Evaluating an early Interdisciplinary Multimodal Assessment for Patients at Risk of Developing Chronic Pain: Results of a Multicentre RCT in Germany by Daniel Szczotkowski, Sandra Meyer-Moock, Thomas Kohlmann, Karin Deppe, Anne Gärtner, Greta Hoffmann, Thomas Isenberg, Gabriele Lindena, Ursula Marschall, Carolin Martin, Beatrice Metz-Oster, Lena Milch, André Möller, Bernd Nagel, Frank Petzke, Anke Preissler, Julia Pritzke-Michael, Leonie Schouten, Katja Schwenk, Catharina Schumacher, Anja Waidner, Ulrike Kaiser

“…An early interdisciplinary multimodal assessment (IMA) includes a systematically integrated view of medical, psychosocial and functional factors to direct patients to need-based treatment services. …”
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Early-life nutritional supplementation protects against home environmental risks in Ghanaian children's social-emotional development by Lindsey C. Partington, Lindsey C. Partington, Haiying Yuan, Haiying Yuan, Maku E. Demuyakor, Seth Adu-Afarwuah, Amanda E. Guyer, Amanda E. Guyer, Kathryn G. Dewey, Sika M. Kumordzie, Brietta M. Oaks, Charles D. Arnold, Elizabeth L. Prado, Paul D. Hastings, Paul D. Hastings, Paul D. Hastings

“…Less academic stimulation was related to more hyperactivity/inattention only for children in the control group.ConclusionEarly-life LNS supplementation and supportive home environments reduce social-emotional difficulties in Ghanaian children. …”
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Effect of Different Fermentation Methods on the Physicochemical, Bioactive and Volatile Characteristics of Wolfberry Vinegar by Xiao Qiang, Man Zhao, Ting Xia, Qi Wang, Junwei Yu, Changsheng Qiao, Huimin Zhang, Shiyang Lv, Yanhua Liu, Min Wang

“…Wolfberry (<i>Lycium barbarum</i> L.) as a functional food is rich in nutrients and bioactive substances. …”
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Cell cycle networks link gene expression dysregulation, mutation, and brain maldevelopment in autistic toddlers by Tiziano Pramparo, Michael V Lombardo, Kathleen Campbell, Cynthia Carter Barnes, Steven Marinero, Stephanie Solso, Julia Young, Maisi Mayo, Anders Dale, Clelia Ahrens‐Barbeau, Sarah S Murray, Linda Lopez, Nathan Lewis, Karen Pierce, Eric Courchesne

“…Overall, alterations were more pronounced in bigger brains. We identified 23 candidate genes for brain maldevelopment linked to 32 genes frequently mutated in ASD. …”
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The Antioxidant Effect of Selenium Is Enhanced by Cortisol Through Nrf2 Pathway in Bovine Endometrial Epithelial Cells by Luying Cui, Jingyi Zhong, Jiangyao Duan, Wanting Li, Peng Mao, Junsheng Dong, Kangjun Liu, Long Guo, Heng Wang, Jianji Li

“…In the absence of LPS, cortisol levels of 15 ng/mL showed a more significant antioxidative effect than cortisol levels of 5 and 30 ng/mL. …”
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Landscape of antisense genes in the human genome and identification of new human hepatic antisense RNAs by long-read sequencing by Juan Jose Rojo-Carrillo, Pedro Garrido-Rodríguez, Maria Llamas-López, Rosa Cifuentes-Riquelme, Jose Padilla, Bruno Ramos-Molina, Maria Luisa Lozano, Belen de la Morena-Barrio, Maria Eugenia de la Morena-Barrio, Javier Corral

“…Abstract Background Protein-coding genes have been considered the functional part of the genome, although they represent only 2% of the genome. …”
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Closed-loop versus open-loop “remind-to-move” treatment using wearables for hemiparetic upper extremity in patients after stroke: A proof-of-concept study by Kenneth N. K. Fong, Jasmine P. Y. Pak, Alissa H. L. Koo, Maggie M. K. Szeto, Natalie M. T. Wong, Keily K. Y. Yau, Sharon F. M. Toh, Vivian W. Lou, Hector W. H. Tsang, Gary K. K. Lau

