Caged-hypocrellin mediated photodynamic therapy induces chromatin remodeling and disrupts mitochondrial energy metabolism in multidrug-resistant Candida auris by Xinyao Liu, Yiran Tao, Linwan Zhang, Yuzhou Liu, Dongmei Shi, Jiao Wang, Peng Xue, Bin Xu, Wenjie Fang, Yuping Ran

“…Antimicrobial photodynamic therapy (aPDT), which generates reactive oxygen species (ROS) through light-activated photosensitizers, has shown promise against C. auris; however, its molecular mechanism remains unclear. …”
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Improving older people’s experiences and safety at transitions of care: the PACT mixed-methods study including RCT by Jenni Murray, Ruth Baxter, Jane O’Hara, Laura Sheard, Catherine Hewitt, Natasha Hardicre, Charles Vincent, Eirini Oikonomou, Gerry Richardson, Rosie Shannon, Kalpita Baird, Stephen Brealey, Robbie Foy, Laura Mandefield, Sarah Hampton, Ed Breckin, Lubena Mirza, Alfredo Palacios, Sally Moore, Jayne Marran, Jacqui Elliot, Jane Schofield, Alison Cracknell, Beth Woods, Sarah Cockayne, Thomas Mills, Yvonne Birks, Olivia Joseph, Rebecca Lawton

“…Work package 4: Development and refinement of a transitions intervention Intervention development Guided by stakeholder workshops with patients and staff we co-designed a prototype intervention to support management of the four key functions (see above): knowing more, moving more, managing medicines and escalation. …”
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ADI-270: an armored allogeneic gamma delta T cell therapy designed to target CD70-expressing solid and hematologic malignancies by Jie Zhang, Jyothi Sethuraman, Marissa Herrman, Pranav Murthy, Ramandeep Kaur, Jonathan T S Wong, Kevin P Nishimoto, Smitha R Y Gundurao, Arun Bhat, Blake T Aftab, Shon Green, Aruna Azameera, Morgan Smith-Boeck, Michael Salum, Yvan Chanthery, Melinda Au, Amy Doan, Christopher J Rold, Swapna Panuganti, Helen Budworth, Gauri Lamture, Alexander G Teague, Yogendra Verma, Elizabeth B Speltz, Katherine M Wang, Dishant Bhatwala, Ana Giner-Rubio, Pavan Puligujja, Aya Jakobovits

“…Homing barriers, immunosuppressive factors, and target antigen heterogeneity can impair CAR-T cell functional activity within the TME. Alternative strategies have contemplated incorporating the use of gamma delta (γδ) T cells as a CAR-T cell approach to potentially overcome these limitations. γδ T cells possess both innate and adaptive immunity to facilitate broad tumor recognition, and their natural propensity for tissue tropism may allow for more effective tumor infiltration. …”
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The Effect of “Carvacrol” on Ischemia-Reperfusion Injury in the Skeletal Muscles of Rats by Barış Mardin, Abdullah Özer, Başak Koçak, Ayşegül Küçük, Mustafa Hakan Zor, Şaban Cem Sezen, Mustafa Kavutçu, Mustafa Arslan, Gürsel Levent Oktar

“…Therefore, we contend that more experimental cohort investigations are needed to examine the impact of the Car molecule on preventing I/R injury.…”
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Novel Klebsiella pneumoniae and Pseudomonas aeruginosa MAPS vaccine combining O polysaccharides and pathogen-specific proteins by Mohammed N. Amin, James E. Sinclair, Brittany Curtis, Lada Sycheva, Heather Fox, Myeong-Jin Choi, Surekha Shridhar, Jacqueline Kolasny, Joseph Nkeze, Ethel Apolinario, Sang Hyun, Nicolas Hegerle, Shaichi Sen, Jasnehta Permala Booth, Mark Leney, Deborah Molrine, Greg Saia, Marcela Pasetti, Teresa Broering, Francis Michon, Richard Malley, George R. Siber, Sharon M. Tennant, Donna Ambrosino, Raphael Simon, Alan Cross

