Developing a multivariate drought index to assess drought characteristics based on the SWAT-Copula method in the Poyang Lake basin, China by Liping Guo, Fusheng Chen, Bin Wang, De Li Liu, Xiulong Chen, Hongsheng Huang, Hua Bai, Kaitao Liao, Zhiming Xia, Keyu Xiang, Linchao Li, Taihui Zheng, Qiang Yu

“…A Multivariate Standardized Drought Index (MSDI) was then developed with simulated Standardized Soil Moisture Index (SSI) and Standardized Precipitation Index (SPI) based on copula functions. We found that (1) The SWAT can simulate monthly streamflow well with NS being 0.76–0.92 for validation data over the sub-basins in the PLB. (2) The MSDI index indicated that there were more drought events during 1960–1979 and 2000–2019, highlighting a cyclical pattern of drought events in the PLB. (3) The Xiushui River Basin encountered the most extreme drought conditions since 2000, indicating the basin faced a high risk of dry conditions. …”
Get full text

Down-regulation of cell membrane localized NTCP expression in proliferating hepatocytes prevents hepatitis B virus infection by Ying Yan, Lena Allweiss, Danli Yang, Jingting Kang, Jianwen Wang, Xiangjun Qian, Ting Zhang, Hui Liu, Lu Wang, Shuhong Liu, Jianhua Sui, Xiangmei Chen, Maura Dandri, Jingmin Zhao, Fengmin Lu

“…Clinically, significantly lower NTCP protein expression was correlated with more active hepatocyte proliferation in CHB patients with severe active necroinflammation and better antiviral treatment outcome. …”
Get full text

STS2 deficiency revives CD8+T cells from exhaustion and augments checkpoint blockade efficacy in cancer immunotherapy by Chunxiao Li, Fei Ma, Ying Zhang, Ting Wang, Hongnan Mo, Ning Zhong, Dongkui Xu, Fangzhou Sun, Yantong Zhou, Jianbin Guo, Zhenguo Zhao, Xiaoqi Yang, Haili Qian

“…STS2-deficient CD8+ TILs maintained a more functional state, exhibiting enhanced effector activity, proliferation, and antitumor efficacy while resisting terminal exhaustion. …”
Get full text

Construction of vascularized liver microtissues recapitulates angiocrine-mediated hepatocytes maturation and enhances therapeutic efficacy for acute liver failure by Liuyang Zhu, Sen Liu, Zhuangzhuang Yang, Long Yang, Yueyue Yang, Pinsheng Han, Yu Miao, Lei Lin, Lilin Xu, Yan Li, Xinyue Li, Libo Wang, Tianyu Zhao, Weiwei Wang, Zilin Cui, Ze Wang, Deling Kong, Zhongyang Shen, Yamin Zhang

“…However, insufficient vascularization and functional immaturity remain major barriers impeding optimal functional recovery after transplantation. …”
Get full text

Targeting olfactory receptor OR2AT4: An innovative aptamer-based treatment for hair growth promotion by Manuel Mataix, Nuria Illera, Inés Hidalgo, Maria del Carmen de Arriba, Elena Martín, Gerónimo Fernández, Carlos González, Fernando Larcher, Victor M. González, Marcela del Rio, Francisco Jiménez, Marta Carretero

“…Non-canonical functions of olfactory receptors, one of the largest families of GPCR receptors not confined to the olfactory system, include an intriguing role on hair physiology. …”
Get full text

Fish Diversity Patterns in Rivers Receiving Ecological Water Supplement Driven by Riparian Land Use by LIU Han, LI Lu-dan, GUO Wei-jie, QIAO Qiang-long, GONG Dan-dan, DU Qi, LI Hang, ZHAO Wei-hua

“…This underscores the need for scale-targeted management measures. Furthermore, functional dispersion (FDis) and taxonomic diversity (Delta) proved more sensitive indicators of community changes than species richness alone, recommending their integration into future monitoring frameworks. …”
Get full text

Gut microbiota differences linked to weight gain and ART in people living with HIV are enterotype specific and minor compared to the large differences linked to sexual behavior by Jan Kehrmann, Alireza Dostmohammadi, Anna-Lena Stumpf, Lara Best, Leah Consten, Hannah Sievert, Felix Maischack, Stefanie Sammet, Sarah Albayrak-Rena, Ann-Kathrin Doerr, Katharina Bohlen, Otgonzul von Velsen, Otgonzul von Velsen, Ivana Kraiselburd, Christina B. Karsten, Farnoush Farahpour, Farnoush Farahpour, Folker Meyer, Stefan Esser, Jan Buer

