Orientation of Conjugated Polymers in Single Crystals: Is It Really Unusual for the Polydiacetylene Backbone to Be Aligned Almost Perpendicular to the Hydrogen Bond Network? by Pierre Baillargeon, Mathieu Desnoyers-Barbeau, Marc-Olivier Pouliot, Émile Gaouette, Rose Champoux, Myriam Veillette, Félix-Antoine Lemieux, Valentina Rojas Riano, Simone Picard, Ophélie Théberge, Jakob Boulanger, Sabrina Cissé, Daniel Fortin, Tarik Rahem

“…An organization of a crystalline polydiacetylene (PDA) with an oblique chain orientation with respect to the network of cooperatives hydrogen bonds is rather rare in the literature (only two cases), and here we have obtained two more examples of this type of structural motif (supported by SCXRD analysis of the polymer). …”
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Meta-transcriptomics Reveals Dysbiosis of the Respiratory Microbiome in Older Adults with Long COVID by Meng’en Liao, Jianpeng Cai, Feng Zhu, Yuanbo Lan, Tianqi Xu, Jingxin Guo, Quanlin Xue, Yilong Wen, Fan Zou, Yu Zhang, Shiliang Zhang, Yan Yan, Jingwen Ai, Jie Cui, Wenhong Zhang

“…Importantly, viral taxa, such as Herpes simplex virus type 1 and Human coronavirus 229E, were more frequently detected in LC patients, indicating the vulnerability of LC patients to viral infections. …”
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Human macrophages engineered to secrete a bispecific T cell engager support antigen-dependent T cell responses to glioblastoma by Shannon A Kreuser, Harrison Chinn, Kole R DeGolier, Lisa R Matsumoto, Richard G Ellenbogen, Courtney A Crane, Jennifer L Gardell, Brooke Prieskorn, Stephanie Balcaitis, Amira Davis

“…Secreted BiTE protein was assayed in a range of T cell functional assays in vitro and in subcutaneous and intracranial GBM xenograft models. …”
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Neoepitope BTLAP267L-specific TCR-T cell immunotherapy unlocks precision treatment for hepatocellular carcinoma by Fang Liu, Hua Chen, Suxin Wu, Chenlu Zhu, Mingji Zhang, Wei Rui, Dong Zhou, Yang Wang, Xin Lin, Xueqiang Zhao, Yunbin Ye

“…Patients with advanced HCC and T cell functional deficiencies may benefit more from cellular immunotherapy, especially tumor neoepitope-targeted T cell receptor (TCR)-T cells. …”
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Implementation of Priority Measures to Eliminate the Accumulated Environmental Damage Caused by Chemical Enterprises in the City of Usolye-Sibirskoye, Irkutsk Region by S. A. Maltsev, E. V. Veber, V. A. Inozemtsev, M. V. Tsapok, P. Y. Belyakov, V. A. Kovtun, A. A. Antokhin

“…In course of the training, the special group of troops (forces) worked out all the issues related to the safe conduct of the work, organized interaction between departments, and distributed the functional responsibilities. After the completion of the preparatory stage, the group began to work. 17 emergency railway tanks containing 104, 3 tons of toxic chemicals were fragmented, the above-ground part of the mercury electrolysis workshop with more than 600 tons of mercury was dismantled, the most dangerous wells Р-2Х and Р-5 with 107 thousand liters of epichlorohydrin production wastes were pumped out. …”
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A tumor-infiltrating B lymphocytes -related index based on machine-learning predicts prognosis and immunotherapy response in lung adenocarcinoma by Jiale Fang, Siyuan Yu, Wei Wang, Wei Wang, Cheng Liu, Xiaojia Lv, Jiaqi Jin, Xiaomin Han, Xiaomin Han, Xiaomin Han, Fang Zhou, Yukun Wang

“…We also found that patients with lower BRI were more likely to respond to immunotherapy and were associated with reduced IC50 values for standard chemotherapy and targeted therapy drugs, in contrast to higher BRI. …”
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Midterm Outcomes of Percutaneous Intramyocardial Septal Radiofrequency Ablation for Hypertrophic Cardiomyopathy: A Single‐Center, Observational Study by Xudong Xie, Siyuan Chen, Yawei Cui, Zhenzhen Zhou, Jianhua Lu, Zhi Du, Jie Ding, Kaidi Xing, Yuesheng Zhang, Yijiang Zhou, Jun Li, Xiaogang Guo

“…The primary outcome was the reduction of left ventricular outflow tract gradient after 6 months or more post‐PIMSRA. Secondary outcomes were periprocedural major adverse clinical events. …”
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Size-dependent effects of oxo-degradable plastic contamination on soil quality and the growth of Zea mays by Do Thi Kim THANH, Robert W. BROWN, Martine GRAF, Michaela K. REAY, Charlotte E. M. LLOYD, Gupeng LI, David R. CHADWICK, Davey L. JONES

“…Oxo-degradable plastics (ODPs) have emerged as a potentially more sustainable alternative to current plastic mulch films, however, uncertainty remains around the degradation rate of ODPs in soil and their impacts on soil quality and crop health. …”
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An insight into the draft genome of the Oriental rat flea, Xenopsylla cheopis, together with its Wolbachia endosymbiont by Stephen Lu, David M. Bland, Eric Dahlstrom, Neelam Redekar, Melina G. Guizzo, Kent Barbian, B. Joseph Hinnebusch, José M. C. Ribeiro

“…Results Sequencing data from both long and short reads were assembled into 7,694 contigs, from which 95,638 putative coding sequences (CDSs) were extracted and functionally annotated, providing insights into various aspects of flea physiology. …”
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Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer by Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti

“…Compared to longer peptides (previously identified), Pep3S binds MDM2 with high affinity, increases p53‐dependent cell death in 2D and 3D colorectal cancer models, and is more efficacious in suppressing xenograft tumor growth. …”
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Comparative transcriptomics analysis of the Oleidesulfovibrio alaskensis G20 biofilms grown on copper and polycarbonate surfaces by Priya Saxena, Dipayan Samanta, Payal Thakur, Vinoj Gopalakrishnan, Rajesh K. Sani

“…Morphological analysis via SEM revealed denser biofilm clusters with precipitates on copper, whereas biofilms on polycarbonate were more dispersed. AFM analysis showed a 4.6-fold increase in roughness on copper (44.3 ± 3.1 to 205.89 ± 8.7 nm) and a 3.8-fold increase on polycarbonate (521.12 ± 15.2 to 1975.64 ± 52.6 nm), indicating surface erosion and structural modifications. …”
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In Situ-Prepared Nanocomposite for Water Management in High-Temperature Reservoirs by Hui Yang, Jian Zhang, Zhiwei Wang, Shichao Li, Qiang Wei, Yunteng He, Luyao Li, Jiachang Zhao, Caihong Xu, Zongbo Zhang

“…We employed a variety of research methods, including bottle tests, viscosity and rheology measurements, scanning electron microscopy (SEM) scanning, density functional theory (DFT) calculations, differential scanning calorimetry (DSC) measurements, quartz crystal microbalance with dissipation (QCM-D) measurement, contact angle (CA) measurement, injectivity and temporary plugging performance evaluations, etc. …”
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Association of intrinsic capacity with leisure activities in community-dwelling older adults: a cross-sectional analysis by Ji Shen, Yuting Kang, Chi Zhang, Jing Pang, Jing Li, Hong Shi, Jie Zhang

“…All the types of LA, except pet-keeping and volunteerism, showed correlation with one or more dimensions of IC. Conclusions LA and LA types are independently associated with IC in community-dwelling older adults. …”
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Oncolytic VSV-IL-2 has enhanced anticancer vaccination adjuvant abilities by Marie-Claude Bourgeois-Daigneault, Victor Mullins-Dansereau, Marie-Lou Myre, Angelina Bardoul, Karen Geoffroy, Marco J Rallo Pita, Delphine Béland, Kim Leclerc Desaulniers, Dominic Guy Roy

“…Treatment efficacy was also measured.Results Our data show that VSV-interleukin-2 is superior as a vaccine boosting adjuvant compared with the parental virus as it induces more antigen-specific CD8 T cells with enhanced effector functions that persist over time. …”
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Transposon insertion sequencing reveals novel hypermutator genes in Acinetobacter baumannii by Francesca L. Short, Ram Maharjan, Liping Li, Nusrat Afrin, Natasha Delgado, Christine J. Boinett, Julian Parkhill, Amy K. Cain, Ian T. Paulsen

“…Our results expand the range of biological functions linked to hypermutator phenotypes in bacteria and provide a workflow for the identification of putative hypermutators by TIS.IMPORTANCEAll organisms have the capacity for evolution through mutation. …”
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Increase in disturbance-induced canopy gaps leads to reorganization of Central European bird communities by Anne Graser, Claudia Frank, Friederike Kunz, Andreas Schuldt, Cornelius Senf, Christoph Sudfeldt, Sven Trautmann, Johannes Kamp

“…Older canopy gaps led to more positive trends in shrub-nesting birds and short-distant migrants. …”
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Zinc and cadmium release from soil aggregate of different size fractions during repeated phytoextraction with Sedum plumbizincicola: Insight from stable isotope analysis by Jiawen Zhou, Jingqi Dong, Rebekah E.T. Moore, Mark Rehkämper, Katharina Kreissig, Barry Coles, Ting Gao, Peter Christie, Longhua Wu

“…The results were due to the enhanced root exudation to mobilize more Cd from soil solids and organic ligands excreted from roots preferentially complexed heavy Cd isotopes based on density functional theory. …”
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Exploring Oxidative Stress Mechanisms of Nanoparticles Using Zebrafish (<i>Danio rerio</i>): Toxicological and Pharmaceutical Insights by Denisa Batir-Marin, Monica Boev, Oana Cioanca, Ionut-Iulian Lungu, George-Alexandru Marin, Ana Flavia Burlec, Andreea-Maria Mitran, Cornelia Mircea, Monica Hancianu

“…The influence of NP physicochemical properties, such as size, surface charge, and functionalization, on oxidative stress responses is explored. …”
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How did New Zealand’s regional District Health Board groupings work to improve service integration and health outcomes: a realist evaluation by Robin Gauld, Rosalina Richards, Tim Stokes, Trudy Sullivan, Fiona Doolan-Noble, Andrew R Gray, Carol Atmore, Erin Penno, Lauralie Richard, Emma Wyeth, Brett Maclennan

“…This research explores how this initiative functioned, examining how, for whom and in what circumstances regional DHB groupings worked to deliver improvements in system integration and health outcomes and equity.Design We used a realist-informed evaluation study design. …”
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Identification of A1/A2 β-Casein Genotypes and Comparison of Their Digestive Properties by Shihang LI, Hongtao XU, Xiao LI, Meiling SUN, Xinyan YANG, Pengyu XIANG, Zhihao YANG, Chaoxin MAN, Yujun JIANG

“…A1 β-casein and A2 β-casein produce different substances after digestion due to differences in primary structure. To more comprehensively explore the possible biological activity effects on the human body, by analyzing and monitoring the changes of this protein during the digestion process, the exploration of the biological functions of A1/A2 β-casein is further achieved. …”
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