Relevant treatment outcomes for individuals aged 60 and older with massive rotator cuff tears: a qualitative study with 16 patients by Cristina Barrufet, Víctor Zamora, Catalina Lizano-Barrantes, Carlos Torrens, Andrea Burón, Emilio Calvo, Lluis Peidró, Joan Miquel, Raúl Barco, Montse Ferrer

“…Special unmet needs were identified for women, with more prolonged diagnostic and therapeutic processes while bearing most household responsibilities. …”
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A comprehensive analysis of forest restoration practices across Europe: Ecological, economic, social and policy dimensions by M. Menéndez-Miguélez, A. Rubio-Cuadrado, J. Bauhus, I. Cañellas, T. Crowther, S. de-Miguel, M. Erdozain, J. Hoffmann, K. Kremer, M. Sotirov, K. Lapin, T. Lundhede, S. Jacobs, E. Schatzdorfer, L. Werden, I. Alberdi

“…Scaling up ecosystem restoration is essential to halt and reverse land degradation and biodiversity loss and ensure future functionality and resilience. However, the implementation of concrete restoration initiatives will present many challenges, such as setting appropriate and realistic goals, selecting or developing the most effective and efficient restoration practices, as well as carrying out effective short- and long-term monitoring of success. …”
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Ultrafast Electron Dynamics at the Water‐Modified InP(100) Surface by Jonathan Diederich, Agnieszka Paszuk, Isaac Azahel Ruiz Alvarado, Marvin Krenz, Mohammad Amin Zare Pour, Diwakar Suresh Babu, Jennifer Velazquez Rojas, Christian Höhn, Yuying Gao, Klaus Schwarzburg, David Ostheimer, Rainer Eichberger, Wolf Gero Schmidt, Thomas Hannappel, Roel van deKrol, Dennis Friedrich

“…These states may thus contribute more strongly to surface reactions than traditionally assumed. …”
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Identification of EXPA4 as a key gene in cotton salt stress adaptation through transcriptomic and coexpression network analysis of root tip protoplasts by Qiankun Liu, Pengtao Li, Muhammad Jawad Umer, Mubashir Abbas, Yongqing Zhao, Yu Chen, Yanfang Li, Aiming Zhang, Yuling Liu, Yangyang Wei, Quanwei Lu, Mengying Yang, Yiman Liu, Xiaoyan Cai, Zhongli Zhou, Shuxun Yu, Fang Liu, Renhai Peng

“…Conclusion These findings underscore the functional significance of GaEXPA4 in the salt stress response. …”
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Lockdown measures in response to COVID-19 in nine sub-Saharan African countries by Richard John Lessells, David McCoy, Alimuddin Zumla, Leonard Mboera, Palwasha Khan, Thomas Czypionka, Richard Kock, Blandina T Mmbaga, David Musoke, Elizabeth Henry Shayo, Najmul Haider, Abdinasir Yusuf Osman, Audrey Gadzekpo, George O Akipede, Rashid Ansumana, Muzamil Mahdi Abdel Hamid, Dorothy Yeboah-Manu, Mark Urassa, Nathan Kapata, Rashida Abbas Ferrand, Pascalina-Chanda Kapata, Florian Stigler

“…However, there are signs of lockdown harming health by affecting the functioning of the health system and causing social and economic disruption.…”
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Implantable continuous-flow total artificial heart for newborns and small pediatric patients: First report of working modelCentral MessagePerspective by Jamshid H. Karimov, MD, PhD, Chihiro Miyagi, MD, PhD, Taiyo Kuroda, MD, Anthony R. Polakowski, BS, MEng, Christine R. Flick, BS, Barry D. Kuban, BS, Kiyotaka Fukamachi, MD, PhD, Tara Karamlou, MD, Munir Ahmad, MD, Hani Najm, MD

“…Objective: The need for safe and reliable mechanical circulatory support (MCS) for smaller children with severe heart failure (HF) is well defined. More specifically, in pediatric patients with advanced congenital HF, there is no implantable total artificial heart (TAH) device available for small patients. …”
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Genome-wide association study identifies loci and candidate genes for root traits in rice grown in Brazil by Gabriel Brandão das Chagas, Latóia Eduarda Maltzahn, Josiane Vargas de Oliveira Maximino, Viviane Kopp da Luz, Ariano Martins de Magalhães Junior, Antonio Costa de Oliveira, Luciano Carlos da Maia, Camila Pegoraro

