BRAF inhibitor resistance of melanoma cells triggers increased susceptibility to natural killer cell-mediated lysis by Antoine Toubert, Eric Pasmant, Alexandra Frazao, Louise Rethacker, Géraldine Jeudy, Marina Colombo, Marie-Françoise Avril, Helene Moins-Teisserenc, Marie Roelens, Sophie Dalac, Eve Maubec, Anne Caignard

“…Soluble NKG2D ligands known to regulate the receptor function have been associated to cancer progression. …”
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Comprehensive Evaluation of Operation Safety of Earth-rock Dams Based on Weight Optimization-cloud Model by ZHANG Jianwei, WU Weitao, HOU Ge, HUANG Jinlin, WANG Bingpeng, LIU Hongze, HU Zixu

“…The membership degree was calculated by generating different numbers of cloud droplets through the forward cloud generators, which were taken as the model solution under each number of cloud droplets. …”
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Effector T cells under hypoxia have an altered transcriptome similar to tumor-stressed T cells found in non-responsive melanoma patients by Ahmad A Tarhini, Zhihua Chen, Dongliang Du, Joshua Davis, Justin C Boucher, Katarzyna A Rejniak, Jose A Guevara-Patino, Timothy I Shaw, Alyssa Obermayer, Mate Z Nagy, Lourdes B Plaza-Rojas, Elena Kostenko, Anna L Austin, Awino Maureiq E Ojwang'

“…We created tumor maps and derived plots showing the fraction of CD4 and CD8 T cells against the distance to the nearest vessel and oxygen pressure. To assess their function and transcriptional changes caused by hypoxia, effector T cells were generated and cultured under hypoxia (0.5% oxygen) or normoxia (21% oxygen). …”
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DEVELOPMENT OF AN AUTOMATED FLUORESCENCE MICROSCOPY ASSAY FOR QUANTIFYING FACTORS AFFECTING RED BLOOD CELL (RBC) SICKLING IN SICKLE CELL DISEASE (SCD) by ML Arrojo, ACS Pinto, SK Haddad, RA Panepucci

“…However, the lack of straightforward functional assays to quantitate how these factor affect cell sickling, hamper a more profound understanding of SCD physiopathology. …”
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Schrödinger Potentials with Polynomial Solutions of Heun-Type Equations by Géza Lévai, Tibor Soltész

“…The present review discusses the solution of the Heun, confluent, biconfluent, double confluent, and triconfluent equations in terms of polynomial expansions, and applies the results to generate exactly solvable Schrödinger potentials. Although there are more general approaches to solve these differential equations in terms of the expansions of certain special functions, the importance of polynomial solutions is unquestionable, as most of the known potentials are solvable in terms of the hypergeometric and confluent hypergeometric functions; i.e., Natanzon-class potentials possess bound-state solutions in terms of classical orthogonal polynomials, to which the (confluent) hypergeometric functions can be reduced. …”
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Environmental Levels and Degradation Behavior of Pharmaceuticals and Personal Care Products (PPCPs) in the Water Environment by Zhaohe ZHANG, Dian CHEN, Wei ZHAO, Guoli YUAN, Jun LI, Xingchun JIAO

“…In general, photodegradation and biodegradation are more common than hydrolysis. In surface water, many PPCPs have avoided the strict biodegradation environment of wastewater treatment, and photochemistry may have a greater effect than the biodegradation under sunlight, in which antibiotics are mainly photodegraded in the water environment; ibuprofen, iopromide and caffeine are more prone to biodegradation; esters and amides are the most common functional groups that are easily hydrolyzed in PPCPs[63], and tetracycline can undergo hydrolysis reactions due to adsorption into sediments. …”
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Quantifying diversity and growth form distribution of scleractinian corals, in Mangrove Bay, El Qoseir, Egypt by Theres Koch, Angelina Ivkić, Lewis Jones, Victor Scharnhorst, Constanze Stix, Antonia Auer, Theda Schöchtner, Gözde Özer, Simon Steinwender, Joseph Wallace Daurella, Martin Zuschin

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Clinical Versatility of the Facility-Equator Implant System as Mandibular Overdenture Retainers by Anna Paula da Rosa Possebon, Alessandra Julie Schuster, Amália Machado Bielemann, Ana Paula Pinto Martins, Samille Biasi Miranda, Otacílio Luiz Chagas-Júnior, Luciana de Rezende Pinto, Fernanda Faot

“…The case with 4 implants and progressive loading showed a slight worsening of masticatory function at 1 year, in addition to a more pronounced MBL compared to other cases, but with improvements in satisfaction and oral health-related quality of life. …”
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CPT1C deficiency in SF1 neurons impairs early metabolic adaptation to dietary fats, leading to obesity by A. Fosch, D.S. Pizarro, S. Zagmutt, A.C. Reguera, G. Batallé, M. Rodríguez-García, J. García-Chica, O. Freire-Agulleiro, C. Miralpeix, P. Zizzari, D. Serra, L. Herrero, M. López, D. Cota, R. Rodríguez-Rodríguez, N. Casals