“…Among them, the class Actinobacteria and genus Bifidobacterium differed between individuals gaining more than 5% weight and less than 5% weight 1 year after ART switch. …”
Get full text

Behaviour change interventions to promote physical activity in people with intermittent claudication: the OPTIMA systematic review by Ukachukwu O Abaraogu, Philippa Dall, Chris Seenan, Sarah Rhodes, Trish Gorely, Joanna McParland, Julie Brittenden, Ebuka M Anieto, Lorna Booth, Cathy Gormal, Jeremy Dearling, Candida Fenton, Sarah Audsley, Kimberley Fairer, Lindsay Bearne, Dawn A Skelton

“…Interventions aimed at improving patients’ intentions to engage in PA were more effective in enhancing PA behaviour than those that did not focus on this theoretical domain. …”
Get full text

Epidemiologic threats and outcome of evolving COVID-19-associated mucormycosis from a referral hospital in Egypt by Safaa Elserougy, Muhammad Abdel-Ghaffar, Eman Medhat, Ahmed Heiba, Weam Shaheen, Elham Mostafa, Hala Mahfouz, Samah Abdel-Hafez, Mohammad S Mahfouz, Shimaa Afify, Omnia Ali, Enass El-Sayed, Ahmed M Mostafa, Ahmed M Salah, Anwar Elbatawy, Hanan M Elghoneimy, Amr A Elshafey, Ahmed Abou-ElFotouh, Tareq Abdul-Ghani, Fatma I Ibrahim, Sarah M Samy, Manal S Elhussini

“…The patients who survived received more surgical interventions than dead patients, including functional endoscopic sinus surgery (FESS) and maxillofacial surgery. …”
Get full text

The cryoprotective effect of Litopenaeus vannamei head-derived peptides and its ice-binding mechanism by Julieth Joram Majura, Xiujuan Chen, Zhongqin Chen, Mingtang Tan, Guoping Zhu, Jialong Gao, Haisheng Lin, Wenhong Cao

“…Our findings suggest that shrimp head-derived AFPs can be developed into functional additives in frozen foods and add more insights into the existing literature on antifreeze peptides.…”
Get full text

Potential influence of geomagnetic activity on blood pressure statistical fluctuations at mid-magnetic latitudes by Pengzhi He, Chen Li, Minlan Xu, Ruilong Guo, Alexander William Degeling, Timo Pitkänen, Yude Bu, Xiangyun Zheng, Yue Zhang, Xianghong Jia, Anmin Tian, Chenyao Han, Shifeng Wang, Tianlu Chen, Jiangping Fang, Shaowei Sun, Wenlong Liu, Jinbin Cao, Kimmen Quan, Zhiyuan Cong, Dedong Ma, Qiugang Zong, Suiyan Fu, Shutao Yao, Huanhu Zhang, Quanqi Shi

“…Abstract Background Solar activity and the consequent geomagnetic activity (GMA) profoundly influence human biological rhythms and cardiovascular system functions. Although the response of blood pressure (BP) to GMA has attracted considerable attention, it is unclear whether the GMA can have an influence alone and how it occurs. …”
Get full text

A longitudinal study of changes in depressive symptoms and risk factors for congestive heart failure by Julia Gallucci, Justin Ng, Maria T. Secara, Brett D. M. Jones, Colin Hawco, M. Omair Husain, Nusrat Husain, Imran B. Chaudhry, Aristotle N. Voineskos, M. Ishrat Husain

“…Key factors related to these classifications included behavioural and functional factors such as quality of life and disability, as well as the clinical severity of CHF. …”
Get full text

Intravenous Thrombolytic Treatment in the Oldest Old by Juan García-Caldentey, María Alonso de Leciñana, Patricia Simal, Blanca Fuentes, Gemma Reig, Fernando Díaz-Otero, Marta Guillán, Ana García, Patricia Martínez, Andrés García-Pastor, José Antonio Egido, Exuperio Díez-Tejedor, Antonio Gil-Núñez, José Vivancos, Jaime Masjuan

“…The primary outcome measures were the percentage of symptomatic intracranial haemorrhage (SICH) and functional outcome at 3 months (modified Rankin Scale, mRS). …”
Get full text