“…Rice is a staple food for more than half of the world's population. In Brazil, this crop plays an important role in consumption, production and economy. …”
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MRI monitoring of USPIO-labeled BMSCs combined with alginate scaffold for cartilage defect repair by Shanyu Lu, Shanyu Lu, Zhenyu Liu, Zhenyu Liu, Meiling Qi, Meiling Qi, Haocheng Zhen, Jing Luo, Yingchao Wang, Yingchao Wang, Le Chang, Le Chang, Xiaolong Bai, Xiaolong Bai, Yingguang Jiao, Yingguang Jiao, Xinyao Chen, Xinyao Chen, Junping Zhen, Junping Zhen

“…Additionally, it assessed the potential of functional magnetic resonance imaging (fMRI) for non-invasive monitoring of the dynamic repair process.MethodsRabbits were randomly divided into four groups: Group A (control), Group B (sodium alginate scaffold), Group C (BMSCs-sodium alginate scaffold), and Group D (USPIO-labeled BMSCs-sodium alginate scaffold). …”
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TET2 orchestrates YAP signaling to potentiate targetable vulnerability in hepatocellular carcinoma by Jing He, Mingen Lin, Fei Teng, Xue Sun, Ziyin Tian, Jiaxi Li, Yan Ma, Yue Dai, Yi Gao, Hongchen Li, Tongguan Tian, Kai Xu, Xinxing Li, Lei Lv, Yanping Xu

“…Although various therapies have substantially ameliorated clinical outcome, patients invariably suffer from cancer relapse, highlighting the need for more optimized therapeutic strategies. Here, we report that deficiency of DNA methylcytosine dioxygenase TET2 sensitizes HCC cells to sorafenib and verteporfin treatments. …”
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Effectiveness of cognitive remediation in subjects with major depressive disorder: A multicenter randomized controlled study in a real-world setting by Stefano Barlati, Gabriele Nibbio, Antonello Bellomo, Bernardo Carpiniello, Cristina Colombo, Serafino De Giorgi, Giacomo Deste, Giuseppe Maina, Giovanni Martinotti, Alfonso Tortorella, Gabriele Di Salvo, Mario Luciano, Federica Pinna, Antonio Ventriglio, Andrea Fiorillo, Antonio Vita

“… Abstract Background Cognitive impairment represents a central component of major depressive disorder (MDD), affecting a large proportion of people living with MDD and showing a consistent negative impact on social, interpersonal, and occupational functioning and subjective quality of life. Cognitive remediation (CR) is a training-based psychosocial intervention targeting cognitive performance and psychosocial functioning that has shown consistent evidence of effectiveness in individuals with schizophrenia and that could provide significant benefits also in people with MDD: this study aimed to assess the effects of a computerized CR intervention in adults living with MDD. …”
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Immunosuppressive cells in acute myeloid leukemia: mechanisms and therapeutic target by Mengnan Liu, Mengting Yang, Mengting Yang, Yue Qi, Yue Qi, Yuting Ma, Yuting Ma, Qulian Guo, Qulian Guo, Ling Guo, Ling Guo, Chunyan Liu, Chunyan Liu, Wenjun Liu, Wenjun Liu, Lan Xiao, Lan Xiao, You Yang, You Yang

“…Through this comprehensive analysis, we aim to provide a mechanistic framework for developing more effective immunotherapeutic interventions against AML.…”
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Time to endovascular thrombectomy for acute ischaemic stroke in language other than English (LOTE) communities in South-Western Sydney by Dennis Cordato, Peter Thomas, Alan McDougall, Cecilia Cappelen-Smith, Christopher Blair, Nathan Manning, Jing ji, Longting Lin, Mark Parsons, Andrew K Cheung, Daniel Wardman, Chushuang Chen, Suzanne J Hodgkinson, Helen Badge, Vivek Pidugun, Timmy Pham

“…Statistical analyses included multivariate logistic regression to evaluate predictors of functional outcomes.Results Of 911 EVT referrals, 721 patients were included. …”
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The human RNASET2 alarmin-like molecule differentially affects prostate cancer cells behavior in both cell autonomous and non-cell autonomous manners by Rossella Roncoroni, Denisa Baci, Martina Cucchiara, Annarosaria de Vito, Matteo Gallazzi, Maria Teresa Palano, Francesca Olmeo, Cristian Rubuano, Alessandra Giannatiempo, Laura Monti, Raffaella Bombelli, Daniele Mercatelli, Giovanna Finzi, Francesca Franzi, Stefano La Rosa, Douglas M. Noonan, Barbara Bassani, Lorenzo Mortara, Antonino Bruno, Francesco Acquati

