Treatment of bacterial biothreat agents with a novel purified bioactive lactoferrin affects both growth and biofilm formation by Christian Xander, Elsie E. Martinez, Ronald G. Toothman, Christina L. Gardner, Ju Qiu, Jonathan Snedeker, Matthew H. Bender, Christopher Hlubb, Crystal W. Burke, Joel A. Bozue, Kevin D. Mlynek

“…The growth of F. tularensis was also significantly inhibited when cultured in the presence of Lactea Lf and appeared more sensitive to treatment when compared to B. pseudomallei. …”
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Association of a four‐gene model with allergic diseases: Two‐year follow‐up of a birth cohort study by Li Hua, Fen Yang, Qian Chen, Quanhua Liu, Ruoxu Ji, Haipei Liu, Jianmin Ye, Jun Zhang, Jianhua Zhang, Yixiao Bao

“…Long‐term follow‐up along with functional and replication studies on the gene model are still needed in future.…”
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Application of the Original Agroecological Survey and Indicator System tool (OASIS) to organic and conventional farms in Belgium, France, and Italy by Alexander Wezel, Alexander Wezel, Paola Migliorini, Paola Migliorini, Anna Brumer, Tommaso Gaifami, Tommaso Gaifami, Angelica Marchetti, Geoffrey Floymont, Garance Guizard, Elsa Michel, Marie-Alix Renaud, Karla Škorjanc, Nicolas Allard, Stefano Bocchi, Alain Peeters, Alain Peeters, Alain Peeters

“…European agriculture faces major challenges in adapting and transforming current farming and food systems to become more sustainable. Agroecology is one transition pathway. …”
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Release Profile and Antibacterial Activity of <i>Thymus sibthorpii</i> Essential Oil-Incorporated, Optimally Stabilized Type I Collagen Hydrogels by Caglar Ersanli, Ioannis Skoufos, Konstantina Fotou, Athina Tzora, Yves Bayon, Despoina Mari, Eleftheria Sarafi, Konstantina Nikolaou, Dimitrios I. Zeugolis

“…Herein, the potential of <i>Thymus sibthorpii</i> EO incorporated in functionalized antibacterial collagen hydrogels was investigated. …”
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Assessment of the histone mark-based epigenomic landscape in human myometrium at term pregnancy by San Pin Steve Wu, Elvis Quiroz, Tianyuan Wang, Skylar G Montague Redecke, Xin Xu, Lin Lin, Matthew L Anderson, Francesco J DeMayo

“…Using CRISPR activation, we assessed the functionality of a PGR putative enhancer 35 kilobases upstream of the contractile-restrictive gene PLCL2. …”
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Screening for endocrine-disrupting chemicals in the serum and cerebrospinal fluid of patients with autoimmune encephalitis by Songyi Huang, Li Xiao, Minqi Luo, Jiehao Li, Xiaojie Li, Chenyan Zeng, Lixin Zhou, Baohua Cao, Yajie Gong, Pan Yang, Yaqing Shu

“…Our findings support an evidence base for the effects of specific chemicals may impair neural functions.…”
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The application of One Health concept in China and its practice and innovation in cross-sector cooperation by Yang Gao, Chengyue Li, Qingyu Zhou, Mo Hao

“…However, to fully realize this concept, more efforts are still needed in the areas of cooperation mechanisms, professional talent training, information exchange and social awareness. …”
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Recombinant protein Ag85B-Rv2660c-MPT70 promotes quality of BCG-induced immune response against Mycobacterium tuberculosis H37Ra by Jiangshan Ouyang, Shaohua Guo, Zhiming Hu, Ting Cao, Jun Mou, Xinxia Gu, Chunxu Huang, Jie Liu, Jie Liu

“…IntroductionBacillus Calmette-Guérin (BCG), the only licensed vaccine against Mycobacterium tuberculosis (Mtb) infection, has been extensively used worldwide for over 100 years, but the epidemic of tuberculosis (TB) remains a major challenge to human health and well-being. The quest for a more effective vaccination strategy against the Mtb infection continues. …”
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MUC2 expression modulates immune infiltration in colorectal cancer by Christophe M. Raynaud, Ayesha Jabeen, Eiman I. Ahmed, Eiman I. Ahmed, Satanay Hubrack, Apryl Sanchez, Shimaa Sherif, Ahmad A. Al-Shaibi, Bernice Lo, Bernice Lo, Jessica Roelands, Davide Bedognetti, Davide Bedognetti, Wouter Hendrickx, Wouter Hendrickx

“…We revealed that the removal of MUC2 protein was compensated in LS-174T by the expression of other gel-forming mucin proteins (MUC6, MUC5B) commonly expressed in the gastrointestinal epithelium, while this was not observed in HT-29 cell line.ConclusionOur study is the first to demonstrate that MUC2 functions as a physical barrier to immune infiltration in colorectal cancer (CRC) in vitro. …”
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A comparative study of plasmonic nanoparticles for targeted photothermal therapy of melanoma tumors using various irradiation modes by Lidia Mikhailova, Elizaveta Vysotina, Maria Timofeeva, Elena Kopoleva, Van Gulinyan, Olesia Pashina, Konstantin Arabuli, Olga Gusliakova, Ekaterina Prikhozhdenko, Xiaoli Qi, Andrey Petrov, Eduard Ageev, Mihail Petrov, Constantino De Angelis, Mikhail Durymanov, Gleb Sukhorukov, Mikhail V. Zyuzin