Advances in diffuse glial tumors diagnosis by Luis Filipe de Souza Godoy, Vitor Ribeiro Paes, Aline Sgnolf Ayres, Gabriela Alencar Bandeira, Raquel Andrade Moreno, Fabiana de Campos Cordeiro Hirata, Frederico Adolfo Benevides Silva, Felipe Nascimento, Guilherme de Carvalho Campos Neto, Andre Felix Gentil, Leandro Tavares Lucato, Edson Amaro Junior, Robert J. Young, Suzana Maria Fleury Malheiros

“…These advancements have deepened our understanding of tumor oncogenesis, enabling a more refined stratification of the biological behavior of these neoplasms. …”
Get full text

Nanostructured GelMA colloidal gels as bioinks for freeform multi-mode 3D printing: better replacement for the classical GelMA polymeric inks by Qifan Wang, Kaiwen Chen, Yonggang Zhang, Fei Shao, Xiangyuan Tan, Qiwei Ying, Libin Wang, Changle Ren, Lijun Zhang, Huanan Wang

“…In general, our nanostructured GelMA colloidal inks present a better replacement for the traditional GelMA polymeric inks in 3D bioprinting, which establishes a foundation for bench-to-bedside translations of 3D printing techniques towards more practical clinical applications.…”
Get full text

Blocking ITGA5 potentiates the efficacy of anti‐PD‐1 therapy on glioblastoma by remodeling tumor‐associated macrophages by Rongrong Zhao, Ziwen Pan, Jiawei Qiu, Boyan Li, Yanhua Qi, Zijie Gao, Wei Qiu, Weijie Tang, Xiaofan Guo, Lin Deng, Gang Li, Hao Xue

“…Fully understanding the cellular heterogeneity and immune adaptations in response to anti‐PD‐1 therapy is necessary to design more effective immunotherapies for GBM. This study aimed to dissect the molecular mechanisms of specific immunosuppressive subpopulations to drive anti‐PD‐1 resistance in GBM. …”
Get full text

VenusMutHub: A systematic evaluation of protein mutation effect predictors on small-scale experimental data by Liang Zhang, Hua Pang, Chenghao Zhang, Song Li, Yang Tan, Fan Jiang, Mingchen Li, Yuanxi Yu, Ziyi Zhou, Banghao Wu, Bingxin Zhou, Hao Liu, Pan Tan, Liang Hong

“…These datasets feature direct biochemical measurements rather than surrogate readouts, providing a more rigorous assessment of model performance in predicting mutations that affect specific molecular functions. …”
Get full text

In Silico and In Vitro Studies of the Approved Antibiotic Ceftaroline Fosamil and Its Metabolites as Inhibitors of SARS-CoV-2 Replication by Cássia Delgado, Pablo Andrei Nogara, Milene Dias Miranda, Alice Santos Rosa, Vivian Neuza Santos Ferreira, Luisa Tozatto Batista, Thamara Kelcya Fonseca Oliveira, Folorunsho Bright Omage, Flávia Motta, Izabela Marques Bastos, Laura Orian, João Batista Teixeira Rocha

“…The 1,2,4-thiadiazole functional group is an inhibitor of cysteine proteases, such as papain and cathepsins. …”
Get full text

Caged-hypocrellin mediated photodynamic therapy induces chromatin remodeling and disrupts mitochondrial energy metabolism in multidrug-resistant Candida auris by Xinyao Liu, Yiran Tao, Linwan Zhang, Yuzhou Liu, Dongmei Shi, Jiao Wang, Peng Xue, Bin Xu, Wenjie Fang, Yuping Ran

“…Our data showed that low-dose PDT causes subtle local adjustments in chromatin topology, whereas high-dose PDT leads to more pronounced changes in A/B compartmentalization, topologically associating domain (TAD) organization, and chromatin looping associated with key genes related to mitochondrial energy metabolism. …”
Get full text

Contribution of gait speed, grip strength, and depression on the risk of serious falls among older adults by Temam Beshir Raru, Julie A. Pasco, Mojtaba Lotfaliany, Shiva Ganjali, Malcolm Forbes, Alice J. Owen, Robyn L Woods, Anna Barker, Suzanne G. Orchard, Joanne Ryan, John J. McNeil, Michael Berk, Mohammadreza Mohebbi

“…Combined slow gait, weak grip, and depressive symptoms were associated with a more than two-fold increase in the risk of serious falls (AHR=2.15, 95 %CI: 1.56–2.97). …”
Get full text