Randomised controlled trial with parallel process evaluation and health economic analysis to evaluate a nutritional management intervention, OptiCALS, for patients with amyotrophic... by Simon Waterhouse, Chin Maguire, Vanessa Halliday, Cindy Cooper, Elizabeth Coates, Mike Bradburn, Pamela J Shaw, Ammar Al-Chalabi, Tracey Anne Young, Christopher J McDermott, Wendy Baird, Paul Norman, Janet Cade, Sean White, Daniel Beever, Gemma Hackney, Elaine Scott, David Alexander White, Arron Peace, Shamila Ditta, Jonathan Woodward, Naseeb Ezaydi, Haris Stavroulakis

“…Primary outcome is functional change measured over 12 months, using the Revised Amyotrophic Lateral Sclerosis Functional Rating Scale. …”
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Urodynamics tests for the diagnosis and management of male bladder outlet obstruction: long-term follow-up of the UPSTREAM non-inferiority RCT by Madeleine Clout, Amanda L Lewis, Madeleine Cochrane, Grace J Young, Paul Abrams, Peter S Blair, Christopher Chapple, Gordon T Taylor, Sian Noble, Tom Steuart-Feilding, Jodi Taylor, J Athene Lane, Marcus J Drake

“…There was also no difference in other lower urinary tract symptoms, sexual function or quality of life. Routine data were received for 98% of men. …”
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Urodynamics tests for the diagnosis and management of male bladder outlet obstruction: long-term follow-up of the UPSTREAM non-inferiority RCT by Madeleine Clout, Amanda L Lewis, Madeleine Cochrane, Grace J Young, Paul Abrams, Peter S Blair, Christopher Chapple, Gordon T Taylor, Sian Noble, Tom Steuart-Feilding, Jodi Taylor, J Athene Lane, Marcus J Drake

“…There was also no difference in other lower urinary tract symptoms, sexual function or quality of life. Routine data were received for 98% of men. …”
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Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity by Mark F. Mabanglo, Brian Wilson, Mahmoud Noureldin, Serah W. Kimani, Ahmed Mamai, Chiara Krausser, Héctor González-Álvarez, Smriti Srivastava, Mohammed Mohammed, Laurent Hoffer, Manuel Chan, Jamie Avrumutsoae, Alice Shi Ming Li, Taraneh Hajian, Sarah Tucker, Stuart Green, Magdalena Szewczyk, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar, Suzanne Ackloo, Peter Loppnau, Yanjun Li, Almagul Seitova, Taira Kiyota, Jue George Wang, Gilbert G. Privé, Douglas A. Kuntz, Bhashant Patel, Vaibhavi Rathod, Anand Vala, Bhimsen Rout, Ahmed Aman, Gennady Poda, David Uehling, Jailall Ramnauth, Levon Halabelian, Richard Marcellus, Rima Al-awar, Masoud Vedadi

“…Abstract Proteolysis-targeting chimeras (PROTACs) have been explored for the degradation of drug targets for more than two decades. However, only a handful of E3 ligase substrate receptors have been efficiently used. …”
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Construction of vascular grafts based on tissue-engineered scaffolds by Zhongliang Lang, Tianao Chen, Shilu Zhu, Xizhi Wu, Yongqi Wu, Xiaoping Miao, Qiang Wang, Liping Zhao, Zhiqiang Zhu, Ronald X. Xu

“…This review examines current research progress in materials, fabrication processes, functionalized modifications, cell implantation, and animal and clinical experiments for scaffold-based preparation of TEVGs. …”
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From laboratory to clinic: a precise treatment strategy of mesenchymal stem cells-derived exosomes pretreated by simulating disease microenvironment by Hailian Ye, Hailian Ye, Hailian Ye, Qi He, Qi He, Qi He, Fang Qi, Fang Qi, Fang Qi, Guangchao Xu, Guangchao Xu, Guangchao Xu, Mulan Qahar, Mulan Qahar, Mulan Qahar, Chenliang Deng, Chenliang Deng, Chenliang Deng, Zairong Wei, Zairong Wei, Zairong Wei

“…This review examines the mechanisms of action of MSCs and MSC-Exos in various diseases and analyzes the impact of inflammatory preconditioning on the functions and paracrine signaling of MSCs. We propose a personalized MSC preconditioning strategy based on the characteristics of the disease microenvironment to enhance the precision and efficacy of MSC-Exos therapy. …”
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Improved corrosion inhibition effect of a green three-component compound to Q235 steel in acidic solution by Chengjia Bao, Weijian Qi, Zhuanjun Zhu, Ting Xu, Long Zhao, Yanhong Ma, Yang Liu, Bowen Yang, Xueru Luo, Hui Yun, Xiaojuan Li

