Patients’ daily reporting of symptoms via mobile application reveals a significant difference between patients’ perceptions and doctors’ interpretations by Cvetka Grašič Kuhar, Cvetka Grašič Kuhar, Nina Privšek, Nina Privšek, Marjetka Sraka, Marjetka Sraka, Ema Grašič, Ema Grašič, Timotej Kovač, Matjaž Kukar

“…Fatigue, insomnia and dry mouth were the three main symptoms reported in more than 75% of patients, but insomnia and dry mouth were also the symptoms most often underreported by doctors. …”
Get full text

Identifying Current Practices and Areas for Improvement in Medication Management During Care Transition Through an Interprofessional Collaboration Framework by Solh Dost L, Maillard G, Cardoso E, Schneider MP

“…Team functioning: common in hospital settings, but inconsistent during transition; 5. …”
Get full text

CLOUD COMPUTING AND BIG DATA AS CONVERGENT TECHNOLOGIES FOR RETAIL PRICING STRATEGIES OF SMEs by George SUCIU, Gyorgy TODORAN, Adelina OCHIAN, Victor SUCIU, Janna CROPOTOVA

“…The analysis makes not only customer profiling possible, but also brand promotion in the form of coupons, discounts or upselling to generate more sales, thus providing the opportunity for retailer SMEs to connect directly to its customers in real time. …”
Get full text

The Spectrum of clinical manifestations in newborns with the COQ4 mutation: case series and literature review by Pianpian Pan, Na Zhou, Yi Sun, Zhengrong Chen, Jin Han, Wei Zhou

“…It will facilitate more in-depth mechanistic studies.…”
Get full text

Neural network prediction model based on Levy flight and natural biomimetic technology for its application in cancer prediction. by Ruiyu Zhan

“…We performed comparative analyses against other methodologies across various functions and public datasets to assess their effectiveness. …”
Get full text

Urbanization leads to asynchronous homogenization of soil microbial communities across biomes by Bangxiao Zheng, Nan Hui, Ari Jumpponen, Changyi Lu, Richard Pouyat, Katalin Szlavecz, David A. Wardle, Ian Yesilonis, Heikki Setälä, D. Johan Kotze

“…Despite these asynchronous responses—bacteria adjusting and homogenizing more than fungi—overlapping functional traits between bacteria and fungi help maintain functional resilience in urban ecosystems.…”
Get full text

Eif2s3y Promotes the Proliferation of Spermatogonial Stem Cells by Activating ERK Signaling by Mengfei Zhang, Na Li, Wenqing Liu, Xiaomin Du, Yudong Wei, Donghui Yang, Zhe Zhou, Fanglin Ma, Sha Peng, Shiqiang Zhang, Xin He, Chunling Bai, Guangpeng Li, Jinlian Hua

“…In addition, how Eif2s3y functions in large animals remains largely unknown. …”
Get full text

Efficacy and preliminary safety assessment of EXG001-307 AAV gene therapy for spinal muscular atrophy by Chunjuan Song, Qingzeng Wang, Peixin Zhu, Junhui Li, Li Dai, Wei Hu, Wenshu Yang, Runyuan Zhang, Dandan Wang, Zhongwan Li, Shuyuan Chen, Lijun Wang, Guojie Ye, Zhenhua Wu

“…Exegenesis Bio is developing EXG001-307, a recombinant adeno-associated virus (rAAV) gene therapy, for SMA type 1 patients lacking functional SMN1 and possessing only 1–2 copies of SMN2. …”
Get full text

TetraRNA, a tetra-class machine learning model for deciphering the coding potential derivation of RNA world by Hanrui Bai, Jie Wang, Xiaoke Jiang, Zhen Guo, Wenjing Yang, Zitian Yang, Jing Li, Changning Liu

