Pecan-medicinal crops intercropping improved soil fertility and promoted interactions between soil microorganisms and metabolites by Ruyuan Wang, Chenyang Liu, Xuesong Bie, Yan Dai, Xu Feng, Ren Wang, Ming Wang, Shu Xu, Yu Chen

“…In addition, the result of metabolomic analysis showed that intercropping promoted the synthesis of functional compounds, such as trehalose and ethanolamine, which enhanced plant disease resistance in bulk soils. …”
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Phosphoglucomutase A-mediated metabolic adaptation is essential for antibiotic and disease persistence in Mycobacterium tuberculosis by Taruna Sharma, Shaifali Tyagi, Rahul Pal, Jayendrajyoti Kundu, Sonu Kumar Gupta, Vishawjeet Barik, Vaibhav Kumar Nain, Manitosh Pandey, Prabhanjan Dwivedi, Bhishma Narayan Panda, Yashwant Kumar, Ranjan Kumar Nanda, Samrat Chatterjee, Amit Kumar Pandey

“…These insights are crucial for developing novel, shorter, and more effective anti-tuberculosis strategies.IMPORTANCEThis study for the first time investigated the role of metabolic enzyme phosphoglucomutase A (pgmA) in Mycobacterium tuberculosis (Mtb), revealing its crucial functions as a toggle switch between biosynthesis and growth. …”
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The TgAMPK-TgPFKII axis essentially regulates protein lactylation in the zoonotic parasite Toxoplasma gondii by Chenghuan Li, Yang Zhao, Qilong Li, Ran Chen, Ying Feng, Xiaoyu Sang, Xiangrui Li, Bang Shen, Ning Jiang, Qijun Chen

“…These insights pave the way for targeted interventions aimed at disrupting key metabolic and signaling pathways in T. gondii, potentially leading to more effective treatments for toxoplasmosis.…”
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Factors driving the variation in soil fertility associated with extension of the alfalfa (Medicago sativa L.) cultivation period by Zeyu Liu, Junqi Wang, Xinhe Shan, Pinhang Liang, Lizhao Fan, Chengyu Song, Zhaopu Jia, Yuxia Zhang, Yunlong Zhang, Lei Liu, Ding Huang

“…Our results suggested that the impacts of planting years on soil fertility in topsoil were more pronounced than those in subsoil, which both primarily driven by SOC, followed by TN. …”
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POSSIBILITIES OF SURGICAL CORRECTION OF INTERNAL CAROTID ARTERY THROMBOSIS IN PATIENTS WITH ACUTE ISCHEMIC STROKE by V. A. Lukyanchikov, E. V. Udodov, N. A. Polunina, A. S. Tokarev, V. A. Dalibaldyan, O. Y. Nakhabin, E. V. Grigoryeva, Y. I. Shatokhina, N. Y. Kudryashova, G. K. Guseynova, E. A. Khodykin, V. G. Dashyan, V. L. Lemenyov, V. V. Krylov

“…The improvement of functional deficit in the early post-operative period was 4.85 scores according to NIHSS, 1.2 scores according to Rankin scale and 2.3 scores according to Rivermead mobility index. …”
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Parvoviruses NS1 oncolytic attributes: mechanistic insights and synergistic anti-tumor therapeutic strategies by Abdul Haseeb, Wafa Yousaf, Zhigang Cao, Kuohai Fan, Kuohai Fan, Na Sun, Panpan Sun, Yaogui Sun, Huizhen Yang, Wei Yin, Hua Zhang, Zhenbiao Zhang, Jia Zhong, Jianzhong Wang, Hongquan Li

“…It also addresses genetic engineering and combinational therapy aimed at augmenting the oncolytic efficacy of NS1 for more potent application as a tumor therapeutic agent. …”
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Anthropogenic Effects on Green Infrastructure Spatial Patterns in Kisangani City and Its Urban–Rural Gradient by Julien Bwazani Balandi, Jean-Pierre Pitchou Meniko To Hulu, Kouagou Raoul Sambieni, Yannick Useni Sikuzani, Jean-François Bastin, Charles Mumbere Musavandalo, Timothée Besisa Nguba, Roselande Jesuka, Carlo Sodalo, Léa Mukubu Pika, Jan Bogaert

