Extending LoRaWAN: Mesh Architecture and Performance Analysis for Long-Range IoT Connectivity in Maritime Environments by Nuno Cruz, Carlos Mendes, Nuno Cota, Gonçalo Esteves, João Pinelo, João Casaleiro, Rafael Teixeira, Leonor Lobo

“…The nodes convert data into LoRaWAN messages and transmit them wirelessly with the hope that one or more LoRaWAN gateway will receive the messages successfully. …”
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The course of ankylosing spondylitis during pregnancy: intermediate data of a prospective follow-up by O. A. Krichevskaya, Z. M. Gandaloeva, A. B. Demina, T. V. Dubinina

“…The onset of ankylosing spondylitis (AS) more frequently occurs at the end of the third decade of life, which corresponds to the time of marriage and the birth of the first child and determines the relevance of a study of the interaction of AS and pregnancy.Objective: to describe the clinical presentations of AS and its therapy during pregnancy and to study AS activity dynamics and the patients' functional status during gestation.Patients and methods. …”
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Low-frequency rTMS modulates small-world network properties in an AVH-related brain network in schizophrenia by Lin Zhang, Li Guo, Xiaohui Liu, Jing Han, Yuanqiang Zhu, Chaozong Ma, Ye Li, Weiliang Ye

“…Resting-state fMRI data were collected before and after treatment to assess functional connectivity within the predefined 35-region AVH-related network. small-worldness (σ), normalized clustering coefficient (γ), and normalized characteristic path length (λ), as well as functional segregation (clustering coefficient [Cp], local efficiency [El]) and functional integration (global efficiency [Eg], characteristic path length [Lp])—were analyzed before and after rTMS. …”
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Interfacial solar‐driven steam and electricity co‐generation using Hydrangea‐like graphene by salt‐assisted carbonization of waste polylactic acid by Huiyue Wang, Xueying Wen, Kuankuan Liu, Qiuxuan Liu, Guixin Hu, Huajian Liu, Yan She, Ran Niu, Tao Tang, Jiang Gong

“…Molecular dynamics simulation result proves that more Na+ ions are attracted by functional groups, especially –COOH/C–OH, to promote Na+ selectivity in nanochannels. …”
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An orally available small molecule that targets soluble TNF to deliver anti-TNF biologic-like efficacy in rheumatoid arthritis by Alexander Vugler, James O’Connell, Mai Anh Nguyen, Dietmar Weitz, Thomas Leeuw, Elizabeth Hickford, Alexander Verbitsky, Xiaoyou Ying, Markus Rehberg, Bruce Carrington, Mark Merriman, Andrew Moss, Jean-Marie Nicholas, Phil Stanley, Sara Wright, Tim Bourne, Yann Foricher, Zhaoning Zhu, Daniel Brookings, Helen Horsley, Jag Heer, Laurent Schio, Matthias Herrmann, Srinivas Rao, Markus Kohlmann, Peter Florian

“…The molecule, SAR441566, stabilizes an asymmetrical form of the soluble TNF trimer, compromises downstream signaling and inhibits the functions of TNF in vitro and in vivo. With SAR441566 being studied in healthy volunteers we hope to deliver a more convenient orally bioavailable and effective treatment option for patients suffering with chronic autoimmune diseases compared to established biologic drugs targeting TNF.…”
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OsPP2C49, a Negative Regulatory Factor in the Abscisic Acid Signaling Pathway, Positively Regulates Grain Yield in Rice by Jun Miao, Liubing Bu, Wenchen Tan, Ping Wang, Xiangbo Li, Xianfeng Li, Chuyan Chen, Kunming Zhang, Wenle Shen, Zhiyun Gong, Gulinaer Bahetibieke, Lei Ren, Guohua Liang, Yong Zhou

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The stifling burden of climate change on African public healthcare systems by Jack Ogony, Jack Ogony, Judith Mangeni, George Ayodo, Esther Amulen, Florenc Scopas, Tusubila Juma, Michael Wagaba, Amos Deogratius Mwaka, Lena Nwanja, Sambila Princewill, Ben Oyugi, Arthy Yongo, Sitraka Rakotosolofo, Alberto Francioli, Eunison Mugamu, Julia Davies, Simon Karanja, Corrie Hannah

