Genetic transcriptional regulation profiling of cartilage reveals pathogenesis of osteoarthritisResearch in context by Wen Tian, Shan-Shan Dong, Feng Jiang, Jun-Qi Zhang, Chen Wang, Chang-Yi He, Shou-Ye Hu, Ruo-Han Hao, Hui-Miao Song, Hui-Wu Gao, Ke An, Dong-Li Zhu, Zhi Yang, Yan Guo, Tie-Lin Yang

“…Summary: Background: Genome-wide association studies (GWAS) have identified more than one hundred risk loci for osteoarthritis (OA). …”
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A novel single-port robotic system in urology: A prospective multicenter single-arm clinical trial evaluating feasibility and efficacy of first 50 cases by Zheng Wang, Chao Zhang, Taile Jing, Yong Wei, Chengwu Xiao, Yang Wang, Yu Fang, Xiaofeng Wu, Shouyan Tang, Hong Xu, Yi Liu, Bo Yang, Shuo Wang, Bin Xu, Qingyi Zhu, Dan Xia, Zhenjie Wu, Xiaofeng Gao, Linhui Wang

“…The study's primary endpoints focused on the success of surgeries, defined as no deviations from planned procedures, no need for more than one port, and no re-operations within 24 h after surgery. …”
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Assessing long term impact of regional climate and human activities on vegetation greenness dynamics in Sundarbans by Muhammad Sadiq Khan, Ayesha Akter, Ismail Khan, Luis Carlos Ramos Aguila, Lina Akter, Mengmeng Yang, Xu Li, Yuelin Li

“…The results revealed a significant annual increase in greenness (0.0021/year, p = 0.01), with a more pronounced improvement in the wet season (0.0026/year, p = 0.001) compared to the dry season (0.0016/year, p = 0.05). …”
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Combatting environmental impacts and microbiological pollution risks in Potato cropping: Benefits of forage cultivation in a semi-arid region by Xudong Sun, Yousif Abdelrahman Yousif Abdellah, Guangyan Wang, Huasen Wang, Jishao Jiang, Yu Zhang, Caspar C.C. Chater, Yongping Yang, Yuanwen Duan, Fuqiang Yu, Dong Liu

“…Moreover, continuous potato cultivation (CPC) results in more specific ARGs than non-potato cultivation (NPC). …”
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Water Stress Promotes Secondary Sexual Dimorphism in Ecophysiological Traits of Papaya Seedlings by Ingrid Trancoso, Guilherme A. R. de Souza, João Vitor Paravidini de Souza, Rosana Maria dos Santos Nani de Miranda, Diesily de Andrade Neves, Miroslava Rakocevic, Eliemar Campostrini

“…Plant genders could express different functional strategies to compensate for different reproductive costs, as females have an additional role in fruit and seed production. …”
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Dissecting the tumor microenvironment in primary breast angiosarcoma: insights from single-cell RNA sequencing by Peikai Ding, Shengbin Pei, Yi Zhai, Zheng Qu, Yazhe Yang, Xiaolong Feng, Qiang Liu, Xiangyu Wang, Wenxiang Zhang, Zhongzhao Wang, Xiangyi Kong, Jing Wang, Yi Fang

“…These findings may inform the development of more effective treatment strategies for this rare and challenging tumor type.…”
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CD137 and PD-L1 targeting with immunovirotherapy induces a potent and durable antitumor immune response in glioblastoma models by Hong Jiang, Sandra Hervás-Stubbs, Sara Labiano, Candelaria Gomez-Manzano, Juan Fueyo, Marta Alonso, Zhihong Chen, Montserrat Puigdelloses, Marc Garcia-Moure, Virginia Laspidea, Marisol Gonzalez-Huarriz, Marta Zalacain, Lucia Marrodan, Naiara Martinez-Velez, Daniel De la Nava, Iker Ausejo, Guillermo Herrador, Dolores Hambardzumyan, Ana Patino Garcia, Jaime Gállego Pérez-Larraya

“…Moreover, Delta-24-ACT expressed functional 4-1BBL that was able to costimulate T lymphocytes in vitro and in vivo. …”
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Flavonoids as Potential Modulators of Pancreatic Lipase Catalytic Activity by Sílvia Rocha, Carina Proença, Alberto N. Araújo, Marisa Freitas, Ismael Rufino, Natália Aniceto, Artur M. S. Silva, Félix Carvalho, Rita C. Guedes, Eduarda Fernandes