“…The Tafel results indicated Chi+Cur + Ger functioned as a mixed-type corrosion inhibitor, inhibiting the cathodic reaction more significantly. …”
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STUDY OF ANTIATHEROSCLEROTIC AND ENDOTHELIOPROTECTIVE ACTIVITY OF PEPTIDE AGONISTS OF EPOR/CD131 HETERORECEPTOR by Olesya A. Puchenkova, Sergey V. Nadezhdin, Vladislav O. Soldatov, Maxim A. Zhuchenko, Diana S. Korshunova, Marina V. Kubekina, Evgeny N. Korshunov, Liliya V. Korokina, Polina A. Golubinskaya, Aleksandr L. Kulikov, Vladimir V. Gureev, Vladimir M. Pokrovskiy, Evgeniy A. Patrakhanov, Petr R. Lebedev, Tatyana A. Denisyuk, Veronika S. Belyaeva, Evgeniya A. Movchan, Elizaveta I. Lepetukha, Mikhail V. Pokrovskiy

“…The erythropoietin-based peptides can be used to improve the functional state of the vascular wall against the background of atherosclerotic lesions and have a depressing effect on pathobiological processes associated with a mitochondrial dysfunction. …”
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Neural connectivity and balance control in aging: Insights from directed cortical networks during sensory conflict by Guozheng Wang, Yi Yang, Xiaoxia Liu, Anke Hua, Xin Luo, Yiming Cai, Yanhua Song, Jian Wang, Jun Liu

“…Electroencephalography (EEG) data were analyzed using generalized partial directed coherence (GPDC) to assess the directed functional connectivity and network efficiency. Older adults exhibited significantly greater postural sway, reduced perceptual accuracy, and a diminished ability to detect sensory conflicts than young adults, particularly under conflict conditions. …”
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Ubiquitin-specific peptidases in lymphoma: a path to novel therapeutics by Maryam Samareh Salavatipour, Shirin Tavakoli, Aram Halimi, Aram Halimi, Shima Tavoosi, Amir-Hossein Baghsheikhi, Abdolkarim Talebi-Taheri, Mehdi Niloufari, Zahra Salehi, Javad Verdi, Soheila Rahgozar, Alireza Mosavi-Jarrahi, Mohammad Ahmadvand

“…The dynamic interplay between USPs and lymphoma biology presents an exciting opportunity for future research and the development of more effective treatments for patients with lymphoma. …”
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One-Year Outcomes of 1 Dose versus 3 Loading Doses Followed by Pro Re Nata Regimen Using Ranibizumab for Neovascular Age-Related Macular Degeneration: The ARTIS Trial by Fenghua Wang, Yuanzhi Yuan, Ling Wang, Xiaofeng Ye, Jingke Zhao, Mengxi Shen, Qi Zhang, Ding Xu, Guoyou Qin, Wei Zhang, Fei Yuan, Qing Chang, Peiquan Zhao, Fang Wang, Xiaodong Sun

“…Purpose. To compare the functional and anatomical outcomes of one dose and three loading doses followed by the pro re nata (PRN) regimen in Chinese neovascular age-related macular degeneration (nvAMD) (including polypoidal choroidal vasculopathy (PCV)) patients. …”
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Fluridone promotes the germination of Polygonatum cyrtonema seeds by modulating hormone signal transduction, phenylpropanoid biosynthesis, and energy metabolism by Xiaogang Jiang, Darong Li, Hua Wang, Yuying Yang, Kaidi Yu, Jinwen You, Haihua Liu, Xiaoliang Guo, Yinsheng He, Wuxian Zhou, Qingfang Wang

“…Abstract Polygonatum cyrtonema Hua functions as a highly valued medicinal herb. However, the seeds of P. cyrtonema exhibit morphophysiological dormancy. …”
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Greenhouse gas emissions from livestock production tripled those from household consumption in the Eurasian desert steppe by Lulu Wang, Xinchao Liu, Susie Wu, Tsegaye Gemechu Legesse, Zhuwen Xu, Jiquan Chen, Yaoqi Zhang, Xiaoping Xin, Xiaobing Dong, Yun Liu, Kexin Cao, Changliang Shao

