulating estrogen hormone, is a critical signaling factor for the growth, differentiation, and function of breast epithelial cells. The effects of E2 on the breast tissue are primarily mediated by the estrogen receptor α (ERα). …”
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5342
Hepatocyte Rho-associated kinase signaling is required for mice to survive experimental porphyria-associated liver injury
Published 2025-02-01“…Rho-associated kinases 1 and 2 (ROCK1 and ROCK2) regulate critical cell functions, including actomyosin contractility, apoptosis, and proliferation. …”
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5343
Blurring the lines: an empirical examination of the interrelationships among acceptability, appropriateness, and feasibility
Published 2024-12-01“…Further, in the interest of reducing research waste, more research is needed to determine if the outcomes could serve as proxies for each other.…”
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5344
Non-parathyroid hypercalcemia in a patient with new-onset hyperthyroidism and silicone-induced granulomas: case report
Published 2025-01-01“…Rarer causes of hypercalcemia, such as hyperthyroidism and granulomatous diseases, need to be addressed after excluding the more prevalent etiologies, namely primary hyperparathyroidism and malignancies. …”
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5345
Advances in Natural-Product-Based Fluorescent Agents and Synthetic Analogues for Analytical and Biomedical Applications
Published 2024-12-01“…Naturally derived fluorescent compounds are generally more biocompatible and environmentally friendly. …”
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5346
AITP-YOLO: improved tomato ripeness detection model based on multiple strategies
Published 2025-05-01“…Secondly, a multi-scale feature fusion technique employing cross-level features is implemented in the feature fusion layer to amalgamate convolutions of varying sizes, enhancing the model's fusion capacity and generalization proficiency for features of diverse scales. …”
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5347
Valorization of Andean Native Potatoes Through Chuño Processing: Effects of Potato Variety and Freezing Temperature on Physicochemical, Bioactive, Nutritional, and Technological Pr...
Published 2025-05-01“…Color differences were also noted, with P presenting reddish tones and a higher luminosity, whereas C had a more intense yellow hue linked to carotenoids. In general, −10 °C and −20 °C better preserved antioxidant compounds than −30 °C. …”
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5348
Novelle approach to simulating spinal cord stimulation during tSCS using CT images and FEM
Published 2024-12-01“…Later versions of FEM models incorporated more organs and had improved on previous mesh generation flaws, but encountered new mesh generation errors which could not be rectified before the conclusion of the master’s project. …”
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5349
A statistical framework for modelling migration corridors
Published 2022-11-01“…We tested the ability of the approach to recover parameters used to generate simulated movements. We then used GPS data from three migrating mule deer Odocoileus hemionus herds in Idaho and Wyoming to model corridors as a function of elevation, slope, aspect, percent shrub, date of peak green‐up, snow‐off date and human footprint. …”
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5350
HyQ2: A Hybrid Quantum Neural Network for NextG Vulnerability Detection
Published 2024-01-01“…As fifth-generation (5G) and next-generation communication systems advance and find widespread application in critical infrastructures, the importance of vulnerability detection becomes increasingly critical. …”
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5351
A Normative Model Representing Autistic Individuals Amidst Autism Spectrum Phenotypic Heterogeneity
Published 2024-12-01“…PCA-projected dimensions supported normative modeling where a multivariate normal distribution was used to calculate percentiles. A Multidimensional General Functionality Score (MGFS) to evaluate new prospective single subjects was developed based on percentiles. …”
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5352
The Ukrainian Pryazovye: composition, uniqueness, variability of the recreational development
Published 2022-06-01“…So, the reassessment of the eco-health-improvement and tourist meaning of the Ukrainian Pryazovye, the "reflashing" of the strategy of its further development against this background becomes more than obvious. This topicality is reinforced with the analysis of the significant array of the publications from the subject-object essence of the research, which expands and deepens the theory of resource-recreational scientific and practical direction (the number of the new concepts has been introduced), emphasizes the anthropocentric character of recreational geography, gives 5 hypothetical scenarios of the development of recreational and tourist branch in the regional and the national format on the operational perspective and contains generalizing cartographic models of the development of the regional environmental and recreational and tourist function. …”
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5353
Therapeutic effect of cardiac rehabilitation on patients with long COVID combined with coronary heart disease: a retrospective study
Published 2025-07-01“…Comparison of differences between the two groups before and after treatment revealed that the CHD group had significantly worse cardiovascular measurements after SARS-CoV-2 infection than the non-CHD group.ConclusionPatients with long COVID combined with CHD have more severe symptoms, especially for their cardiac function. …”
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5354
Visual integration deficits associated with psychosis are independent of diagnosis
Published 2025-04-01“…The findings indicate that contour integration deficits are not specific to schizophrenia spectrum disorders, and instead the neurobiological underpinnings of visual integration impairment may share commonality with psychosis more generally. The findings are also consistent with cognitive factors playing a potential role in JOVI performance and highlight the difficulty in teasing apart altered perceptual and cognitive function in psychiatric patient groups.…”
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5355
Insights into the interplay among zinc, biological aging, fasting, energy intake, and inflammation: A cross-sectional analysis using 2015-2018 NHANES participants
Published 2025-06-01“…Introduction: Although it is documented that zinc plays an essential role in immune function, little is known about its relationship to factors that influence biological aging. …”
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5356
Unveiling the third dimension of glass
Published 2019-11-01“…At present, the load-bearing function of cast glass in architecture remains an uncharted field. …”
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5357
Secondary metabolite compounds of Moringa oleifera leaves in two different urban altitude locations, Indonesia
Published 2023-12-01“…Moringa plants from the Moringa oleifera species are widely cultivated and used by residents in tropical regions, including Indonesia. Indonesians generally in rural areas use this plant as food and traditional medicine. …”
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5358
Procalcitonin-guided initiation of antibiotics in AECOPD inpatients: study protocol for a multicenter randomised controlled trial
Published 2021-08-01“…Introduction Current antibiotic prescription for acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is generally based on the Anthonisen criteria in The Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) guideline that have a potential risk of antibiotics overuse. …”
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5359
Dynamically Cyclic Fe2+/Fe3+ Active Sites as Electron and Proton-Feeding Centers Boosting CO2 Photoreduction Powered by Benzyl Alcohol Oxidation
Published 2025-01-01“…In situ Raman and ultraviolet-visible diffuse reflectance spectra revealed that the dynamic Fe2+/Fe3+ redox loop within the Fc unit serves as the actual active site, facilitating the activation of substrate molecules. More importantly, in situ attenuated total reflection Fourier transform infrared spectroscopy and gas chromatography–mass spectrometry spectroscopy, with isotope labeling of Deuteron-benzyl alcohol and 13CO2, confirmed that proton transfer from the hydroxyl group generates reactive protons at the Fe2+/Fe3+ site, enabling efficient CO2 photoreduction through subsequent protonation steps. …”
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5360
Encuesta Nacional de Tendencias de Fitness en España para 2018 (National Survey of Fitness Trends in Spain for 2018)
Published 2018-01-01“…The more relevant trends in the Spanish context are "educated, certified and experienced fitness professionals", "functional training", "exercise and weight loss", "high intensity intervallic training", "personal training" and “body weight training”. …”
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