“…The human RNASET2 protein has demonstrated both oncosuppressive and immunoregulatory functions across various cancer types, yet its role as an oncosuppressor or alarmin-like molecule in prostate cancer (PCa) is unexplored. …”
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Identification of intratumoral bacteria that enhance breast tumor metastasis by Zachary J. Gerbec, Antonio Serapio-Palacios, Avril Metcalfe-Roach, Zakhar Krekhno, Haggai Bar-Yoseph, Sarah E. Woodward, Jorge Pena-Díaz, Oksana Nemirovsky, Shannon Awrey, Sebastian H. Moreno, Sean Beatty, Esther Kong, Nina Radisavljevic, Mihai Cirstea, Shawn Chafe, Paul C. McDonald, Sam Aparicio, B. Brett Finlay, Shoukat Dedhar

“…We tested for the presence of these bacterial genes in patient tumor samples and found they were more likely to be associated with mortality. We also identified enrichment of specific bacterial functions, providing insight into possible sources of bacteria-driven increases in the metastatic potential of multiple cancer types.…”
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A clinical case of single-stage correction of penetration combined orofacial defect with two microsurgical autografts by A. D. Kaprin, A. P. Polyakov, M. V. Ratushnyi, O. V. Matorin, M. M. Filyushin, V. N. Vasilyev, I. V. Rebrikova, A. L. Sugaipov

“…The most functionally incapacitating and life-incompatible defect was removed at Stage 1 of reconstructive treatment. …”
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No difference in failure between static, articulating, and prosthetic low-friction spacers for periprosthetic joint infection of total knee arthroplasty by M. F. Shannon, T. Edwards, T. Maurer, A. J. Frear, V. R. Wong, S. Sadhwani, C. Smith, A. Kamson, B. Omslaer, C. Cisneros, A. Gordon, A. Williams, N. B. Shah, K. L. Urish, K. L. Urish, K. L. Urish, K. L. Urish, K. L. Urish

“…Static spacers may lead to adverse events more frequently compared to other designs, and a longer interstage duration for prosthetic spacers may reflect greater functionality.…”
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Surface hardening of ductile austenitic lightweight steel through powder bed fusion 3D printing by Joonoh Moon, Hyun-Uk Hong, Hyungkwon Park, Hyo-Haeng Jo, Seong-Jun Park, Chansun Shin, Heung Nam Han, Myoung-Gyu Lee, Jae Suk Jeong, Bong Ho Lee, Chang-Hoon Lee

“…After L-PBF, an aging treatment led to more precipitation of κ-carbides in the surface layer, producing a functionally graded hard surface layer. …”
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Effects of electron beam irradiation on microbial loads, physicochemical properties, stability of active ingredients, and antioxidant activity in Angelica sinensis Radix by Yunxia Hu, Haijun Wang, Zhijun Xin, Wensheng Gou, Zhuanzi Wang, Xiao Liu, Xihong Lu, Aimei Yang, Xuehu Li, Libin Zhou

“…As the demand for safe, wholesome, and high-quality food continues to rise, more research is being done on innovative food processing technologies that maximize efficiency while reducing negative effects on food quality. …”
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Exosomes derived from syncytia induced by SARS-2-S promote the proliferation and metastasis of hepatocellular carcinoma cells by Huilong Li, Huilong Li, Haotian Lin, Haotian Lin, Tinghui Fan, Linfei Huang, Li Zhou, Xiaoyu Tian, Ruzhou Zhao, Yanhong Zhang, Xiaopan Yang, Luming Wan, Hui Zhong, Nan Jiang, Congwen Wei, Wei Chen, Wei Chen, Lihua Hou, Lihua Hou

“…Differentially expressed proteins in syncytia-derived exosomes (Syn-Exos) and their functions was analyzed by Proteomic sequencing. Syn-Exo-mediated promotion of hepatocellular carcinoma cells was measured by CCK-8 and Transwell migration assays. …”
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SARS-CoV-2 infection-induced immunity reduces rates of reinfection and hospitalization caused by the Delta or Omicron variants by Marc-Antoine de La Vega, Efstathia Polychronopoulou, Ara XIII, Zhe Ding, Tong Chen, Qixing Liu, Jiaming Lan, Marie-Edith Nepveu-Traversy, Hugues Fausther-Bovendo, Mohammed F. Zaidan, Gary Wong, Gulshan Sharma, Gary P. Kobinger

“…Lastly, we conducted studies using mice and pre-pandemic human samples for IgG responses to viral nucleocapsid compared to spike protein toward showing a functional component supportive of the medical data results in relation to the immunity types. …”
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