An Adiabatic-Expansion-Induced Perturbation Study on Gas–Aerosol Partitioning in Ambient Air—Formation of NH₄NO₃ and Microdroplet Nitrogen Fixation (2) by Yating Gao, Qinchu Fan, Yujiao Zhu, Hengqing Shen, Qi Yuan, Yang Gao, Huiwang Gao, Xiaohong Yao

“…These findings suggest that microdroplet redox reactions are more likely responsible for the generation of NH₃ + HNO₃ than conventional atmospheric NH₃ chemistry. …”
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Effect of metabolic disorders on reactive gliosis and glial scarring at the early subacute phase of stroke in a mouse model of diabetes and obesity by Julien Clain, David Couret, Matthieu Bringart, Olivier Meilhac, Christian Lefebvre d’Hellencourt, Nicolas Diotel

“…Our observations argue in favor of a stronger and more persistent activation of astrocytes and microglia in db/db mice. …”
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Unveiling the Full Protein Effectorome of the Black Sigatoka Pathogen <i>Pseudocercospora fijiensis</i>—An In Silico Approach by Karla Gisel Carreón-Anguiano, Jewel Nicole Anna Todd, César De los Santos-Briones, Santy Peraza-Echeverría, Ignacio Islas-Flores, Blondy Canto-Canché

“…Protein families related to key functions of the hemibiotrophic lifestyle, such as Salicylate hydroxylase and Isochorismatase, are widely represented families of effectors in the <i>P. fijiensis</i> genome. …”
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Unlocking liver physiology: comprehensive pathway maps for mechanistic understanding by Luiz Ladeira, Anouk Verhoeven, Jonas van Ertvelde, Jian Jiang, Alessio Gamba, Julen Sanz-Serrano, Tamara Vanhaecke, Harm J. Heusinkveld, Ramiro Jover, Mathieu Vinken, Liesbet Geris, Liesbet Geris, Liesbet Geris, Bernard Staumont

“…They can revolutionize chemical safety assessment by offering more efficient and human-relevant alternatives to traditional animal testing. …”
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Menstrual blood and ritual beliefs: a qualitative study on menstrual health and hygiene practices among senior high school girls in Volta Region, Ghana by Sitsofe Gbogbo, Israel Wuresah, Wisdom Axame, Priscilla Klutse, Emmanuel Gbogbo, Robert Kokou Dowou, Sarah Odi Mantey, Sarah Abena Yeome Ayitey, Ishmael Boateng, Paramount Eli Nelson, Nuworza Kugbey, Victor Christian Korley Doku, Julie Hennegan, Frank E. Baiden, Fred N. Binka

“…Improving menstrual hygiene in schools requires more than infrastructure – secure, private disposal options and culturally sensitive education are essential.…”
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Understanding facilitators and barriers to adherence in home-based pulmonary rehabilitation for chronic obstructive pulmonary disease patients using the Health Belief Model: a qual... by Qiuxuan Zeng, Wenli Chen, Siyi Xu, Xu Yang, Dandan Xue, Yuhang Peng, Xiaohong Lin, Yingwen Yu, Huixin Huang, Ping Huang, Min Dong, Jiaying Li

“…This study aims to identify the factors that promote or hinder adherence to home-based rehabilitation in COPD patients, to inform more effective and personalized strategies.MethodsThis study guided by Health Belief Model (HBM), and data were collected through semi-structured in-depth interviews with eligible COPD patients during May and July 2024. …”
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Targeting the major pro-inflammatory interleukin-6-type cytokine receptor gp130 by antagonistic single domain antibodies by Silke Pudewell, Julia Heuser, Inna Dorogobed, Britta Lipinski, Thi Hong Hue Tran, Pia Metzenmacher, Richard Kunze, Felix Geyer, Stefan Zielonka, Doreen M. Floss, Harald Kolmar, Jens M. Moll, Jürgen Scheller