“…These results raise concerns regarding the functions, services, and opportunities provided by mature and short forests in the context of global change. …”
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Application of multi-objective neural network algorithm in industrial polymerization reactors for reducing energy cost and maximising productivity by Fakhrony Sholahudin Rohman, Sharifah Rafidah Wan Alwi, Dinie Muhammad, Ashraf Azmi, Zainuddin Abd Manan, Jeng Shiun Lim, Hong An Er, Siti Nor Azreen Ahmad Termizi

“…Optimization on an industrial scale is a complex task that involves fine-tuning the performance of large-scale systems and applications to make them more efficient and effective. This process can be challenging due to the increasing volume of work, growing system complexity, and the need to maintain optimal performance. …”
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Novel Klebsiella pneumoniae and Pseudomonas aeruginosa MAPS vaccine combining O polysaccharides and pathogen-specific proteins by Mohammed N. Amin, James E. Sinclair, Brittany Curtis, Lada Sycheva, Heather Fox, Myeong-Jin Choi, Surekha Shridhar, Jacqueline Kolasny, Joseph Nkeze, Ethel Apolinario, Sang Hyun, Nicolas Hegerle, Shaichi Sen, Jasnehta Permala Booth, Mark Leney, Deborah Molrine, Greg Saia, Marcela Pasetti, Teresa Broering, Francis Michon, Richard Malley, George R. Siber, Sharon M. Tennant, Donna Ambrosino, Raphael Simon, Alan Cross

“…The use of pathogen-relevant proteins that may contribute to vaccine efficacy in place of the more traditional carrier proteins is a novel concept. …”
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Expression Profile of Human Cytomegalovirus <i>UL111A</i> cmvIL-10 and LAcmvIL-10 Transcripts in Primary Cells and Cells from Renal Transplant Recipients by Giovana W. C. Almeida, Martha T. Oliveira, Isabella G. L. Martines, Giuliano C. Fiori, Michael M. Nevels, Ian J. Groves, John Sinclair, José Medina-Pestana, Rayra Sampaio da Silva, Monica Nakamura, Lucio Requião-Moura, Emma Poole, Maria C. Carlan da Silva

“…The cmvIL-10 (isoform A) has similar properties to cIL-10, while LAcmvIL-10 (isoform B) has more restricted biological properties. Other isoforms are produced (C to H) but have unknown functions. …”
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Sex differences and rehabilitation needs after hospital discharge for COVID-19: an Italian cross-sectional study by Luca Braglia, Monica Denti, Stefania Fugazzaro, Stefania Costi, Carlotta Mainini, Monia Allisen Accogli, Ginevra Bedogni, Daniele Ghizzoni, Anna Bertolini, Otmen Esseroukh, Cecilia Gualdi, Margherita Schiavi

“…Sex differences should be monitored, as women may recover more slowly than men.Trial registration number NCT04438239.…”
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Quantitative SISCOM assessment for epileptogenic zone localization: insights from a multicenter study comparing two software platforms in temporal lobe epilepsy by Carla Oliveira Young, Brunno Machado de Campos, Edna Marina de Souza, Sergio Querino Brunetto, Maria Julia de Oliveira Santos Gualberto, Leonardo Alexandre-Santos, Marcos Geraldo Merichelo de Oliveira, Marina Koutsodontis Machado Alvim, Fernando Cendes, Elba Etchebehere, Lauro Wichert-Ana, Bárbara Juarez Amorim

“…However, SPM generated smaller, more localized clusters, while Analyze produced larger clusters with broader spatial coverage. …”
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Cardiac MRI of differing ischemia and reperfusion times in a myocardial infarction pig model by David Boll, Simon Reiss, Heidi R. Cristina Schmitz, Christian Weber, Julien Thielmann, Felix Spreter, Kian Tadjalli Mehr, Diana Chiang, Markus Jäckel, Lukas Heger, Jonathan Rilinger, Dirk Westermann, Constantin von zur Mühlen, Timo Heidt, Michael Bock, Alexander Maier

