Study protocol for a randomized double-blinded placebo-controlled trial on ASA therapy for patients with chronic rhinosinusitis with nasal polyps, NSAID-exacerbated respiratory dis... by Sanna Toppila-Salmi, Sanna Toppila-Salmi, Sanna Toppila-Salmi, Annina Lyly, Annina Lyly, Viljami Salmi, Viljami Salmi, Mikko Nuutinen, Mikko Nuutinen, Michael Kilpiö, Michael Kilpiö, Tanzeela Hanif, Tanzeela Hanif, Tanzeela Hanif, Mikko Niemi, Mikko Niemi, Mikko Niemi, Anu Laulajainen-Hongisto, Lena Hafrén, Mika Mäkelä, Paula Kauppi, Paula Virkkula, Alma Helevä, Alma Helevä

“…Secondary measures include variations in nasal polyp scores, CRS symptom control, general HRQoL, work productivity loss, peak nasal inspiratory flow (PNIF) with or without acoustic rhinometry (ARM), olfactory function assessed by the Sniffin' Sticks identification test, spirometry, peak expiratory flow (PEF), and histopathological findings at the 12-month follow-up.DiscussionThe AirGOs Medical trial is expected to generate data on the therapeutic value and safety profile of ATAD in patients with coexisting severe CRSwNP, N-ERD, and asthma, potentially informing future clinical practice. …”
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Female Adolescent Soccer Players Utilize Different Neuromuscular Strategies Between Limbs During the Propulsion Phase of a Lateral Vertical Jump by Matthew D DeLang, Joseph P Hannon, Shiho Goto, James M Bothwell, J Craig Garrison

“…These findings are important to research on functional performance measures related to attaining between-limb symmetry, as measures of energy generation contribution open the door for a more thorough understanding of joint-by-joint intra-limb contributions during a functional task.…”
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An optimized integrin α6-targeted peptide capable of delivering toxins for melanoma treatment by Zheng Zhao, Zi-Qian Li, Ying-Bin Huang, Meng-meng Liu, Fei Cao, Guo-Long Bu, Peng-Fei Xu, Qi Fang, Zhu-Long Hu, Di Wu, Guo-Kai Feng, Xue-Kui Liu

“…Methods We developed a new combination strategy for the synthesis of penetrating peptides functionalized with targeting of integrin α6. The linear peptide S5 was multimerized with 4 copies in linear sequential order spaced by GSG between each copy to yield the 4S5 peptide. …”
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Novel trispecific killer engager targeting B7-H3 enhances natural killer cell antitumor activity against head and neck cancer by Jeffrey S Miller, Martin Felices, Peter Hinderlie, James Lim, Naomi Fujioka, Shee Kwan Phung, Yvette Soignier, Joshua T Walker, Melissa A Geller, Madison Shackelford, Carly Selleck, Philippa R Kennedy, Mihir Shetty, Melissa J Khaw, Paolo P Provenzano, Nicholas A Zorko, Laura E Bendzick, Riley C Lyons, Elise L Femino, Terran Stenger, Tumpa Dasgupta, Laura E Kotz, Eng Hock Lee, Quynhanh Lu, Zachary B Davis, John E Wagner, Margaret L MacMillan

“…This TriKE is comprised of a camelid nanobody that binds to CD16 on NK cells, an interleukin (IL)-15 moiety, and another novel camelid nanobody that binds to the B7-H3 antigen, which is highly and specifically expressed on the tumor cell surface.Methods The B7H3 TriKE was generated using a mammalian expression system. Its functionality was evaluated using flow cytometry-based NK cell degranulation, cytokine production, proliferation and live cell imaging cytotoxicity assays. …”
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Cell-Type-Specific Heat-Induced Changes in the Proteomes of Pollen Mother Cells and Microspores Provide New Insights into Tomato Pollen Production Under Elevated Temperature by Priya Thapa, Jun Guo, Kajol Pradhan, Dibya Thapa, Sudhakar Madhavarapu, Jing Zou, Jesse Potts, Hui Li, Joshua O’Hair, Chen Wang, Suping Zhou, Yong Yang, Tara Fish, Theodore W. Thannhauser