“…Furthermore, we functionally demonstrate the inhibitory effect of the selected nanobodies in cell-based transmigration assays of the human colorectal cancer cell line HT-29.DiscussionIn summary, our study has identified and characterized four novel inhibitory high-affinity gp130 nanobodies with potential for use in cytokine-dependent autoimmunity or cancer therapy.…”
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Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotype by Marianna Hellén, Isabelle Weert, Stephan A. Müller, Noora Räsänen, Pinja Kettunen, Šárka Lehtonen, Michael Peitz, Klaus Fließbach, Mari Takalo, Marja Koskuvi, Stefan F. Lichtenthaler, Ville Leinonen, Alfredo Ramirez, Olli Kärkkäinen, Mikko Hiltunen, Jari Koistinaho, Taisia Rõlova

“…The responses of iMGs to Aβ42, LPS and IFNγ were studied by metabolomics, proteomics, and functional assays. Results Here, we demonstrate that iMGs with the APOE4/4 genotype exhibit reduced basal pinocytosis levels compared to APOE3/3 iMGs. …”
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Artificial intelligence-based spatial analysis of tertiary lymphoid structures and clinical significance for endometrial cancer by Haruka Suzuki, Kohei Hamada, Junzo Hamanishi, Akihiko Ueda, Ryusuke Murakami, Mana Taki, Rin Mizuno, Koichi Watanabe, Hanako Sato, Yuko Hosoe, Hiroaki Ito, Koji Yamanoi, Hiroyuki Yoshitomi, Nobuyuki Kakiuchi, Ken Yamaguchi, Noriomi Matsumura, Seishi Ogawa, Hideki Ueno, Masaki Mandai

“…B cell receptor repertoire analysis performed using six TLS samples located at various distances from the tumor showed that TLSs in distal areas had more shared B cell clones with tumor-infiltrating lymphocytes. …”
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Microsurgical and endovascular treatment of large and giant aneurysms of the anterior circulation: A systematic review by Alejandra Mosteiro, Leire Pedrosa, Marta Codes, Luís Reyes, Mariano Werner, Sergio Amaro, Joaquim Enseñat, Ana Rodríguez-Hernández, Marlien Aalbers, Jeroen Boogaarts, Ramon Torné

“…Discussion and conclusions: According to contemporary data about occlusion rates, functional outcomes, and complications, primary or secondary treatment of LGIAs of the anterior circulation seems justified. …”
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Proteomic profiling improves prognostic risk stratification of the Sarculator nomogram in soft tissue sarcomas of the extremities and trunk wall by Madhumeeta Chadha, Sara Iadecola, Andrew Jenks, Valeriya Pankova, Yuen Bun Tam, Jessica Burns, Amani Arthur, Christopher P. Wilding, Liang Chen, Priya Chudasama, Dario Callegaro, Dirk C. Strauss, Khin Thway, Alessandro Gronchi, Robin L. Jones, Rosalba Miceli, Sandro Pasquali, Paul H. Huang

“…Abstract Background High‐risk soft tissue sarcomas of the extremities and trunk wall (eSTS), as defined by the Sarculator nomogram, are more likely to benefit from (neo)adjuvant anthracycline‐based therapy compared to low/intermediate‐risk patients. …”
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Construction of mitochondrial signature (MS) for the prognosis of ovarian cancer by Miao Ao, You Wu, Kunyu Wang, Haixia Luo, Wei Mao, Anqi Zhao, Xiaomeng Su, Yan Song, Bin Li

“…GO and KEGG analysis confirmed these genes were enriched in the generation of precursor metabolites and energy. It illustrated more lymphocyte infiltration in the high MS group than low MS group. …”
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Garlic Extracts Nanoliposome as an Enhancer of Bioavailability of ABA and Thiamine Content and as an Antifungal Agent Against <i>Fusarium oxysporum</i> f. sp. <i>pisi</i> Infecting... by Barbara Kutasy, Géza Hegedűs, Márta Kiniczky, József Péter Pallos, Ágnes Nagy, István Pócsi, Klaudia Pákozdi, Máté Kállai, Csaba Weingart, Katalin Andor, Bettina Kovács, Eszter Virág

