Generation and engineering of potent single domain antibody-based bispecific IL-18 mimetics resistant to IL-18BP decoy receptor inhibition by Britta Lipinski, Laura Unmuth, Paul Arras, Stefan Becker, Christina Bauer, Lars Toleikis, Simon Krah, Achim Doerner, Desislava Yanakieva, Ammelie Svea Boje, Katja Klausz, Matthias Peipp, Vanessa Siegmund, Andreas Evers, Harald Kolmar, Lukas Pekar, Stefan Zielonka

“…By engineering paratope valencies and the spatial orientation of individual paratopes within the overall design architecture, we were able to generate IL-18 mimetics displaying significantly augmented functionalities, resulting in bispecific cytokine mimetics that were more potent than IL-18 in triggering proinflammatory cytokine release. …”
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Decade-long delayed diagnosis of hypophosphatasia until next generation tooth loss: case reports on dental rehabilitation, diagnostic challenges and clinical implications by Yating Cao, Feng Zhang, Xingxing Huang, Ai Jiang, Shaoyun Jiang, Min Wu

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Facilitating real-time LED-based photoacoustic imaging with DenP2P: An optimized conditional generative adversarial deep learning solution by Avijit Paul, Srivalleesha Mallidi

“…To mitigate those issues, we explored a gamut of architectural options of the Pix2Pix-based conditional generative adversarial network (cGAN) analyzing objective functions, optimizers, activation, and normalization layers. …”
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IDE Support of String-Embedded Languages by S. Grigorev, E. Verbitskaia, M. Polubelova, A. Ivanov, E. Mavchun

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Information and Life: Towards a Biological Understanding of Informational Phenomena by Pedro C. Marijuán

“…The variant in-formation spelling emphasizes that the cellular coupling among constitutive (proteomic), generative (genomic), and communicational (signaling) information genera produces a differentiated mode of existence, the living state, which is always in the making, perpetually in formation. …”
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Plumbagin, a natural derivative of 1,4-naphthoquinone, induces cyclopic phenomenon via increased apoptosis and ROS generation in the early stage of zebrafish embryos by Yeonju Lim, Chaeeun Kim, Donghyeon Kim, Myoung-Jin Kim, Ji-Woo Yu, Min-Ho Song, Yurim Kim, Junhee Son, Ji-Ho Lee, Sung-Eun Lee

“…The cyclopia induced by PL was more severe than that of the positive controls, ethanol, forskolin, and cyclopamine. …”
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Generation of transchromosomic mice harboring HLA-A/B/C and human B2M via mouse artificial chromosome and triple BAC integration by Nanami Kishima, Takashi Moriwaki, Narumi Uno, Teruhiko Suzuki, Satoshi Abe, Masaki Sugawara, Yuichi Nagashima, Kanako Kazuki, Takeshi Endo, Kyotaro Yamazaki, Wakana Nakagawa, Reika Yuno, Yui Moriguchi, Satoko Matsukura, Kazuma Tomizuka, Yasuhiro Kazuki

“…Abstract Humanized transgenic mice carrying human genes are useful for research on gene function and disease. Bacterial artificial chromosomes (BACs) that carry human genomic sequences with regulatory elements enable the expression of transgenes at physiological levels in vivo. …”
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GenePixKolor (GPK) Fusion: A Novel Evolutionary Algorithm-Based Optimized NFT Card Generation and Rarity Ranking Method for Gaming Tokenomics by J. Guruprakash, P. Pradeep, L. B. Krithika

“…Fusing pixel rarity with trait rarity provides a more holistic assessment of an NFT’s uniqueness, balancing functional value with visual attractiveness. …”
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COMPARATIVE ANALYSIS OF THE ANTHROPOMETRIC CHARACTERISTICS, PHYSICAL PREPAREDNESS AND TECHNICAL SKILLS OF 14-YEAR-OLD BASKETBALL PLAYERS – BOYS AND GIRLS by Mariana Borukova

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CROSS-SECTION GENERATION OF VARIOUS GEO-SCIENTIFIC FEATURES WITHOUT CONTOUR DIGITIZATION USING A VISUAL C++ BASED SOFTWARE APPLICATION ‘VIGAT 2005’ by Dasgupta A. R., Solanki Ajay M., Rathod Brijesh G., Srivastava Naveenchandra N., Patel Vivek R., Machhar Suresh P.