“…According to our model, all human RNAs can be reclassified into one of four categories — mRNA, untr-mRNA, lncRNA, and tr-ncRNA — representing a novel RNA classification system and allowing the discovery of more potential cncRNAs. Further analysis revealed significant differences among the four types of RNAs in tissue-specific expression, functional annotation, sequence composition, and other factors, providing insights into their divergent evolution trajectories. …”
Get full text

The Support Needs of Patients Requesting Medical Aid in Dying and Their Relatives: A Qualitative Study Using Semi-Structured Interviews and Written Narratives by Stijn Vissers, Stijn Vissers, Joni Gilissen, Joni Gilissen, Joachim Cohen, Joachim Cohen, Luc Deliens, Luc Deliens, Freddy Mortier, Freddy Mortier, Freddy Mortier, Kenneth Chambaere, Kenneth Chambaere, Sigrid Dierickx, Sigrid Dierickx

“…Our findings suggest that they experience these trajectories more as social/existential pathways than as medical ones. …”
Get full text

Flow-based Text Style Transfer Model by Zihan ZHANG, Jinqiao DAI, Pin YANG

“…It constructs a transformation function based on neural spline flows to address the issue of preserving text content during the TST task. …”
Get full text

Transcriptomic and Proteomic Analyses of the Liver and Ileum Identify Key Genes and Pathways Associated with Low and High Groups of Social Genetic Effect of Residual Feed Intake by Patrick Kofi Makafui Tecku, Zhenjian Zhao, Kai Wang, Xiang Ji, Dong Chen, Qi Shen, Yang Yu, Shengdi Cui, Junge Wang, Ziyang Chen, Jia Xue, Guoqing Tang

“…Pigs with higher SGE values exhibited distinct feeding patterns, spending more time at the feeder but making fewer visits. …”
Get full text

Inhalable biohybrid microrobots: a non-invasive approach for lung treatment by Zhengxing Li, Zhongyuan Guo, Fangyu Zhang, Lei Sun, Hao Luan, Zheng Fang, Jeramy L. Dedrick, Yichen Zhang, Christine Tang, Audrey Zhu, Yiyan Yu, Shichao Ding, Dan Wang, An-Yi Chang, Lu Yin, Lynn M. Russell, Weiwei Gao, Ronnie H. Fang, Liangfang Zhang, Joseph Wang

“…Abstract Amidst the rising prevalence of respiratory diseases, the importance of effective lung treatment modalities is more critical than ever. However, current drug delivery systems face significant limitations that impede their efficacy and therapeutic outcome. …”
Get full text

Michigan tobacco cessation champions: A rapid qualitative analysis by Devin C. Tomlinson, Chelsea Wilkins, Natalie Bayrakdarian, Frank Dolecki Jr., Erin E. Bonar, Anne Fernandez, Golfo Tzilos Wernette, Lara N. Coughlin

“…Results: Three key themes were identified across the Tobacco Cessation Champion interviews: 1) Facilitators and Barriers of Smoking Cessation Efforts; 2) Smoking Cessation Efforts: Underfunded, Underutilized, Not Marketable or Accessible, and 3) Need for more inclusive, person-centered smoking cessation interventions. …”
Get full text

Establishing a core outcome set for creatine transporter deficiency and guanidinoacetate methyltransferase deficiency by Zahra Nasseri Moghaddam, Emily K. Reinhardt, Audrey Thurm, Beth K. Potter, Maureen Smith, Celeste Graham, Beth H. Tiller, Steven A. Baker, Deborah A. Bilder, Regina Bogar, Jacobus Britz, Rachel Cafferty, Daniel P. Coller, Ton J. DeGrauw, Vicky Hall, Gerald S. Lipshutz, Nicola Longo, Saadet Mercimek-Andrews, Judith S. Miller, Marzia Pasquali, Gajja S. Salomons, Andreas Schulze, Celine P. Wheaton, Kayla F. Williams, Sarah P. Young, Jasmine Li, Sofia Balog, Theresa Selucky, Sylvia Stöckler-Ipsiroglu, Heidi Wallis

