Proteomic profiling identifies a stromal TGF-β1/podoplanin axis as a driver of colorectal cancer progression by Silvia Di Agostino, Davide La Padula, Vittoria Rago, Caterina Gabriele, Francesco Conforti, Elio Aprigliano, Lidia Urlandini, Elvira Parrotta, Danilo Lofaro, Francesca Vescio, Andrea Sacconi, Valeria Cernaro, Giuseppe Currò, Angela Alibrandi, Girolamo Ranieri, Valeria Zuccalà, Antonio Ieni, Marco Gaspari, Giovanni Cuda, Michele Ammendola, Vittorio Abbonante

“…Stromal cells pre-conditioned with M2-like macrophages upregulated PDPN and more effectively supported the growth of three colon adenocarcinoma cell lines. …”
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Who gets referred for knee or hip replacement? A theoretical model of the potential impact of evidence-based referral thresholds using data from a retrospective review of clinic re... by Andrew J Price, Andrew Judge, Alastair Gray, Rachael Gooberman-Hill, David Beard, Adrian Sayers, Rob Middleton, Stephanie Smith, Karen L Barker, David Murray, Sujin Kang, Elena Benedetto, James Smith, Ray Fitzpatrick, Helen A Dakin, Peter Eibich, Nigel Arden, Andy Carr, Kristina Harris, Elizabeth Gibbons, Jill Dawson, Laura Miller, Elsa Marques, Ashley Blom

“…More research is required to explore other important patient characteristics currently influencing hub decisions.…”
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Novel Potent and Selective Dopamine D4 Receptor Piperidine Antagonists as Potential Alternatives for the Treatment of Glioblastoma by Federica Matteucci, Pegi Pavletić, Alessandro Bonifazi, Rian Garland, Hideaki Yano, Consuelo Amantini, Laura Zeppa, Emanuela Sabato, Giulio Vistoli, Valerio Mammoli, Loredana Cappellacci, Fabio Del Bello, Gianfabio Giorgioni, Riccardo Petrelli, Alessia Piergentili, Wilma Quaglia, Alessandro Piergentili

“…<b>Results</b>: Radioligand binding results highlighted that the derivatives bearing a terminal butyl chain showed structure–activity relationships different from those with a benzyl terminal. From functional studies performed on the best derivatives <b>12</b> and <b>16</b>, the response profiles of both compounds were more robust in antagonist mode, with derivative <b>16</b> showing higher antagonist potency than <b>12</b> across all three transducers. …”
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Patient-reported Outcome Measures and Decision Regret After Prostate-specific Membrane Antigen–targeted Radioguided Surgery for Oligorecurrent Prostate Cancer by Fabian Falkenbach, Giovanni Mazzucato, Zhe Tian, Pierre I. Karakiewicz, Markus Graefen, Thomas Steuber, Derya Tilki, Daniel Koehler, Burkhard Beyer, Pierre Tennstedt, Sophie Knipper, Lars Budäus, Tobias Maurer

“…Conclusions and clinical Implications: We recorded no significant decrease in quality of life or any functional status domain, except sexual. While decision regret was low, sexual functioning might deteriorate further. …”
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Application of <i>Lactobacillus plantarum</i> and <i>Pediococcus lactis</i> on Lipid Metabolism, Anti-Inflammatory, and Fecal Microbiota in Cats by Shukun Liang, Xinshu Gu, Jintao Sun, Xiumin Wang, Hui Tao, Zhenlong Wang, Yougang Zhong, Jinquan Wang, Bing Han

“…Probiotics have been used in functional foods and dietary supplements, and in recent years, they have become more widely used in pets. …”
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3D‐printed patient‐specific instrumentation and the freehand technique in high‐tibial osteotomy: A prospective cohort‐comparative study in an outpatient setting by Giovanni Grillo, Alexandre Coelho, Xavier Pelfort, Ferran Fillat‐Gomà, Arnau Verdaguer Figuerola, Sergi Gil‐Gonzalez, Juan Manuel Peñalver, Christian Yela‐Verdú

“…Conclusion Customized 3D‐printed guides do not permit better correction or functional results than the conventional technique; rather, they reduce surgical time and intraoperative radiation exposure. …”
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Mentalization-based treatment versus bona fide treatment for patients with borderline personality disorder in Germany (MAGNET): study protocol of a prospective, multi-centre random... by Sophie Hauschild, Svenja Taubner, Thorsten Vidalón Blachowiak, Ulrike Dinger, Harald Gündel, Sabine C. Herpertz, Jörg Rademacher, Bernhard Strauss, Timo Storck, Ralitsa Vassileva, Ina Burghaus, Manuel Herbst, Simiao Chen, Christoph Nikendei, Sebastian Euler, Jana Volkert

