Evaluation of the clinical and cost effectiveness of intermediate care clinics for diabetes (ICCD): a multicentre cluster randomised controlled trial. by Andrew Wilson, Joseph Paul O'Hare, Ainsley Hardy, Neil Raymond, Ala Szczepura, Ric Crossman, Darrin Baines, Kamlesh Khunti, Sudhesh Kumar, Ponnusamy Saravanan, ICCD trial group

“…Community based, intermediate care clinics for diabetes (ICCDs) were considered one solution and are functioning across the UK. However, there is no randomised trial evidence for the effectiveness of such clinics.…”
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Gegen-Sangshen oral liquid and its active fractions mitigate alcoholic liver disease in mice through repairing intestinal epithelial injury and regulating gut microbiota by Shulin Wei, Mingxing Li, Long Zhao, Tiangang Wang, Ke Wu, Jiayue Yang, Yubin Liu, Yueshui Zhao, Fukuan Du, Yu Chen, Shuai Deng, Jing Shen, Zhangang Xiao, Wanping Li, Xiaobing Li, Yuhong Sun, Li Gu, Mei Wei, Zhi Li, Xu Wu

“…Notably, LGS, LGSP, and LGSF mitigated intestinal damage and maintained barrier function in ALD mice. The intestinal barrier protection function of LGS, LGSP, and LGSF was generally more obvious than that of the positive drug meltadosine. …”
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Social Networks Link Prediction Based on Incremental Learning by Jian SHU, Zhichen CHEN

“…An incremental update strategy is designed for each network layer to generate updated random walk sequences, employing a temporal random walk approach. …”
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Predictive Validity of Hospital-Associated Complications of Older People Identified Using Diagnosis Procedure Combination Data From an Acute Care Hospital in Japan: Observational S... by Seigo Mitsutake, Tatsuro Ishizaki, Shohei Yano, Takumi Hirata, Kae Ito, Ko Furuta, Yoshitomo Shimazaki, Hideki Ito, Alison Mudge, Kenji Toba

“… BackgroundA composite outcome of hospital-associated complications of older people (HAC-OP; comprising functional decline, delirium, incontinence, falls, and pressure injuries) has been proposed as an outcome measure reflecting quality of acute hospital care. …”
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Increasing the capacity of electric grids based on the integration of meteorological data by M. Ya. Kletsel, E. V. Petrova, S. S. Girshin, V. A. Krivolapov, V. N. Goryunov, V. M. Trotsenko

“…The efficient and sustainable functioning of energy systems is a critical element for supplying of electricity necessary to maintain the vital functions of modern society. …”
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Comparative transcriptomic and proteomic analyses of hypoxia response in wild and cultivated tomato roots by Zhihan Zhang, Yabing Hou, Hao Yin, Song Lu, Daliang Liu, Lin Cheng, Houlin Yu, Tao Li, Yiyong Zhao

“…By analyzing the gene and protein networks of FZZ and T178 under hypoxic conditions, we inferred that T178 enhances hypoxia adaptation by forming more independent small modules and multilevel regulatory networks, whereas FZZ relies on a few large modules with limited functional diversity, resulting in weaker hypoxia tolerance. …”
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Spatial Analysis of the Relationship between Ecological Factors and Housing Prices in Tehran by Atefeh Kolyaei, Tahir Prizadi, Habibollah Fasihi

“…Conversely, the indicators of elevation, average annual precipitation, slope, and number of days with clean air exhibited a positive correlation with housing prices. Generally, properties with higher exchange values were situated at greater elevations, received more annual rainfall, and had more favorable slope characteristics and a higher number of clean air days per year. …”
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Lysosomal NKG7 restrains mTORC1 activity to promote CD8+ T cell durability and tumor control by Hyoungjun Ham, Jacob B. Hirdler, Daniel T. Bihnam, Zhiming Mao, Joanina K. Gicobi, Bruna Gois Macedo, Maria F. Rodriguez-Quevedo, Destiny F. Schultz, Cristina Correia, Jun Zhong, Kodi E. Martinez, Alma Banuelos, Dallin S. Ashton, Anthony B. Lagnado, Ruifeng Guo, Rodrigo Pessoa, Akhilesh Pandey, Hu Li, Fabrice Lucien, Henrique Borges da Silva, Haidong Dong, Daniel D. Billadeau

“…Human and mouse CD8+ T cells lacking NKG7 show more acidic lysosomes and increased activation of mTORC1 signaling, which could be reversed by inhibition of v-ATPase activity. …”
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Flavones enrich rhizosphere Pseudomonas to enhance nitrogen utilization and secondary root growth in Populus by Jiadong Wu, Sijia Liu, Haoyu Zhang, Sisi Chen, Jingna Si, Lin Liu, Yue Wang, Shuxian Tan, Yuxin Du, Zhelun Jin, Jianbo Xie, Deqiang Zhang

“…Abstract Plant growth behavior is a function of genetic network architecture. The importance of root microbiome variation driving plant functional traits is increasingly recognized, but the genetic mechanisms governing this variation are less studied. …”
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Single-cell atlas reveals multi-faced responses of losartan on tubular mitochondria in diabetic kidney disease by Zhen Zhu, Guangxin Luan, Song Wu, Yiyi Song, Shuang Shen, Kaiyue Wu, Shengnan Qian, Weiping Jia, Jun Yin, Tao Ren, Jianping Ye, Li Wei

“…To reveal the effects of losartan on gene function and pathway changes in renal tubular mitochondria, Gene Ontology (GO) enrichment analysis and GSEA/GSVA scoring were performed to analyze the specific response of proximal tubular (PT) cell mitochondria to losartan treatment, including key events in mitochondrial homeostasis such as mitochondrial morphology, dynamics, mitophagy, autophagic flux, mitochondrial respiratory chain, apoptosis, and ROS generation. …”
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Optimization of the treatment of patients with severe chronic urticaria by Ye.M. Dytiatkovska, N.O. Nedohybchenko

