MOG-specific CAR Tregs: a novel approach to treat multiple sclerosis by Jihane Frikeche, Marion David, Xavier Mouska, Damien Treguer, Yue Cui, Sandrine Rouquier, Enora Lecorgne, Emma Proics, Papa Babacar Fall, Audrey Lafon, Gregory Lara, Alexandra Menardi, David Fenard, Tobias Abel, Julie Gertner-Dardenne, Maurus de la Rosa, Celine Dumont

“…While several disease-modifying therapies are available to treat MS, these therapies are not universally effective and do not stop disease progression. More personalized long-term treatment options that target specific aspects of the disease, such as reducing relapse frequency, delaying disability accumulation, and addressing symptoms that impact daily functioning, as well as therapies that can promote neuroprotection and repair are needed. …”
Get full text

Targeting key angiogenic pathways with a bispecific CrossMAb optimized for neovascular eye diseases by Jörg T Regula, Peter Lundh von Leithner, Richard Foxton, Veluchamy A Barathi, Chui Ming Gemmy Cheung, Sai Bo Bo Tun, Yeo Sia Wey, Daiju Iwata, Miroslav Dostalek, Jörg Moelleken, Kay G Stubenrauch, Everson Nogoceke, Gabriella Widmer, Pamela Strassburger, Michael J Koss, Christian Klein, David T Shima, Guido Hartmann

“…These properties make RG7716 a potential next‐generation therapy for neovascular indications of the eye.…”
Get full text

Enhanced Control of Single Crystalline Ag Dendritic Growth on Al Foil via Galvanic Displacement and Simultaneous Oxidation of D‐Glucose by Lidija D. Rafailović, Stefan M. Noisternig, Jana Bischoff, Christian Rentenberger, Daniel Bautista – Anguis, Huaping Sheng, Christoph Gammer, Jia Min Chin, Adam Elbataioui, Huanqing Zhang, Jürgen Eckert, Tomislav Lj. Trišović

Get full text

Mass Spectrometry Identification and Computational Chemistry Study of Fluoromethcathinone Isomers by Xiao-wei LI, Xiang-li LIN, Xuan-yu ZHOU, Xing KE, Yi-lei FAN, Yu XU, Jia-wei XU

“…In addition, the fragmentation mechanisms of 3-FMC and 4-FMC were investigated by applying density functional theory calculation, which can more accurately elucidate the mass spectral behavior and structure characteristics of compounds as reflected by mass spectrometric data. …”
Get full text

LABORATORY STUDY OF POLYMERIZATION DEPTH OF COMPOSITE MATERIALS by O.A. Udod, Kh.I. Bekuzarova

“… With the advent of modern improved restorative materials, the process of teeth restoration has become even more complex, but it provides an impeccable anatomical, functional and aesthetic result. …”
Get full text

Unraveling the potential of microbial diversity in pesticide remediation: An eco-friendly approach for environmental sustainability by Adhi Singh, Kailash Chand Kumawat

“…Their subsequent use in contemporary agriculture for pesticides breakdown highlights the need of promoting pesticide stress tolerance. The functions of soil-dwelling PGPR's in reducing pesticide stress, the supply of nutrients (nitrogen fixation and phosphorus solubilization), the generation of phytohormones, and the variables that may significantly impact their efficacy. …”
Get full text

An Improved Multi-Chaotic Public Key Algorithm Based on Chebyshev Polynomials by Chunfu Zhang, Jing Bai, Yanchun Liang, Adriano Tavares, Lidong Wang, Tiago Gomes, Sandro Pinto

“…The improved cryptographic algorithm also utilizes chaotic hash functions and logistic mapping to generate pseudo-random sequences and overcomes shortcomings of the Bose algorithm by iteratively iterating the selected Chebyshev polynomials based on the number of 0s or 1s in the pseudo-random sequence, thus providing better security. …”
Get full text

Molecular mechanisms of leukemogenesis by D. A. Domninskiy

“…Modern medicine is on the verge of the emergence of a large number of new generation drugs whose activity is aimed at modulating (activating or suppressing) the functions of certain target molecules that are involved in the processes of leukemia. …”
Get full text

Circulating CXCR5⁺CD4⁺ T Follicular-Like Helper Cell and Memory B Cell Responses to Human Papillomavirus Vaccines. by Ken Matsui, Joseph W Adelsberger, Troy J Kemp, Michael W Baseler, Julie E Ledgerwood, Ligia A Pinto

“…Through the interaction of T follicular helper (Tfh) cells and B cells, efficacious vaccines can generate high-affinity, pathogen-neutralizing antibodies, and memory B cells. …”
Get full text

Gut microbiome composition and diversity of wild-caught and hatchery-bred milkfish (Chanos chanos) fry by Gardel Xyza L. Silvederio, Therese F. Javellana, Ande Bryle N. Genciana, Maria Alexandra G. Fontanilla, Rex Ferdinand M. Traifalgar, Fredson H. Huervana, Carmelo S. del Castillo

“…Despite numerous studies on gut microbiota of wild and cultured fish species, the diversity and functional roles of the milkfish fry gut microbiome remain poorly understood. …”
Get full text

Multi-Objective Improved Differential Evolution Algorithm-Based Smart Home Energy Management System Considering Energy Storage System, Photovoltaic, and Electric Vehicle by Mina GhasemiGarpachi, Moslem Dehghani, Mokhtar Aly, Jose Rodriguez

