Immunological effects of CD19.CAR-T cell therapy in systemic sclerosis: an extended case study by Maren Claus, Merle Freitag, Meike Ewald, Lea Rodon, Franca Deicher, Carsten Watzl, Philipp Kolb, Hanns-Martin Lorenz, Michael Schmitt, Wolfgang Merkt

“…Decreasing autoantibody levels associated with a reduced ability to form functional immune complexes, the latter appearing to contribute to pathology in SSc via activation of Fcγ receptor IIIA + cells such as NK cells. …”
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Acceptability of veggie bread among Lebanese adults by Asma Chanbour, Hussein F. Hassan, Dima Kreidieh, Salma Khazaal, Tareq Osaili, Tareq Osaili, Khaled El Omari, Khaled El Omari, Nada El Darra

“…Incorporating vegetables as functional ingredients has gained interest in enhancing its nutritional profile. …”
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The ADAMTS2 metalloproteinase inhibits tumor growth by regulating the innate immune system by Loïc Joannes, Laura Dupont, Louis Stock, Esther Arpigny, Pascale Hubert, Marie Ancion, Margaux Luyckx, Joan Abinet, Wen Peng, Didier Calaldo, Agnes Noel, Thomas Marichal, Michael Herfs, Christophe Deroanne, Alain Colige

“…These data identify ADAMTS2 as a cancer regulator with antagonistic functions, limiting initial progression but promoting efficient metastatic dissemination.…”
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Unveiling the Microbial Symphony of Amasi: A Targeted Metagenomic 16S rRNA, ITS, and Metabolites Insights Using Bovine and Caprine Milk by Betty Olusola Ajibade, Titilayo Adenike Ajayeoba, Saheed Sabiu, Konstantin V. Moiseenko, Sizwe Vincent Mbona, Errol D. Cason, Tatyana V. Fedorova, Oluwatosin Ademola Ijabadeniyi

“…Comparatively, ACM showed more microbial diversity than AGM, though there were relative similarities in their microbiome composition. …”
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Biosynthesis of selenium nanoparticles from Dahlia pinnata tuberous roots with antibacterial, antidiabetic, and erythrocyte membrane protective activities by Alsayed E. Mekky, Abdullah M. Abdo, Muhammed I. Haggag, Mohammed H. Elhaw, Mostafa M. Kadry, Sameh M. Ghanem, Mokhtar M. Salama, Amal M. Soliman, Nashaat N. Mahmoud

“…Non-MDR isolates (78.6%) were more sensitive, with MICs of 10–25 µg/ml (mean: 15 ± 4.5 µg/ml) and MBCs of 25–50 µg/ml (mean: 35 ± 12 µg/ml), outperforming selenium precursors and vancomycin. …”
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Effect of alternating salinity stress on the gut microbiota of razor clam Sinonovacula constricta by Yi Yuan, Qunqun Jiang, Qinggang Xue, Qinggang Xue, Zhihua Lin, Zhihua Lin, Wenfang Dai, Wenfang Dai

“…Furthermore, the gut bacterial interspecies interaction networks exhibited more complex and higher connected topology in two alternating salinity stress groups compared with the control group (NN), and the interaction relationships between core OTUs in gut networks were altered after salinity stress. …”
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Exploring physiological and molecular dynamics of drought stress responses in plants: challenges and future directions by Sajad Ali, Rakeeb Ahmad Mir, Md Azizul Haque, Danishuddin, Mohammed A. Almalki, Mohammad Alfredan, Ashraf Khalifa, Henda Mahmoudi, Mohammad Shahid, Anshika Tyagi, Zahoor Ahmad Mir

“…For instance, the role of calcium (Ca2+), reactive oxygen species (ROS) and abscisic acid (ABA) in modulating different cellular responses like stomata functioning, osmotic adjustment, and other adaptive traits. …”
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Mild and reversible nephrotoxicity following repeated administration of damnacanthal in nude mice by Noppanan Kotsaouppara, Thunyatorn Yimsoo, Worapapar Treesuppharat, Jeeraphong Thanongsaksrikul, Potjanee Srimanote

“…However, further large-scale investigations are warranted to gain a more comprehensive understanding of damnacanthal toxicity profile and to ensure its safe use in potential therapeutic applications.…”
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FeNO as a biomarker of interstitial and fibrotic pulmonary sequelae in patients admitted for severe SARS-CoV-2 pneumonia by Diego Ferrer-Pargada, Carlos A. Amado, Beatriz Abascal-Bolado, Sandra Tello Mena, Pilar Alonso Lecue, Carlos Armiñanzas, Francisco Arnaiz de las Revillas, Miguel Santibáñez, Juan Agüero, Víctor Fernández Lobo, J. Gonzalo Ocejo-Vinyals, José Manuel Cifrian

“…Fractional exhaled nitric oxide (FeNO) is a marker of airway inflammation, easy to obtain and available in most functional testing laboratories of pulmonology services. …”
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Comparative analysis of regenerative activity of bone marrow cells and total RNA extracted from them in chronic fibrosing liver disease by Z. Z. Gonikova, A. O. Nikolskaya, L. A. Kirsanova, M. Yu. Shagidulin, N. A. Onishchenko, V. I. Sevastyanov

“…However, regulatory effect from the use of tRNA appears earlier and is more effective.…”
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A review of the response and the emergency medical team (EMT) deployment following a tanker explosion in Freetown, Sierra Leone by Boniface Oyugi, Ibrahim Franklyn Kamara, Innocent Nuwagira, Robert Musoke, Sulaiman Lakoh, Abdulai Jalloh, Rashidatu Fouad Kamara, Pryanka Relan, Camila Lajolo, René André Macodou Ndiaye, Babacar Niang, Mouhamadou Mansour Fall, Thierno Balde, Flavio Salio, Mustapha Kabba

