Improved CAR internalization and recycling through transmembrane domain optimization reduces CAR-T cytokine release and exhaustion by Shufeng Xie, Shufeng Xie, Jinlan Long, Ruiheng Wang, Ruiheng Wang, Rufang Xiang, Rufang Xiang, Huajian Xian, Yixin Wang, Weiyu Dou, Wenjie Zhang, Dan Li, Ting Kang, Zhihong Chen, Zhihong Chen, Chunjun Zhao, Zhenshu Xu, Han Liu

“…In this study, we aim to enhance CAR-T cell function by focusing on the solely transmembrane domain design.MethodsUtilizing plasmid construction and lentivirus generation, we get two different transmembrane CAR-T cells [19CAR-T(1a) and 19CAR-T(8α)]. …”
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Deep reinforcement learning based online lifting path planning for tower cranes in unknown dynamic environments by Kai Wang, Jing Li, Zhiyuan Yin, Jiankang Zhang, Xin Ma

“…A discrete-continuous hybrid action space for tower cranes is proposed to optimize planned lifting paths more suitable for practical engineering operations. …”
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Exact block encoding of imaginary time evolution with universal quantum neural networks by Ermal Rrapaj, Evan Rule

“…We prove that this wave-function Ansatz is closed under the action of the imaginary time propagator and, more generally, can represent the action of a universal set of quantum gate operations. …”
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Effect of random terms on the shape of dendrites analyzed by the phase-field model. by Shinya Fujiwara, Kiyoshiro Okada, Katsuhiro Endo, Kenta Hirayama, Mayu Muramatsu

“…The probability density function of random numbers does not affect the shape of dendrites. …”
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Super-resolution mapping of anisotropic tissue structure with diffusion MRI and deep learning by Alfredo Ordinola, David Abramian, Magnus Herberthson, Anders Eklund, Evren Özarslan

“…At low signal-to-noise ratios, our super-resolution method provides more accurate estimates of the fODF compared to data collected with 8 times smaller voxel volume.…”
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Utilizing small molecules to probe and harness the proteome by pooled protein tagging with ligandable domains by Katherine E. Larrimore, Yevgeniy V. Serebrenik

“…These libraries unlock opportunities to explore the proteome with a versatile toolbox of small molecule probes designed to interact with the fused tags, allowing researchers to visualize protein localization, induce protein misfolding, manipulate protein-protein interactions, modulate protein stability, and more in a scalable, systematic manner. This review explores recent studies employing multifunctional domains at proteome scale, delving into how the associated chemical probes have been employed to enable insights into endogenous protein function, cellular processes, and disease mechanisms. …”
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A Dynamic Load Modulation Power Amplifier with Ferroelectric-Based Tunable Matching Network by Pavel Turalchuk, Irina Filipiuk, Bayazet Iskakov

“…Measurement studies of the dynamic load modulation power amplifier have demonstrated an efficiency of at least 50% at 8 dB back-off and more than 60% at peak power at 2.5 GHz. Furthermore, it was found that the modulator output voltage adjustment function on input power of the bias modulator affects the linearity of the output power. …”
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Genetic clustering algorithm by M. A. Anfyorov

“…As a result, it has been found that stabilization of splitting into clusters is reached when the number of completed generations of evolution is 200 and more, and the population size is rather small: from 150 chromosomes (in this case no considerable amount of random-access store is required). …”
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Operational monitoring of acoustic sensor networks by V. A. Boltenkov, G. Kh. M. Al-Jasri

“…The second method requires significantly more time control.…”
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Research on multi-sensor fusion detection and tracking technology for autonomous-rail rapid transit tram by PAN Wenbo, YUAN Xiwen, LIN Jun, XIE Guotao, LONG Teng, HUANG Wenyu

“…Firstly, a millimeter-wave radar and LiDAR are used to perceive by single sensor, and the sensing results were merged by using a multi-source fusion algorithm, to generate more accurate detection results. Based on the false alarm filtering algorithm, the problem of false alarm probably caused by the millimeter wave radar was solved. …”
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Strategies for choice of antiretroviral therapy in patients with HIV infection and concomitant cardiovascular disease: A review by Vasily I. Shakhgildyan, Simon T. Matskeplishvili

