Blood pressure change and hypertension incidence among Ghanaians living in rural Ghana, urban Ghana and The Netherlands: a prospective cohort studyResearch in context by Eva L. van der Linden, Marieke Hoevenaar-Blom, Erik Beune, Samuel Nkansah Darko, Sampson Twumasi Ankrah, Karlijn A.C. Meeks, Felix Chilunga, Charles Hayfron-Benjamin, Peter Henneman, Bert-Jan van den Born, Ellis Owusu Dabo, Charles Agyemang

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Sirtuin 4 accelerates heart failure development by enhancing reactive oxygen species-mediated profibrotic transcriptional signaling by Nikole J. Byrne, Christoph Koentges, Elisabeth Khan, Katharina Pfeil, Robert Sandulescu, Sayan Bakshi, Carolin Költgen, Ivan Vosko, Johannes Gollmer, Thomas Rathner, Günter Roth, Michael M. Hoffmann, Katja E. Odening, Hauke Horstmann, Luke A. Potter, Christoph Bode, Dennis Wolf, Harald Sourij, Senka Ljubojevic-Holzer, Markus Wallner, Peter P. Rainer, Simon Sedej, Daniel Scherr, Dirk von Lewinski, Adam R. Wende, Andreas Zirlik, Heiko Bugger

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Spinal muscular atrophy is also a disorder of spermatogenesis by Armelle Magot, Arnaud Reignier, Olivier Binois, Anne Laure Bedat-Millet, Jean-Baptiste Davion, Louise Debergé, Karima Ghorab, Lucie Guyant, Émilie Laheranne, Pascal Laforet, Claire Lefeuvre, Martial Mallaret, Maud Michaud, Chahla Omar, Aleksandra Nadaj-Pakleza, Guillaume Nicolas, Jean Baptiste Noury, Antoine Pegat, Morgane Péré, Emmanuelle Salort-Campana, Guilhem Sole, Marco Spinazzi, Céline Tard, Carole Vuillerot, Yann Péréon

“…The Motor Function Measure (MFM) determined that the sperm counts were also correlated with disease severity (p < 0·01). …”
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Unique target binding by the C-terminal region of FHR1 provides a new perception of aHUS pathology by Luce Perie, Selina Stippa, Christoph Saffer, Christoph Saffer, Andrea Hartmann, Mathias Mörgelin, Svante L. H. Zipfel, Marc Thilo Figge, Marc Thilo Figge, Thorsten Wiech, Christine Skerka, Peter F. Zipfel, Peter F. Zipfel

“…By contrast, SCR5, the most C-terminal domain, was more relevant for C3b/C3d contact. Notably, wild-type FHR1LA selected C3d, while pathogenic aHUS-associated alterations FHR1SV selected C3b. …”
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RNA interference of Aspergillus flavus in response to Aspergillus flavus partitivirus 1 infection by Yinhui Jiang, Yinhui Jiang, Xiang Liu, Xiang Liu, Xun Tian, Xun Tian, Jianhong Zhou, Jianhong Zhou, Qinrong Wang, Qinrong Wang, Bi Wang, Bi Wang, Wenfeng Yu, Wenfeng Yu, Yanping Jiang, Tom Hsiang, Xiaolan Qi, Xiaolan Qi

“…The mutants of DCLs and AGOs infected by AfPV1 displayed more changes than RDRP mutants in response to the first three stresses. …”
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Hospitalizations in adolescents with anorexia nervosa in Spain over two decades by Vicente Soriano, José Manuel Ramos, Manuel Faraco, Lucía Gallego, María Inés López-Ibor, Carlos Chiclana-Actis, Eduardo González-Fraile, Gemma Mestre-Bach, Héctor Pinargote, Manuel Corpas, Octavio Corral, Hilario Blasco-Fontecilla

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Clinical and instrumental characteristics of osteoarthritis in hyperuricemia by E. A. Taskina, A. M. Lila, L. I. Alekseeva, N. G. Kashevarova, K. M. Mikhailov, A. R. Halmetova, E. A. Strebkova, E. P. Sharapova, N. M. Savushkina, D. M. Kudinskiy, T. A. Raskina, I. B. Vinogradova

“…Statistically significant differences were also found in the assessment of the severity of OA course: there were higher pain indices according to VAS, WOMAC total score and its components (pain and functional impairment, FI), GHA in the HU group. On MRI, osteitis was more common in the medial aspect of the tibia (odds ratio 5.75; 95% confidence interval 1.29–25.6; p=0.03). …”
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DCLTV: An Improved Dual-Condition Diffusion Model for Laser-Visible Image Translation by Xiaoyu Zhang, Laixian Zhang, Huichao Guo, Haijing Zheng, Houpeng Sun, Yingchun Li, Rong Li, Chenglong Luan, Xiaoyun Tong

“…In recent studies, diffusion models have demonstrated superior image generation and translation abilities and been shown to be capable of generating high-quality images. …”
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A glyco-engineering approach for site-specific conjugation to Fab glycans by Maria L. Jaramillo, Traian Sulea, Yves Durocher, Mauro Acchione, Melissa J. Schur, Anna Robotham, John F. Kelly, Marie-France Goneau, Alma Robert, Yuneivy Cepero-Donates, Michel Gilbert

