Association between medication adherence and health-related quality of life among type 2 diabetic adults in Mexico by Sara I. Olvera-Cruz, Araceli Cano-Estrada, José Á. Hernández-Mariano, Ana C. Castañeda-Márquez, Yaneth C. O. Orihuela, María A. Mejía-Blanquel

“…After adjusting for confounders, we observed that non-adherent adults were more likely to have poor HRQoL in six domains of SF-36: physical functioning (adjusted odds ratio [ORa] =2.02; 95% confidence interval [95% CI] =1.06, 3.80); physical role (ORa = 2.37; 95% CI = 1.13, 4.96); bodily pain (ORa = 2.71; 95% CI = 1.45, 5.06); general health (ORa = 2.57; 95% CI = 1.37, 4.80); vitality (ORa = 3.30; 95% CI = 1.70, 6.39); social functioning (ORa = 2.97; 95% CI = 1.56, 5.65); and mental health (ORa = 2.66; 95% CI = 1.42, 4.98). …”
Get full text

Reverse Engineering Segment Routing Policies and Link Costs With Inverse Reinforcement Learning and EM by Kai Wang, Chee Wei Tan

“…Network routing is a core functionality in computer networks that holds significant potential for integrating newly developed techniques with minimal software effort through the use of Software-Defined Networking (SDN). …”
Get full text

Local communities in cities as a subject of control over solving local issues by Alexander A. Larichev

“…This article is devoted to exploring the possibilities of formalizing the institution of local communities of citizens in urban areas, with the goal to more extensively involve local population in solving local issues, including controlling the organization of relevant processes.The purpose of the article to refute or confirm the hypothesis that local communities may exercise local control functions effectively to improve the quality of local services and reduce the number of local government officials.The methodology of the study includes methods of theoretical analysis, as well as legal methods, including the formal legal method.The main results and scope of their application. …”
Get full text

Pattern and severity of multimorbidity among patients attending primary care settings in Odisha, India. by Sanghamitra Pati, Subhashisa Swain, Job Metsemakers, J André Knottnerus, Marjan van den Akker

“…Multimorbidity patterns (dyad and triad) were identified for 21 chronic conditions, functional limitation was assessed as a proxy measure of severity and the mean severity score for each pattern, was determined after adjusting for age. …”
Get full text

The role of community health workers in the reengineering of primary health care in rural Eastern Cape by Karl le Roux, Ingrid M. le Roux, Nokwanele Mbewu, Emily Davis

“…From hospitals to clinics, in the community and in the home, health care will focus more on prevention, health promotion, and advocacy for healthy lifestyles and well-being, in addition to clinical services. …”
Get full text

Cofilin1 controls transcolumnar plasticity in dendritic spines in adult barrel cortex. by Tadashi Tsubota, Reiko Okubo-Suzuki, Yohei Ohashi, Keita Tamura, Koshin Ogata, Masae Yaguchi, Makoto Matsuyama, Kaoru Inokuchi, Yasushi Miyashita

“…These new mechanistic insights into transcolumnar plasticity in adult rats may have a general significance for understanding reorganization of neocortical circuits that have more sophisticated columnar organization than the rodent neocortex, such as the primate neocortex.…”
Get full text

NMDA receptor inhibition increases, synchronizes, and stabilizes the collective pancreatic beta cell activity: Insights through multilayer network analysis. by Marko Šterk, Lidija Križančić Bombek, Maša Skelin Klemen, Marjan Slak Rupnik, Marko Marhl, Andraž Stožer, Marko Gosak

“…Since a disrupted collective activity is an important and possibly early contributor to impaired insulin secretion and glucose intolerance, it is of utmost importance to understand possible effects of NMDA receptor inhibition on beta cell functional connectivity. To address this issue, we combined confocal functional multicellular calcium imaging in mouse tissue slices with network science approaches. …”
Get full text

The parental non-equivalence of imprinting control regions during mammalian development and evolution. by Reiner Schulz, Charlotte Proudhon, Timothy H Bestor, Kathryn Woodfine, Chyuan-Sheng Lin, Shau-Ping Lin, Marine Prissette, Rebecca J Oakey, Déborah Bourc'his

“…Using comparative genomics of 17 extant mammalian species, we show here that, while ICRs in general have been constrained to maintain more CpGs than non-imprinted sequences, the rate of CpG loss at paternal ICRs has indeed been higher than at maternal ICRs during evolution. …”
Get full text

The genus Entomophthora: bringing the insect destroyers into the twenty-first century by Carolyn Elya, Henrik H. De Fine Licht

“…However, we are only starting to understand the functions of unusual molecular and genomic characteristics, such as having large > 1 Gb genomes full of repetitive elements and potential functional diploidy. …”
Get full text

Boosting GWAS using biological networks: A study on susceptibility to familial breast cancer. by Héctor Climente-González, Christine Lonjou, Fabienne Lesueur, GENESIS study group, Dominique Stoppa-Lyonnet, Nadine Andrieu, Chloé-Agathe Azencott

“…To address this shortcoming, one can use biological networks, which model functional relationships, to search for functionally related susceptibility loci. …”
Get full text

Short-term Wind Power Forecasting Based on BWO‒VMD and TCN‒BiGRU by LU Jing, ZHANG Yanru, WANG Rui

“…This combination model aims to use the advantages of TCN and BiGRU to process data and make more accurate predictions. Finally, the pre-dicted values of each subsequence are sequentially stacked to obtain the result, which is expected to provide reliable predictions for wind power generation.Results and DiscussionsThe RF algorithm is strategically employed to screen meteorological features and systematically rank their importance, enabling the accurate selection of features that significantly impact wind power forecasting. …”
Get full text

