Resistance to recombinant human erythropoietin therapy in haemodialysis patients by Elísio Costa, Margarida Lima, Susana Rocha, Petronila Rocha-Pereira, Flávio Reis, Elisabeth Castro, Frederico Teixeira, Vasco Miranda, Maria do Sameiro Faria, Alfredo Loureiro, Alexandre Quintanilha, Luís Belo, Alice Santos-Silva

“…When comparing the two groups of patients, we found that non-responders presented a significant decrease in total lymphocyte and CD4+ T-cell counts, a more accentuated inflammatory process and indicators of enhanced neutrophil activation. …”
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Interactive effects of triploidy induction and culture densities on growth performance and stress, immune, and metabolic responses in juvenile rainbow trout (Oncorhynchus mykiss) by Roghayeh Mahmoudi, Mahdi Naderi, Hakimeh Dopeikar, Seyed Ali Khorasaninasab, Seyed Hadi Seyedalhosseini

“…Chronic high density stress exhibited harmful impacts on liver functions, resulting in elevated activities of serum ALT and AST enzymes (P < 0.05). …”
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Long-term effects of combining anaerobic digestate with other organic waste products on soil microbial communities by Daniela Mora-Salguero, Denis Montenach, Manon Gilles, Vincent Jean-Baptiste, Sophie Sadet-Bourgeteau, Sophie Sadet-Bourgeteau

“…Notably, fungal communities responded more strongly to treatment variations than prokaryotic communities.DiscussionThis study provides new insights into the cumulative effects of substituting mineral fertilizers with digestates on soil microbial communities and soil physicochemical parameters. …”
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Overcoming challenges of developing a live-attenuated dengue vaccine and the path forward by Dr Walid Kandeil, Dr Mayuri Sharma

“…Methods: Development of TAK-003 involved more than a decade of investigation including pre-clinical studies and an extensive clinical development program conducted with >28,000 volunteers aged 1.5-60 years from 13 countries. …”
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Gestión de los Colegios Profesionales de Educación Física y Deporte desde una perspectiva interna (Management of Professional Colleges of Physical Education and Sport from an inte... by Roberto Silva Piñeiro, Jorge Fernando García Unanue

“…The Professional Collegues of Physical Education and Sport (COLEF) guarantee the quality and safety of qualified services, but they have also been affected by various regulations and obligations that have hindered their operational capacity. A study of the functioning of these entities at state level was proposed to help interpret the present and the more immediate future they will have to face. …”
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Morphological and immunohistochemical features of deobliterated femoral arteries and saphenous veins of patients with obliterating atherosclerosis of the lower extremities vessels... by I. S. Shpon’ka, O. L. Tkachuk, O. I. Gudz, O. V. Poslavs’ka

“…In such cases, for saving the limb synthetic material is used, which functions for a brief period due to non-compliance properties with the arterial wall. …”
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Single-cell RNA sequencing reveals palmitoylation-driven cellular heterogeneity and prognostic biomarkers in lung adenocarcinoma by Taibo Huang, Lijie Kou, Qianqian Zhang, Xueya Liu, Xingang Hu

“…Patients in the high-risk group had increased tumor mutational burden and a more immunosuppressive tumor environment. Laboratory findings revealed that raising ASPH expression promoted cell growth, motility, and epithelial–mesenchymal transition. …”
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Iodine Content of Salt Use after Years of Universal Iodization Policy and Knowledge on Iodized Salt among Households in the Sissala East Municipality in Upper West Region of Ghana by Prince Kubi Appiah, Clement Tiimim Yanbom, Martin Amogre Ayanore, Alex Bapula

“…Iodine deficiency is a global public health concern as it leads to inadequate production of thyroid hormone in the body, causing too many destructive consequences on the roles and functions of different human organs and muscles including brain growth and can manifest into many damaging effects such as intestinal cerebral impedance, cancer of intestine, breast disorders, and physical deformities like goitre and cretinism to one’s body. …”
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BRAVA: A randomized controlled trial of a brief group intervention for youth with suicidal ideation and their caregivers by Allison Kennedy, Clare Gray, Nicole Sheridan, Leigh Dunn, Jayme Stewart, Stéphanie Drouin, Hannah Elliott, Ademola Adeponle, Nicholas Barrowman, Ewa Sucha, Mario Cappelli, Mark L. Norris, Mona Jabbour, Paula Cloutier

“…As wait times for mental health (MH) support have increased, adolescents with mild-to-moderate suicidal ideation (SI) are waiting longer for support compared to those with more acute SI. Building Resilience and Attachment in Vulnerable Adolescents (BRAVA) is a 6-week virtual group intervention designed to provide support to adolescents with mild to moderate SI and their caregivers. …”
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Abstract 278: Patterns of Mechanical Thrombectomy for Stroke Before and After the 2015 Pivotal Trials:5 Years Follow‐up by Yaswanth S Chintaluru, Kunakorn Atchaneeyasakul, Nicholas Liaw, Keiko Fukuda, Aldo Mendez, Okkes Kuybu, Shasvat Desai, Agostinho Pinheiro, Ashutosh Jadhav, Kathryn C Fitzgerald, Bradley Gross, Sandra Narayanan, Raul Nogueira, Michael Lang

“…A prior published analysis of national trends after one year in mechanical thrombectomy use and outcomes for stroke before and after publication of the 2015 US guideline update showed improved functional outcomes and lower peri‐procedural mortality. …”
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Excellent hardening effect in lead-free piezoceramics by embedding local Cu-doped defect dipoles in phase boundary engineering by Xinyue Qiu, Chao Wu, Daniel Q. Tan, Ruihong Liang, Chen Liu, Yinchang Ma, Xi-xiang Zhang, Shiyang Wei, Junwei Zhang, Zhi Tan, Zhipeng Wang, Xiang Lv, Jiagang Wu

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BLACK HUMOUR: ORIGIN DESCRIPTION AND AN ATTEMPT OF IDENTIFICATION by Iryna A. Blynova.