“…The use of pathogen-relevant proteins that may contribute to vaccine efficacy in place of the more traditional carrier proteins is a novel concept. …”
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CD81-guided heterologous EVs present heterogeneous interactions with breast cancer cells by Elena Gurrieri, Giulia Carradori, Michela Roccuzzo, Michael Pancher, Daniele Peroni, Romina Belli, Caterina Trevisan, Michela Notarangelo, Wen-Qiu Huang, Agata S. A. Carreira, Alessandro Quattrone, Guido Jenster, Timo L. M. Ten Hagen, Vito Giuseppe D’Agostino

“…Conclusions This study highlights the quantitative aspects underlying the creation of a platform for secreted heterologous EVs and shows the limits of single receptor-ligand interactions behind EV-cell engagement mechanisms, which now become the pivotal step to predict functional tropism and design new generations of EV-based nanovehicles.…”
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Phosphoglucomutase A-mediated metabolic adaptation is essential for antibiotic and disease persistence in Mycobacterium tuberculosis by Taruna Sharma, Shaifali Tyagi, Rahul Pal, Jayendrajyoti Kundu, Sonu Kumar Gupta, Vishawjeet Barik, Vaibhav Kumar Nain, Manitosh Pandey, Prabhanjan Dwivedi, Bhishma Narayan Panda, Yashwant Kumar, Ranjan Kumar Nanda, Samrat Chatterjee, Amit Kumar Pandey

“…These insights are crucial for developing novel, shorter, and more effective anti-tuberculosis strategies.IMPORTANCEThis study for the first time investigated the role of metabolic enzyme phosphoglucomutase A (pgmA) in Mycobacterium tuberculosis (Mtb), revealing its crucial functions as a toggle switch between biosynthesis and growth. …”
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Orchard variable-rate spraying method integrating GNSS and wind-excited audio-conducted leaf area density by Hangxing Zhao, Hangxing Zhao, Hangxing Zhao, Shenghui Yang, Shenghui Yang, Shenghui Yang, Wenwei Li, Wenwei Li, Han Feng, Han Feng, Shijie Jiang, Shijie Jiang, Weihong Liu, Weihong Liu, Jingbin Li, Yongjun Zheng, Yongjun Zheng, Songchao Zhang

“…Based on this, a method was established for generating prescription maps that integrate spatial positioning and canopy density information. …”
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Advancements in sorption-enhanced steam reforming for clean hydrogen production: A comprehensive review by Ahmad Salam Farooqi, Abdelwahab N. Allam, Muhammad Zubair Shahid, Anas Aqil, Kevin Fajri, Sunhwa Park, Omar Y. Abdelaziz, Mahmoud M. Abdelnaby, Mohammad M. Hossain, Mohamed A. Habib, Syed Muhammad Wajahat ul Hasnain, Ali Nabavi, Mingming Zhu, Vasilije Manovic, Medhat A. Nemitallah

“…The review outlines the potential of SE-SMR to offer more efficient hydrogen production, with the added benefit of in situ carbon capture simplifying the process design. …”
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Unveiling the Therapeutic Potential: Targeting Fibroblast-like Synoviocytes in Rheumatoid Arthritis by Siran Yue, Junyu Fan, Duoli Xie, Chunhao Cao, Zhuqian Wang, Jie Huang, Fang Qiu, Xu Yang, Dongyi He, Aiping Lu, Chao Liang

“…A deeper understanding of the molecular and functional heterogeneity of FLS may pave the way for more effective and precise therapeutic interventions in RA.…”
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eCBT-I dialogue system: a comparative evaluation of large language models and adaptation strategies for insomnia treatment by Xueying Bao, Xingyu Zhu, Dongren Yang, Hao Lou, Ruoyun Wang, Yutong Wu, Wenhui Li, Yu Xia, Li Zeng, Yingying Pan, Xiqin Wang, Xian Zhang, Cheng Ling, Youhui Ling, Yan Zhang, Qi Zhao, Mei Yang

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Improved estimation of two-phase capillary pressure with nuclear magnetic resonance measurements via machine learning by Oriyomi Raheem, Misael M. Morales, Wen Pan, Carlos Torres-Verdín

“…By predicting vector functions from vector input features, we effectively reduced prediction errors. …”
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Emerging Diagnostic Approaches for Musculoskeletal Disorders: Advances in Imaging, Biomarkers, and Clinical Assessment by Rahul Kumar, Kiran Marla, Kyle Sporn, Phani Paladugu, Akshay Khanna, Chirag Gowda, Alex Ngo, Ethan Waisberg, Ram Jagadeesan, Alireza Tavakkoli