“…Home energy management systems (HEMSs) are becoming increasingly popular as smart homes become more prevalent, along with their ability to reduce peak network loads and generate and store green energy locally. …”
Get full text

Normal stress on surface of mesenchymal stem cells boosts extracellular vesicle secretion and regenerative bioactivity by Chengmeng Bai, Huifang Ren, Feng Zhang, Dandan Li, Qingyu Feng, Ying Li, Ting Chen, Chengxu Li, Xuan Xiao, Hengrui Zhang, Liang Hu

“…Here, we present a user-friendly method to manipulate the extracellular mechanical microenvironment of umbilical cord-derived mesenchymal stem cells (MSCs), a promising cell type for generating sEVs with therapeutic benefits, to boost sEV secretion and regenerative bioactivity. …”
Get full text

Constructing a knee osteoarthritis transplant via the neutrality aggregation operators under spherical fuzzy Z-numbers framework by Shahzaib Ashraf, Maria Akram, Subrata Jana, Jungeun Kim, Ibrahim M. Hezam, Chiranjibe Jana

“…We first investigate the SFZˆN notion, their accuracy and scoring functions, and the fundamental ideas that underlie their work. …”
Get full text

Improved Translational Relevance of In Vitro Fibrosis Models by Integrating IOX2-Mediated Hypoxia-Mimicking Pathways by Manuel A. González Hernández, Jennifer Venhorst, Lars Verschuren, Karin Toet, Martien P. M. Caspers, Martine C. Morrison, Beatrice Coornaert, Gerard J. P. van Westen, Roeland Hanemaaijer

“…Here, the ability of a hypoxia-mimicking compound (IOX2) to more accurately reflect the human fibrotic phenotype on a functional level was investigated. …”
Get full text

Clinical and cost-effectiveness of lithium versus quetiapine augmentation for treatment-resistant depression in adults: LQD a pragmatic randomised controlled trial by Jess Kerr-Gaffney, Zohra Zenasni, Kimberley Goldsmith, Nahel Yaziji, Huajie Jin, Alessandro Colasanti, John Geddes, David Kessler, R Hamish McAllister-Williams, Allan H Young, Alvaro Barrera, Lindsey Marwood, Rachael W Taylor, Helena Tee, Anthony J Cleare

“…Conclusions As well as being more cost-effective, quetiapine may be a more clinically effective augmentation option for treatment-resistant depression. …”
Get full text

A stable and biocompatible shortwave infrared nanoribbon for dual-channel in vivo imaging by Cheng Yao, Ruwei Wei, Xiao Luo, Jie Zhou, Xiaodong Zhang, Xicun Lu, Yan Dong, Ruofan Chu, Yuxin Sun, Yu Wang, Wencheng Xia, Dahui Qu, Cong Liu, Jun Ren, Guangbo Ge, Jinquan Chen, Xuhong Qian, Youjun Yang

Get full text

Screening and characterization of the scFv for chimeric antigen receptor T cells targeting CEA-positive carcinoma by Chengcheng Zhang, Linling Wang, Qianzhen Zhang, Junjie Shen, Xia Huang, Meiling Wang, Yi Huang, Jun Chen, Yanmin Xu, Wenxu Zhao, Yanan Qi, Yunyan Li, Yanjiao Ou, Zhi Yang, Cheng Qian

“…Therefore, this study aimed to identify the optimal scFv and investigate its biological functions to further optimize the therapeutic potential of CAR-T cells targeting CEA-positive carcinoma.MethodsWe screened four reported humanized or fully human anti-CEA antibodies (M5A, hMN-14, BW431/26, and C2-45), and inserted them into a 3rd-generation CAR structure. …”
Get full text

Glycerol-assisted grain modulation in femtosecond-laser-induced photochemical synthesis of patterned ZnO nanomaterials by Yingchen Wang, Songyan Xue, Yinuo Xu, Jing Long, Binzhang Jiao, Hui Gao, Xuhao Fan, Yuncheng Liu, Leimin Deng, Wei Xiong

“…ZnO nanomaterials have become appealing for next-generation micro/nanodevices owing to their remarkable functionality and outstanding performance. …”
Get full text

Association Aamong Ppolymorphisms in the Aapoptosis‐Rrelated NKX3‐1, Caspase‐3, Caspase‐9, and BCL‐2 Genes and Prostate Cancer Susceptibility From 9706 Cases and 12,567 Controls... by Yanyan Feng, Zhenting Feng, Dan Li, Jiandong Gui, Zhihong Song, Xiaohua Xie, Lijie Zhu, Yuanyuan Mi

“…Aims This meta‐analysis was thus developed with the goal of generating more precise estimates of the relationships between polymorphisms in four apoptosis‐associated genes (NKX3‐1, caspase‐3, caspase‐9, and BCL‐2) and the risk of PCa. …”
Get full text

Chromosome-level genome assembly, reannotation and decoding of a Trichomonas vaginalis clinical isolate from Shiyan, Central China by Yanqing Zhao, Yinjie Lian, Wei Guan, Peng Wu, Shuguo Yang, Jian Li

“…Results: The present assembled TV-THS1 genome, spanning 185.45 Mb, was comprised of 934 contigs with a contig N50 length of 467.79 kb anchored to six pseudochromosomes, accounting for more than 88 % of the assembled genome (164.56 Mb). …”
Get full text