“…The COS developed includes seven outcomes (“Adaptive Functioning”, “Cognitive Functioning”, “Emotional Dysregulation”, “MRS Brain Creatine”, “Seizure/Convulsions”, “Expressive Communication”, and “Fine Motor Functions”) for both CTD and GAMT, and an additional outcome for GAMT (“Serum/Plasma Guanidinoacetate”) that are important to stakeholders and consequently should be considered for measurement in every clinical trial. …”
Get full text

Left Atrial Appendage Opacification on Cardiac Computed Tomography in Acute Ischemic Stroke: The Clinical Implications of Slow‐Flow by Shan Sui Nio, Leon A. Rinkel, Olivia N. Cramer, Z. Beyda Özata, Chiel F. P. Beemsterboer, Valeria Guglielmi, Berto J. Bouma, S. Matthijs Boekholdt, Nick H. J. Lobé, Ludo F. M. Beenen, Henk A. Marquering, Charles B. L. M. Majoie, Yvo B. W. E. M. Roos, Adrienne van Randen, R. Nils Planken, Jonathan M. Coutinho

“…Patients with thrombus or slow‐flow more often had known atrial fibrillation compared with normal filling (45%, 39%, and 9%, P<0.001). …”
Get full text

Anesthesiological management in endovascular mechanical thrombectomy: a propensity score-matched retrospective analysis in Italy by Antonio Romanelli, Aniello Iovino, Antonella Langone, Rosa Napoletano, Giulia Frauenfelder, Flora Minichino, Liliana D’Ambrosio, Miriam Caterino, Raffaele Tortora, Renato Gammaldi, Paolo Barone, Renato Saponiero, Daniele Giuseppe Romano

“…Physiological stability during EMT may impact outcomes more significantly than anesthesiological management. …”
Get full text

Establishment and application of highly efficient regeneration, genetic transformation and genome editing system for cucurbitacins biosynthesis in Hemsleya chinensis by Juan Wang, Chao-Hui Li, Chun-Fan Xiang, Pin-Han Zhou, Le-Song Li, Xia Li, Sheng-Chao Yang, Guang-Hui Zhang, Yan Zhao

“…The lack of genetic transformation systems makes it difficult to verify the functions of genes controlling important traits and conduct molecular breeding in H. chinensis. …”
Get full text

Steam Distillation of Citrus Waste Extract for Antimicrobial Metal Nanoparticle Synthesis by Javier Emanuel Castañeda-Aude, Enrique Díaz Barriga-Castro, Lizbeth Liliana Díaz-Muñoz, Javier Alberto Garza-Cervantes, José Rodríguez-Mirasol, José Rubén Morones-Ramírez, Héctor Javier Amézquita-García, David Alejandro De Haro-Del Río, Angel León-Buitimea, Noe Macias-Segura, Carlos Enrique Escárcega-González

“…This study underscored the promise of valorizing citrus waste for nanomaterial synthesis and introduced a novel, scalable methodology for producing bioactive nanoparticles, promoting a more sustainable technology for this purpose. Notably, this research aligns with United Nations Sustainable Development Goal 12, which promotes responsible consumption and production by transforming organic waste into high-value functional nanomaterials for biomedical and environmental applications.…”
Get full text

Baicalin-modified polyethylenimine for miR-34a efficient and safe delivery by Yingying Wang, Yingying Wang, Baiyan Wang, Yangfan Xiao, Qingchun Cai, Junyue Xing, Hao Tang, Ruiqin Li, Hongtao Zhang, Hongtao Zhang, Hongtao Zhang, Hongtao Zhang

“…This work provides a practical method to construct a charge-regulated, hydrophobic-modified, and functionally modified polyethylenimine (PEI) with effective gene delivery and perfect transfection performance through a condensation reaction, named BA-PEI. …”
Get full text