“…It disrupts the physical environment, natural and human systems, and the functionality of healthcare systems, acting as a multiplier threat that jeopardizes and potentially reverses decades of health gains. …”
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The Role of Cardiac Computed Tomography Angiography in Risk Stratification for Coronary Artery Disease by Sophie E. van Rosendael, MD, PhD, Arthur Shiyovich, MD, Rhanderson N. Cardoso, MD, Camila Veronica Souza Freire, MD, Alexander R. van Rosendael, MD, PhD, Fay Y. Lin, MD, Gina Larocca, MD, Solomon W. Bienstock, MD, Ron Blankstein, MD, Leslee J. Shaw, PhD

“…Current trials largely compare a CCTA vs functional testing strategy, yet there is minimal evidence on CCTA plaque-guided therapeutic trials to measure regression of atherosclerosis and prevention of major coronary artery disease events. …”
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Membrane Technology in the Production of Immunobiological Preparations Produced by the Branch Office of the FSBE «48 Central Scientific Research Institute» of the Ministry of Defen... by A. A. Leshchenko, D. A. Sharov, V. V. Biryukov, I. V. Kosenkov, I. P. Pogorelsky, A. G. Lazykin, A. V. Ezhov, S. V. Bagin, S. V. Logvinov, D. A. Mokhov, V. V. Krupin

“…The filtration in a tangential stream at the ASF-020 installation from the point of view of the production of the sporous product of anthrax vaccine STI-1 (in millions of doses), is 1.8 times more effective in comparison with the centrifugal separation. …”
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Targeting key angiogenic pathways with a bispecific CrossMAb optimized for neovascular eye diseases by Jörg T Regula, Peter Lundh von Leithner, Richard Foxton, Veluchamy A Barathi, Chui Ming Gemmy Cheung, Sai Bo Bo Tun, Yeo Sia Wey, Daiju Iwata, Miroslav Dostalek, Jörg Moelleken, Kay G Stubenrauch, Everson Nogoceke, Gabriella Widmer, Pamela Strassburger, Michael J Koss, Christian Klein, David T Shima, Guido Hartmann

“…Modification of RG7716's FcRn and FcγR binding sites disabled the antibodies' Fc‐mediated effector functions. This resulted in increased systemic, but not ocular, clearance. …”
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The interplay between species and locations shapes vector fleas microbial communities in plague foci: pathogens rather than symbionts? by Shahin Seidi, Shahin Seidi, Abbasali Raz, Naseh Maleki-Ravasan, Esmaeil Forouzan, Fateh Karimian, Florent Sebbane, Aria Sohrabi, Aria Sohrabi, Saber Esmaeili, Saber Esmaeili, Ehsan Mostafavi, Ehsan Mostafavi

“…Here, the microbial communities of fleas were characterized using 16S rRNA Next-Generation Sequencing to understand microbial interactions and functions in areas with historical plague-outbreaks in Iran with the ultimate idea of ​​managing flea-borne diseases. …”
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Modern approaches to treating drug-resistant epilepsy - ketogenic diet, innovative drugs and neurosurgery by Robert Rzenno, Monika Brzozowska, Wiktoria Wardal, Natalia Furlepa, Karolina Wojciechowska, Marcelina Matuszewska, Katarzyna Wicha, Natalia Sidz, Magdalena Tomaszewska, Wiktoria Jedlikowska

“…This condition severely affects the quality of life of those impacted, often leading to difficulties in daily functioning and associated mental health issues such as anxiety and depression. …”
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PRMT5 Inhibitor Synergizes with Chemotherapy to Induce Resembling Mismatch Repair Deficiency and Enhance Anti‐TIGIT Therapy in Microsatellite‐Stable Colorectal Cancer by Jiang Zhu, Shenao Fu, Xi Zou, Hanjiang Zeng, Guangzu Cui, Yinghui Peng, Diya Tang, Fan Zhang, Hong Shen, Shan Zeng, Ying Han

“…The specific mechanism that enhances chemotherapy sensitivity and mediated immunogenicity renders MSS CRC more responsive to immunotherapy remains elusive. …”
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Graphitic porous carbon fabricated from waste coffee grounds for supercapacitors by Thao Phuong Nguyen, Toan Ngoc Vu, Duy Huynh Minh Nguyen, Thy Thi Anh Ho, Minh Hong Le, Son Hoang Thai Ton, Han Ngoc Tran, Tam Thi My Luu, Son Truong Nguyen, Van Thi Thanh Ho

