Proteins derived from green biomass: Alfalfa (Medicago sativa L.) and water lentil concentrate (Lemna minor L.) in the focus as stabilizers for emulsions by Maren Müller, Olaf Holderer, Kuno Schwärzer, Anika Wiese-Klinkenberg, Beate Förster, Stephan Förster, Joachim Kohlbrecher, Kathleen Wood, Baohu Wu, Stephan Hauschild, Henrich Frielinghaus, Theresia Heiden-Hecht

“…Key parameters are a narrow oil droplet size distribution with rather small oil droplets with a median of about 3.5 μm, a low interfacial tension with around 15 mN/m and an elastic interfacial layer with an elastic modulus of about 45 mN/m comparable to functional whey or plant proteins. The oil/water interface of the emulsion revealed a more pronounced structural rearrangement for alfalfa protein compared to water lentil proteins as quantified by small-angle neutron scattering (SANS), indicating the relevance of plant protein source to the final structure.Green biomass proteins from alfalfa and water lentil represent a novel protein source to stabilize emulsions.…”
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Age-linked DNA methylation and gene expression patterns in parameningeal head and neck alveolar rhabdomyosarcoma reveal CDK9 as a promising therapeutic target by Sara Patrizi, Silvia Vallese, Sabina Barresi, Matteo Cassandri, Isabella Giovannoni, Lucia Pedace, Luana Abballe, Flavia Vinciarelli, Celeste Antonacci, Alessandra Stracuzzi, Barbara Mancini, Ida Russo, Angela Di Giannatale, Rossella Rota, Rita Alaggio, Franco Locatelli, Giuseppe Maria Milano, Evelina Miele

“…We validated the biological relevance of molecules of interest through functional experiments on rhabdomyosarcoma cell lines. …”
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Phyllotaxy and environmental factors influences on leaf trait dimensions in Fraxinus mandshurica: a multidimensional approach within temperate forests by Mingyue Jin, Mingyue Jin, Mingyue Jin, Yunfei Diao, Yunfei Diao, Yunlong Wang, Mingke Zhang, Tianyi Wang, Yajun Ren, Yajun Ren, Yajun Ren, Ming Zhong, Ming Zhong, Ming Zhong, Wanting Cheng, Wanting Cheng, Wanting Cheng, Chengdong Wang, Chengdong Wang, Chengdong Wang, Honghui Teng, Honghui Teng, Honghui Teng

“…No significant variation in the dimensions of economic and stomatal traits was observed across the phyllotaxy gradient; (2) phyllotaxy modulates trait coordination, with decoupled economic and stomatal traits at phyllotaxy 1 but coupled relationships at phyllotaxy 2–6; (3) environmental factors had a greater impact on economic trait dimensions variation, whereas phyllotaxy was more important for stomatal trait dimensions.DiscussionOur study highlights the significance of trait dimensions in understanding plant functional strategies. …”
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Dap10 co-stimulation enhances the anti-HCC efficacy of NKp30 chimeric antigen receptor T cells by JieYu Li, LiMei Chen, MingShui Chen, Miao Lin, Zineng Xie, HuiLing Wu, ZhiFeng Zhou, WanSong Lin

“…In addition, chNKp30-Dap10 T cells secreted higher levels of pro-inflammatory cytokines such as IL-2, IFN-γ, and TNF-α, while chNKp30-CD28 T cells secreted more of the anti-inflammatory cytokine IL-10. In the killing assay, chNKp30-Dap10 T cells demonstrated stronger anti-tumor effects. …”
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International Consensus on Evidence Gaps and Research Opportunities in Extracorporeal Cardiopulmonary Resuscitation for Refractory Out‐of‐Hospital Cardiac Arrest: A Report From the... by Laurie J. Morrison, Elizabeth A. Hunt, Brian Grunau, Thomas P. Aufderheide, Clifton Callaway, Joseph E. Tonna, Comilla Sasson, Audrey Blewer, Bryan F. McNally, Demetris Yannopoulos, Jan Belohlavek, Jason Bartos, Alain Combes, Ahamed Idris, Raina M. Merchant, Leith States, Emily Tinsley, Renee Wong, Scott T. Youngquist, George Sopko, Karl B. Kern

“…The increased accessibility of extracorporeal membrane oxygenation following the COVID‐19 pandemic and the publication of the first randomized trial of extracorporeal cardiopulmonary resuscitation (ECPR) prompted the National Heart, Lung, and Blood Institute to sponsor a workshop on ECPR. Two more randomized trials have since been published in 2022 and 2023. …”
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Optimizing hybrid models for forest leaf and canopy trait mapping from EnMAP hyperspectral data with limited field samples by Nizom Farmonov, Susanne Walden, Eric Martinée, Christian Lampei, Mona Schreiber, Lars Opgenoorth, Anjaharinony Andry Ny Aina Rakotomalala, Tobias Müller, Nina Farwig, Stefan Pinkert, Lucy Saueressig, Annabell Rosemarie Wagner, Robert R. Junker, Jochem Verrelst, Jörg Bendix