“…The closed-loop group showed a more significant improvement in movement frequency, hand functions, and actual arm use than did the open-loop group. …”
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Exogenous melatonin alleviates drought stress in cotton by enhancing root cortical activity and metabolic adaptation by Haitao Zhang, Congcong Guo, Congcong Guo, Hongchun Sun, Lingxiao Zhu, Ke Zhang, Yongjiang Zhang, Zhanbiao Wang, Cundong Li, Liantao Liu

“…IntroductionThe root cortex plays a critical role in water uptake and metabolic activity, directly influencing root functionality. However, despite melatonin’s known role in plant stress tolerance, its mechanisms in modulating root cortical anatomy and metabolic adaptation under drought remain unclear. …”
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Clinical Recommendations of the Northwest Society for Enteral and Parenteral Nutrition, Interregional Association for Emergency Surgery, Russian Gastroenterological Association, Un... by Yu. V. Averyanova, E. M. Batyrshin, A. E. Demko, G. E. Ivanova, V. T. Ivashkin, L. N. Kostyuchenko, A. V. Lapitsky, I. N. Leiderman, V. M. Luft, I. V. Maev, I. G. Nikitin, M. S. Novruzbekov, Е. A. Poluektova, A. L. Potapov, A. V. Sytov, A. S. Trukhmanov

“…The main referral indications for small bowel transplantation (SBT) are: fast-progressing cholestatic liver disease-complicated irreversible intestinal failure; thrombosis of two or more central venous conduits used for parenteral nutrition; recurrent catheter-associated bloodstream infection.Conclusion. …”
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The Role of Physical Activity in Managing ADHD Symptoms in Children and Adolescents – Review of Current Literature by Barbara Chojnacka, Aleksandra Ożga, Julia Wątor, Agnieszka Woźniacka, Jerzy Krzeszowiak, Barbara Boba, Tomasz Pulanecki, Alicja Podolska, Sylwia Bryksy, Patrycja Kolano

“…What is more children and adolescents should participate in physical activities that they like in order to guarantee compliance and the durability of the intervention. …”
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Case Report: The intersection of psychiatry and medicine: diagnostic and ethical insights from case studies by Francesco Monaco, Francesco Monaco, Annarita Vignapiano, Annarita Vignapiano, Martina D’Angelo, Fabiola Raffone, Valeria Di Stefano, Antonella Boccia, Anna Longobardi, Benedetta Di Gruttola, Michele Fornaro, Giulio Corrivetti, Giulio Corrivetti, Iolanda Martino, Luca Steardo, Luca Steardo, Luca Steardo

“…The article critically examines terms like medically unexplained symptoms and functional disorders, highlighting their limitations and potential for misuse. …”
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Meta-analysis of muscle transcriptome data identifies key genes influencing intramuscular fat content in pigs by Yan Wang, Jiahao Wang, Yanhui Zhao, Xihui Sheng, Xiaolong Qi, Lei Zhou, Jianfeng Liu, Chuduan Wang, Jianliang Wu, Yongchun Cao, Kai Xing

“…Subsequently, we conducted protein-protein interaction network analysis, Gene Ontology and Kyoto encyclopedia of genes and genomes functional enrichment analysis, and quantitative trait locus (QTL) analysis on the DEGs. …”
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Sustainability of small dams for livestock and farming, a case study from Chitongo dam, rural Zambia by Livia Serrao, Livia Serrao, Simone Caridi, Ali Farrokhi, Diego Avesani, Muyaka Kamamba, Mireille Galli, Chalwe Chibwe, Federica Medici, Sara Treccani, Joel Kabika, Kawawa Banda, Marco Bezzi, Massimo Zortea, Maybin Ng’ambi, Guido Zolezzi, Guido Zolezzi

