Structure-dependent degradation of milk oligosaccharides by newly isolated intestinal commensal bacterial strains from suckling piglets and rabbits by Mathilde Rumeau, Sead Chadi, Frederic Pepke, Martin Beaumont, Cláudia M. Vicente, Agathe Juppeau, Céline Vandecasteele, Laurent Cauquil, Géraldine Pascal, Philippe Langella, Christelle Knudsen, Sylvie Combes, Rebeca Martín

“…Milk oligosaccharide fermentation generated a more diverse metabolome compared to glucose. …”
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Amniotic fluid-derived stem cells: potential factories of natural and mimetic strategies for congenital malformations by Cristiane S. R. Fonteles, Julia Enterria-Rosales, Ying Lin, John W. Steele, Ramiro A. Villarreal-Leal, Jing Xiao, Daniel I. Idowu, Beck Burgelin, Bogdan J. Wlodarczyk, Richard H. Finnell, Bruna Corradetti

“…The possibility to exploit both formulations as mRNA-therapeutics was explored by evaluating cell uptake in two different cell types(fibroblasts, and macrophages) and mRNA functionality overtime in an in vitro experimental setting as well as in an ex vivo, whole embryo culture using pregnant C57BL6 dams. …”
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Acridocarpus smeathmannii root extracts inhibit human prostate and bladder smooth muscle contraction, porcine arterial vasoconstriction, and cytotoxicity of prostate stromal cells by Oluwafemi Ezekiel Kale, Sheng Hu, Claudia Huber, Felix Schierholz, Anna Ciotkowska, Alexander Tamalunas, Christian G. Stief, Wolfgang Eisenreich, Martin Hennenberg

“…In addition, assays were conducted to evaluate cell proliferation and viability, providing complementary insights into functional and cellular-level effects. The bioactive compounds in the extract were characterized using gas chromatography–mass spectrometry (GC-MS) and nuclear magnetic resonance spectroscopy and were subsequently evaluated in silico for their interaction with the α1-adrenergic receptor.ResultsProstate tissue contractions induced by α1-adrenergic agonists (0.1–100 µM) were reduced by 50% or more with A. smeathmannii at concentrations of 0.25 and 0.50 mg/mL. …”
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Deficiency of T cell CD40L has minor beneficial effects on obesity-induced metabolic dysfunction by Lisa Willemsen, Myrthe den Toom, Myrthe E Reiche, Marion J J Gijbels, Esther Lutgens, Bram van Os, Norbert Gerdes, Suzanne A B M Aarts

“…Our data indicate that other CD40L-expressing cell types are more relevant in the pathogenesis of obesity-associated metabolic dysfunction.…”
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Engineering adoptive T cell therapy to co-opt Fas ligand-mediated death signaling in ovarian cancer enhances therapeutic efficacy by Philip D Greenberg, Kristin G Anderson, Shannon K Oda, Breanna M Bates, Madison G Burnett, Magdalia Rodgers Suarez, Susan L Ruskin

“…Background In the USA, more than 50% of patients with ovarian cancer die within 5 years of diagnosis, highlighting the need for therapeutic innovations. …”
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A Monocyte-Driven Prognostic Model for Multiple Myeloma: Multi-Omics and Machine Learning Insights by Xie L, Gao M, Tan S, Zhou Y, Liu J, Wang L, Li X

“…Results indicated that low-risk patients are more likely to benefit from immunotherapy, while a high MGPS score reflects cellular functional impairment.Conclusion: Our findings reveal a complex interplay between immune cells and MM. …”
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Construction and characterization of chimeric FcγR T cells for universal T cell therapy by Juanjuan Zhao, Manling Chen, Xudong Li, Zhaoqi Chen, Wei Li, Rongqun Guo, Min Wang, Zhongxing Jiang, Yongping Song, Jianxiang Wang, Delong Liu

“…Methods Chimeric FcγR (CFR) constructs were generated using three distinct forms of FcγR, namely CD16A, CD32A, and CD64. …”
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The sensor histidine kinase PhcS participates in the regulation of quorum sensing-dependent virulence genes in Ralstonia pseudosolanacearum strain OE1-1 by Wakana Senuma, Masayuki Tsuzuki, Chika Takemura, Yuki Terazawa, Akinori Kiba, Kouhei Ohnishi, Kenji Kai, Yasufumi Hikichi

“…It is thus thought that PhcS participates in not only the 3-OH MAME sensing-independently PhcK-mediated regulation of phcA but also the PhcA activation following 3-OH MAME sensing. Both functions of PhcS are significantly influenced by the autophosphorylation of H230-PhcS.IMPORTANCEThe soil-borne Ralstonia solanacearum species complex (RSSC) infects more than 300 plant species in over 50 families, including solanaceous plants, causing the devastating wilt disease that substantially decreases agricultural production worldwide. …”
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A high clinically translatable strategy to anti-aging using hyaluronic acid and silk fibroin co-crosslinked hydrogels as dermal regenerative fillers by Jialing Cheng, Zhiyang Chen, Demin Lin, Yanfang Yang, Yanjing Bai, Lingshuang Wang, Jie Li, Yuchen Wang, Hongliang Wang, Youbai Chen, Jun Ye, Yuling Liu