“…In conventional ADCs, the drug molecules are chemically attached randomly to antibody surface residues (typically Lys or Cys), which can interfere with epitope binding and targeting, and lead to overall product heterogeneity, long-term colloidal instability and unfavorable pharmacokinetics. Here, we present a more controlled process for generating ADCs where drug is specifically conjugated to only Fab N-linked glycans in a narrow ratio range through functionalized sialic acids. …”
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Hyaluronic Acid Interactions with Pork Myofibrillar Proteins in Emulsion Gel-Type Systems by Marzena Zając, Lei Zhou, Magdalena Mika, Ziyi Yang, Jingyu Wang, Ye Tao, Wangang Zhang

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Towards non-virtual inertia control of renewable energy for frequency regulation: Modeling, analysis and new control scheme by Haishu Gao, Feng Zhang, Lei Ding, Gang Zhang, Libin Yang, Athuman Salimu

“…Currently, when renewable generation participates in frequency regulation, the traditional control method is to emulate synchronous generators through virtual inertia control. …”
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Fluid balance-adjusted creatinine at initiation of continuous venovenous hemofiltration and mortality. A post-hoc analysis of a multicenter randomized controlled trial. by Susanne Stads, Louise Schilder, S Azam Nurmohamed, Frank H Bosch, Ilse M Purmer, Sylvia S den Boer, Cynthia G Kleppe, Marc G Vervloet, Albertus Beishuizen, Armand R J Girbes, Pieter M Ter Wee, Diederik Gommers, A B Johan Groeneveld, Heleen M Oudemans-van Straaten, CASH study group

“…However, creatinine is not only determined by renal function (excretion), but also by dilution (fluid balance) and creatinine generation (muscle mass). …”
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Prostruc: an open-source tool for 3D structure prediction using homology modeling by Shivani V. Pawar, Wilson Sena Kwaku Banini, Musa Muhammad Shamsuddeen, Toheeb A. Jumah, Nigel N. O. Dolling, Abdulwasiu Tiamiyu, Olaitan I. Awe

“…IntroductionHomology modeling is a widely used computational technique for predicting the three-dimensional (3D) structures of proteins based on known templates,evolutionary relationships to provide structural insights critical for understanding protein function, interactions, and potential therapeutic targets. …”
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Graphdiyne biomaterials: from characterization to properties and applications by Ling-Xiao Zhao, Yong-Gang Fan, Xue Zhang, Chan Li, Xue-Yan Cheng, Feng Guo, Zhan-You Wang

“…Abstract Graphdiyne (GDY), the sole synthetic carbon allotrope with sp-hybridized carbon atoms, has been extensively researched that benefit from its pore structure, fully conjugated surfaces, wide band gaps, and more reactive C≡C bonds. In addition to the intrinsic features of GDY, engineering at the nanoscale, including metal/transition metal ion modification, chemical elemental doping, and other biomolecular modifications, endowed GDY with a broader functionality. …”
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“Cura te ipsum”: Healthy public safety leaders for healthy organizations by Rosemary Ricciardelli, Stan MacLellan, Alessandra Mazoza, Tom Stamatakis, Pierre Poirier, Taylor Sayers, Randy Mellow, Ken McMullen, Nadia Aleem, Leah Dunbar, Heidi Cramm

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Multimodal physical therapy intervention based on a biobehavioral approach in a patient with chronic upper limb pain: a case report by Fernando-Balbino Blanco-Fernández, Carlos Forner-Álvarez, Celia Vidal-Quevedo, Ferran Cuenca-Martínez, Mónica Grande-Alonso

“…Chronic upper limb pain is rather common among people in general and is characterized by a complex diagnosis due to the wide variety of factors that are involved in its development. …”
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Descriptive and temporal analysis of the mortality rate and average hospital stay due to burns and corrosion in the elderly in Brazil between 2010 and 2019 by Arthur Antunes Coimbra Pinheiro Pacífico, Ester Saraiva Carvalho Feitosa, Anna Letícia Silveira Parnaíba, Pedro Lucena de Aquino, Amanda de Andrade Cavalcante, Thalia de Souza Bezerra, Leandro Dantas Rolim, Samy Lima Carneiro

“…Introduction: Aging leads to physical and cognitive limitations and decreased functional capacity. Therefore, there is a greater risk, a higher rate of complications and death in elderly patients from burns. …”
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A versatile framework for attitude tuning of beamlines at light source facilities by Peng-Cheng Li, Xiao-Xue Bi, Zhen Zhang, Xiao-Bao Deng, Chun Li, Li-Wen Wang, Gong-Fa Liu, Yi Zhang, Ai-Yu Zhou, Yu Liu

“…It supports flexible input/output ports, easy integration of diverse evaluation functions and free selection of optimization algorithms. …”
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Probe-screened carbon nanotube field-effect transistor biosensor to enhance breast cancer-related gene assay by Pei Liu, Yiwei Liu, Bingjie Cai, Jiahao Li, Guo-Jun Zhang

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Improved YOLOv8 Model for Multi-type Lung Nodule Detection by BAO Qiangqiang, TANG Siyuan, LI Qingqian, WANG Naiyu, YANG Min, GU Yu, ZHAO Jinliang, GAO Jingbo, WANG Jiaxin, QU Yuhan

“…The generalizability is tested on a mixed dataset of LUNA16 and local hospitals, and the improved model has strong generalization ability. The improvement of the model is more effective for the task of detecting multiple types of lung nodules and it can accurately detect different types of lung nodules.…”
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