Modulating the serine metabolism in human differentiated astrocytes: an integrated multi omics approach by Farida Tripodi, Elisa Maffioli, Silvia Sacchi, Valentina Rabattoni, Zoraide Motta, Claudia Bearzi, Gabriella Tedeschi, Gabriella Tedeschi, Loredano Pollegioni, Paola Coccetti

“…IntroductionAstrocytes are the major source of L-serine (L-Ser) in the brain: the glycolytic intermediate D-3-phosphoglycerate is converted into L-Ser through the phosphorylated pathway (PP) made up of three enzymes, phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase (PSAT) and phosphoserine phosphatase (PSP), recently proposed to generate a metabolic assembly named serinosome. In the central nervous system, L-Ser is used for a number of functions, including the synthesis of glycine (Gly) and D-serine (D-Ser), the two key NMDAR co-agonists.MethodsHere, we used iPSC-derived human astrocytes as a cellular model to evaluate the impact on cell metabolism of the overexpression of each of the three enzymes of the PP as GFP-tagged proteins.ResultsThe subcellular cytosolic localization of PP enzymes remains unchanged compared to endogenous proteins, while the complex formation is increased in all cases. …”
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Deciphering the role of dietary modifications and gut dysbiosis in Non-Alcoholic Fatty Liver Disease by Meenakshi Vachher, Kohinoor Kaur, Manisha Marothia, Archana Burman, Deepanjana, Savita Bansal

“…Approximately one-third of the total population is affected by NAFLD. The more aggressive form of NAFLD, non-alcoholic steatohepatitis (NASH) could progress to liver failure, fibrosis, cirrhosis, hepatocellular carcinoma and even death. …”
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Software with artificial intelligence-derived algorithms for detecting and analysing lung nodules in CT scans: systematic review and economic evaluation by Julia Geppert, Peter Auguste, Asra Asgharzadeh, Hesam Ghiasvand, Mubarak Patel, Anna Brown, Surangi Jayakody, Emma Helm, Dan Todkill, Jason Madan, Chris Stinton, Daniel Gallacher, Sian Taylor-Phillips, Yen-Fu Chen

“…When using software with vessel suppression function only, reading time was similar with and without software (one study). …”
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Using the optimal seed germination temperature approach to determine the potential distribution of Inga jinicuil in Mexico under climate change scenarios by Salvador Sampayo-Maldonado, Daniel Cabrera-Santos, Patricia Dávila-Aranda, Norma Isela Rodríguez-Arévalo, Alma Orozco-Segovia, Maraeva Gianella, Elizabeth Bell, Michael Way, Robert H. Manson, Gabina S. Quintas, Cesar M. Flores-Ortíz, Tiziana Ulian

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Special Issue on Contemporary Research Studies in Operations Research, Business Analytics, and Business Intelligence by Viswanath Kumar Ganesan, S. Vinodh, Malolan Sundararaman, M. Vimala Rani, M. Mathirajan

“…Hybrid Anomaly Detection: Proposing a hybrid framework that combines multivariate extension of Hierarchical Temporal Memory with multivariate Sequential Probability Ratio Test for enhanced anomaly detection. 9. Advanced Text Generation: Utilizing advanced text generation techniques like prompt engineering and fine-tuning to produce more readable and engaging content. …”
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TGFβ-specific T cells induced by a TGFβ-derived immune modulatory vaccine both directly and indirectly modulate the phenotype of tumor-associated macrophages and fibroblasts by Mads Hald Andersen, Inés Lecoq, Evelina Martinenaite, Maria Perez-Penco, Lucia Lara de la Torre

“…Reducing immunosuppression and immune exclusion in pancreatic tumors by targeting TAMs and CAFs with the TGFβ-based immune modulatory vaccine emerges as an innovative strategy for the generation of a more favorable environment for immune-based therapies, such as immune checkpoint inhibitors.…”
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Agrobiological features of the new naked oat variety Baget by G. A. Batalova, O. A. Zhuikova, N. V. Krotova, E. N. Vologzhanina, M. V. Tulyakova

“…Naked oat variety Baget was created by method of individual selection from cross population ОА 503/1 (Canada) * Tumensky golozerny (Russia) with following control of trait in further generations. The variety is intended for production of food grain (children, diet, functional, and gluten-free nutrition) as well as for grain forage. …”
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Application Models and Innovative Approaches of Smart Libraries from the Perspective of MR Technology by Jiaxin HUANG, Xiaofang ZHANG

“…The mixed reality (MR) Technology is a new intelligent technology that integrates the advantages of augmented reality (AR) and virtual reality (VR), makes virtual objects coexist in the physical world, and integrates the functions of human perception, computer processing and environmental input. …”
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Descriptive epidemiology of gynecologic and breast cancers between 1988 and 2018 in Burkina Faso, West Africa by Smaila Ouedraogo, Nayi Zongo, Adeline Djiguemde, Hyacinthe Zaman, Aimé Sosthène Ouedraogo, Blandine Thieba