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PATH PLANNING AND OBSTACLE AVOIDANCE METHODS FOR AUTONOMOUS MOBILE ROBOTS by Ihor Berizka

“…In summary, the gradual robotization of many processes in everyday life or production generates a high demand for research in the field of mobile robotics in general and methods for obstacle detection, avoidance and path planning in particular.…”
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Emerging Tumor Biomarkers in Pancreatic Cancer and Their Clinical Implications by Dimitrios Stefanoudakis, Maximos Frountzas, Nikolaos V. Michalopoulos, Dimitrios Schizas, Dimitrios Theodorou, Konstantinos G. Toutouzas

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Association of Trace Elements with Polycystic Ovary Syndrome in Women—A Case-Control Study by Tinkara Srnovršnik, Bojana Pinter, Milena Horvat, Janja Snoj Tratnik, Ingrid Falnoga, Darja Mazej, Ivan Verdenik, Irma Virant-Klun

“…Additional research is needed to provide more insights into the causality of the PCOS relationship with Mo and Cu in humans.…”
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Central Hemodynamics and Extravascular Lung Water Index in Varying Degrees of Community-Acquired Pneumonia by S. N. Avdeykin, I. N. Tyurin, N. A. Karpun, A. V. Salikov

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The Influence of Regional Anesthesia on the Systemic Stress Response by Tomasz Reysner, Katarzyna Wieczorowska-Tobis, Grzegorz Kowalski, Monika Grochowicka, Monika Pyszczorska, Aleksander Mularski, Malgorzata Reysner

“…Regional anesthesia (RA) has been shown to modulate this stress response more effectively than general anesthesia (GA) by blocking nociceptive signaling and attenuating the release of stress mediators. …”
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Role of Iron in Children With Immunoglobulin A Nephropathy and Macrohematuria-Induced Acute Kidney Injury by Shingo Ishimori, Tomoko Horinouchi, Tomohiko Yamamura, Junya Fujimura, Naohiro Kamiyoshi, Hiroshi Kaito, Yuriko Tanaka, Hiroyoshi Matsukura, Wataru Shimabukuro, Yuko Shima, Azusa Kawaguchi, Yoshinori Araki, Koichi Nakanishi, Shigeo Hara, Kandai Nozu

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E3 ubiquitin ligase FBXW11-mediated downregulation of S100A11 promotes sensitivity to PARP inhibitor in ovarian cancer by Ligang Chen, Mingyi Wang, Yunge Gao, Yanhong Lv, Lianghao Zhai, Jian Dong, Yan Chen, Xia Li, Xin Guo, Biliang Chen, Yi Ru, Xiaohui Lv

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CHANGE IN TESTOSTERONE LEVELS IN ENDOSCOPIC OPERATIONS ON THE PROSTATE GLAND by E. A. Efremov, S. Yu. Shekhovtsov, D. S. Merinov, A. O. Butov, Yu. V. Kastrikin, T. I. Garaev

“…In the group of patients receiving HRT, there was an improvement in the general condition and erectile function, confirmed by the results of the AMS and IIEF-5 questionnaires.Conclusion. …”
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Preserved Ratio Impaired Spirometry in US Primary Care Patients Diagnosed with Chronic Obstructive Pulmonary Disease by Evans A, Tarabichi Y, Pace WD, Make B, Bushell N, Carter V, Chang KL, Fox C, Han MK, Kaplan A, Kocks JWH, Le Lievre C, Roussos A, Skolnik N, Soriano JB, Yawn BP, Price D

“…Those with PRISm were more likely female (55.9% vs 46.9%), younger (66.3± 11.1 vs 69.2± 10.3 years), with a greater mean BMI (33.5± 9.2 vs 27.8± 7.2 kg/m2), more often African American or Hispanic (37.2% vs 26.3%), and with fewer current smokers (33.1% vs 36.8%) when compared to those meeting COPD spirometry criteria (all p< 0.05). …”
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Vision-related Quality of Life (VRQOL) and its determinants among the Elderly in rural blocks of Haryana, India by Mona Duggal, Ankita Kankaria, Latika Rohilla, Harashish Jindal, Limalemla Jamir, Parul Chawla Gupta, Debarati Sarkar, Vaibhav Miglani, Akash Kumar, Drishti Sharma, Neha Dahiya, Siddhartha Sharma, Sandeep Grover

“…The study found higher VR-QOL scores in General Health, Distance activities, and Near activities, while lower scores were observed in Mental health, Dependency, Social functioning, Ocular pain, General vision, and Role difficulties. …”
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Dietary Habits as Acne Trigger by Esma Karahmet Farhat, Ines Banjari, Tamara Jovović Sadiković

“…Adults consume a more balanced diet compared to adolescents. Subjects and methods: Using a questionnaire, data were collected (anthropometry, general health status, comorbidities, use of medicines and supplements, dietary and lifestyle habits; additional data on women and the menstrual cycle) from 60 dermatological patients of both genders, aged 15–46 years, from Sarajevo. …”
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