“…After long-term HFD exposure, SF1-Cpt1c-KO mice are more prone to developing obesity and glucose intolerance than control littermates, with males exhibiting a more severe phenotype. …”
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Human motion similarity evaluation based on deep metric learning by Yidan Zhang, Lei Nie

“…In addition, the dynamic time warping (DWT) algorithm is exploited to align the sequence of action information feature vectors temporally, which solves the problem of temporal axis discrepancies in realizing similarity metrics based on action information feature vectors. More accurate and reliable human action similarity evaluation results were achieved by the loss function composed of three components, namely, cross-reconstruction loss, reconstruction loss and triplet loss. …”
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The importance of compatibility of Customer Relationship Management, e-marketing, and e-commerce information systems to improve business efficiency by Dimitrijević Dragan, Dimitrijević Natalija, Adamović Živoslav

“…The paper analyzes and points to correlational relationships, as well as elements of necessary coherence and cause-and-effect complementarity and compatibility of CRM information systems with information systems of e-marketing, e-commerce, and techniques and tools of ICT support for users, with the aim of more efficient business and generation sustainable competitiveness.…”
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Establishing a 3D Spheroid Model of Cholinergic Neurons from SH-SY5Y Cells for Neurotoxicity Assessment by Felipe Franco-Campos, Mónica Fernández-Franzón, Yelko Rodríguez-Carrasco, María-José Ruiz

“…SH-SY5Y cells, an immortalized human neuroblastoma cell line, provide a more accessible alternative for studying neuronal processes and neurotoxicity. …”
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A DEM super resolution reconstruction method based on normalizing flow by Jie Yu, Yangtenglong Li, Xuan Bai, Ronghao Yang, Mengxue Cui, Haohao Wu, Zheng Li, Fangzheng Su, Ze Li, Taohuai Liang, Hongliang Yan

“…The negative log-likelihood function and pixel loss function are used to accelerate the optimization to generate high-resolution DEM images that are closer to the natural terrain. …”
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Contrasting responses of soil bacterial and fungal networks to photovoltaic power station by Teng Li, Leilei Lu, Ziqing Kang, Huijun Li, Jihua Wu, Weiguo Du

“…These findings provide new evidence that soil bacterial networks are more sensitive to PV panels installation than fungal networks, deepening our understanding of land-use change effects on soil ecosystem functions. …”
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Control of Regime of Unified Interphase Power Controller by the Use of Rotary Transformer by Kalinin L.P., Zaitsev D.A., Kaloshin D.N, Golub I.V.

“…The increase of IPC controllability allows assigning some control function upon them and ensuring a more favorable operation of the energy system generators. …”
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Cell type-specific driver lines targeting the Drosophila central complex and their use to investigate neuropeptide expression and sleep regulation by Tanya Wolff, Mark Eddison, Nan Chen, Aljoscha Nern, Preeti Sundaramurthi, Divya Sitaraman, Gerald M Rubin

“…Genetic tools for manipulating individual cell types, and knowledge of what neurotransmitters and neuromodulators they express, will be required to gain mechanistic understanding of how these functions are implemented. We generated and characterized split-GAL4 driver lines that express in individual or small subsets of about half of CX cell types. …”
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Improved YOLOv5s With Coordinate Attention for Small and Dense Object Detection From Optical Remote Sensing Images by Qinggang Wu, Yonglei Wu, Yang Li, Wei Huang

“…Third, we replace the commonly used complete intersection over union (IoU) loss function in YOLOv5s with the AW-IoU loss function based on both α-IoU and wise-IoU. …”
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Cisplatin-Induced Stria Vascularis Damage Is Associated with Inflammation and Fibrosis by Na Zhang, Jing Cai, Lei Xu, Haibo Wang, Wenwen Liu

“…The stria vascularis (SV) generates the endocochlear potential (EP) in the inner ear and is necessary for proper hair cell (HC) mechanotransduction and hearing. …”
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Mitochondrial Dysfunction in Glycogen Storage Disorders (GSDs) by Kumudesh Mishra, Or Kakhlon

“…Deficiencies in enzymes responsible for glycogen breakdown and synthesis can impair mitochondrial function. For instance, in GSD type II (Pompe disease), acid alpha-glucosidase deficiency leads to lysosomal glycogen accumulation, which secondarily impacts mitochondrial function through dysfunctional mitophagy, which disrupts mitochondrial quality control, generating oxidative stress. …”
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High resolution genome wide binding event finding and motif discovery reveals transcription factor spatial binding constraints. by Yuchun Guo, Shaun Mahony, David K Gifford

“…An essential component of genome function is the syntax of genomic regulatory elements that determine how diverse transcription factors interact to orchestrate a program of regulatory control. …”
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