“…Therefore, optimizing the formulation of biopesticides and plant conditioning agents is essential to improve the absorption and bioavailability of active ingredients, ensuring more effective disease management in <i>P. sativum</i> cultivation. …”
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Effects of Three Different Bee Pollen on Digestion, Immunity, Antioxidant Capacity, and Gut Microbes in <i>Apis mellifera</i> by Xin-Meng Li, Ying Wang, Li Lei, Ge Zhang, Bao-Hua Xu

“…Feeding assays demonstrated that honeybees consumed significantly more sunflower bee-collected pollen than maize bee-collected pollen or lotus bee-collected pollen. …”
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Older surgical patients’ preferences for follow-up care after hospital discharge: A multi-method qualitative study into their underlying needs by Aafke J de Groot, Marike E de Boer, Elizabeth M Wattel, Cees MPM Hertogh, Marja FIA Depla

“…Background: Almost 30 % of older patients suffer from functional decline during hospital stay which often makes follow-up care decisions necessary. …”
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Repurposed clindamycin suppresses pyroptosis in tumor-associated macrophages through Inhibition of caspase-1 by Adrian Weich, Johannes Berges, Cindy Flamann, Katrin Bitterer, Krishna Pal Singh, David Chambers, Christopher Lischer, Xin Lai, Olaf Wolkenhauer, Carola Berking, Gerhard Krönke, Shailendra Gupta, Heiko Bruns, Julio Vera, Research Group Macrophages

“…We hypothesize that the immunomodulation of TAMs can remodel the UM tumor microenvironment and make it more susceptible to therapeutic interventions. Methods In our work, we designed a novel computational pipeline that combines single-cell transcriptomics data, network analysis, multicriteria decision techniques, and pharmacophore-based docking simulations to select molecular targets and matching repurposable drugs for TAM immunomodulation. …”
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HDL from 36-h fasted participants potently promotes efflux of cholesteryl ester from activated microglia by Joanne K. Agus, Oscar M. Muñoz Herrera, Oscar M. Muñoz Herrera, Christopher H. Rhodes, Jack Jingyuan Zheng, Chenghao Zhu, Maurice Wong, Xinyu Tang, Izumi Maezawa, Lee-Way Jin, Carlito B. Lebrilla, Danielle J. Harvey, Angela M. Zivkovic

“…HDL from 36-h fasted individuals were significantly more effective in effluxing cholesteryl esters from treated microglia, showing a remarkable 10-fold improvement compared to HDL from the postprandial state. …”
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A novel self-assembled nanocarrier-mediated dsRNA fungicide for broad-spectrum management of Rhizoctonia solani by Xiaojie Ding, Xinchun Li, Yan Li, Huiyan Guo, Kexin Cao, Mengnan An, Chong Zhang, Yuanhua Wu, He Liu, Rujun Zhou

“…In this study, R. solani glycosyl hydrolase family 1 (RsGH1), which functions as a cell wall degrading enzyme (CWDE), and was screened as a prospective RNAi target gene for managing R. solani AG3 TB. …”
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N-terminus GTPase domain of the cytoskeleton protein FtsZ plays a critical role in its adaptation to high hydrostatic pressure by Xue-Hua Cui, Xue-Hua Cui, Yu-Chen Wei, Xue-Gong Li, Xue-Gong Li, Xiao-Qing Qi, Xiao-Qing Qi, Long-Fei Wu, Long-Fei Wu, Long-Fei Wu, Wei-Jia Zhang, Wei-Jia Zhang

“…The specific characteristics of FtsZ that allow for functional cell division in the deep-sea environments, especially in obligate piezophiles that grow exclusively under HHP condition, remain enigmatic. …”
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Proteomic Analysis of Extracellular Vesicles Identifies CDCP1 as Critical Metastasis‐Related Glycoprotein in Lung Cancer by Lu Zhang, Yan Wu, Suntao Li, Miao Guo, Jiaqi Zhao, Chengxi Cao, Yan Zhang, Hua Xiao

“…Compared to 95C EVs, 23 glycoproteins were significantly upregulated more than 20‐fold in 95D EVs, including CDCP1, TNC, NCAM2, and ITGA4. …”
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