Allocating treatment resources for hepatitis C in the UK: a constrained optimization modelling approach by Ru Han, Shuyao Liang, Clément François, Samuel Aballea, Emilie Clay, Mondher Toumi

“…The model was designated with the objective function of minimizing liver-related deaths by varying the decision variables, representing the number of patients receiving each treatment (elbasvir-grazoprevir, ombitasvir-paritaprevir-ritonavir-dasabuvir, sofosbuvir-ledipasvir, and pegylated interferon-ribavirin) in each population (the general population, PWID, and MSM). …”
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SUMO modification of a heterochromatin histone demethylase JMJD2A enables viral gene transactivation and viral replication. by Wan-Shan Yang, Mel Campbell, Pei-Ching Chang

“…These finding suggest that SUMO-2/3 modification plays an essential role in the epigenetic regulatory function of JMJD2A. Consistently, hierarchical clustering analysis of RNA-seq data showed that a SUMO-deficient mutant of JMJD2A was more closely related to JMJD2A knockdown than to wild-type. …”
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NDAWL-PINN: a new non-dimensionalization and multi-task learning approach for efficient training of physics-informed neural networks to solve the shallow water equations by Xin Qi, Dawei Zhang, Fan Wang, Wuxia Bi, Mingda Lu

“…This paper introduces a novel training approach that integrates non-dimensionalization with a multi-task learning technique, termed Automatic Weighted Loss (AWL), to autonomously achieve an optimal balance for each loss function. In the baseline PINN training for solving time-dependent PDEs, multiple weights (usually more than six) must be manually tuned for the model, whereas this method can reduce the number of scaling weights to only one. …”
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Human cardiac tissues produce lower contractile stress and exhibit slower cross-bridge cycling in type 2 diabetes by J. H. Musgrave, J.-C. Han, M.-L. Ward, N. Kang, A. J. Taberner, K. Tran

“…Results Diabetic trabeculae generated 20% lower active stress and had 16% lower cross-bridge stiffness on average. …”
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Effect of Strain Path on Retained Austenite Transformation Rates and Material Ductility in Transformation-Induced Plasticity-Assisted Advanced High-Strength Steel by Parker Gibbs, Derrik Adams, David T. Fullwood, Eric R. Homer, Anil K. Sachdev, Michael P. Miles

“…The retained austenite (RA) levels were measured, as a function of the plastic strain, using electron backscatter diffraction (EBSD). …”
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Adipocyte-expressed SIRT3 manipulates carnitine pool to orchestrate metabolic reprogramming and polarization of macrophages by Jiali Chen, Fei Zhou, Lei Zhang, Ruohan Lou, Cangman Zhang, Jianbo Wan, Xiaojun Ma, Ligen Lin

“…The deacetylase Sirtuin 3 (SIRT3) participates in inflammatory responses via regulating mitochondrial function and FAO. Herein, an AT-specific SIRT3 overexpression mice model (AT-SIRT3OE) was generated using adeno-associated virus transduction. …”
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The dynamics and longevity of circulating CD4+ memory T cells depend on cell age and not the chronological age of the host. by M Elise Bullock, Thea Hogan, Cayman Williams, Sinead Morris, Maria Nowicka, Minahil Sharjeel, Christiaan van Dorp, Andrew J Yates, Benedict Seddon

“…This behaviour may limit memory CD4 T cell diversity by skewing TCR repertoires towards clones generated early in life, but may also compensate for functional defects in new memory cells generated in old age.…”
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Speech-dependent data augmentation for own voice reconstruction with hearable microphones in noisy environments by Mattes Ohlenbusch, Christian Rollwage, Simon Doclo

“…In this paper, we investigate several data augmentation techniques to simulate a large amount of in-ear own voice signals from a limited amount of recorded own voice signals. More specifically, we consider different models for the own voice transfer characteristics between the outer microphone and the in-ear microphone, ranging from a fixed talker-averaged relative transfer function to a phoneme-dependent individual model. …”
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How to map soil organic carbon stocks at field scale in South Africa? by Willie Herman Cloete, Gerhard du Preez, George Munnik Van Zijl

“…For dry bulk density (ρb), a pedo-transfer function was created for predicting the ρb at unsampled locations. …”
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Ionospheric Correction Based on Ingestion of Global Ionospheric Maps into the NeQuick 2 Model by Xiao Yu, Chengli She, Weimin Zhen, Nava Bruno, Dun Liu, Xinan Yue, Ming Ou, Jisheng Xu