“…Comorbidity is gradually becoming one of the main drivers for premature mortality in HIV patients: in Russia, from 2007 to 2022, mortality rates in HIV patients not related to opportunistic infections increased more than twofold. People living with HIV have all the common cardiovascular risk factors, moreover, special attention should be paid to kidney function, since its impact on cardiovascular disease (CVD) risk is frequently underestimated. …”
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Seeking Optimal Region-Of-Interest (ROI) Single-Value Summary Measures for fMRI Studies in Imaging Genetics. by Yunxia Tong, Qiang Chen, Thomas E Nichols, Roberta Rasetti, Joseph H Callicott, Karen F Berman, Daniel R Weinberger, Venkata S Mattay

“…Our results show that four of these measures, particularly those that represent values from the top most-activated voxels within an ROI are more powerful at reliably detecting group differences and generating greater effect sizes than the others.…”
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Boyer-Moore String Matching Algorithm and SHA512 Implementation for Jpeg/exif File Fingerprint Compilation in DSA by Rachmad Fitriyanto, Anton Yudhana, Sunardi Sunardi

“…Hash value is important element inside DSA to identify information data integrity using hash function to generate message digest. Jpeg/exif is image file format that produce by digital camera as in smartphone. …”
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Structural strength analysis and optimization of converter lug based on Kriging model by HE Guanqiang, LIU Yongjiang, LI Hua, CHEN Liming

“…For typical rail transit converters, each static strength analysis with four working conditions costs at least 1 hour, and each random vibration analysis with one axis costs more than 8 hours. As a result, for using traditional engineering optimization methods to optimize the converter structure, the optimization efficiency will be severely limited, since these methods need to invoke a large amount of simulations as function evaluations. …”
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MMFOSOM: A Novel Multi-objective Moth–Flame Optimization Algorithm Based on Self-Organizing Mapping by Zhifu Li, Ziyang Zheng, Chengkai Ni, Mingzong Li

“…However, in cases with multiple objectives, selecting the best solution becomes more complex, as these objective functions often conflict with one another. …”
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Age-related changes in Kv4/Shal and Kv1/Shaker expression in Drosophila and a role for reactive oxygen species. by Maximiliano J Vallejos, Abdunaser Eadaim, Eu-Teum Hahm, Susan Tsunoda

“…We show that Kv4/Shal protein levels decline sharply from 3 days to 10 days, then more gradually from 10 to 40 days after eclosion. …”
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Advancing Insights into Large-Artery Stiffening in Humans Through the Application of Multi-omics by Marie-Joe Dib

“…Aging and various pathologic states impair this cushioning function, a phenomenon known as large-artery stiffening (LAS). …”
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Cyanidin-3-glucoside: targeting atherosclerosis through gut microbiota and anti-inflammation by Zihan Tang

“…Cyanidin-3-glucoside (C3G), a water-soluble flavonoid abundant in pigmented fruits and vegetables, exhibits potent antioxidant, anti-inflammatory, and anti-hypertensive bioactivities. More importantly, C3G engages in bidirectional interactions with the gut microbiota. …”
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Humidity measurements in carbon dioxide with Sensirion SHT85 humidity sensors under simulated Martian atmospheric conditions by A. Lorek, S. P. Garland

“…However, the SHT75 sensors from Sensirion used at that time are no longer in production and have been replaced by a new generation of sensors: SHT85. The SHT85 sensors are more precise than their predecessors, have a new sensor chip, and feature a PTFE membrane over the humidity-sensitive layer to protect the sensor from dust and liquids. …”
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The Influence of the working fluid and Regenerator material on the Performance of the types Gamma Stirling Engine by yahya abbas, Ali A. F. Al-Hamadani

“…The engine's most notable features are minimal noise, vibration, and pollution, as well as its capacity to function with any external heat source, including biomass, solar energy, and industrial waste. …”
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