“…Point-of-care ultrasound and portable diagnostic devices have expanded real-time imaging and functional assessment capabilities across diverse clinical settings. …”
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Characterization of FosA13, a novel fosfomycin glutathione transferase identified in a Morganella morganii isolate from poultry by Runzhi Zhang, Runzhi Zhang, Yan Yu, Yan Yu, Lulu Huang, Susu Chen, Ruxi Hu, Xiuxiu Wang, Dawei Huang, Chunhan Song, Junwan Lu, Qiyu Bao, Qiyu Bao, Qiyu Bao, Qiyu Bao, Yunliang Hu, Pengfei Jiang, Wei Pan

“…This protein shares the highest aa identity of 55.6% with the functionally characterized protein FosA and has all the essential functional residues of FosA proteins. …”
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Analyzing the Impact of the Presence of Foreign Tourists in Religious Places on Their Attitude Towards Shiism by Marziyeh Farshiddost, Behrooz Badkoo, Mohamad Ghasemisiani

“…The results and findings of this research also showed that foreign tourists in Iran are more familiar with the culture and history of Iran and the tourism infrastructure of the country along with the existing security made them more willing to visit Iran again. …”
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Diseño de un Software de Intermediación de Comunicación para Sistemas Distribuidos de Tiempo Real Críticos en Java by Daniel Tejera, Alejandro Alonso, Miguel A. de Miguel

“…The JRMP protocol was modified to include two phases, non-functional parameters, and message size optimizations. …”
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Genetic transcriptional regulation profiling of cartilage reveals pathogenesis of osteoarthritisResearch in context by Wen Tian, Shan-Shan Dong, Feng Jiang, Jun-Qi Zhang, Chen Wang, Chang-Yi He, Shou-Ye Hu, Ruo-Han Hao, Hui-Miao Song, Hui-Wu Gao, Ke An, Dong-Li Zhu, Zhi Yang, Yan Guo, Tie-Lin Yang

“…This study aims to address this issue by generating a cartilage expression quantitative trait loci (eQTLs) and a functional fine-mapping resource. …”
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Methylation and gene expression patterns in adamantinomatous craniopharyngioma highlight a panel of genes associated with disease progression-free survival by Junier Marrero-Gutiérrez, Ana Carolina Bueno, Ana Carolina Bueno, Clarissa Silva Martins, Rui Milton Patrício Silva-Júnior, Antônio Carlos dos Santos, Marcelo Volpon Santos, Luiz Eduardo Wildemberg, Ximene Lima da Silva Antunes, Monica R. Gadelha, Ayrton Custodio Moreira, Ricardo Zorzetto Nicoliello Vêncio, Sonir Roberto R. Antonini, Margaret de Castro

“…Clustering analyses based on the methylation levels of probes and expression levels of the stringently filtered 212- and 37-gene sets further confirmed these two distinct ACP subgroups. Functional enrichment analysis highlighted key roles in synaptic modulation, nervous system development, cell adhesion, as well as pathways linked to RAS signaling, GTPase activity, and membrane potential regulation.ConclusionAlthough clinical characteristics were largely comparable between the clusters, ACP-B patients exhibited shorter median progression-free survival, suggesting a more aggressive phenotype. …”
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THE PERIPHERY OF THE SPECTACLE: THE SPOILER AND THE TEASER / ПЕРИФЕРИЯ ЗРЕЛИЩА: СПОЙЛЕР И ТИЗЕР by KOZLOV EVGENY V. / КОЗЛОВ Е.В.

“…The redundancy of modern information endows the periphery of a work of art with a very important functional load. The valorization of intrigue and the tension of narrative associated with it are the most important elements of narration which generate interest and control the attention of the audience. …”
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Isostatic Crustal Thickness Under The Tibetan Plateau And Himalayas From Satellite Gravity Gradiometry Data by Robert Tenzer, Mohammad Bagherbandi, Lars E Sjöberg, Pavel Novák

“…We explain this bias by more localized information on the Earth’s inner structure in the gravity gradient eld compared to the potential or gravity fields.  …”
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