The human Dicer helicase domain is capable of ATP hydrolysis and single-stranded nucleic acid binding by Kinga Ciechanowska, Agnieszka Szczepanska, Kamil Szpotkowski, Klaudia Wojcik, Anna Urbanowicz, Anna Kurzynska-Kokorniak

“…Conclusions Preservation of ATPase activity by hDicer suggests that this enzyme performs many more functions in the cell than is currently assumed. …”
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Noise-resilient designs and analysis for optical neural networks by Gianluca Kosmella, Ripalta Stabile, Jaron Sanders

“…All analog signal processing is fundamentally subject to noise, and this is also the case in next generation implementations of optical neural networks (ONNs). …”
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Adaptive GCN and Bi-GRU-Based Dual Branch for Motor Imagery EEG Decoding by Yelan Wu, Pugang Cao, Meng Xu, Yue Zhang, Xiaoqin Lian, Chongchong Yu

“…The Adaptive GCN, specifically designed for the MI-EEG context, captures functional connectivity between channels more effectively than conventional GCN models, enabling accurate spatial–spectral feature extraction. …”
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Improved Bald Eagle Search Optimization Algorithm for the Inverse Kinematics of Robotic Manipulators by Guojun Zhao, Bo Tao, Du Jiang, Juntong Yun, Hanwen Fan

“…This algorithm combines the advantages of evolutionary and swarm techniques, making it more effective at solving nonlinear problems and improving search efficiency. …”
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The Effect of Through-Silicon-Via Thermal Stress on Metal-Oxide-Semiconductor Field-Effect Transistor Properties Under Cooling to Ultra-Low Temperatures by Wenting Xie, Xiaoting Chen, Liting Zhang, Xiangjun Lu, Bing Ding, An Xie

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Life cycle assessment of additively manufactured elastocaloric Ni-Ti heat pump/refrigeration components and the effect of design geometry on the environmental impact categories by Anesu Nyabadza, Karthikeyan Tamil, Lehar Asip Khan, Sujith S. Kumar, Corné Muilwijk, Greg McNamara, Kevin O'Toole, Lorna Fitzsimons, Dermot Brabazon

“…A 10 x 10 × 55 mm Ni-Ti structure, providing >2 °C temperature span under compressive cycles, served as the functional unit.…”
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Exploring the Potential of Gold Nanoparticles in Proton Therapy: Mechanisms, Advances, and Clinical Horizons by Giorgio Giuseppe Carbone, Stefania Mariano, Alessandra Gabriele, Sabrina Cennamo, Vitantonio Primiceri, Muhammad Rizwan Aziz, Elisa Panzarini, Lucio Calcagnile

“…This enhances DNA damage in tumor cells while preserving healthy tissues. Additionally, functionalization of gold nanoparticles with tumor-targeting ligands offers improved precision, making proton therapy more effective against a broader range of cancers. …”
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Feasibility and case studies on converting small hydropower stations to pumped storage by Yangqing Dan, Qingyue Chen, Daren Li, Wenhuan Bai, Weiming Zhou, Anyu Yang, Jia Yang

“…This research establishes a comprehensive framework for the conversion of conventional hydropower stations into pumped storage facilities, offering a model for medium-small scale pumped storage and distributed generation technologies. It is recommended to implement photovoltaic forecasting systems at the PV site to achieve more precise control over photovoltaic output and enhance the responsiveness of the pumped storage station to fluctuations in solar power.…”
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Clinical and cost-effectiveness of lithium versus quetiapine augmentation for treatment-resistant depression in adults: LQD a pragmatic randomised controlled trial by Jess Kerr-Gaffney, Zohra Zenasni, Kimberley Goldsmith, Nahel Yaziji, Huajie Jin, Alessandro Colasanti, John Geddes, David Kessler, R Hamish McAllister-Williams, Allan H Young, Alvaro Barrera, Lindsey Marwood, Rachael W Taylor, Helena Tee, Anthony J Cleare

“…Conclusions As well as being more cost-effective, quetiapine may be a more clinically effective augmentation option for treatment-resistant depression. …”
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Photoinduced ferroelectric phase transition triggering photocatalytic water splitting by Jun Wen, Zhi-rui Luo, Lin-can Fang, Wen-xian Chen, Gui-lin Zhuang

“…This study employs real-time time-dependent density functional theory (rt-TDDFT) and first-principle calculations to propose a “one stone, two birds” strategy: light induces ferroelectric phase transitions and triggers PWS on monolayer Hf2Ge2S6. …”
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Establishing the best step-up treatments for children with uncontrolled asthma despite inhaled corticosteroids: the EINSTEIN systematic review, network meta-analysis and cost-effec... by Sofia Cividini, Ian Sinha, Giovanna Culeddu, Sarah Donegan, Michelle Maden, Katie Rose, Olivia Fulton, Dyfrig Hughes, Stephen Turner, Catrin Tudur Smith

