Disparate and shared transcriptomic signatures associated with cortical atrophy in genetic behavioral variant frontotemporal degeneration by Ting Shen, Jacob W. Vogel, Vivianna M. Van Deerlin, EunRan Suh, Laynie Dratch, Jeffrey S. Phillips, Lauren Massimo, Edward B. Lee, David J. Irwin, Corey T. McMillan

“…Methods We employed an integrative imaging transcriptomics approach to identify both disparate and shared transcriptomic signatures associated with cortical thickness in bvFTD with C9orf72 repeat expansions or pathogenic variants in GRN or MAPT. Functional enrichment analyses were conducted on each gene list significantly associated with cortical thickness. …”
Get full text

Comparative transcriptomics of atrazine-tolerant and sensitive alfalfa varieties under atrazine stress by Yingao Li, Chunyang Dong, Zeshan Zulfiqar, Haojie Wang, Jiading Lu, Xiaoxia Zhang, Jun Li, Yinghua Shi, Chengzhang Wang, Xiaoyan Zhu, Hao Sun

“…This differential gene expression helps JN5010 maintain stability in its functions under stress, demonstrating better adaptability. …”
Get full text

Optimizing health-related quality of life assessments for stroke survivors: a validation study of psychometric properties for the Vietnamese version of stroke impact scale 3.0 by Thao Thi Phuong Nguyen, Thao Thi Phuong Nguyen, Hai Bui Hoang, Hai Bui Hoang, Huyen Thi Thanh Vu, Huyen Thi Thanh Vu, Seung Won Lee, Seung Won Lee, Seung Won Lee, Seung Won Lee

“…BackgroundEnsuring lifelong health among aging populations necessitates comprehensive assessments of functional recovery and quality of life, particularly for vulnerable groups such as older adult stroke survivors. …”
Get full text

Beta-adrenergic reactivity of erythrocyte membranes in various phenotypes of uncontrolled hypertension by M. A. Manukyan, A. Yu. Falkovskaya, V. F. Mordovin, I. V. Zyubanova, V. A. Lichikaki, E. I. Solonskaya, A. A. Vtorushina, S. A. Khunkhinova, I. A. Skomkina, V. V. Rudenko, T. Yu. Rebrova, E. F. Muslimova, S. A. Afanasyev

“…Aim. To assess the functional state of the sympathetic nervous system according to β-adrenergic reactivity of erythrocyte membranes (EM) in patients with refractory (rfHTN) and resistant hypertension (rHTN) in relation to target organ damage.Material and methods. …”
Get full text

Shining light on knee osteoarthritis: an overview of vitamin D supplementation studies by Di Zhang, Miaoyu Ye, Yao Xu, Luyu Jiang, Yanmei Hu, Qi Zhang, Xiao Han, Qian Dai, Junhui Qian, Jian Luo, Qiang Yuan

“…BackgroundThe impact of knee osteoarthritis on individuals’ daily functioning is significant. In recent years, Vitamin D supplements cure osteoarthritis has garnered attention from medical professionals and patients due to its simplicity and portability. …”
Get full text

Distinct bone metabolic networks identified in Phospho1−/− mice vs. wild type mice using [18F]FDG total-body PET by Abigail F. Hellman, Paul S. Clegg, Colin Farquharson, José Luis Millán, Carlos J. Alcaide-Corral, Carlos J. Alcaide-Corral, Karla J. Suchacki, Karla J. Suchacki, Adriana A. S. Tavares, Adriana A. S. Tavares

“…The skeletal system provides a good model for applying network analysis to total-body PET, as bone serves many classical whole-body functions as well as being an endocrine regulator of metabolism. …”
Get full text

Vascular Remodeling Markers in Patients with Essential Arterial Hypertension Depending on Presence of Type 2 Diabetes Mellitus by Yu. A. Danilogorskaya, E. A. Zheleznykh, E. A. Privalova, Yu. N. Belenkov, A. A. Shchendrigina, M. V. Kozhevnikova, G. A. Shakaryants, V. Y. Zektser, A. S. Lishuta, I. S. Ilgisonis

“…Using photoplethysmography in combination with reactive hyperemia test structural and functional markers of vascular remodeling were determined: in large vessels – stiffness index and phase shift; in microvessels – reflection index and the occlusion index. …”
Get full text

Cinnamaldehyde Alleviates Salmonellosis in Chicks by Regulating Gut Health by Lizi Yin, Luxin Li, Xue Lv, Fengsheng Sun, Yuyun Dai, Yingzi Guo, Shihao Peng, Chenyu Ye, Xiaoxia Liang, Changliang He, Gang Shu, Ping Ouyang

“…CA treatment was the most effective method for reducing PD intestinal colonization and maintaining better intestinal homeostasis, possibly by regulating intestinal microbiota and metabolic functions.…”
Get full text

FRET Visualization of High Mechanosensation of von Willebrand Factor to Hydrodynamic Force by Mingxing Ouyang, Yao Gao, Binqian Zhou, Jia Guo, Lei Lei, Yingxiao Wang, Linhong Deng

“…This study provides new insights into the vWF’s mechanosensitive feature for its physiological functions and implicated disorders.…”
Get full text

The Effect of “Carvacrol” on Ischemia-Reperfusion Injury in the Skeletal Muscles of Rats by Barış Mardin, Abdullah Özer, Başak Koçak, Ayşegül Küçük, Mustafa Hakan Zor, Şaban Cem Sezen, Mustafa Kavutçu, Mustafa Arslan, Gürsel Levent Oktar

