Oncogenic and teratogenic effects of Trp53Y217C, an inflammation-prone mouse model of the human hotspot mutant TP53Y220C by Sara Jaber, Eliana Eldawra, Jeanne Rakotopare, Iva Simeonova, Vincent Lejour, Marc Gabriel, Tatiana Cañeque, Vitalina Volochtchouk, Monika Licaj, Anne Fajac, Raphaël Rodriguez, Antonin Morillon, Boris Bardot, Franck Toledo

“…Hotspot p53 mutants have lost the tumor suppressive functions of the wildtype protein, but whether and how they may gain additional functions promoting tumorigenesis remain controversial. …”
Get full text

Viral replication modulated by hallmark conformational ensembles: how AlphaFold-predicted features of RdRp folding dynamics combined with intrinsic disorder-mediated function enabl... by Rachid Tahzima, Rachid Tahzima, Rachid Tahzima, Rachid Tahzima, Justine Charon, Adrian Diaz, Kris De Jonghe, Sebastien Massart, Thierry Michon, Wim Vranken, Wim Vranken, Wim Vranken, Wim Vranken

“…The functions of RNA-dependent RNA polymerases (RdRps) in RNA viruses are demonstrably modulated by native substrates of dynamic and interconvertible conformational ensembles. …”
Get full text

Imaging of adult ocular neoplasms on a standard 1.5 Tesla MRI magnet: evaluation by improved diagnostic performance of “anatomical” images through feasible technical innovations, s... by Lamyaa Abdel Galil Eissa, Sara Mohamed ElBannan, Hisham Farouk Idriss, Aya Mohammed Abdel Aziz

“…Results The generated images of 33 patients were of fairly good quality comparable to those generated from higher-field MRI machine. …”
Get full text

Innovative Approaches to Sustainable Urban Planning: Analysing Current Trends by Meruyert Baidrakhmanova, Gani Karabayev, Seimur Mamedov

“…Artificial intelligence facilitates urban planning through data analysis and pattern recognition, while generative adversarial networks and transformers improve design and data processing functionalities. …”
Get full text

Unveiling the regulatory potential of the non-coding genome: Insights from the human genome project to precision medicine by Paola Ruffo, Bryan J. Traynor, Francesca Luisa Conforti

“…This review explores the legacy of the HGP and subsequent advancements in genomic technologies, particularly next-generation sequencing, which have enabled more profound insights into the non-coding genome's role in gene regulation. …”
Get full text

HARMONIC INTERPOLATING WAVELETS IN NEUMANN BOUNDARY VALUE PROBLEM IN A CIRCLE by Dmitry A. Yamkovoi

“…We will use three kinds of such functions, where two out of the three generates systems, which are orthogonal and simultaneous interpolating on uniform grids of the corresponding scale and the last one generates only interpolating on the same uniform grids system. …”
Get full text

p17 Variant Expression and Evolution in HIV-Mediated Lymphomagenesis by Nicoleta Arnaut, Mark Slevin, Claudia Bănescu, Mihaela Straistă, Arnaldo Caruso, Francesca Caccuri

“…Specifically, vp17s endowed with amino acid (aa) insertions in their C-terminal region, at positions 114–115 (Glu-Lys), 117–118 (Ala–Ala) and 125–126 (Gly–Asp), were found to be significantly more prevalent in HIV-positive individuals with lymphoma as compared to those without. …”
Get full text

Optimization of Metal-Based Nanoparticle Composite Formulations and Their Application in Wound Dressings by Wang M, Luo Y, Yang Q, Chen J, Feng M, Tang Y, Xiao W, Tang Z, Zheng Y, Li L

“…Keywords: metal-based nanoparticles, nanocomposite, wound dressing, multi-functional, review…”
Get full text

Phygitalization of educational technologies in Russia: directions, examples, problems by Andrey I. Kapterev

“…Results. 1) The main directions of phygitalization of educational technologies are analyzed: a) use of teachers’ personal websites, b) the development of virtual laboratories, c) the use of generative language models of artificial intelligence.; 2) the importance of each component is analyzed and examples of how they can be implemented in practice are given, the main problems are discussed and potential solutions are proposed; 3) an overview of the main functions of the phygitalization of educational technologies is presented, including the definition of this trend, characteristics and main problems; 4) the main methods and tools used in the phygitalization of educational technologies are discussed; 5) the most promising areas of research in this field are determined. …”
Get full text

