Association of bone fracture type and degree of callus formation with leptin concentration in children with long bone fractures by Paunović Zoran, Stanojević Ivan, Abazović Džihan, Rakić Mia, Stanković Nikola, Đukić Mirjana, Milutinović Sanja, Starčević Srđan, Šupić Gordana, Vojvodić Danilo, Jović Milena, Marić Dušan

“…Recent data indicate that adipokine leptin functions as a regulator of bone growth at multiple levels, systemically and locally. …”
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ADI-270: an armored allogeneic gamma delta T cell therapy designed to target CD70-expressing solid and hematologic malignancies by Jie Zhang, Jyothi Sethuraman, Marissa Herrman, Pranav Murthy, Ramandeep Kaur, Jonathan T S Wong, Kevin P Nishimoto, Smitha R Y Gundurao, Arun Bhat, Blake T Aftab, Shon Green, Aruna Azameera, Morgan Smith-Boeck, Michael Salum, Yvan Chanthery, Melinda Au, Amy Doan, Christopher J Rold, Swapna Panuganti, Helen Budworth, Gauri Lamture, Alexander G Teague, Yogendra Verma, Elizabeth B Speltz, Katherine M Wang, Dishant Bhatwala, Ana Giner-Rubio, Pavan Puligujja, Aya Jakobovits

“…Homing barriers, immunosuppressive factors, and target antigen heterogeneity can impair CAR-T cell functional activity within the TME. Alternative strategies have contemplated incorporating the use of gamma delta (γδ) T cells as a CAR-T cell approach to potentially overcome these limitations. γδ T cells possess both innate and adaptive immunity to facilitate broad tumor recognition, and their natural propensity for tissue tropism may allow for more effective tumor infiltration. …”
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Effects and formula optimization of Rosa roxbunghii pomace substrate on the yield and volatile flavor compounds of Lentinulaedodes by Tingfei Deng, Tingfei Deng, Liangqun Li, Liangqun Li, Chunyan Li, Chunyan Li, Yanfang Yan, Yanfang Yan, Anqin Gao, Xiaolan Liu, Xiaolan Liu, Xiong Pan, Xiong Pan, Ming Gao, Ming Gao, Lijuan Ge, Lijuan Ge, Mei Peng, Mei Peng, Zhongsheng Luo, Zhongsheng Luo, Yan Tian, Juan Yang, Juan Yang, Xiaosheng Yang, Xiaosheng Yang

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Computational ranking identifies Plexin-B2 in circulating tumor cell clustering with monocytes in breast cancer metastasis by Emma Schuster, Nurmaa K. Dashzeveg, Fangjia Tong, Yuzhi Jia, Lamiaa El-Shennawy, Tong Zhang, Andrew D. Hoffman, Reta Birhanu Kitata, Golam Kibria, Youbin Zhang, Joshua R. Squires, Chunlei Zheng, Erika Ramos, Rokana Taftaf, David Scholten, Hannah F. Almubarak, Valery Adorno-Cruz, David P. Sullivan, Carolina Reduzzi, Allegra C. Minor, William Purev-Ochir, Sabina Spahija, Rong Xu, Kalliopi P. Siziopikou, Leonidas C. Platanias, Ami Shah, William A. Muller, William J. Gradishar, Massimo Cristofanilli, Chia-Feng Tsai, Tujin Shi, Huiping Liu

“…Abstract Multicellular circulating tumor cell (CTC) clusters can be up to 50 times more efficient than single CTCs in mediating viable metastasis. …”
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Biosynthetic potential of Inonotus obliquus in symbiosis with bacterial cellulose: Optimisation and prospects by Parshenkov Mikhail Alekseevich, Skovorodko Polina Petrovna, Petrusevich Danila Alexandrovich, Makaeva Shagun Narimanovna, Osipova Svetlana Guramovna, Ibragimova Gumru, Istyagina Alexandra Olegovna, Balaeva Kristina Anatolievna

“…Morphological analysis revealed a denser, more organised fungal network under co-cultivation, suggesting improved metabolic efficiency and bioactive compound synthesis. …”
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Cell-specific nanoengineering strategy to disrupt tolerogenic signaling from myeloid-derived suppressor cells and invigorate antitumor immunity in pancreatic cancer by Nilesh U. Deshpande, Anna Bianchi, Haleh Amirian, Iago De Castro Silva, Christine I. Rafie, Bapurao Surnar, Karthik Rajkumar, Akash Ashokan, Ifeanyichukwu C. Ogobuiro, Manan Patel, Erietta Stelekati, Shanta Dhar, Jashodeep Datta