“…Therefore, we contend that more experimental cohort investigations are needed to examine the impact of the Car molecule on preventing I/R injury.…”
Get full text

Recognition of pivotal immune genes NR1H4 and IL4R as diagnostic biomarkers in distinguishing ovarian clear cell cancer from high-grade serous cancer by Yumin Ke, Meili Liang, Zhimei Zhou, Yajing Xie, Li Huang, Liying Sheng, Yueli Wang, Xinyan Zhou, Zhuna Wu

“…To identify differentially immune-related genes (DIRGs) linked to OCCC. We assessed DIRGs functional enrichment and built a protein-protein interaction (PPI) to explore DIRGs interactions. …”
Get full text

Evaluation of the efficiency and safety of magnet therapy for osteoarthritis. Results of the multicenter blind placebo-controlled study COSMO (Clinical Evaluation of Current Magnet... by A. E. Karateev, E. Yu. Pogozheva, M. L. Sukhareva, A. M. Lila, A. V. Ivanov, I. P. Osnovina, O. V. Shchashkova, S. V. Borisova, N. Е. Larinsky, Yu. A. Israelyan, S. А. Afoshin, T. P. Bondarenko, E. А. Repchanskaya, L. A. Chernyavskaya, S. P. Pupina, T. V. Darmova

“…The changes of all parameters were statistically more significant in Group 1 than in Group 2. Treatment results were assessed as good and excellent by 58.5% and 39.8% patients in Groups 1 and 2, respectively (p<0.001). …”
Get full text

The impact of family environment on social avoidance in adolescents with depressive disorders: a chain mediation model involving basic psychological needs and core self-evaluations by Xin Tian, Xin Tian, Liqi Gu, Xinrong Ma, Yuelan Zhang, Ling Dang, Furong Gou, Mengyuan Zhang, Wenjun Wang, Hao Duan

“…BackgroundSocial avoidance is a critical barrier to functional recovery among adolescents with depressive disorders. …”
Get full text

Knee-Sparing Resection and Reconstruction Surgery for Bone Sarcoma Using 3D-Surgical Approach: Average of 5-Year Follow-Up by Amit Benady, Noy Yehiel, Ortal Segal, Omri Merose, Amir Sterenheim, Osnat Sher, Ben Efrima, Eran Golden, Yair Gortzak, Solomon Dadia

“…As personalized healthcare and additive manufacturing continue to advance, the future of orthopedic oncology will likely see more precise, durable, and biologically integrated implants, further improving patient outcomes.…”
Get full text

Mass Spectrometry Identification and Computational Chemistry Study of Fluoromethcathinone Isomers by Xiao-wei LI, Xiang-li LIN, Xuan-yu ZHOU, Xing KE, Yi-lei FAN, Yu XU, Jia-wei XU

“…In addition, the fragmentation mechanisms of 3-FMC and 4-FMC were investigated by applying density functional theory calculation, which can more accurately elucidate the mass spectral behavior and structure characteristics of compounds as reflected by mass spectrometric data. …”
Get full text

Optimizing Small Cell Performance: A New MIMO Paradigm With Distributed ASTAR-RISs by Shakil Ahmed, Ahmed E. Kamal, Mohamed Y. Selim, Md Akbar Hossain, Saifur Rahman Sabuj

“…As the demand for high-speed data transmission grows with the expected emergence of 6G networks and the proliferation of wireless devices, more than traditional wireless infrastructure may be required. …”
Get full text

Determination of left ventricular ejection fraction and C-reactive protein by the state of ischemic myocardium – capabilities of ECG digitalization by V. K. Tashchuk, O. V. Malinevska-Biliichuk

“…The negative direction of the T wave and various types of rhythm disturbances in SA patients led to more significant decrease in MSR indicator of the differentiated ECG. …”
Get full text

Impaired central sensitivity to thyroid hormone is associated with hypertriglyceridemia in euthyroid population by Yu Gong, Yu Gong, Guojuan Wang, Qianqian Zhang, Xu Jiang, Zhangxiang Zhu, Ying Li

“…Biochemical parameters including thyroid hormones (THs), liver and kidney functions, blood glucose, and blood lipids were measured. …”
Get full text

Proof-of-concept MALDI-TOF-MS assay for the detection of Toxin B enzymatic activity in Clostridioides difficile infection by Josef Dvorak, Lukáš Fojtík, Ljubina Adámková, Katerina Vlkova, Vendula Studentova, Katerina Chudejova, Lenka Geigerová, Michael Volny, Petr Novak, Jaroslav Hrabak, Petr Pompach

“…The testing protocol is also more complicated when it comes to anaerobes. In our work, we focused on the functional detection of Clostridioides difficile, an important nosocomial human pathogen that is responsible for diarrhea and can lead to life-threatening colitis, as a model diagnostic problem. …”
Get full text

Effectiveness and safety of perampanel for pediatric patients with epilepsy: A real‐world study from China by Xiaohui Wang, Taoyun Ji, Maomao Liu, Xiaofei Wang, Zhixian Yang, Sanmei Wang, Liping Zou, Jiong Qin, Xiaotun Ren, Liankun Ren, Liri Jin, Jie Shi, Dantao Peng, Kui Chen, Jindong Dai, Nan Zhang, Jun Wang, Tianyu Song, Fang Fang, Yuehua Zhang, Qun Wang

Get full text