IMDM-20 enhances neutrophilic features during 1.3 % DMSO-mediated differentiation of HL-60 cells by Jorge Andrés Cázares-Preciado, José Antonio Cruz-Cárdenas, Alejandra López-Arredondo, Marco V. Gallardo-Camarena, Marion E.G. Brunck

“…IMDM-20 produced significantly more IL-6 and IL-1β in culture supernatant following stimulation with opsonized E. coli. …”
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Artificial intelligence analysis of thermal energy for convectively heated ternary nanofluid flow in radiated channel considering viscous dissipations aspects by Hamid Qureshi, Amjad Ali Pasha, Muhammad Asif Zahoor Raja, Zahoor Shah, Salem Algarni, Talal Alqahtani, Waqar Azeem Khan, Moinul Haq

“…This research works to establish the convective heat transfer coefficient (CHTC) of new improved ternary hybrid functionalized nanofluids with CuO, Fe2O3, and SiO2 nanoparticles in polymeric fluid. …”
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A stratified therapeutic model incorporated with studies on regulatory B cells for elderly patients with newly diagnosed multiple myeloma by Wenjiao Tang, Yan Li, Zhongqing Zou, Jian Cui, Fangfang Wang, Yuhuan Zheng, Li Hou, Ling Pan, Bing Xiang, Hong Chang, Li Zhang, Ting Niu

“…Regulatory B cells (Bregs) can be involved in immune defects by exerting immune regulatory functions in MM. In order to provide more evidence‐based practice for the elderly MM, the study established and assessed a stratified therapeutic model with studies on Bregs for Chinese Elderly Multiple Myeloma in 2021 (CEMM2021). …”
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Optimisation of bioaerosol sampling using an ultralight aircraft: A novel approach in determining the 3-D atmospheric biodiversity by Maria P. Plaza, Athanasios Charalampopoulos, Vivien Leier-Wirtz, Pia Viuf Ørby, Mathilde Kloster, Michael Dines Christiansen, Claudia Traidl-Hoffmann, Athanasios Damialis, Ulrich Gosewinkel

“…The device consisted of duplicate isokinetic impactors that match the physical functioning and the microscopic quantification method of the widely used ground-based Hirst-type impactors. …”
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Integration of single-cell RNA and bulk RNA sequencing revealed malignant ductal cell heterogeneity and prognosis signatures in pancreatic cancer by Haiyang Du, Haiyang Du, Gao Si, Jiqing Si, Xuejie Song, Xuejie Song, Fuchun Si, Fuchun Si

“…Early diagnostic markers and an improved understanding of tumor-microenvironment interactions are essential for developing more effective therapies.MethodsWe analyzed 74 single-cell RNA sequencing (scRNA-seq) samples, performing unsupervised clustering and marker-gene expression profiling to define major cell types. …”
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Outcomes of peripartum cardiomyopathy in North Africa: insights from a single-center observational study in Tunisia by Rania Hammami, Omar Abdelhedi, Fatma Khanfir, Raeesah Sohawon Oummée Shahlaq, Rania Gargouri, Leila Abid, Sahar Elleuch, Mootez Billah Oueslati, Hassen IbnHadj Amor, Mohamed Derbel, Aymen Dammak, Faiza Safi, Kais Chaabene

“…Dyspnea New York Heart Association III/IV(NYHA III/IV) was the most common functional symptom (85%). The median left ventricle ejection fraction (LVEF) was 30% (IQR = 11%). …”
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Modified transforaminal epidural steroid injection combined with pulsed radiofrequency: an effective treatment measure for lumbar radiculopathy by Qi Yan, Xianggu Zhong, Jiarong Li, Leyu Zhao, Junjie Niu, Dawei Song, Jinning Wang, Yun Teng, Tianyi Wu, Xiao Sun, Rui Chen, Shuangfei Wang, Jun Zou