“…Accurate estimation of functional vegetation traits is essential for understanding ecosystem dynamics and supporting environmental monitoring. …”
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Efficient removal of cadmium (II) and arsenic (III) from water by nano-zero-valent iron modified biochar-zeolite composite by Mengyuan Wu, Lijuan Wu, Wen Zhang, Xianbao Zhong, Runfeng Guo, Ziying Cui, Yajun Yang, Jialong Lv

“…The influence of pH on removal efficiency was more pronounced than that of temperature, with nZVI-BCZo exhibiting a higher affinity for As(III) compared to Cd(II). …”
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Analyzing the Impact of the Presence of Foreign Tourists in Religious Places on Their Attitude Towards Shiism by Marziyeh Farshiddost, Behrooz Badkoo, Mohamad Ghasemisiani

“…The results and findings of this research also showed that foreign tourists in Iran are more familiar with the culture and history of Iran and the tourism infrastructure of the country along with the existing security made them more willing to visit Iran again. …”
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Time to treat the climate and nature crisis as one indivisible global health emergency by Kamran Abbasi, Parveen Ali, Virginia Barbour, Thomas Benfield, Kirsten Bibbins-Domingo, Stephen Hancocks, Richard Horton, Laurie Laybourn-Langton, Robert Mash, Peush Sahni, Wadeia Mohammad Sharief, Paul Yonga, Chris Zielinski

“…This has allowed ecosystems to be pushed further to the brink, greatly increasing the risk of arriving at ‘tipping points’, abrupt breakdowns in the functioning of nature.2,24 If these events were to occur, the impacts on health would be globally catastrophic. …”
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ADAR1 Promotes Myogenic Proliferation and Differentiation of Goat Skeletal Muscle Satellite Cells by Zihao Zhao, Miao Xiao, Xiaoli Xu, Meijun Song, Dinghui Dai, Siyuan Zhan, Jiaxue Cao, Jiazhong Guo, Tao Zhong, Linjie Wang, Li Li, Hongping Zhang

“…Here, we explored the functions of ADAR1 in the myogenic process of goat skeletal muscle satellite cells (MuSCs). …”
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Exploring the multi-targeted mechanism of Saikosaponin A in prostate cancer treatment: a network pharmacology and molecular docking approach by Genbao Zhu, Genbao Zhu, Genbao Zhu, Zhiming Jiang, Niuping Zhu, Niuping Zhu, Donghui Wang, Donghui Wang, Tianpeng Guo, Tianpeng Guo, Yiqing Meng, Yiqing Meng, Yi Zhu, Yi Zhu, Kemeng Tan, Mengxue Hu, Heng Tang, Xuannian Wang, Xuannian Wang

“…It can progress to castration-resistant prostate cancer (CRPC), which is significantly more challenging to treat. Saikosaponin A (SSA), a triterpenoid saponin extracted from the genus Bupleurum, exerts numerous pharmacological effects, including anti-inflammatory and anti-tumorigenic effects. …”
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Multi‑omics analysis identifies different molecular subtypes with unique outcomes in early-stage poorly differentiated lung adenocarcinoma by Bing Liu, Wei Tao, Xuantong Zhou, Li-Di Xu, Yanrui Luo, Xin Yang, Qingjie Min, Miao Huang, Yuge Zhu, Xinrun Cui, Yaqi Wang, Tongyang Gong, Enli Zhang, Yu S. Huang, Weizhi Chen, Shi Yan, Nan Wu

“…Integrated analyses were conducted to disclose molecular characteristics and explore molecular subtyping. Functional validation of key molecules was carried out through in vitro and in vivo experiments. …”
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Transcriptomic and proteomic analysis reveals wall-associated and glucan-degrading proteins with potential roles in Phytophthora infestans sexual spore development. by Xiaofan Niu, Audrey M V Ah-Fong, Lilianna A Lopez, Howard S Judelson

“…Despite being dormant, oospores contained a mostly normal complement of proteins required for core cellular functions. The RNA-seq data generated here and in prior studies were used to identify new housekeeping controls for gene expression studies that are more stable than existing normalization standards. …”
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Collagen prolyl 4-hydroxylase subunit α member-induced head and neck squamous cell carcinoma aggressiveness is antagonized by LLGL2 via redu... by Xu Miao, Shi Run, Yang Jie, Chen Heng, Liu Shihua, Yu Shupei, Li Sasa, He Wenqiang, Sy Man-Sun, Lu Mingjian, Zhang Huixia, Li Chaoyang