“…A cradle-to-farmgate life cycle assessment (LCA) was performed with functional units standardized as 1 kg live weight (LW) for beef cattle and meat sheep breeds. …”
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Electroacupuncture enhances mesenchymal stem cell therapy via improved perfusion and inflammation modulation in peripheral nerve injury: an IVIM-MRI study in rats by Junfeng Li, Qiuyi Chen, Jintong Pan, Jintong Pan, Fanqi Meng, Wensheng Huang, Yingying Liang, Xuewen Yu, Ruirui Qi, Peiyin Luo, Haodong Qin, Yueyao Chen, Xiaofeng Lin

“…Furthermore, f values were strongly correlated with histological and functional outcomes (p < 0.05).ConclusionEA is more effective than BMSCs alone in promoting nerve repair, enhancing blood flow, and reducing inflammation. …”
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Preclinic evaluation of the safety of potential anticovid-19 phytomedicine: SAYE PLUS impacts on Wistar rat biochemical and histopathological parameters in sub-chronic toxicity stu... by Joël Ouédraogo, Sylvain Ilboudo, Geoffroy Gueswindé Ouédraogo, Gaétan Donzèo Somda, Barthélemy Bonogo, Virginie Dakuyo, Salfo Ouédraogo, Raïnatou Boly, Mathieu Nitiéma, Dofini Réné Magnini, Rasmané Semdé, Sylvin Ouédraogo

“…Further long-term studies focusing on the hematological parameters and certain kidney and liver functional indicators will add the scientific merit and interest of the present work.…”
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The Osteoarthritis Thumb Therapy (OTTER) II Trial: a study protocol for a three-arm multi-centre randomised placebo controlled trial of the clinical effectiveness and efficacy and... by Michael Doherty, Rachael Gooberman-Hill, Susan Dutton, Peter White, Nigel K Arden, Mark Williams, Jo Adams, Paula Barratt, Sofia Barbosa Bouças, Sarah Bradley, Krysia Dziedzic, Kelly Hislop Lennie, Corinne Hutt Greenyer, Victoria Jansen, Ramon Luengo-Fernandez, Claire Meagher

“…Symptomatic thumb base OA affects 20% of people over 55 years, causing more pain, work and functional disability than OA elsewhere in the hand. …”
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Mechanism study on improving chloropicrin fumigation effect by covering fumigated soil with appropriate thickness film by Chunyan Dai, Chunyan Dai, Minghua Li, Minghua Li, Rongfeng Pu, Rongfeng Pu, Yameng Lin, Yameng Lin, Hualin Liu, Hualin Liu, Yuan Liu, Yuan Liu, Xiuming Cui, Xiuming Cui, Peiran Liao, Ye Yang, Ye Yang

“…Overall, F6S treatment improved fumigation efficacy and the yield and quality of P. notoginseng, making it a strategic solution to regenerate the soil health, quality, and production of functional root crops facing continuous cropping obstacles.…”
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Social context affects tissue-specific copper distribution and behaviour of threespine stickleback (Gasterosteus aculeatus) by Sienna L. Overduin, Shaun S. Killen, Alex M. Zimmer, Jenelle D. McCuaig, Lucy Cotgrove, Isabel Aragao, Kelly J. Rozanitis, Kurt O. Konhauser, Daniel S. Alessi, Tamzin A. Blewett

“…Many species exhibit social living which offers ecological advantages such as increased foraging opportunities, more efficient locomotion and reduced predation risk. …”
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In silico analysis reveals distinct changes in markers of epithelial to mesenchymal transition in glioma subtypes by Nives Pećina-Šlaus, Alja Zottel, Željko Škripek, Borna Puljko, Fran Dumančić, Anja Bukovac, Ivana Jovčevska, Anja Kafka

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Can invasive interventions be avoided with a holistic swallowing therapy program in older patients in intensive care units: percutaneous endoscopic gastrostomy tubes or oral intake... by Çağla Eliküçük, Fatma Esen Aydinli, Nazan Has Selmi, Cansu Uzunoğlu, Murathan Köksal, Volkan Öter, Belgin Akan, Erdal Birol Bostanci, Güldeniz Argun

“…Further studies are required to investigate and identify the interventions that improve QoL in older patients. More studies with better research designs are required to establish whether nutritional intervention is effective in enhancing QoL in this vulnerable group.…”
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