“…The potential catchment sediment yield to the reservoir is estimating by integrating the RUSLE soil erosion method with a measure of sediment connectivity, suggesting the reservoir may fill up in 25 years or more, highlighting its vulnerability to siltation. …”
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Gut microbial metabolism of bile acids modifies the effect of Mediterranean diet interventions on cardiometabolic risk in a randomized controlled trial by Peipei Gao, Ehud Rinott, Danyue Dong, Zhendong Mei, Fenglei Wang, Yuxi Liu, Omer Kamer, Anat Yaskolka Meir, Kieran M. Tuohy, Matthias Blüher, Michael Stumvoll, Meir J. Stampfer, Iris Shai, Dong D. Wang

“…Bile acids (BAs) undergo extensive microbial metabolism in the gut and exert hormone-like functions on physiological processes underlying metabolic risk. …”
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Identification and characterization of long-term meteorological drought events in the Yellow River Basin by Jiepeng Li, Lajiao Chen, Geli Zhang, Hui Liu, Hongchang Hu, Mengzhen Xu, Xingyan Guo, Zibo Meng, Zhiqiang Dong

“…Droughts are relatively more common during summer and autumn in the YRB. …”
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ZIKV prM hijacks PIM1 kinase for phosphorylation to prevent ubiquitin−mediated degradation and facilitate viral replication by Yingying Ren, Yingying Ren, Yishuo Liu, Rui Pang, Gang Xu, Yining Lei, Yining Lei, Hang Fai Kwok, Yingliang Wu, Zhijian Cao, Zhijian Cao, Zhijian Cao, Zhijian Cao

“…Therefore, the S101/T107-D phosphorylation mimic mutant of prM was more resistant to PIM1-induced increases in cellular abundance.DiscussionThese findings revealed PIM1 as a critical host factor that is advantageous to ZIKV and revealed that targeting the PIM1‒prM axis is a conducive strategy for controlling ZIKV infection.…”
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Amyloid precursor-like protein 2 expression in macrophages: differentiation and M1/M2 macrophage dynamics by Gabrielle L. Brumfield, Gabrielle L. Brumfield, Shelby M. Knoche, Shelby M. Knoche, Kenadie R. Doty, Kenadie R. Doty, Alaina C. Larson, Alaina C. Larson, Brittany J. Poelaert, Brittany J. Poelaert, Don W. Coulter, Don W. Coulter, Don W. Coulter, Joyce C. Solheim, Joyce C. Solheim

“…Evaluation of human mRNA data revealed that APLP2 is more highly expressed in human M2/anti-inflammatory (pro-tumor) macrophages than in M1 macrophages (which have a pro-inflammatory, anti-tumor phenotype). …”
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A platform for multisite immune profiling of premetastatic pancreatic cancer at single-cell resolution by Elishama N. Kanu, Ashley A. Fletcher, Jiayin Bao, Ethan S. Agritelley, Julia Button, Austin M. Eckhoff, Karrie Comatas, Tao Wang, Bin-Jin Hwang, Michael E. Lidsky, Sabino Zani, Dan G. Blazer, Peter J. Allen, Zhicheng Ji, Frank J. Lowery, Sri Krishna, Nicholas D. Klemen, Daniel P. Nussbaum, Erika J. Crosby

“…Immune composition, cell-type functional profiles, and T cell clonal expansion patterns were evaluated across tissue sites. …”
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Primary deltoid ligament repair versus trans-syndesmotic fixation for acute bimalleolar equivalent ankle fractures: A meta-analysis of comparative studies by Osama Z. Alzobi, Hammam Kayali, Loay Salman, Mohamed Kenawey, Ashraf Hantouly, Motasem Salameh, Bashir Zikria, Pieter D'Hooghe, Vinod Panchbhavi, Mohamed Mekhaimar, Salah AlBurdeni, Jasim Alsaei

“…Primary outcomes included functional outcomes and symptomatic implant removal, while secondary outcomes included pain scores and complication rate. …”
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The overview and role of heat shock proteins (HSP) especially HSP 60 and 70 in reproduction and other pathologies (a literature review) by V.O. Berestoviy, Ahmad Mahmood, I.B. Venckivska, V.G. Ginzburg, I.V. Sokol, O.O. Berestoviy, D.O. Govsieiev

“…Gynaecological and obstetrical complications were more prevalent in most studies. Pregnant women were mostly affected subjects. …”
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