“…XRD confirmed the transformation into an amorphous carbon structure with rich aromatic characteristics while FT-IR spectra indicated the progressive removal of organic functional groups and an enhancement in thermal stability, and Raman Spectroscopy provided more evidence for the presence of graphitic interfaces. …”
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Deep‐UV Light‐Emitting Based on the hBN:S/hBN: Mg Homojunction by Ransheng Chen, Qiang Li, Wannian Fang, Qifan Zhang, Jiaxing Li, Zhihao Zhang, Kangkang Liu, Feng Yun, Yanan Guo, Tao Wang, Yue Hao

“…The structure and the electric properties of S‐doped hBN is studied via density functional theory, indicating that the orbital coupling between S 3p and B 2p orbital introduces shallow donor energy levels. …”
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Comprehension of acoustically degraded emotional prosody in Alzheimer’s disease and primary progressive aphasia by Jessica Jiang, Jeremy C. S. Johnson, Maï-Carmen Requena-Komuro, Elia Benhamou, Harri Sivasathiaseelan, Anthipa Chokesuwattanaskul, Annabel Nelson, Ross Nortley, Rimona S. Weil, Anna Volkmer, Charles R. Marshall, Doris-Eva Bamiou, Jason D. Warren, Chris J. D. Hardy

“…Significant correlations with social cognition measures were observed more consistently for noise-vocoded than clear emotional prosody comprehension. …”
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Intradermal delivery of SARS-CoV-2 RBD3-Fc mRNA vaccines via a needle-free injection system induces robust immune responses in rats by Cenrong Wang, Xin Tang, Xin Tang, Chenghan Jiang, Yu Zhang, Bo Han, Yi Sun, Jianfeng Guo, Hanyu Peng, Zihan Wang, Yipeng Wang, Jialu Zhang, Yong Zhang, Yong Zhang, Chunlai Jiang, Chunlai Jiang, Chunlai Jiang

“…Besides, NFIS can increase the interaction of antigens in a more dispersed manner with immune cell at local injection site, which may improve the immune responses of mRNA vaccines. …”
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Borderline personality disorder Athens study: a quasi-experimental pragmatic trial for the assessment of a public, psychodynamic, stepped care service for borderline personality di... by Ioannis Malogiannis, Lida Anagnostaki, Maria Aspradaki, Panagiotis Aristotelidis, Katerina Karambela, Maria Amperiadou, Vasiliki Efthymiou, Phaithra Kriezi, Ioanna Theodoridou, Pentagiotissa Stefanatou, Pentagiotissa Stefanatou, George Konstantakopoulos, George Konstantakopoulos, Kyriakos Souliotis, Lily E. Peppou, Eleni Giannoulis, Eleni Giannoulis

“…BackgroundBorderline personality disorder (BPD) is a common mental disorder that severely impairs patients’ psychosocial functioning and quality of life and results in prolonged use of health services. …”
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Whole blood transcriptome profiles of trypanotolerant and trypanosusceptible cattle highlight a differential modulation of metabolism and immune response during infection by Trypan... by Peylhard, Moana, Berthier, David, Dayo, Guiguigbaza-Kossigan, Chantal, Isabelle, Sylla, Souleymane, Nidelet, Sabine, Dubois, Emeric, Martin, Guillaume, Sempéré, Guilhem, Flori, Laurence, Thévenon, Sophie

“…As expected, infection had a major impact on cattle blood transcriptome regardless of the breed. The functional analysis of differentially expressed genes over time in each breed confirmed an early activation of the innate immune response, followed by an activation of the humoral response and an inhibition of T cell functions at the chronic stage of infection. …”
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Numerical thermodynamic-economic study and machine learning-based optimization of an innovative biogas-driven integrated power plant combined with sustainable liquid CO2 and liquid... by Ruijia Yuan, Fan Shi, Azher M. Abed, Mohamed Shaban, Sarminah Samad, Ahmad Almadhor, Barno Abdullaeva, Mouloud Aoudia, Salem Alkhalaf, Samah G. Babiker

“…Hence, a machine learning algorithm is implemented using artificial neural networks combined with the NSGA-II method for multi-criteria optimization, focusing on exergy efficiency, net present value, and products' sum unit cost as objective functions. The implemented optimization reduces the optimization time to under 30 min, which is significantly more efficient than traditional heuristic techniques, which typically require several hours for similar systems. …”
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