“…Abstract Pancreatic ductal adenocarcinoma (PDAC) is characterized by intratumoral abundance of neutrophilic/polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC) which exert anti-T-cell functions through multiple mechanisms, especially JAK2/STAT3-regulated arginase activity. …”
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Study on the changes in the microbiome before and after seed embryo after-ripening of Fritillaria cirrhosa by Wenshang Li, Wenshang Li, Can Zhao, Can Zhao, Qian Tao, Qian Tao, Weimin Zhang, Weimin Zhang, Hai Wang, Guiqi Han, Guiqi Han, Zhuyun Yan, Zhuyun Yan

“…IntroductionMicroorganisms play an important role in the embryonic development of plant seeds; however, there are no existing reports on the microbial communities associated with Fritillaria cirrhosa before and after embryo after-ripening.MethodsIn this study, the microbial communities of Fritillaria cirrhosa seeds before and after after-ripening were analyzed using the Illumina MiSeq platform, targeting the V4–V5 region of the bacterial 16S rRNA gene and the ITS1 and ITS2 regions of fungal ribosomal RNA.ResultsThe results showed that bacterial communities were more susceptible to environmental stress and exhibited greater fluctuations compared to fungal communities, as reflected in higher diversity and significant changes in the relative abundance of dominant genera and species. …”
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Significant contributions of biomass burning to PM_2.5-bound aromatic compounds: insights from field observations and quantum chemical calculations by Y. Ren, Z. Wu, F. Bi, H. Li, H. Zhang, J. Li, R. Gao, F. Long, Z. Liu, Y. Ji, G. Wang

“…The daily concentrations of <span class="inline-formula">∑</span>13PAHs during heating were more than twice higher compared to those before the heating period. …”
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Comorbidity Burden in Chronic Thromboembolic Pulmonary Hypertension: Implications and Outcome by Burcak Kilickiran Avci, Ibrahim Basarici, Mehmet Akbulut, Halil Atas, Yalin Tolga Yaylali, Umit Yasar Sinan, Ersan Atahan, Murat Meric, Baris Kaya, Kardelen Ohtaroglu Tokdil, Ozden Calay, Hasan Tokdil, Bulent Mutlu, Mehmet Serdar Kucukoglu, Zeki Ongen

“…<i>Conclusions</i>: A high comorbidity burden is common in CTEPH and influences functional status, hemodynamics, and operability decisions. …”
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External negative pressure improves lung aeration in near-term rabbit kittens at risk of developing respiratory distress by C. Diedericks, C. Diedericks, K. J. Crossley, K. J. Crossley, D. Jurkschat, M. J. Wallace, M. J. Wallace, I. M. Davies, I. M. Davies, P. J. Riddington, P. J. Riddington, A. B. te Pas, M. J. Kitchen, M. J. Kitchen, S. B. Hooper, S. B. Hooper

“…External positive pressures reduced FRC levels in Control (6.3 ± 0.8 vs. 12.6 ± 2.2 ml/kg; P &lt; 0.05), but not in EL kittens, and directed tidal ventilation into upper lung regions.DiscussionExternal negative pressures increased lung aeration and resulted in a more evenly distributed tidal ventilation immediately after birth in near-term rabbit kittens, whereas external positive pressures reduced lung aeration and compliance.…”
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Symptom-specific gut microbial and metabolic profiles in ADHD reveal SCFA deficiency as a Key pathogenic mechanism by Xinyue Wang, Ning Wang, Teng Gao, Yunfan Zhang, Zhao Fu, Yilu Zhao, Yujingwen Huang, Xiangyu Zheng, Xuping Gao, Lin Lu, Li Yang

“…Fecal microbiota transplantation in mice validated the hypothesis that gut microbial composition affects ADHD symptoms through metabolic alterations. This study provides more insight into the mechanisms underlying metabolic disturbances in ADHD and elucidates the role of gut microbiota in these processes.…”
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Why do patients with isolated PCL rupture experience no subjective knee joint instability during walking? An in vivo biomechanical study by Mingfeng Lu, Mingfeng Lu, Wei Chen, Jinpeng Lin, Jinpeng Lin, Wenhan Huang, Junqing Gao, Junqing Gao, Lilian Zhao, Shilin Li, Lilei He, Yu Zhang

“…Clinical evaluations of PCLD should incorporate dynamic functional assessments, thereby providing a more comprehensive basis for treatment decisions.…”
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Effect of fusion and arthroplasty for cervical degenerative disc disease in patients with physically demanding occupations by Harjot Uppal, MBA, George Abdelmalek, MD, Neil Patel, MD, Daniel Coban, MD, Stuart Changoor, MD, Nikhil Sahai, MD, Kumar Sinha, MD, Ki Hwang, MD, Arash Emami, MD