“…However, there are no data on its full extent in Burkina Faso given the lack of functioning national registry of cancer. This study aims to determine the incidence of gynecologic and breast cancers. …”
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Linear Active Disturbance Rejection Control-Based Voltage Controller for Buck and Boost DC/DC Converters in DC Distribution Grids by Asimenia Korompili, Oemer Ekin, Marija Stevic, Veit Hagenmeyer, Antonello Monti

“…In addition, the physical significance of the converter’s states allows the integration of additional control functions, relying on the electrical quantities of the converter, for the enhancement of the performance of the voltage controller. …”
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Mental health disorders among children with special health needs: A population-based cohort study using linked administrative data from Manitoba, Canada. by Jennifer E Enns, Caroline Reid-Westoby, Gilles R Detillieux, Marni Brownell, Nathan C Nickel, Anne Gadermann, Astrid Guttmann, Teresa Bennett, Eric Duku, Barry Forer, Monique Gagné Petteni, Katholiki Georgiades, Martin Guhn, Ana Hanlon-Dearman, Brenda T Poon, Magdalena Janus

“…<h4>Objective</h4>An estimated 15-22% of Canadian kindergarten-age children have a special health need (SHN), defined as a clinical diagnosis, a functional need requiring special accommodation at school, or a health condition leading to increased needs. …”
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Research progress on high-entropy alloys for extreme loading environments by GAO Wei, ZHOU Xichen, ZHU Qianyong, PANG Shujie, ZHAO Shiteng

“…Additionally，tailored optimization approaches should be implemented for distinct advantageous systems and phase structures，particularly those capable of activating dislocation movements，twinning，phase transformations and incorporating novel processing methodologies such as additive manufacturing. Finally，conducting more realistic simulation experiments that closely replicate extreme environments along with generating relevant engineering data are vital steps toward accelerating the practical application of HEAs in challenging settings.…”
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Digital Twin-Based Technical Research on Comprehensive Gear Fault Diagnosis and Structural Performance Evaluation by Qiang Zhang, Zhe Wu, Boshuo An, Ruitian Sun, Yanping Cui

“…Taking the QPZZ-ii gearbox test bed as the physical entity, the research establishes a five-layer architecture: functional service layer, software support layer, model integration layer, data-driven layer, and digital twin layer, forming a closed-loop feedback mechanism. …”
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Benefits of Probiotics—Biodetoxification by Barbara Sionek, Aleksandra Szydłowska, Danuta Jaworska, Danuta Kołożyn-Krajewska

“…The rapid growth of the world’s population is generating escalating demands for food production. Global food demand is expected to increase by 35% to 56% between 2010 and 2050. …”
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The sporophytic type of fertility restoration in the A3 CMS-inducing cytoplasm of sorghum and its modification by plant water availability conditions by L. A. Elkonin, V. V. Kozhemyakin, M. I. Tsvetova

“…For the first time, the transgenerational effect of water availability conditions of growing a fertility-restoring line on male fertility of the F2 generation was detected: a pollinator grown in a plot with additional irrigation produced more fertile and less sterile individuals compared to the same pollinator grown under a rainfall shelter (p &lt; 0.01), and the segregation pattern changed from digenic to monogenic, indicating heritable inhibition of the expression of one of the fertility-restoring genes (kind of “grandfather effect”). …”
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Innovative gene delivery systems for retinal disease therapy by Hongguang Wu, Ling Dong, Shibo Jin, Yongwang Zhao, Lili Zhu

“…Gene delivery systems hold great promise for treating retinal diseases by enabling the targeted delivery of therapeutic genes to affected cells or by converting endogenous cells into functional ones to facilitate nerve regeneration, potentially restoring vision. …”
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VANTAGE: An open‐source application for visualisation, navigation and analysis of video and ancillary time‐series data in bio‐logging studies by Stefan Schoombie, Tagen deWet, Stefan Britz, Andrew D. Lowther, W. Chris Oosthuizen

“…VANTAGE allows the integration of video and other time‐series data recorded at the same time, allowing more efficient analysis and labelling of the data. …”
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Reactive Oxygen Species: A Double-Edged Sword in the Modulation of Cancer Signaling Pathway Dynamics by Manisha Nigam, Bajrang Punia, Deen Bandhu Dimri, Abhay Prakash Mishra, Andrei-Flavius Radu, Gabriela Bungau

“…Additionally, the specific contributions of ROS-generating enzymes, like NOX isoforms and xanthine oxidase, to tumor microenvironment remodeling and immune modulation remain poorly understood. …”
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Care-associated adverse events related to the use of laser in urological interventions: the French experience by Maher Abdessater, Maher Abdessater, Frédéric Panthier, Philippe Michel, Vanessa Avrillon, Bertrand Pogu, Bertrand Pogu, Stéphane Bart, Stéphane Bart

“…Training teams on the use of laser generators and providing feedback on functional results and related specific morbidity seem necessary to guarantee the proper use of these technologies and the safety of staff and patients.…”
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Agent-based modeling of macrophage-fibroblast interactions in the immune response to biomaterials. by Jennifer Riccio, Luca Presotto, Shir Bahiri, Liad Doniza, Donato Inverso, Laura Sironi, Uri Nevo, Giuseppe Chirico

“…They exhibit a variety of functional phenotypes (or states) induced by the stimulus they receive and the microenvironment. …”
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