“…The compositional and speech means of organising black humour is based on opposition, antonymy of lexical units, contrast. The functioning of hyperbole, verbal and situational irony, and paradox are frequent at the lexical and semantic level. …”
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Impaired sensitivity to thyroid hormones is associated with increased body fat mass/muscle mass ratio (F/M) in the euthyroid population by Ying Li, Qianqian Zhang, Li Chen, Yue Wang, Qibao Ye, Wei Liu, Yan Liu, Guojuan Wang

“…Biochemical indexes including blood glucose, blood lipids, liver and kidney functions and thyrotropic hormones (THs) were detected. …”
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Gut Microbiome and Metabolite Characteristics Associated With Different Clinical Stages in Non-Small Cell Lung Cancer Patients by Liu F, Lu X, Tang M, Chen Y, Zheng X

“…Notably, Lachnospira and Blautia were more abundant in healthy controls. The distribution of gut microbial species in patients with varying stages of NSCLC was uneven, with Bacteroides and Bacteroidaceae being most prevalent in stage T2, and Prevotella dominating in stage T4. …”
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Effect of essential oils as vitamin C preservatives and chia seed (Salvia hispanica) in the fortification of pineapple jam by Tanima Jarin, Md Nazrul Islam, Shormin Choudhury, Md Rabiul Islam, Reana Raen, Redwanul Islam, Sika Mustaki

“…The outcomes could offer valuable insights into natural preservation techniques and fortification strategies, potentially contributing to more sustainable and consumer-friendly food products in the market.…”
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177Lu-DOTATATE peptide receptor radionuclide therapy in metastatic or advanced and inoperable primary neuroendocrine tumors of rare sites by Pradeep Thapa, Rahul Parghane, Sandip Basu

“…All patients underwent dual-tracer molecular functional imaging with somatostatin receptor (SSTR)-based imaging (with either 99mTc-HYNIC-TOC or 68Ga-DOTATATE) and 18fluorine fludeoxyglucose positron emission tomography-computed tomography as the pretherapy assessment. …”
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5-Item Modified Frailty Index Score is Associated with Increased Postoperative Complications Following Ankle Fracture ORIF by Ronit Kulkarni BS, Alexander S. Guareshi BS, Nikhil Vallabhaneni BA, Joshua L. Morningstar BS, Daniel J. Scott MBA, MD, Christopher E. Gross MD

“…(Table 1) Mortality was strongly predicted by mFI-5 with the risk more than tripling for each point increase in mFI-5 score (odds ratio (OR)=3.639, 95% CI= 3.038-4.360). …”
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Minimally Invasive Techniques for Large-Volume Benign Prostatic Hyperplasia: A Comparative Study Between HoLEP and Robotic Simple Prostatectomy by Silvia Juste-Alvarez, Claudia Zaccaro, Javier Gil-Moradillo, Javier Romero-Otero, Ignacio Moncada, Alfredo Rodríguez-Antolín, Borja Garcia-Gomez

“…<b>Background/Objectives</b>: The aim of this research was to compare perioperative outcomes, functional results, quality of life, and complications between robot-assisted simple prostatectomy (RASP) and holmium laser prostate enucleation (HoLEP) as minimally invasive techniques for treating benign prostatic hyperplasia (BPH) in large prostates (>150 cm³). …”
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Pharmacological mechanisms of probenecid for SARS-CoV-2 and RSV co-infection: findings of system pharmacology, molecular docking, molecular dynamics simulation, and structure–activ... by Junbin Hong, Zhendong Guo, XiaoMei Huang, Peng Wu, Xinying Chen, Xiaoyi Liu, Jinghua Yang, Yanni Lai

“…Meanwhile, according to molecular dynamics (MD) simulations and structure-activity relationship (SAR) analysis, we speculated that SRC and HSP90AA1 are more likely to be the target proteins of probenecid than the other proteins.ConclusionOur findings from systems pharmacology and bioinformatics analysis indicate that immune and inflammatory responses play a pivotal role in the therapeutic effects of probenecid. …”
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Biofilm matrix regulation by Candida glabrata Zap1 under acidic conditions: transcriptomic and proteomic analyses by Bruna Gonçalves, Diana Priscila Pires, Liliana Fernandes, Miguel Pacheco, Tiago Ferreira, Hugo Osório, Ana Raquel Soares, Mariana Henriques, Sónia Silva

“…Accordingly, various genes and matrix proteins with predicted functions in the regulation of carbohydrate metabolism, sugar binding, sugar transport, and adhesion (including Epa family) were repressed by Zap1. …”
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