“…Results: CDA patients returned to full-time work faster (4.3 vs 6.7 months, p=.025). More CDA patients resumed work by 6 weeks (p=.018) and 3 months (p=.022), though these differences waned by 6 months. …”
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Human urine stem cells protect against cyclophosphamide-induced premature ovarian failure by inhibiting SLC1A4-mediated outflux of intracellular serine in ovarian granulosa cells by Hao-Cheng Gu, Ling-Fang Wang, Yu-Wei Zhang, You-Qiong Zhuo, Zhou-Hang Zhang, Xing-Yu Wei, Quan-Wen Liu, Ke-Yu Deng, Hong-Bo Xin

“…Morphological, histological, and functional alternations were examined using multiple approaches. …”
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Multimodal versus non-contrast computed tomography for assessment of acute ischaemic stroke: the PRACTISE RCT by Keith W Muir, Salwa El Tawil, Alex McConnachie, Alicia Murray, Ian Ford, Grant Mair, Joanna Wardlaw

“…Higher sensitivity of computed tomography perfusion and computed tomography angiography may identify more thrombolysis-eligible patients, but the role of these imaging modalities in thrombolysis treatment decisions within 4.5 hours is unclear. …”
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Label-Free Optical Transmission Tomography for Direct Mycological Examination and Monitoring of Intracellular Dynamics by Eliott Teston, Marc Sautour, Léa Boulnois, Nicolas Augey, Abdellah Dighab, Christophe Guillet, Dea Garcia-Hermoso, Fanny Lanternier, Marie-Elisabeth Bougnoux, Frédéric Dalle, Louise Basmaciyan, Mathieu Blot, Pierre-Emmanuel Charles, Jean-Pierre Quenot, Bianca Podac, Catherine Neuwirth, Claude Boccara, Martine Boccara, Olivier Thouvenin, Thomas Maldiney

“…Live-cell imaging generally requires pretreatment with fluorophores to either monitor cellular functions or the dynamics of intracellular processes and structures. …”
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CD81-guided heterologous EVs present heterogeneous interactions with breast cancer cells by Elena Gurrieri, Giulia Carradori, Michela Roccuzzo, Michael Pancher, Daniele Peroni, Romina Belli, Caterina Trevisan, Michela Notarangelo, Wen-Qiu Huang, Agata S. A. Carreira, Alessandro Quattrone, Guido Jenster, Timo L. M. Ten Hagen, Vito Giuseppe D’Agostino

“…The capacity to entrap heterogeneous molecular cargoes and target specific cell populations through EV functionalization promises advancements in biomedical applications. …”
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Click on Click: Click-Flavone Glycosides Encapsulated in Click-Functionalised Polymersomes for Glioblastoma Therapy by Nuno M. Saraiva, Ana Alves, Ana Isabel Barbosa, Andreia Marinho, Salette Reis, Marta Correia-da-Silva, Paulo C. Costa

“…To enhance therapeutic effect, improve local drug delivery, and overcome solubility issues of these high molecular weight compounds, the synthesised compounds were encapsulated in polymeric particles (polymersomes, PMs) composed of polylactic acid-polyethylene glycol (PEG-PLA) functionalized, once more by click chemistry, with 0.1 mol% transferrin mimetic (T7—HRPYIAH) peptide. …”
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Short light/dark cycles favour photosynthetic efficiency and growth in grapevines by Mariana Gómez Tournier, Laurent Torregrosa, Jana Kändler, Angélique Christophe, Romain Boulord, Anna Medici, Anne Pellegrino

“…GENOT 102 showed a tendency to prioritise biomass partitioning to the reproductive organ and also produced more DMtotal (+38 %) compared to GENOT 16. Lastly, the efficiency in the use of resources (light and water) over the cycle was similar, regardless of the treatments and genotypes. …”
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Differential effects of inulin and fructooligosaccharides on gut microbiota composition and glycemic metabolism in overweight/obese and healthy individuals: a randomized, double-bl... by Jie Li, Feitong Liu, Yuemei Luo, Anisha Wijeyesekera, Shan Wang, Xiaojiao Chen, Yamei Lv, Jing Jin, Huafang Sheng, Guopan Wang, Yuanan Wei, Zhuang Li, Muxuan Chen, Hongwei Zhou

“…Conclusions Practically, inulin may be more suitable for managing glycemic dysregulation in overweight or obese individuals, while FOS may be considered for HCY reduction in individuals with normal glycemic status. …”
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