“…Consequently, clinicians require an expedited and efficacious approach to address radicular discomfort resulting from lumbar radiculopathy and promptly reinstate the patient's normal functionality.ObjectivesThis study seeks to assess the effectiveness of a modified transforaminal epidural steroid injection (TFESI) in conjunction with pulsed radiofrequency (PRF) for treating lumbar radiculopathy using a retrospective analysis.MethodsOur study examined patients with unilateral lower limb radicular pain persisting for three months or more due to LDH, in whom conservative therapies were ineffective, from January 1, 2023, to October 31, 2023. …”
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Genetic variants in HLA-DQA1/DQB1 genes modulate the risk of gestational diabetes mellitus in a southern Chinese population by Lijie Nie, Yan Sun, Ruiqi Li, Qiulian Liang, Guocun Deng, Xinyu He, Yifei Zeng, Hui Zheng, Xinhe Xiao, Xiaodong Ding, Jian Huang, Xiangyuan Yu, Xiangyuan Yu

“…Furthermore, stratified analysis revealed that the increased GDM risk was more likely to occur in individuals with higher blood pressure and TG, and lower HDL-c levels (P<0.05). …”
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Identification of bioaccessible and neuroprotective peptides from fermented casein hydrolysate by Ruirui Li, Shufang Shan, Yujie Xu, Jingyuan Xiong, Guo Cheng

“…However, known neuroprotective peptides are mostly prepared by enzymatic hydrolysis, and physicochemical screening of food-derived functional peptides typically overlooks the interference of biotransport after ingestion. …”
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Blood RNA-seq in rare disease diagnostics: a comparative study of cases with and without candidate variants by Xiaomei Luo, Bing Xiao, Lili Liang, Kaichuang Zhang, Ting Xu, Huili Liu, Yi Liu, Yongguo Yu, Yanjie Fan

“…Meanwhile, RNA-driven identification of causal variants shows a more modest yield in cases without prior candidates. …”
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Cryo-EM structure of an activated GPR4–Gs signaling complex by Yitong Ma, Yijie Wang, Mengyuan Tang, Yuan Weng, Ying Chen, Yueming Xu, Shuxiao An, Yiran Wu, Suwen Zhao, Huanhuan Xu, Dali Li, Mingyao Liu, Weiqiang Lu, Heng Ru, Gaojie Song

“…This study provides a framework for future signaling and functional investigation of psGPCRs.…”
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Cardiac organoids: a new tool for disease modeling and drug screening applications by Ahmed Yaqinuddin, Abdullah Jabri, Abdulaziz Mhannayeh, Bader Taftafa, Mohamed Alsharif, Tasnim Abbad, Jibran Khan, Abdulrahman Elsalti, Raja Chinnappan, Raja Chinnappan, Eman A. Alshehri, Alaa Alzhrani, Alaa Alzhrani, Alaa Alzhrani, Dalia A. Obeid, Iriya Fujitsuka, Mahmood Khan, Mati ur Rehman, Tanveer Ahmad Mir, Tanveer Ahmad Mir

“…Cardiac organoid is a miniature and simplified three-dimensional (3D) cellular model system grown from progenitor cells or stem cells that more accurately mimic the significant biological characteristics and functions of the normal cardiac system than conventional two-dimensional (2D) models. …”
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The superior oxidation resistance of 60NiTi aircraft bearing alloy by introducing TiN and Ni3Ti multiple-layer structure by Yunfei Wang, Huan Yang, Zheng Guo, Yanqing Wu, Guohao Zhang, Xinjian Cao, Yiping Zheng, Yang Li, Haizhen Wang, Xianglong Meng, Zhiyong Gao, Xiaoyang Yi

“…The amount of NiTiO3 oxides is less and the volume percentage of Ti2O3 oxide is more in the nitrided 60NiTi alloy, compared to the solution treated 60NiTi alloy. …”
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Excessive MYC Orchestrates Macrophages induced Chromatin Remodeling to Sustain Micropapillary‐Patterned Malignancy in Lung Adenocarcinoma by Xuming Song, Zehao Pan, Yi Zhang, Wenmin Yang, Te Zhang, Hui Wang, Yuzhong Chen, Xinnian Yu, Hanlin Ding, Rutao Li, Pengfei Ge, Lin Xu, Gaochao Dong, Feng Jiang