“…The kinetic parameters and inhibitory mechanisms of the most active flavonoids were determined, and in silico docking studies of the more potent flavonoids were also performed, using the active site of HPL. …”
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Methylation and gene expression patterns in adamantinomatous craniopharyngioma highlight a panel of genes associated with disease progression-free survival by Junier Marrero-Gutiérrez, Ana Carolina Bueno, Ana Carolina Bueno, Clarissa Silva Martins, Rui Milton Patrício Silva-Júnior, Antônio Carlos dos Santos, Marcelo Volpon Santos, Luiz Eduardo Wildemberg, Ximene Lima da Silva Antunes, Monica R. Gadelha, Ayrton Custodio Moreira, Ricardo Zorzetto Nicoliello Vêncio, Sonir Roberto R. Antonini, Margaret de Castro

“…Clustering analyses based on the methylation levels of probes and expression levels of the stringently filtered 212- and 37-gene sets further confirmed these two distinct ACP subgroups. Functional enrichment analysis highlighted key roles in synaptic modulation, nervous system development, cell adhesion, as well as pathways linked to RAS signaling, GTPase activity, and membrane potential regulation.ConclusionAlthough clinical characteristics were largely comparable between the clusters, ACP-B patients exhibited shorter median progression-free survival, suggesting a more aggressive phenotype. …”
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Eight basic principles for the elaboration of public policies and development projects for the Pantanal by Walfrido Moraes Tomas, Maria Helena Andrade, Christian Niel Berlinck, Fábio Bolzan, André Restel Camilo, Agostinho Carlos Catella, Rafael Morais Chiaravalloti, Catia Nunes daCunha, Geraldo Alves Damasceno Junior, Adriana Maria Espinoza Fernando, Letícia Couto Garcia, Pierre Girard, Solange Kimie Ikeda‐Castrillon, Carolina Joana daSilva, Rudi Laps, Lucia Mateus, Ronaldo Gonçalves Morato, Guilherme Mourão, André Valle Nunes, Maxwell daRosa Oliveira, Márcia Divina deOliveira, Carlos Roberto Padovani, Jerry Penha, Miriam Lucia Lages Perilli, Danilo Bandini Ribeiro, Fabio deOliveira Roque, Balbina Maria Araújo Soriano, Christine Strussmann, Cristina F. Tófoli, Fernando Rodrigo Tortato, Catia Urbanetz

“…However, the elaboration of public policies should be a participatory and inclusive decision‐making process towards a more just and sustainable future.…”
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Calcium-dependent adhesion protein CDH18, a potential biomarker for prognosis in uterine corpus endometrial carcinoma by Xiaoxuan Tang, Shanxing Dang, Jie Qiu, Ruilan Zhou, Jing Ling, Limei Zhang, Xiaopeng Peng, Qingyun Li, Jin Liu, Wei Liao, Qingxiu Mei, Miao Xie, Yehong Sun, Jianmei Huang, Xuelian Du, Wencong Song

“…Additional analyses included functional enrichment, tumor mutational burden, tumor microenvironment (TME) estimates via ESTIMATE, and immune infiltration assessment to clarify CDH18’s potential mechanisms in UCEC. …”
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NRF2 maintains redox balance via ME1 and NRF2 inhibitor synergizes with venetoclax in NPM1-mutated acute myeloid leukemia by Jiayuan Hu, Zihao Yuan, Yan Shu, Jun Ren, Jing Yang, Lisha Tang, Xingyu Wei, Yongcan Liu, Fangfang Jin, Qiaoling Xiao, Xinyi Chen, Nan Wu, Wen Zhao, Ziwei Li, Ling Zhang

“…Targeting NRF2/ME1 axis reduced NADPH/NADP+ ratio, increased ROS levels, impaired leukemia cell viability, and promoted apoptosis. More importantly, NRF2 inhibitor ML385 in combination with venetoclax showed synergistic anti-leukemic activity in vitro and in vivo. …”
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A comparative DFT study to investigate structural, electronic, and optical properties and bandgap engineering of 2D XSn4O7(X=Ba, Ca) and XSi4O9(X=Ba, Ca) materials for photocatalyt... by Muhammad Hasnain Jameel, Alaa Nihad Tuama, Salim Oudah Mezan, Basheer A. Abdulkhudher, Aqeela Yasin, Mohd Zul Hilmi Bin Mayzan, Muhammad Sufi bin Roslan, Karrar Mahdi Badi, Laith H. Alzubaidi

“…This comparison study is based on Density Functional Theory (DFT) to investigate the structural, electrical, and optical properties of two-dimensional XSn4O7(X=Ba, Ca) and XSi4O9(X = Ba, Ca) materials. …”
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White Matter Magnetic Resonance Diffusion Measures in Multiple Sclerosis with Overactive Bladder by Xixi Yang, Martina D. Liechti, Baris Kanber, Carole H. Sudre, Gloria Castellazzi, Jiaying Zhang, Marios C. Yiannakas, Gwen Gonzales, Ferran Prados, Ahmed T. Toosy, Claudia A. M. Gandini Wheeler-Kingshott, Jalesh N. Panicker