“…A cost-effectiveness curve was generated to depict the probability of each intervention being cost-effective at different willingness-to-pay thresholds. …”
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Molecular tools for genome editing in plants: a synthetic overview by Nicolau Brito da Cunha, Michel Lopes Leite, Júlio Carlyle Macedo Rodrigues, Jéssica Carrijo, Fabrício Falconi Costa, Simoni Campos Dias, Elíbio Leopoldo Rech, Giovanni Rodrigues Vianna

“…However, the stochastic nature of the DNA delivery systems, with little control over where the genome modification occurred, required regulatory measures to ensure environmental, human, and animal safety, which has hindered the ability and speed to generate new and more adapted varieties. New technological advances have made it possible to increase the precision of genome modifications leading to a third generation of agricultural products. …”
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Picture: A web application for decision support in glioma surgery by Maisa N.G. van Genderen, Raymond M. Martens, Frederik Barkhof, Philip C. de Witt Hamer, Roelant S. Eijgelaar

“…Background and Objective: Patients with glioma, the most common primary malignant brain tumor, often undergo surgery, aiming to remove as much tumor as possible while maintaining functional integrity. However, there is large variation in surgical decisions. …”
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Self-supported β-Ga2O3 nanowires and for stretchable solar-blind UV photodetectors by Wuxu Zhang, Ziyin Xiang, Tengfei Ma, Baoru Bian, Jinyun Liu, Yuanzhao Wu, Yiwei Liu, Jie Shang, Run-Wei Li

“…We further demonstrate the practical applicability of this technology by fabricating a functional photodetector array capable of solar-blind UV imaging, paving the way for next-generation intelligent firefighting systems.…”
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A reference database enabling in-depth proteome and PTM analysis of mouse immune cells by Devon Siemes, Hannah Voss, Federica Benvenuti, Francesca Simoncello, Dominik Kopczynski, Bente Siebels, Hartmut Schlüter, Laxmikanth Kollipara, Albert Sickmann, Daniel Robert Engel, Olga Shevchuk

“…Abstract Spectral libraries fulfill multiple functions in biological and analytical applications. …”
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Optimizing Transmembrane Protein Assemblies in Nanodiscs for Structural Studies: A Comprehensive Manual by Fernando Vilela, Cécile Sauvanet, Armel Bezault, Niels Volkmann, Dorit Hanein

“…Membrane protein structures offer a more accurate basis for understanding their functional correlates when derived from full-length proteins in their native lipid environment. …”
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Neurophysiological Correlates of Central Fatigue in Healthy Subjects and Multiple Sclerosis Patients before and after Treatment with Amantadine by Emiliano Santarnecchi, Simone Rossi, Sabina Bartalini, Massimo Cincotta, Fabio Giovannelli, Elisa Tatti, Monica Ulivelli

“…In ten healthy subjects and in ten patients suffering from Multiple Sclerosis (MS), we investigated the cortical functional changes induced by a standard fatiguing repetitive tapping task. …”
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Improving the quantification of peak concentrations for air quality sensors via data weighting by C. Frischmon, J. Silberstein, A. Guth, E. Mattson, J. Porter, M. Hannigan

“…Leveraging two different weighting functions, a sigmoidal and a piecewise weighting regime, we explored the impacts of the base model choice (multilinear regression, MLR, vs. random forest, RF, models), the sensitivity of weighting functions, and the ability of data weighting to improve high-concentration pollution measurements. …”
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Tribochemistry of organic friction modifiers in lubrication of bio-hydrogenated diesel by Paweekan Hansungnoen, Ekarong Sukjit, Anawat Phatthanaphon, Atthaphon Maneedaeng

“…A clear hierarchical ranking of functional group effectiveness in reducing friction and wear was established: COOH > –CONH2 > –OH > –COOR, with polar head group chemistry playing a more dominant role than hydrocarbon tail configuration. …”
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Generalization and dilution of association results from European GWAS in populations of non-European ancestry: the PAGE study. by Christopher S Carlson, Tara C Matise, Kari E North, Christopher A Haiman, Megan D Fesinmeyer, Steven Buyske, Fredrick R Schumacher, Ulrike Peters, Nora Franceschini, Marylyn D Ritchie, David J Duggan, Kylee L Spencer, Logan Dumitrescu, Charles B Eaton, Fridtjof Thomas, Alicia Young, Cara Carty, Gerardo Heiss, Loic Le Marchand, Dana C Crawford, Lucia A Hindorff, Charles L Kooperberg, PAGE Consortium

“…Models based directly on functional variation may generalize more robustly, but the identification of functional variants remains challenging.…”
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