“…Unraveling the major regulatory programs underlying MP patterned malignancy offers opportunities to identify more feasible therapeutic targets for patients with MP LUAD. …”
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Advantages, applications, and future directions of in vivo aptamer SELEX: A review by Minchuan Lyu, Chi Ho Chan, Ziqi Chen, Yumeng Liu, Yuanyuan Yu

“…This strategy significantly enhances the specificity, functionality, and physiological relevance of the selected aptamers, making them more viable for therapeutic, diagnostic, and imaging applications. …”
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Effects of pharmacological and non-pharmacological interventions for the management of sleep problems in people with fibromyalgia: a multi-methods evidence synthesis by Mari Imamura, Clare Robertson, Jemma Hudson, Daniel Whibley, Lorna Aucott, Katie Gillies, Marcus Beasley, Martin J Stevens, Paul Manson, Debra Dulake, Abhishek Abhishek, Nicole KY Tang, Gary J Macfarlane, Miriam Brazzelli

“…All items were examined and systematically categorised into conceptual health domains according to the aspect they aimed to capture; however, where appropriate, items were coded to more than one domain. Domains were generated inductively from the identified individual items and were informed by terms and definitions contained in the Sleep Foundation Dictionary and the World Health Organization International Classification of Functioning, Disability and Health. …”
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Interhemispheric effects of iTBS on the fronto-parietal network: Evidence from dual-site stimulation by Isabell Int-Veen, Beatrix Barth, Ramona Täglich, Betti Schopp, Hans-Christoph Nuerk, Christian Plewnia, Stefanie De Smet, Marie-Anne Vanderhasselt, Andreas J. Fallgatter, Ann-Christine Ehlis, David Rosenbaum

“…This study investigated the neuromodulatory effects of Theta Burst Stimulation (TBS) on resting-state functional connectivity (FC) following psychosocial stress induced by the Trier Social Stress Test (TSST). …”
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RNA interference of Aspergillus flavus in response to Aspergillus flavus partitivirus 1 infection by Yinhui Jiang, Yinhui Jiang, Xiang Liu, Xiang Liu, Xun Tian, Xun Tian, Jianhong Zhou, Jianhong Zhou, Qinrong Wang, Qinrong Wang, Bi Wang, Bi Wang, Wenfeng Yu, Wenfeng Yu, Yanping Jiang, Tom Hsiang, Xiaolan Qi, Xiaolan Qi

“…The mutants of DCLs and AGOs infected by AfPV1 displayed more changes than RDRP mutants in response to the first three stresses. …”
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Transcriptomic profiling of Schlemm’s canal cells reveals a lymphatic-biased identity and three major cell states by Revathi Balasubramanian, Krishnakumar Kizhatil, Taibo Li, Nicholas Tolman, Aakriti Bhandari, Graham Clark, Violet Bupp-Chickering, Ruth A Kelly, Sally Zhou, John Peregrin, Marina Simón, Christa Montgomery, W Daniel Stamer, Jiang Qian, Simon WM John

“…To gain a more comprehensive understanding of SC biology, we performed bulk RNA sequencing on C57BL/6 J SC, blood vessel, and lymphatic endothelial cells from limbal tissue (~4,500 SECs). …”
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Revealing genes related teat number traits via genetic variation in Yorkshire pigs based on whole-genome sequencing by Jialin Wei, Jingchun Sun, Yi Pan, Minghao Cao, Yulong Wang, Tiantian Yuan, Ao Guo, Ruihua Han, Xiangdong Ding, Gongshe Yang, Taiyong Yu, Rongrong Ding

“…Conclusion Our study shows that more candidate genes associated with pig teat number traits can be identified by GWAS with different variant types. …”
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