Repurposed clindamycin suppresses pyroptosis in tumor-associated macrophages through Inhibition of caspase-1 by Adrian Weich, Johannes Berges, Cindy Flamann, Katrin Bitterer, Krishna Pal Singh, David Chambers, Christopher Lischer, Xin Lai, Olaf Wolkenhauer, Carola Berking, Gerhard Krönke, Shailendra Gupta, Heiko Bruns, Julio Vera, Research Group Macrophages

“…The method generates a ranking of drug-target interactions, the most promising of which are channeled towards experimental validation. …”
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Illumina complete long read assay yields contiguous bacterial genomes from human gut metagenomes by Dylan G. Maghini, Yuya Kiguchi, Aaron E. Darling, Leigh G. Monahan, Aaron L. Halpern, Catherine M. Burke, Erich Jaeger, Aaron Statham, Tiffany Truong, Kevin Ying, Stephen P. Bruinsma, Gary P. Schroth, Ami S. Bhatt

“…ABSTRACT Metagenomics enables direct investigation of the gene content and potential functions of gut bacteria without isolation and culture. …”
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Sol–gel auto-combustion synthesis of a novel ternary magnetic-recyclable ZnFe2O4/ZnO/CeO2 nano-photocatalyst for highly efficient visible-light-induced degradation of organic conta... by Saba Roostaei, Hanieh Ansarinejad, Elmuez A. Dawi, Forat H. Alsultany, Salman Khalaf Issa, Mina Ahmadi-Kashani, Masoud Salavati-Niasari

“…Furthermore, insights into the photocatalytic reaction mechanism and the •OH generation process on the ternary photocatalyst were provided. …”
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Educational Technologies in Modern Higher Education Institutions (Analysis of Russian and Foreign Research and Practice) by N. V. Bordovskaia, E. A. Koshkina, N. A. Bochkina

“…Statistically significant differences were identified for all considered functional characteristics of educational technology in Russian and foreign publications, with the exception of “Student Attitude to Educational Technology”. …”
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Integrating genome and transcriptome analysis to decipher balanced structural variants in unsolved cases of neurodevelopmental disorders by Simona Mellone, Alice Spano, Denise Vurchio, Giulia Borgonovi, Giulia Borgonovi, Alessandro Ugonotti, Giulia Paglino, Alba Bianco, Sara Ronzani, Maurizio Sciancalepore, Flavia Prodam, Flavia Prodam, Amanda Papa, Maurizio Viri, Umberto Dianzani, Umberto Dianzani, Mara Giordano, Mara Giordano

“…Transcriptomic analysis demonstrated the monoallelic and significantly reduced expression of EP300.ConclusionThese findings highlight the crucial role of WGS in identifying disease-associated BCAs and underscore the complementary value of RNA-Seq in assessing their functional consequences. This integrated approach enhanced diagnostic accuracy and clinical management, paving the way for more comprehensive and personalized care in these two patients.…”
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Low-frequency rTMS modulates small-world network properties in an AVH-related brain network in schizophrenia by Lin Zhang, Li Guo, Xiaohui Liu, Jing Han, Yuanqiang Zhu, Chaozong Ma, Ye Li, Weiliang Ye

“…Furthermore, most previous studies have analyzed whole-brain networks, lacking specificity regarding disease-relevant circuits.ObjectiveThis study aimed to investigate how low-frequency rTMS modulates the small-world network properties of a refined AVH-related network composed of 35 brain regions specifically implicated in hallucination generation and rTMS treatment effects, thereby providing a more targeted perspective on network reorganization. …”
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Transcriptional regulatory network reveals key transcription factors for regulating agronomic traits in soybean by Wu Jiao, Mangmang Wang, Yijian Guan, Wei Guo, Chang Zhang, Yuanchun Wei, Zhenwei Zhao, Hongyu Ma, Longfei Wang, Xinyu Jiang, Wenxue Ye, Dong Cao, Qingxin Song

“…We find TF binding sites (TFBSs) exhibit elevated chromatin accessibility and contain more rare alleles than other genomic regions. Intriguingly, the methylation variations at TFBSs partially contribute to expression bias among whole genome duplication paralogs. …”
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IMDM-20 enhances neutrophilic features during 1.3 % DMSO-mediated differentiation of HL-60 cells by Jorge Andrés Cázares-Preciado, José Antonio Cruz-Cárdenas, Alejandra López-Arredondo, Marco V. Gallardo-Camarena, Marion E.G. Brunck

“…Multiple differentiation protocols have been reported to generate neutrophil-like HL-60 cells, with limited consideration of how methodological variations might influence cell identity and functions. …”
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Immunological and biochemical changes in young children with recurrent course of respiratory infections and cytomegaloviral infection by L. N. Boyarskaya, T. S. Herasimchuk, Yu. V. Kotlova, L. N. Boyarskaya, A. H. Davydova