“…Furthermore, simultaneously downregulating three C-P4HAs has more pronounced effects on inhibiting cell migration and invasion. …”
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Unexpected HBsAg decrease after nucleoside analogues retreatment among HBeAg positive postpartum women: a pilot study by Qiao Tang, Chunrui Wang, Hu Li, Zhiwei Chen, Li Zhang, Jing Zhang, Xiaoqing Liu, Yunling Xue, Yue Qiu, Mingli Peng, Yi Zeng, Peng Hu

“…Conclusion HBeAg positive patients received NAs treatment during pregnancy and discontinued it postpartum can benefit from NAs retreatment because of unexpected decrease of HBsAg, which may be helpful for achieve the goal of functional cure. Trial registration number ClinicalTrials.gov (No.ChiCTR2100054116).…”
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Physiological and transcriptomic-based analysis reveal the common and specific pathways of clove basil (Ocimum gratissimum) organs in response to cadmium stress by Bin Wang, Yanhui Xiao, Xiao Yuan, Yukun Wang, Dengyue Jiang, Zhaoxia Zhan, Jinming He

“…The overlapping DEGs across organs were more enriched in multiple metabolite biosynthesis pathways. …”
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LRP1 involvement in FHIT-regulated HER2 signaling in non-small cell lung cancer by Théophile Ponchel, Emma Loeffler, Julien Ancel, Audrey Brisebarre, Nathalie Lalun, Véronique Dalstein, Anne Durlach, Gaëtan Deslée, Stéphane Dedieu, Myriam Polette, Béatrice Nawrocki-Raby

“…Dual targeting of HER2 and LRP1 might represent a therapeutic strategy to more efficiently inhibit HER2 signaling in FHIT-negative NSCLC.…”
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Investigating heterogeneity across autism, ADHD, and typical development using measures of cortical thickness, surface area, cortical/subcortical volume, and structural covariance by Younes Sadat-Nejad, Younes Sadat-Nejad, Marlee M. Vandewouw, Marlee M. Vandewouw, R. Cardy, J. Lerch, J. Lerch, J. Lerch, M. J. Taylor, M. J. Taylor, A. Iaboni, C. Hammill, B. Syed, J. A. Brian, J. A. Brian, E. Kelley, E. Kelley, E. Kelley, M. Ayub, J. Crosbie, J. Crosbie, R. Schachar, R. Schachar, S. Georgiades, R. Nicolson, E. Anagnostou, E. Anagnostou, A. Kushki, A. Kushki

“…We integrated cortical thickness, surface area, and cortical/subcortical volume, with a measure of single-participant structural covariance using a graph neural network approach.ResultsOur findings suggest two large clusters, which differed in measures of adaptive functioning (χ2 = 7.8, P = 0.004), inattention (χ2 = 11.169, P < 0.001), hyperactivity (χ2 = 18.44, P < 0.001), IQ (χ2 = 9.24, P = 0.002), age (χ2 = 70.87, P < 0.001), and sex (χ2 = 105.6, P < 0.001).DiscussionThese clusters did not align with existing diagnostic labels, suggesting that brain structure is more likely to be associated with differences in adaptive functioning, IQ, and ADHD features.…”
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Analysis of endophytic bacterial diversity of Puerariae thomsonii from different production areas and their correlation with secondary metabolites by Yang Xu, Yang Xu, Lihua Zeng, Lihua Zeng, Zheng Peng, Zheng Peng, Nana Chang, Nana Chang, Ye Wang, Ye Wang, Lingling Zheng, Lingling Zheng, Yan Ren, Yan Ren, Hui Li, Hui Li, Hui Li, Tielin Wang, Tielin Wang

“…In addition, differences in endophytic bacteria across the samples from different productions were analyzed using LEfSe analysis. The functional capabilities of these bacteria were analyzed through PICRUSt2 to explore potential microbial functional traits.ResultsThe findings indicated that the alpha diversity of endophytic bacteria in P. thomsonii differed among production areas and the unique bacterial genera could be found in different areas. …”
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Artistic Features of Jiangnan Gardens During the Mid-16th Century as Reflected in the Picture of a Famous Garden in Jinchang by Shiyuan PANG, Xiao HUANG

“…This period is characterized by a gradual weakening of the connection between garden making and agricultural economy, the enhancement of social functions of private gardens, and the infiltration of social atmosphere of entertainment and extravagance into the life of literati. …”
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