Proteomic Analysis of Extracellular Vesicles Identifies CDCP1 as Critical Metastasis‐Related Glycoprotein in Lung Cancer by Lu Zhang, Yan Wu, Suntao Li, Miao Guo, Jiaqi Zhao, Chengxi Cao, Yan Zhang, Hua Xiao

“…Compared to 95C EVs, 23 glycoproteins were significantly upregulated more than 20‐fold in 95D EVs, including CDCP1, TNC, NCAM2, and ITGA4. …”
Get full text

Development and Pilot Testing of an Addiction Clinic–Based Pre-Exposure Prophylaxis Uptake and Adherence Intervention for Women with Substance Use Disorders: Protocol for a Pilot R... by Angela M Heads, Diane Santa Maria, Mandy J Hill, Robert Suchting, Kimberly N Evans, Zaneta Gaul, Luba Yammine, Constanza de Dios, Joy M Schmitz

“…Following phase 3, generalized linear modeling will be used to model effects of the proportion of participants who fill their prescription and take at least 1 dose as a function of the intervention group. …”
Get full text

Cytotoxic Effects of ZnO and Ag Nanoparticles Synthesized in Microalgae Extracts on PC12 Cells by Giacomo Fais, Agnieszka Sidorowicz, Giovanni Perra, Debora Dessì, Francesco Loy, Nicola Lai, Paolo Follesa, Roberto Orrù, Giacomo Cao, Alessandro Concas

“…This study emphasizes the crucial role of the synthesis environment and bioactive compounds from <i>C. vulgaris</i> in modulating nanoparticle surface chemistry, ROS generation, and cytotoxicity. The results provide valuable insights for designing safer and more effective nanomaterials for biomedical applications, especially for targeting tumor-like cells, by exploring the relationships between nanoparticle size, polarity, capping agents, and nanocomposite structures.…”
Get full text

Artificial intelligence analysis of thermal energy for convectively heated ternary nanofluid flow in radiated channel considering viscous dissipations aspects by Hamid Qureshi, Amjad Ali Pasha, Muhammad Asif Zahoor Raja, Zahoor Shah, Salem Algarni, Talal Alqahtani, Waqar Azeem Khan, Moinul Haq

“…This research works to establish the convective heat transfer coefficient (CHTC) of new improved ternary hybrid functionalized nanofluids with CuO, Fe2O3, and SiO2 nanoparticles in polymeric fluid. …”
Get full text

Shotgun metagenomic sequencing reveals the influence of artisanal dairy environments on the microbiomes, quality, and safety of Idiazabal, a raw ewe milk PDO cheese by Gorka Santamarina-García, Min Yap, Fiona Crispie, Gustavo Amores, Cathy Lordan, Mailo Virto, Paul D. Cotter

“…Results The results revealed diverse microbial ecosystems across sample types, comprising more than 1300 bacterial genera and 3400 species. …”
Get full text

Structure-dependent degradation of milk oligosaccharides by newly isolated intestinal commensal bacterial strains from suckling piglets and rabbits by Mathilde Rumeau, Sead Chadi, Frederic Pepke, Martin Beaumont, Cláudia M. Vicente, Agathe Juppeau, Céline Vandecasteele, Laurent Cauquil, Géraldine Pascal, Philippe Langella, Christelle Knudsen, Sylvie Combes, Rebeca Martín

“…Milk oligosaccharide fermentation generated a more diverse metabolome compared to glucose. …”
Get full text

Amniotic fluid-derived stem cells: potential factories of natural and mimetic strategies for congenital malformations by Cristiane S. R. Fonteles, Julia Enterria-Rosales, Ying Lin, John W. Steele, Ramiro A. Villarreal-Leal, Jing Xiao, Daniel I. Idowu, Beck Burgelin, Bogdan J. Wlodarczyk, Richard H. Finnell, Bruna Corradetti

“…The possibility to exploit both formulations as mRNA-therapeutics was explored by evaluating cell uptake in two different cell types(fibroblasts, and macrophages) and mRNA functionality overtime in an in vitro experimental setting as well as in an ex vivo, whole embryo culture using pregnant C57BL6 dams. …”
Get full text

Acridocarpus smeathmannii root extracts inhibit human prostate and bladder smooth muscle contraction, porcine arterial vasoconstriction, and cytotoxicity of prostate stromal cells by Oluwafemi Ezekiel Kale, Sheng Hu, Claudia Huber, Felix Schierholz, Anna Ciotkowska, Alexander Tamalunas, Christian G. Stief, Wolfgang Eisenreich, Martin Hennenberg

“…In addition, assays were conducted to evaluate cell proliferation and viability, providing complementary insights into functional and cellular-level effects. The bioactive compounds in the extract were characterized using gas chromatography–mass spectrometry (GC-MS) and nuclear magnetic resonance spectroscopy and were subsequently evaluated in silico for their interaction with the α1-adrenergic receptor.ResultsProstate tissue contractions induced by α1-adrenergic agonists (0.1–100 µM) were reduced by 50% or more with A. smeathmannii at concentrations of 0.25 and 0.50 mg/mL. …”
Get full text

Deficiency of T cell CD40L has minor beneficial effects on obesity-induced metabolic dysfunction by Lisa Willemsen, Myrthe den Toom, Myrthe E Reiche, Marion J J Gijbels, Esther Lutgens, Bram van Os, Norbert Gerdes, Suzanne A B M Aarts

“…Our data indicate that other CD40L-expressing cell types are more relevant in the pathogenesis of obesity-associated metabolic dysfunction.…”
Get full text