“…The EMTs dispensed their functions with professionalism, adapted to the environment and available resources, and augmented the care the national health workers provided. …”
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Molecular dynamics simulation and docking studies reveals inhibition of NF-kB signaling as a promising therapeutic drug target for reduction in cytokines storms by Abhishek Kumar, Tharun Bharadwaj, Likith Muthuraj, Jitendra Kumar, Pravin Kumar, Roopa Lalitha, Gladstone Sigamani, Shaban Ahmad, Piyush Bhanu, Ravi Kant Pathak, Akshay Uttarkar, Vidya Niranjan, Vachaspati Mishra

“…The discovered novel compounds by computational studies could be of relevance to identify more potent inhibitors of NF-kB dependent biological functions beneficial to control the cytokine storm occurring in the patients affected with Covid-19.…”
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Impacts of Legacy and Contemporary Nitrogen Inputs on N2O and CO2 Emissions in Miscanthus and Maize Cultivated Soils by Jaejin Lee, Paul Villanueva, Kate Glanville, Andy Vanloocke, Wendy H. Yang, Angela Kent, Marshall McDaniel, Steven J. Hall, Adina Howe

“…However, the relative importance of contemporary and legacy effects and how that could vary by crop functional types is poorly understood. Considering its rhizomatous roots and perennial growth, we hypothesized that Miscanthus × giganteus (M×g) would be more sensitive to legacy N fertilization and the historical context of its environment than an annual crop like maize. …”
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LONG TERM FOLLOW-UP ON EFFECTIVENESS AND SAFETY OF ETANERCEPT IN JUVENILE IDIOPATHIC ARTHRITIS WITHOUT SYSTEMIC MANIFESTATIONS by A. A. Baranov, E. I. Alexeeva, T. M. Bzarova, S. I. Valieva, K. B. Isaeva, E. G. Chistyakova, A. M. Chomakhidze, R. V. Denisova, T. V. Sleptsova, A. N. Fetisova, O. L. Lomakina

“…Conclusion: Etanercept has a significantly faster and more pronounced anti-inflammatory effect than the classic immunosuppressant methotrexate.…”
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NETWORK APPROACH TO ANALYSIS OF QUANTITATIVE TRAIT LOCI FOR TUMOR NECROSIS FACTOR (TNFα-863, TNFα-308, TNFα-238), VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF-2578, VEGF+936) AND MATRI... by A. V. Shevchenko, V. F. Prokofyev, V. I. Konenkov, V. V. Chernykh, A. V. Eremina, L. V. Dudnikova, N. Yu. Kashkina, A. N. Trunov

“…Age-related macular degeneration is one of the most widespread multifactorial eye diseases. Polymorphic functional alleles of vascular endothelial growth factor (VEGF) combined with matrix metalloproteinase (MMP) gene and tumor necrosis factor (TNF) gene variants may influence the development of disease. …”
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Pelagic fish camouflage in shallow waters from the humboldt current system through intracellular structures and reflectance mechanisms by Caroline S. Montes, Ricardo F. Soto, Mario I. Sanhueza, Ignacio Sanhueza, Danny Luarte, Sebastián E. Godoy, Sergio N. Torres, Rosario Castillo, Rubén Escribano, Mauricio A. Urbina

“…Furthermore, this study presents the first fish classifiers based on the analysis of spatial frequency features, achieving up to 92.14% accuracy using a K-Nearest Neighbors classifier, highlighting the functional and taxonomic relevance of guanine microstructure organization. …”
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Polyphenolic Metabolites and Antioxidant Activities of Alpinia katsumadai Hayata. and Its Adulterants by DING Shuxian, YANG Qing, WANG Qinglong, WANG Zhunian, YUAN Langxing, FENG Shixiu,LIU Mengting, YIN Haiquan, ZHANG Aling, WANG Maoyuan

“…In contrast, A. blepharocalyx K. Schum. contained more unique polyphenolic substances, whose composition and functions warrant further investigation. …”
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Novel HSA-PMEMA Nanomicelles Prepared via Site-Specific In Situ Polymerization-Induced Self-Assembly for Improved Intracellular Delivery of Paclitaxel by Yang Chen, Shuang Liang, Binglin Chen, Fei Jiao, Xuliang Deng, Xinyu Liu

“…Tremendous potential lies in these micelles for developing safer and more efficient next-generation PTX formulations for tumor treatment.…”
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New genomic resources inform transcriptomic responses to heavy metal toxins in the common Eastern bumble bee Bombus impatiens by Amy L. Toth, Christopher D. R. Wyatt, Rick E. Masonbrink, Katherine S. Geist, Ryan Fortune, Sarah B. Scott, Emeline Favreau, Sandra M. Rehan, Seirian Sumner, Mary M. Gardiner, Frances S. Sivakoff

“…In the brain, differentially expressed genes had biological functions related to chaperone activity and protein folding. …”
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Placental Mesenchymal Stromal Cells (PMSCs) and PMSC-Derived Extracellular Vesicles (PMSC-EVs) Attenuated Renal Fibrosis in Rats with Unilateral Ureteral Obstruction (UUO) by Regul... by Zhu Zhu, Chaonan Han, Shuli Xian, Feng Zhuang, Feng Ding, Wei Zhang, Yingli Liu

“…Compared with that of control rats, the renal tissue of PMSC-treated rats exhibited lower renal Masson scores and more Foxp3+ cell infiltration, with a significantly decreased IL17A+CD4+ T cell/CD4+ T cell ratio and a significantly elevated anti-inflammatory cytokine (IL-10) level. …”
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