“…CMR was performed at a clinical 3 T system including functional imaging, T1 and T2 mapping and late gadolinium enhancement (LGE) 2–5 h or three days post-reperfusion. …”
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A novel therapeutic approach to hemangiomas: Combining photothermal therapy and ferroptosis in a microneedle delivery system by Yiming Geng, Cancan Meng, Hanzhi Zhang, Chuan Ma, Xiao Fu, Haiwei Wu

“…This approach can also become a more effective and safer treatment method for other diseases characterized by abnormal angiogenesis.…”
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Orchard variable-rate spraying method integrating GNSS and wind-excited audio-conducted leaf area density by Hangxing Zhao, Hangxing Zhao, Hangxing Zhao, Shenghui Yang, Shenghui Yang, Shenghui Yang, Wenwei Li, Wenwei Li, Han Feng, Han Feng, Shijie Jiang, Shijie Jiang, Weihong Liu, Weihong Liu, Jingbin Li, Yongjun Zheng, Yongjun Zheng, Songchao Zhang

“…As a result, few fully functional variable-rate spraying systems have been developed based on this parameter.MethodsThis study presents a variable-rate spraying method that integrates global navigation satellite system (GNSS) positioning with wind-excited audio-conducted estimation of canopy leaf area density. …”
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A Novel Cystatin Gene from Sea Cucumber (<i>Apostichopus japonicus</i>): Characterization and Comparative Expression with Cathepsin L During Early Stage of Hypoxic Exposure-Induced... by Siyu Yao, Rui Zhang, Siyuan Ma, Ting Zhao, Qinhao Liu, Lin Zhu, Chang Liu, Liming Sun, Ming Du

“…The results of this study indicated that the anti-autolytic regulation of SjCyt functions at the very early stage of hypoxic exposure, exerting effects at both the transcriptional and translational levels. …”
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Polyphosphate-enriched algae fertilizer as a slow-release phosphorus resource can improve plant growth and soil health by Jiahong Yu, Bingbing Luo, Yujie Yang, Suna Ren, Lei Xu, Long Wang, Xianqing Jia, Yiyong Zhu, Keke Yi

“…Microbial diversity analysis showed that algae fertilizers could recruit more beneficial microbes than CP, like phosphorus-solubilizing bacteria, plant growth-promoting bacteria, and stress-resistant bacteria. …”
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HpFBH3 transactivates HpCO7 via binding to the E-boxes in the promoter and may accelerate flower formation in pitaya by Xiaowei Cai, Ling Xiao, Xiangmei Nie, Qiandong Hou, Sulin Wen, Kun Yang, Xiaopeng Wen

“…In practice, accelerating flower formation and inducing more flowers usually result in higher yield. However, the genes for this purpose have not been well characterized in pitaya. …”
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Comprehensive analysis of phagocytosis regulatory genes in bladder cancer: implications for prognosis and immunotherapy by Xueming Ma, Xueming Ma, Xueming Ma, Dongnuan Yao, Dongnuan Yao, Dongnuan Yao, Weitao Yu, Weitao Yu, Weitao Yu, Gongping Wu, Gongping Wu, Gongping Wu, Chengwei Fan, Chengwei Fan, Chengwei Fan, Junqiang Tian, Junqiang Tian, Junqiang Tian

“…A variety of algorithms and analysis techniques, such as Kaplan-Meier analysis, Cox regression analysis, and ConsensusClusterPlus clustering analysis, were used to identify PRGs related to the prognosis of bladder cancer patients, and functional analysis and clustering analysis were conducted in depth. …”
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Development and Validation of a New LC-MS/MS Method for Simultaneous Quantification of Ivacaftor, Tezacaftor and Elexacaftor Plasma Levels in Pediatric Cystic Fibrosis Patients by Alessandro Mancini, Raffaele Simeoli, Luca Cristiani, Sara Cairoli, Fabiana Ciciriello, Alessandra Boni, Federico Alghisi, Chiara Rossi, Giacomo Antonetti, Carlo Dionisi Vici, Alessandro Giovanni Fiocchi, Renato Cutrera, Bianca Maria Goffredo

“…Considering also the high cost burden of these medications to the health system, a TDM-based approach could facilitate more cost-effective patient management.…”
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