“…The primary objective of this RCT is to investigate whether outpatient MBT is more effective in the reduction of crisis events (incidences of NSSI and suicide attempts) compared with BFT (namely psychodynamic or cognitive-behavioural psychotherapy) in Germany. …”
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LONG-TERM RETENTION RATE OF CERTOLIZUMAB PEGOL IN PATIENTS WITH AXIAL SPONDYLOARTHRITIS: DATA FROM THE TURKBIO REGISTRY by Ahmet Karataş, Yavuz Pehlivan, Servet Akar, Soner Şenel, Aslıhan Avanoğlu Güler, Özgül Soysal Gündüz, Ayten Yazıcı, Sema Yılmaz, Rabia Pişkin Sağır, Nevsun İnanç, Gözde Yıldırım Çetin, Mehmet Pamir Atagündüz, Fatoş Önen

“…Patients who discontinued CZP had significantly higher health assessment questionnaire, bath ankylosing spondylitis (AS) functional index, and bath AS disease activity index values compared to those who continued with CZP. …”
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Strategic supplementation of sanguinarine in a soybean meal free diet for grass carp (Ctenopharyngodon idella) significantly enhances growth performance by promoting liver and inte... by Yuhua Yue, Yong Shi, Meilin Zhang, Shanshan Shi, Guanping Liu, Hairong Shi, Yi Hu, Lei Zhong

“…Besides, histopathological examination of the CM group revealed hepatocellular damage, increased lipid droplet accumulation, elevated glycogen deposition, and more severe fibrosis, along with degeneration of gallbladder columnar epithelium; these lesions were markedly attenuated in the CMS1 and CMS2 groups. …”
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Proteogenomic annotation of T6SS components identified in Bacteroides fragilis secretome by Natalya B. Zakharzhevskaya, Olga Yu Shagaleeva, Daria A. Kashatnikova, Daria A. Kashatnikova, Anton O. Goncharov, Anton O. Goncharov, Daria V. Evsyutina, Dmitry A. Kardonsky, Elizaveta A. Vorobeva, Artemiy S. Silantiev, Viktoria D. Kazakova, Irina V. Kolesnikova, Ivan O. Butenko, Anna A. Vanyushkina, Svetlana V. Smirnova, Andrei V. Chaplin, Andrei V. Chaplin, Boris A. Efimov, Boris A. Efimov

“…IntroductionBacteroides fragilis (Bf)’s T6SS locus has been characterized and shown to have functional activity in competition experiments. It has been demonstrated that symbiont nontoxigenic Bf strains have a more effective “weapon” effect on pathogenic Bf, which is realized through the activity of effector-immune (E-I) protein pairs. …”
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Characterizing spatial immune architecture in metastatic melanoma using high-dimensional multiplex imaging by Joel Eliason, Santhoshi Krishnan, Yasunari Fukuda, Matias A. Bustos, Dan Winkowski, Sungnam Cho, Akshay Basi, Akshay Basi, Regan Baird, Elizabeth A. Grimm, Michael A. Davies, Dave S. B. Hoon, Arvind Rao, Arvind Rao, Arvind Rao, Arvind Rao, Jared K. Burks, Jared K. Burks, Suhendan Ekmekcioglu

“…Cytotoxic T lymphocytes (CTLs) and tumor cells were more prevalent in Stage IV TIME, while B cells and NK cells were depleted. …”
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Integrative Analysis Provides Insights into Genes Encoding LEA_5 Domain-Containing Proteins in Tigernut (<i>Cyperus esculentus</i> L.) by Zhi Zou, Xiaowen Fu, Xiaoping Yi, Chunqiang Li, Jiaquan Huang, Yongguo Zhao

“…Though no syntenic relationship was observed between <i>CeLEA5</i> genes, comparative genomics analyses indicated that LEA5b and LEA5c are more likely to arise from LEA5a via whole-genome duplication. …”
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A mechanism-based group psychotherapy approach to aggressive behavior (MAAP) in borderline personality disorder: a multicenter randomized controlled clinical trial by Christine Sigrist, Andreas Bechdolf, Katja Bertsch, Robin Bullenkamp, Martin Busse, Ute gr. Darrelmann, Astrid Dempfle, Martin Driessen, Thomas Frodl, Jan-Michael Kersting, Jessica Kesik, Burkhart Matzke, Corinne Neukel, Eva Niessen, Svenja Nückel, Viola Oertel, Frank Padberg, Alexandra Philipsen, Dorothee Pink, Andreas Reif, Matthias Reinhard, Carolin Steuwe, Larissa Wolkenstein, Sabine C. Herpertz, the MAAP Consortium