“…Background: Lower urinary tract (LUT) symptoms are reported in more than 80% of patients with multiple sclerosis (MS), most commonly an overactive bladder (OAB). …”
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Differential Role of NKG2A/HLA-E Interaction in the Outcomes of Bladder Cancer Patients Treated with <i>M. bovis</i> BCG or Other Therapies by Inmaculada Ruiz-Lorente, Lourdes Gimeno, Alicia López-Abad, Pedro López Cubillana, Tomás Fernández Aparicio, Lucas Jesús Asensio Egea, Juan Moreno Avilés, Gloria Doñate Iñiguez, Pablo Luis Guzmán Martínez-Valls, Gerardo Server, Belén Ferri, José Antonio Campillo, María Victoria Martínez-Sánchez, Alfredo Minguela

“…<b>Background</b>: Immunotherapy is gaining great relevance in both non-muscle-invasive bladder cancer (NMIBC), with the use of bacille Calmette–Guerin (BCG), and in muscle-invasive BC (MIBC) with anti-checkpoint therapies blocking PD-1/PD-L1, CTLA-4/CD80-CD86, and, more recently, NKG2A/HLA-E interactions. Biomarkers are necessary to optimize the use of these therapies. …”
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Mandibular reconstruction outcomes for in-house patient-specific solutions by Matthew D. Marquardt, Erin Cowen, Rachel Fenberg, Natalia von Windheim, Margaret Lashutka, Abigail E. Reid, Amit Agarwal, Enver K. Ozer, Ricardo L. Carrau, James W. Rocco, Catherine T. Haring, Stephen Y. Kang, Nolan B. Seim, Matthew O. Old, Kyle K. VanKoevering

“…The advent of computer-aided design and manufacturing (CAD/CAM) has enhanced aesthetic and functional outcomes in mandibular reconstruction by enabling patient-specific solutions like 3D-printed anatomic models. …”
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Exploring the gut microbiota associated with peripheral nerve invasion in colorectal cancer patients and constructing predictive models by Chuanbin Chen, Qingmin Chen, Shenghai Liu, Guoxi Li, Jiawei Zhao, Jingting Huang, Tianyi Ye, Xinting Yang, Zigui Huang, Zhen Wang, Fuhai He, Mingjian Qin, Chenyan Long, Binzhe Tang, Yongqi Huang, Weizhong Tang, Jungang Liu, Xiaoliang Huang

“…Abstract Objective This study aims to explore the differences in composition, abundance, and biological functions of the gut microbiota between colorectal cancer (CRC) patients with peripheral nerve invasion (PNI) and those without peripheral nerve invasion (NPNI). …”
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Molecular Clouds in the Outer Milky Way Disk: Sample, Integrated Properties, and Radial Trends with Galactocentric Radius by Yan Sun, Ji Yang, Qing-Zeng Yan, Shaobo Zhang, Yang Su, Xuepeng Chen, Xin Zhou, Yuehui Ma, Lixia Yuan

“…These scaling relations show slightly steeper correlations observed in more distant locations and notably deviate from Larson’s relations. …”
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Novel insecticide resistance mutations associated with variable PBO synergy in Anopheles gambiae s.l. from the Democratic Republic of Congo by Bethanie Pelloquin, Fiacre Agossa, Holly Acford-Palmer, Tiffany Clark, Sheila B. Ogoma, Miriam Williams, Narcisse Basosila, Francis Watsenga, Emery Metelo, Richard M. Oxborough, Yibayiri Osee Sanogo, Ferdinand Ntoya, Emma Collins, Sophie Moss, Charles McLoughlin, Monica Campos, Jody Phelan, Mark Rowland, Thomas Walker, Noboru Minakawa, Emile Zola Manzambi, Eric Mukomena, Susana Campino, Louisa A. Messenger

“…Gste2-L119V was significantly associated with resistance to deltamethrin following PBO-pre-exposure, warranting functional validation to determine its putative role in reduced PBO synergy. …”
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Transcriptome-wide identification of 5-methylcytosine by deaminase and reader protein-assisted sequencing by Jiale Zhou, Ding Zhao, Jinze Li, Deqiang Kong, Xiangrui Li, Renquan Zhang, Yuru Liang, Xun Gao, Yuqiang Qian, Di Wang, Jiahui Chen, Liangxue Lai, Yang Han, Zhanjun Li

“…We anticipate that the DRAM system could pave the way for uncovering further biological functions of m5C modifications.…”
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