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The operational municipal solid waste management policy focuses on identifying waste generation behavior across multiple levels in mega cities, a case study by Hamed Alimoradiyan, Ahmad Hajinezhad, Hossein Yousefi, Mario Giampietro

“…Moreover, developed regions produce more waste per person, attributed to higher input (consumption) and consequently higher waste generation. …”
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Modifying Parallel Excitations into One Framework for C(sp3)─H Bond Activation with Energy Combined More Than Two Photons by Qingbo Shen, Jiali Chen, Xu Jing, Chunying Duan

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Adult Neuroplasticity: More Than 40 Years of Research by Eberhard Fuchs, Gabriele Flügge

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Amplifying the Voices of South Korean Youths as a Generational Minority Against Conventional Paths of Success Through Hip Hop Music: A Text Analysis of Lyrics by James Jungho An, Yoona Kim, Wonjae Choi, Myunggu Jung

“…These findings suggest that, just as hip hop has historically functioned as a tool for empowering racial minorities, hip hop can provide a platform for younger or less dominant generations to challenge and potentially redefine the conventional measures of success imposed by previous or more dominant generations in South Korea.…”
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Thrombomodulin is a stronger indicator of combined oral contraceptives-induced activated protein C pathway resistance in the thrombin generation test than activated protein C by Marisa Ninivaggi, Lily Sokolova, Lily Sokolova, Demy Donkervoort, Bas de Laat, Bas de Laat, Romy de Laat-Kremers

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Association between sensitization to common fungi and severe asthma by Ziqiu Chen, Yu He, Huaien Bu

“…Subgroup analyses further revealed that Aspergillus (A. fumigatus) sensitization was more strongly linked to severe asthma risk in younger and male populations: ORs with 95% CIs were 2.55 (1.35–4.83) in the ≥40 years subgroup, 3.04 (1.01–9.12) in the <40 years subgroup, and 2.77 (1.16–6.62) in the female-majority subgroup.ConclusionIn this study, we quantified the risk of sensitization to distinct fungal genera/species, aiming to provide a scientific rationale for screening high-risk fungal sensitization, early detection of severe asthma risk, and personalized health management for patients.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier [CRD42024620737].…”
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Do women prefer more complex music around ovulation? by Benjamin D Charlton, Piera Filippi, W Tecumseh Fitch

“…If so, women may be expected to show heightened preferences for more complex music when they are most fertile. Here, we used computer-generated musical pieces and ovulation predictor kits to test this hypothesis. …”
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Enhancement of the operating time of the overcurrent relay of the distribution network with high-level penetration of renewable energy sources by Mahmoud Aref, Mahmoud A. Mossa, Emad Abdelkarim, Khairy Sayed, Mishari Metab Almalki, Alaa F.M. Ali

“…The calculation of the output current of distribution generation (DG) units interfaced with an inverter during the fault is a major issue for isolated and grid-connected distributed networks. …”
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Development of Human Mast Cells from Hematopoietic Stem Cells within a 3D Collagen Matrix: Effect of Stem Cell Media on Mast Cell Generation by Tahereh Derakhshan, Rudra Bhowmick, Jerry W. Ritchey, Heather Gappa-Fahlenkamp

“…This work demonstrates the development of functional MCs within a 3D collagen matrix using a stem cell media that supports fibroblast and ECs.…”
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Isoliensinine Induces Ferroptosis in Urothelial Carcinoma Cells via the PI3K/AKT/HIF-1α Axis: Molecular Evidence from Next-Generation Sequencing by Yun-Chen Li, Hsuan-En Huang, Chia-Ying Yu, Ya-Chuan Chang, Shu-Yu Lin, Shao-Chuan Wang, Wen-Wei Sung

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