Hybrid Sensor Placement Framework Using Criterion-Guided Candidate Selection and Optimization by Se-Hee Kim, JungHyun Kyung, Jae-Hyoung An, Hee-Chang Eun

Get full text

Early evidence for establishment of a Chinook salmon population in a restored watershed by Lauren G. Hitt, Malte Willmes, George Whitman, Mackenzie C. Miner, Carson Jeffres, Rachel C. Johnson, Dennis E. Cocherell, Nann A. Fangue, Andrew L. Rypel

Get full text

Healthy body as a normative model in the perceptions of student youth by N. L. Antonova, S. B. Abramova, V. R. Lopatina

“…The analysis of body care practices indicates the presence of a core, including physical activity and balanced nutrition, which students use to achieve a healthy body as a body that is aesthetically attractive and functionally hardy. Highly appreciating satisfaction with their body, the younger generation strives for a normative model of a healthy body, which gives a sense of comfort to its wearer and allows the realisation of a wide range of needs and interests. …”
Get full text

A micro-costing study of mass-spectrometry based quantitative proteomics testing applied to the diagnostic pipeline of mitochondrial and other rare disorders by Francisco Santos Gonzalez, Daniella H. Hock, David R. Thorburn, Dylan Mordaunt, Nicholas A. Williamson, Ching-Seng Ang, David A. Stroud, John Christodoulou, Ilias Goranitis

“…Using PBMC samples may be a cheaper and more efficient alternative to generating fibroblasts, although their use has not been extensively tested yet. …”
Get full text

A lightweight authentication scheme for telecare medical information system by Lijun Xiao, Songyou Xie, Dezhi Han, Wei Liang, Jun Guo, Wen-Kuang Chou

“…The comparative analysis results show that the proposed scheme has higher security and is more suitable for TMIS.…”
Get full text

Metagenome Analysis Identified Novel Microbial Diversity of Sandy Soils Surrounded by Natural Lakes and Artificial Water Points in King Salman Bin Abdulaziz Royal Natural Reserve,... by Yahya S. Al-Awthan, Rashid Mir, Fuad A. Alatawi, Abdulaziz S. Alatawi, Fahad M. Almutairi, Tamer Khafaga, Wael M. Shohdi, Amal M. Fakhry, Basmah M. Alharbi

“…Additionally, metagenomic studies offer valuable insights into the composition and functional potential of soil microbial communities. …”
Get full text

Research on Welfare Robots: A Multifunctional Assistive Robot and Human–Machine System by Shuoyu Wang

“…This paper proposes a method for constructing a human–machine system for welfare robots that includes the estimation of the user’s work intention, a measurement of riding comfort, and motion generation. Furthermore, various types of welfare equipment for people with walking disabilities have been developed, but most of them have a single function. …”
Get full text

Wild rice species from Pantanal are hotspots for associations with plant growth-promoting rhizobacteria by Analice Paula de Sousa Campelo, José Ivo Baldani, Gecele Matos Paggi, Luciana Cristina Vitorino, Layara Alexandre Bessa, Marivaine da Silva Brasil

“…We obtained 201 potential diazotrophic bacteria (103 from O. latifolia and 98 from O. glumaepatula), verifying that these wild rice species host a large population of diazotrophs. The genera Pantoea, Achromobacter, Enterobacter, Stenotrophomonas, Pseudomonas, and Bacillus were most common, with O. glumaepatula hosting a more diverse diazotrophic community. …”
Get full text

Antenna systems for IoT applications: a review by Sunawar Khan, Tehseen Mazhar, Tariq Shahzad, Afsha Bibi, Wasim Ahmad, Muhammad Amir Khan, Mamoon M. Saeed, Habib Hamam

“…For the growing range of IoT applications, this research suggests more flexible and reconfigurable antennas that can function across numerous frequency bands. …”
Get full text

A study on land use change simulation based on PLUS model and the U-net structure: A case study of Jilin Province by Jiafu Liu, Xiangli Kong, Yue Zhu, Baihao Zhang

Get full text

Flame Combustion State Detection Method of Cement Rotary Furnace Based on Improved RE-DDPM and DAF-FasterNet by Yizhuo Zhang, Zixuan Gu, Huiling Yu, Shen Shi

“…The RE-DDPM method exhibits faster convergence and lower FID scores, indicating that the generated images are more realistic. DAF-FasterNet achieves 98.9% training accuracy, 98.1% test accuracy, and a 22.3 ms delay, making it superior to existing methods in flame state recognition.…”
Get full text