“…These HS-induced DAPs include proteases, antioxidant proteins, and proteins related to cell wall remodeling and the generation of pollen exine. Conclusions: HS induced more dynamic proteomic changes in meiotic PMCs compared to microspores, and the inter-varietal differences in the PMC proteomes align with the effects of HS on pollen productivity observed in the two varieties. …”
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Development mechanism and practical significance of deep coalbed methane (coal rock gas) infiltration and displacement by Lihong ZHOU, Xia YAN, Hongtao LIU, Xianyue XIONG, Feng WANG, Shuguang LI, Jiyuan ZHANG, Chuanqing LIU, Xiong HU, Pu YUAN, Qianli MA, Xueguang ZHU

“…For 2 nm pores under reservoir and post-fracturing pressure conditions, strong hydrophilic (30° contact angle) and weakly hydrophilic (70°) pores generated capillary forces exceeding 40.1 MPa and 15.8 MPa, respectively, creating intense imbibition driving forces. …”
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Sensing of Liver‐Derived Nicotinamide by Intestinal Group 2 Innate Lymphoid Cells Links Liver Cirrhosis and Ulcerative Colitis Susceptibility by Jing Shen, Zhen Li, Xiaoyu Liu, Mengqi Zheng, Peng Zhang, Yatai Chen, Qiuheng Tian, Wenyu Tian, Guanjun Kou, Yanyan Cui, Bowen Xu, Yunjiao Zhai, Weijia Li, Xiaohuan Guo, Ju Qiu, Chunyang Li, Ran He, Lixiang Li, Chunhong Ma, Yanqing Li, Xiuli Zuo, Detian Yuan, Shiyang Li

“…Mechanistically, the NAD+ salvage pathway regulates gut ILC2s in a cell‐intrinsic manner by supporting the generation of succinate, which fuels the electron transport chain to sustaining ILC2s function. …”
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Low expression of CCKBR in the acinar cells is associated with insufficient starch hydrolysis in ruminants by Yan Cheng, Tianxi Zhang, Chao Yang, Kefyalew Gebeyew, Chengyu Ye, Xinxin Zhou, Tianqi Zhang, Ganyi Feng, Rui Li, Zhixiong He, Oren Parnas, Zhiliang Tan

“…A better understanding of the physiological mechanisms that regulate digestion patterns in ruminants could lead to an increased use of starch concentrates. Here we show more robust pancreatic exocrine function in adult goats (AG) than in neonatal goats (NG) by combining scRNA-seq and proteomic analysis. …”
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Cacao Agroforestry in Mahakam Ulu: Transformation Strategy from Traditional to Good Agricultural Practices and Smart Agroforestry System by Catur Budi Wiati, Eddy Mangopo Angi, Karmilasanti Karmilasanti, Murniati Murniati, Sri Suharti, Indra A.S.L.P. Putri, Aris Pudji Hadi, Muhammad Furkan, Belasius Anyeq, Krista Tala, Veronica Carolina, Awaluddin Aziz, Ria Andiana, Yuliara Limbong, Yosua Naibaho, Mukrimin Mukrimin

“…The implementation of cacao SAF is anticipated to enhance cacao productivity, improve the welfare of local communities, and preserve the forest’s function as a crucial life support system for the Dayak Community in Mahakam Ulu (Mahulu) District. …”
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Real-world validation of safe reinforcement learning, model predictive control and decision tree-based home energy management systems by Julian Ruddick, Glenn Ceusters, Gilles Van Kriekinge, Evgenii Genov, Cedric De Cauwer, Thierry Coosemans, Maarten Messagie

“…Recent advancements in machine learning based energy management approaches, specifically reinforcement learning with a safety layer (OptLayerPolicy) and a metaheuristic algorithm generating a decision tree control policy (TreeC), have shown promise. …”
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SARS-CoV-2 antibody responses in children exhibit higher FcR engagement and avidity than in adults by Carolyn A. Cohen, Ludivine Grzelak, Susan S. Chiu, David SC Hui, Mike YW Kwan, Owen TY Tsang, Wai Hung Chan, Yat Sun Yau, Kelly WK Lee, Masashi Mori, Gaya K. Amarasinghe, Samuel MS Cheng, Leo LM Poon, Malik Peiris, Sophie A. Valkenburg