“…The accuracy of TEC prediction can be improved further through performing a four-coefficient function expression of Az versus MODIP. As more measurements from earlier days are involved in the Az optimization procedure, the accuracy may decrease. …”
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Influence of Interleukin-8 and Neutrophil Extracellular Trap (NET) Formation in the Tumor Microenvironment: Is There a Pathogenic Role? by Manuela Gonzalez-Aparicio, Carlos Alfaro

“…However, the extent to which NETs affect the function of other cells of the immune system in the tumor context has not been directly demonstrated. …”
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A Study on the Coarse-to-Fine Error Decomposition and Compensation Method of Free-Form Surface Machining by Yueping Chen, Junchao Wang, Qingchun Tang, Jie Li

“…The simulation and analysis results of the design show that the method has a more ideal processing error decomposition ability and can decompose the systematic error contained in the processing error in a more complete way. …”
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Lower frequency of TLR9 variant associated with protection from breast cancer among African Americans. by Madison R Chandler, Kimberly S Keene, Johanna M Tuomela, Andres Forero-Torres, Renee Desmond, Katri S Vuopala, Kevin W Harris, Nancy D Merner, Katri S Selander

“…They may affect TLR9 expression and function. Rs352140, which may protect from breast cancer, is 1.6 X more common among EAs. …”
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Relationships between neurodivergence status and adverse childhood experiences, and impacts on health, wellbeing, and criminal justice outcomes: findings from a regional household... by Charley Wilson, Nadia Butler, Zara Quigg, David Moore, Mark Bellis

“…While controlling for sociodemographics, each outcome measure was more likely amongst those who were ND, and each outcome measure except for poor general health was more likely amongst those with higher ACE counts. …”
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Cognitive weaknesses or impairments on the NIH toolbox cognition battery in children and adolescents: base rates in a normative sample and proposed methods for classification by Nathan E. Cook, Nathan E. Cook, Nathan E. Cook, Grant L. Iverson, Grant L. Iverson, Grant L. Iverson, Grant L. Iverson, Justin E. Karr

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Effectiveness of 4 weeks of electrical vestibular stimulation in the management of temporomandibular pain by Yashica Gowda R, Asha G, Doreswamy Kanakaiah, Karthik N, Sai Sailesh Kumar Goothy, Mukkadan JK

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Dynamics of quality of life of head and neck cancer patients after treatment. Clinical significance by A. V. Karpenko, R. R. Sibgatullin, A. A. Boyko, M. G. Kostova, O. M. Nikolayeva, E. M. Trunin

“…According to EORTC QLQ-C30 questionnaire only positive shifts turned out to be statistically significant: general health, emotional function, pain, insomnia and diarrhea. …”
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Prevalence of erectile dysfunction and its association with age in patients with metastatic renal cell carcinoma: results from a prospective multicenter study by Yulia Tishova, Ruslan Zukov, Lev Demidov, Pavel Borisov, Vladimir Kuznetsov, Valentina Leonenko, Anastasia Tarasova, Kristina Zakurdaeva, Ilya Tsimafeyeu

“…Background This study aimed to evaluate the prevalence of erectile dysfunction (ED) and assess its associations in a large cohort of patients with metastatic renal cell carcinoma (mRCC) prior to initiating and during therapy.Methods In this prospective multicenter study, male patients with clear-cell mRCC were assessed. Erectile function was evaluated using the 5-item International Index of Erectile Function (IIEF-5), and general health status was assessed using the Functional Assessment of Cancer Therapy-Kidney Symptom Index (FKSI-19). …”
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Introduction to Thermal Field Theory: From First Principles to Applications by Alberto Salvio

“…A more applicative part of the review is dedicated to the production of particles in a medium and to phase transitions in field theory, including the process of vacuum decay in a general theory featuring a first-order phase transition. …”
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Architectural Rehabilitation Built as Living Heritage by José Luis Martínez Raído, Luis W. Muñoz Fontenla, Felipe Peña Pereda

“…Only a small part of the inherited architectural heritage can be preserved in a more or less consolidated ruined state. The majority, however, has to recover its usefulness through a new function that satisfies new needs. …”
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