“…In BPD, patterns of reactive aggression often lead to functional impairment affecting important areas of life. …”
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BdNRT2A and BdNRT3.2 Are the Major Components of the High‐Affinity Nitrate Transport System in Brachypodium distachyon by Laure C. David, Mathilde Grégoire, Patrick Berquin, Anne Marmagne, Marion Dalmais, Abdelhafid Bendahmane, Tony J. Miller, Anne Krapp, Françoise Daniel‐Vedele, Thomas Girin, Sylvie Ferrario‐Méry

“…An effective nitrate transport in the heterologous expression system Xenopus oocytes required the coexpression of BdNRT2A and BdNRT3.2 that characterizes two‐component system of the HATS. Functional interaction between BdNRT2A‐GFP and BdNRT3.2‐RFP fusion proteins was observed at the plasma membrane in Arabidopsis protoplasts in transient expression experiments with BdNRT3.2 being necessary for the plasma membrane localization of BdNRT2A. …”
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CURRENT LEVELS OF MEDICAL EXPOSURE IN RUSSIA by M. I. Balonov, V. Ju. Golikov, I. A. Zvonova, S. A. Kal’nickij, V. S. Repin, S. S. Sarycheva, L. A. Chipiga

“…Due to replacement of low-dose ‘functional’ nuclear medicine examinations with more informative modern scintigraphy and tomography examination, patient doses substantially increased over the last decade. …”
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Case Report: A case of occult insulinoma localized by [18F] FB (ePEG12)12-exendin-4 positron emission tomography with negative findings of selective arterial calcium stimulation te... by Kentaro Sakaki, Takaaki Murakami, Hiroyuki Fujimoto, Yoichi Shimizu, Kanae Kawai Miyake, Daisuke Otani, Shinya Otsuki, Hironori Shimizu, Kazuyuki Nagai, Takumi Nomura, Daisuke Yabe, Yuji Nakamoto, Nobuya Inagaki

“…BackgroundInsulinomas, the most common functional pancreatic neuroendocrine tumors, cause hypoglycemia due to excessive insulin production, leading to severe clinical symptoms like coma or death. …”
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IQUB mutation induces radial spoke 1 deficiency causing asthenozoospermia with normal sperm morphology in humans and mice by Tingwenyi Hu, Xiangrong Tang, Tiechao Ruan, Shunhua Long, Guicen Liu, Jing Ma, Xueqi Li, Ruoxuan Zhang, Guoning Huang, Ying Shen, Tingting Lin

“…To date, many components of RSs and their functions in human sperm flagella remain unclear. Methods We recruited a cohort of 323 infertile males with ASZ between August 2019 and June 2024. …”
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Multivariate geostatistical methods for analysing the contribution of urban lakes and neighbouring greenery to mitigating PM2.5 under stressor indicators by Han Liu, Wenyu An, Arkadiusz Przybysz, Dingyi Hao, Yimei Sun, Junze Song, Jiayi Sui, Jiahan Sun, Chunyang Zhu

“…Maintaining the ecological integrity and functionality of ecosystems is one of the major challenges faced in the sustainable management of natural capital. …”
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Photodynamic therapy in treatment of squamous cell carcinoma of oral cavity with chlorine e6 photosensitizer with long-term follow up by Y. A. Panaseykin, V. N. Kapinus, E. V. Filonenko, V. V. Polkin, F. E. Sevrukov, M. A. Smirnova, P. A. Isaev, S. A. Ivanov, A. D. Kaprin

“…Moreover, after using photodynamic therapy, the underlying connective-muscular structures are preserved, which promotes rapid healing with minimal scarring, the functions of the affected organ remain intact, and cosmetic defects do not form.…”
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SwinDAF3D: Pyramid Swin Transformers with Deep Attentive Features for Automated Finger Joint Segmentation in 3D Ultrasound Images for Rheumatoid Arthritis Assessment by Jianwei Qiu, Grigorios M. Karageorgos, Xiaorui Peng, Soumya Ghose, Zhaoyuan Yang, Aaron Dentinger, Zhanpeng Xu, Janggun Jo, Siddarth Ragupathi, Guan Xu, Nada Abdulaziz, Girish Gandikota, Xueding Wang, David Mills

“…Rheumatoid arthritis (RA) is a chronic autoimmune disease that can cause severe joint damage and functional impairment. Ultrasound imaging has shown promise in providing real-time assessment of synovium inflammation associated with the early stages of RA. …”
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