“…Adults’ SARS-CoV-2 antibody responses could be derived from high avidity pre-existing cross-reactive common cold coronavirus B cell responses, whilst children appear to generate a de novo SARS-CoV-2- specific Spike and Nucleocapsid IgG with robust Fc receptor (FcR) binding ability and high avidity at a higher proportion than adults, thus their responses are more targeted and functional for SARS-CoV-2.…”
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Global disparities in access to hepatitis C medicines before and during the early phase of the COVID-19 pandemic: an ARIMA-based interrupted time series analysis by Nick Bansback, Mina Tadrous, Marie Paul Nisingizwe, Michael R Law, Bethany Hedt-Gauthier, Naveed Z Janjua, Katie J Suda

“…High-income countries purchased more units than other groups. In terms of geographic location, North America (124 144 per 100 000 HCV cases) and Europe (81 001 per 100 000 HCV cases) had the highest DAA sales over time; the newer generation of combination DAAs was mainly used in high-income countries. …”
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Unités Paysagères et services écosystémiques, l’exemple des récifs coralliens by Gilbert David, Émilie Mirault, Gwenaëlle Pennober, Christophe Révillion

“…Thus the reef is not only a natural capital but also a landscape composed of associated resources spaces generating specific ecosystem services. But the finance orientated trend for valuing the environment makes more and more weak this cross cutting view and drives to a deadlock. …”
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Root cause analysis of noise transfer in an entire tractor system using multi-layer operational transfer path analysis by Hyun-Woo Han, Min-Woo Kang, Seong-Hyun Lee, Yun-Ho Seo, Seung-Je Cho, Jeong-Gil Kim, Young-Joo Kim, Young-Jun Park

“…Electric-powered next-generation tractor systems lack masking effects in engines. …”
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Effect of <i>Paulownia</i> and Buckwheat Intercropping on Soil Microbial Biodiversity, Dehydrogenase Activity, and Glomalin-Related Soil Protein by Małgorzata Woźniak, Marek Liszewski, Anna Jama-Rodzeńska, Elżbieta Gębarowska, Sylwia Siebielec, Agata Kaczmarek, Bernard Gałka, Dariusz Zalewski, Przemysław Bąbelewski

“…This study shows that tree-based intercropping (TBI) systems promote a more diverse soil microbial community and function than conventional agriculture. …”
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The Coaching for Cognition in Alzheimer's (COCOA) trial: Study design by Jared C. Roach, Junko Hara, Deborah Fridman, Jennifer C. Lovejoy, Kathleen Jade, Laura Heim, Rachel Romansik, Adrienne Swietlikowski, Sheree Phillips, Molly K. Rapozo, Maria A. Shay, Dan Fischer, Cory Funk, Lauren Dill, Michael Brant‐Zawadzki, Leroy Hood, William R. Shankle

“…Secondary outcome measures include the Functional Assessment Staging Test (FAST), a measure of function. …”
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Reaching new frontiers in nanoelectronics through artificial intelligence by Santhosh Sivasubramani, Themis Prodromakis

“…In materials discovery, AI aids in identifying new, more efficient and sustainable materials. In device design, it enhances the functionality and integration of components. …”
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Grown up in the face of values. The subjective dimension of shaping values in human life. by Rafał Bodarski

“…More and more advanced technological progress, changes in the area of the life model, transforming economies from fossil fuels to renewable energy sources pose a number of challenges and the need to forecast the future. …”
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Inference of Impulse Responses via Bayesian Graphical Structural VAR Models by Daniel Felix Ahelegbey

“…Impulse response functions (IRFs) are crucial for analyzing the dynamic interactions of macroeconomic variables in vector autoregressive (VAR) models. …”
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ICOS-expressing CAR-T cells mediate durable eradication of triple-negative breast cancer and metastasis by Hui Zhang, Fei Yu, Xinxin Chen, Haiyan Ye, Tao Zeng, Lixue Cao, Haojie Peng, Yanzhen Chen, Baijin Xia, Jialing Guo

“…We developed ICOS-enhanced B7H3-CAR-T cells (ICOS-B7H3-CAR) using the third-generation CAR-T cell technology, which featured magnified ICOS expression and targeted the B7H3 antigen. …”
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