“…In the early convalescence period after respiratory infection process in children with CMV and RRI the immune response is characterized by a decreasing of the functional and metabolic activity of neutrophile granulocytes (р<0,05) and imbalance of humoral immunity consisting in decreased antibody generation (IgА (р<0,05), IgМ (р<0,05), tendency to IgG decreasing). …”
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Expectation Confirmation and Technology Acceptance: A Study of the Public's Attention to Accept the Government's Digital Human Avatar by Jinghao CHEN, Feng JIA, Qianxi LIU

“…[Purpose/Significance] In the digital age, government digital avatars represent a significant innovative application of the integration of generative artificial intelligence and digital government. …”
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Paper and cardboard as sustainable materials by Jerzy F. Latka

“…With regard to operating energy, materials can be rendered more sustainable by ensuring they have a higher thermal insulation value or greater thermal mass. …”
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Development and Analysis of a Non-Resonant Wide-Band Tri-Axial Electromagnetic Energy Harvester by Hamid Khan, Farid Ullah Khan

“…Additionally, experimental results show that the developed harvester can generate much more power than single-coil energy harvesters. …”
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Living and living with nature. A need of today's population for the common good by Manuel Gregorio Loza-Murguia

“…Finally, as human race we depend on the environment and the environment depends on us, we both must live in harmony conserving and preserving our house, each one from its place of origin and its relevance, if only we would do it with integrity we would keep our house at least fit to live in, since there is no other place to go, unless we have a ticket to another planet, although it sounds ridiculous, there is nowhere else to go as human species, in order to preserve ourselves, but being more aware of what we do and what house we want to have and leave to our future generations. …”
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The study of promising secure information systems based on signal modeling by V. A. Sizov, D. M. Malinichev, Kh. K. Kuchmezov

“…Mobile network operators, like consumer electronics manufacturers, will be able to offer “security as a service,” with the result that application providers will be able to apply additional levels of security over existing secure cellular network channels when transferring certain types of data. [7] Due to the better spectral density, the proposed signal conditioning method makes it possible to use prototypes of window functions with the best spatial localization properties without violating the orthogonality condition of the signal bases, and accordingly does not require the use of cyclic prefixes when generating the OFDM signal.…”
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Re-use of Building Products in the Netherlands by Loriane Icibaci

“… Over the years, the consumption of materials for construction exceeded more than half of the total materials consumed in the Netherlands, and construction waste exceeded the volume of solid waste produced by households. …”
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Illumination-adaptative granularity progressive multimodal image fusion method by Chuanyun WANG, Dongdong SUN, Mingqi ZHOU, Tian WANG, Qian GAO, Zhaokui LI

“…During the training phase, prior knowledge is used to generate augmented images as pseudo-labels. Homogeneous and heterogeneous loss functions are constructed based on different environmental conditions, enabling adaptive learning. …”
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Smartphone-based Monitoring and cognition Modification Against Recurrence of Depression (SMARD): An RCT of Memory Bias Modification Training vs. Cognitive Control Training vs. Atte... by N. Ikani, A. Tyborowska, N. Kohn, N. Günther, G J. Siegle, A. H. Schene, J. A. S. Vorstman, C. J. Harmer, M. J. Kas, J. N. Vrijsen, H. G. Ruhé

“…Abstract Background Major Depressive Disorder (MDD) has a 50–80% recurrence rate highlighting the urgent need for more efficient recurrence prevention programs. Currently, recurrences are often identified too late, while existing preventive strategies may not sufficiently address ethio-patho-physiological mechanisms for recurrence. …”
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Surface hardening of ductile austenitic lightweight steel through powder bed fusion 3D printing by Joonoh Moon, Hyun-Uk Hong, Hyungkwon Park, Hyo-Haeng Jo, Seong-Jun Park, Chansun Shin, Heung Nam Han, Myoung-Gyu Lee, Jae Suk Jeong, Bong Ho Lee, Chang-Hoon Lee

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Simultaneously acquired rSUV and rCBF of 18F-FDG/MRI in peritumoral brain zone can help to differentiate the grade of gliomas by Hong Qu, Yuping Zeng, Lifeng Hang, Jin Fang, Hui Sun, Hong Li, Guihua Jiang

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In Silico and In Vitro Studies of the Approved Antibiotic Ceftaroline Fosamil and Its Metabolites as Inhibitors of SARS-CoV-2 Replication by Cássia Delgado, Pablo Andrei Nogara, Milene Dias Miranda, Alice Santos Rosa, Vivian Neuza Santos Ferreira, Luisa Tozatto Batista, Thamara Kelcya Fonseca Oliveira, Folorunsho Bright Omage, Flávia Motta, Izabela Marques Bastos, Laura Orian, João Batista Teixeira Rocha

“…The 1,2,4-thiadiazole functional group is an inhibitor of cysteine proteases, such as papain and cathepsins. …”
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