“…According to our data, patients with SCU are mostly people of working age, more than half of whom have a history of the disease for five years or more, in 70% of cases of a valid study, they are characterized by an increased content of total IgE and have a low level of indicators according to the questionnaire SKINDEX-29 at the level of physical symptoms, emotional sphere and functioning. …”
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Proteogenomic annotation of T6SS components identified in Bacteroides fragilis secretome by Natalya B. Zakharzhevskaya, Olga Yu Shagaleeva, Daria A. Kashatnikova, Daria A. Kashatnikova, Anton O. Goncharov, Anton O. Goncharov, Daria V. Evsyutina, Dmitry A. Kardonsky, Elizaveta A. Vorobeva, Artemiy S. Silantiev, Viktoria D. Kazakova, Irina V. Kolesnikova, Ivan O. Butenko, Anna A. Vanyushkina, Svetlana V. Smirnova, Andrei V. Chaplin, Andrei V. Chaplin, Boris A. Efimov, Boris A. Efimov

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Transcriptomic and proteomic analysis reveals wall-associated and glucan-degrading proteins with potential roles in Phytophthora infestans sexual spore development. by Xiaofan Niu, Audrey M V Ah-Fong, Lilianna A Lopez, Howard S Judelson

“…Despite being dormant, oospores contained a mostly normal complement of proteins required for core cellular functions. The RNA-seq data generated here and in prior studies were used to identify new housekeeping controls for gene expression studies that are more stable than existing normalization standards. …”
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Studies оf Geographical Features оf the Stavropol Krai By V.G. Gnilovskoy by A. A. Likhovid, A. O. Berberyan

“…The paper uses a comparative historical method and a system-functional analysis of the material using a problem-chronological approach. …”
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Developments in Legal Education: Beyond the Primary School Model by William Twining

“…In this paper I propose to adopt a broader perspective in two respects: I shall look at some general trends and issues in the Commonwealth, that vast and amorphous network of countries that are loosely linked together by a shared imperial past, by the common law, and perhaps most important in the long run, by the English language: I shall interpret legal education more broody to include not only specialized education and vocational training in university, polytechnic and independent professional training schools, but also a whole range of activities from law in schools to continuing education of the judiciary at all levels; from formation of paraprofessionals to the development and retraining of specialists; and the vast but relatively neglected subject of legal education for non-lawyers, which ranges far beyond mis-named “service” teaching of law for businessmen, accountants , social workers and the police to include activities aimed at raising the consciousness of and providing practical tools for grass-roots activists, trade unionists and ordinary citizens to help them to understand and use and cope with law as it affects them in their daily lives and work. …”
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KIF13B C.*3163G>A SINGLE NUCLEOTIDE VARIANT ON OROPHARYNGEAL SQUAMOUS CELL CARCINOMA SUSCEPTIBILITY AND TUMOR CHARACTERISTICS by Ericka Francislaine Dias Costa, Gustavo Jacob Lourenço, Carmen Silvia Passos Lima

“…The let-7e-3p miRNA exhibited more efficient binding to the 3’-UTR of the ancestral G allele compared to the variant A allele in the FaDu (p = 0.004) and Detroit 562 (p = 0.04) cell lines. …”
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Skeletal muscle reprogramming enhances reinnervation after peripheral nerve injury by Pihu Mehrotra, James Jablonski, John Toftegaard, Yali Zhang, Shahryar Shahini, Jianmin Wang, Carey W. Hung, Reilly Ellis, Gabriella Kayal, Nika Rajabian, Song Liu, Kelly C. S. Roballo, Susan B. Udin, Stelios T. Andreadis, Kirkwood E. Personius

“…Abstract Peripheral Nerve Injuries (PNI) affect more than 20 million Americans and severely impact quality of life by causing long-term disability. …”
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Trustworthy Analytics in ETSI ZSM: A 5G Security Case Study by Panagiotis Radoglou-Grammatikis, Efklidis Katsaros, Evangelos Syrmos, Georgios P. Katsikas, Dimitrios Klonidis, Vasileios Argyriou, Thomas Lagkas, Panagiotis Sarigiannidis

“…For this purpose, we take into account a particular case study which focuses on the orchestration of security services within the 5G core. More specifically, the deployment of a new User Plane Function (UPF) equipped with intrusion detection services that leverage Artificial Intelligence (AI) is investigated. …”
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Quantitative SISCOM assessment for epileptogenic zone localization: insights from a multicenter study comparing two software platforms in temporal lobe epilepsy by Carla Oliveira Young, Brunno Machado de Campos, Edna Marina de Souza, Sergio Querino Brunetto, Maria Julia de Oliveira Santos Gualberto, Leonardo Alexandre-Santos, Marcos Geraldo Merichelo de Oliveira, Marina Koutsodontis Machado Alvim, Fernando Cendes, Elba Etchebehere, Lauro Wichert-Ana, Bárbara Juarez Amorim

“…Both SPM and Analyze were concordant with the EZ reference standard in 14 cases (70%), showing no difference in sensitivity between the methods. However, SPM generated smaller, more localized clusters, while Analyze produced larger clusters with broader spatial coverage. …”
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HpFBH3 transactivates HpCO7 via binding to the E-boxes in the promoter and may accelerate flower formation in pitaya by Xiaowei Cai, Ling Xiao, Xiangmei Nie, Qiandong Hou, Sulin Wen, Kun Yang, Xiaopeng Wen

“…In practice, accelerating flower formation and inducing more flowers usually result in higher yield. However, the genes for this purpose have not been well characterized in pitaya. …”
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