“…Our investigation reveals greater heat release from Au NRs under irradiation with FS laser, due to the relaxation rates of the electron and phonon temperatures dissipating in the surrounding, which correlates with a more pronounced 17.6 times inhibition of tumor growth when using FS-pulsed regime.…”
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Co-obligate symbioses have repeatedly evolved across aphids, but partner identity and nutritional contributions vary across lineages by Manzano-Marín, Alejandro, Coeur d’acier, Armelle, Clamens, Anne-Laure, Cruaud, Corinne, Barbe, Valérie, Jousselin, Emmanuelle

“…However, in two lineages, Buchnera has lost some essential symbiotic functions and is now complemented by additional symbionts. …”
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Al–20Sn–1Cu self-lubricating alloy: Correlations between microstructure coarsening, mechanical, and application properties by Sarah De Albuquerque, Vinicius Leme Andrade, Rodrigo V. Reyes, Guillaume Reinhart, Danielle Cristina Camilo Magalhães, Henri Nguyen-Thi, José Eduardo Spinelli

“…The results showed that more refined samples had better tensile properties but compromised wear behavior. …”
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Allelic Variation of Hd17 for Rice Heading Date is Caused by Natural Selection by Zifeng Yang, Yun Li, Jin Liu, Shuiqing Wu, Xuelin Wang, Min Guan, Yanyun Li, Haitao Zhu, Guifu Liu, Shaokui Wang, Guiquan Zhang

“…The Hd17-2 allele was caused by the functional nucleotide polymorphism (FNP) of C to T at position 1016 of the gene and exhibits delay heading. …”
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GWAS and RNA-seq reveal novel loci and genes of low-nitrogen tolerance in cucumber (Cucumis sativus L.) by Huaxiang Wu, Huiming Yan, Bowen Li, Yike Han, Yike Han, Nan Liu, Mengyu Fan, Yahan Liu, Mingjie Lyu, Shengli Du, Shengli Du, Shengli Du, Aimin Wei, Aimin Wei

“…These 20 genes were defined as more valuable candidate genes for low-nitrogen tolerance. …”
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Disentangling the effects of eutrophication and natural variability on macrobenthic communities across French coastal lagoons by Jones, Auriane G., Schaal, Gauthier, Boyé, Aurélien, Creemers, Marie, Derolez, Valérie, Desroy, Nicolas, Fiandrino, Annie, Mouton, Théophile L., Simier, Monique, Smith, Niamh, Ouisse, Vincent

“…Owing to their position at the interface between land and sea, they are also subject to increasing human impacts, which alter their ecological functioning. Because coastal lagoons are naturally highly variable in their environmental conditions, disentangling the effects of anthropogenic disturbances like eutrophication from those of natural variability is a challenging, yet necessary issue to address. …”
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Research Progress on Extraction, Isolation, Purification, Structure Characterization, and Bioactivities of Polysaccharides from Sugarcane Leaves and Bagasse by Jinhua LU, Qingxia YUAN, Zhenzhen YANG, Chunxiu HUANG, Ling Tang Pei, Zheng LI, Yaowen LIAO, Jian ZHANG, Longyan ZHAO, Xiaotao HOU, Jiagang DENG

“…These materials are abundant in resources and rich in bioactive compounds, and their significant potential for the development of functional foods and health products is acknowledged. …”
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Food Restriction Induces Changes in Ovarian Folliculogenesis, Cell Proliferation, Apoptosis, and Production of Regulatory Peptides in Rabbits by Imane Hadjadj, Zuzana Fabova, María-Luz García, Iván Agea, Barbora Loncová, Martin Morovic, Peter Makovicky, María-José Argente, Alexander V. Sirotkin

“…The aim of this study is to examine the influence of food restriction on rabbit ovarian functions. A total of eight females were fed ad libitum (NF), while eight females were subjected to 50% food restriction (RF). …”
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Intranasal administration of a panreactive influenza antibody reveals Fc-independent mode of protection by Anna L. Beukenhorst, Keira L. Rice, Jacopo Frallicciardi, Martin H. Koldijk, Carolyn M. Boudreau, Justin Crawford, Lisette A. H. M. Cornelissen, Kelly A. S. da Costa, Babette A. de Jong, Stephanie Fischinger, Boris Julg, Jaco M. Klap, Clarissa M. Koch, Zoltán Magyarics, Faez A. Nait Mohamed, Vintus Okonkwo, Lindsey Adams, Caitlin M. McCarthy, Larance Ronsard, Nigel Temperton, Helene Vietsch, Kanin Wichapong, Bertjan Ziere, Daniel Lingwood, Jaap Goudsmit

“…Abstract Monoclonal antibodies have two core mechanisms of protection: an antibody’s antigen-binding fragment (Fab) can bind and neutralize viral pathogens and its fragment crystallizable domain (Fc) catalyzes effector functions. We investigated the relative contribution of Fab- versus Fc-mediated mechanisms of protection through passive administration of distinct forms of the pan-reactive anti-influenza antibody CR9114. …”
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HNF4α inhibits the malignancy of intrahepatic cholangiocarcinoma by suppressing the Wnt signaling pathway by Bo-Nan Xu, Cheng-Hong Ding, Yi-Long Liu, Yuan-Yuan Luo, Juan Deng, Shu-Qing Liu, Meng-Chao Xiao, Nan Jiang, Xin Zhang, Wen-Ping Xu, Wei-Fen Xie

“…The reintroduction of HNF4α might help achieve more effective and precise targeted therapy, benefiting the survival of patients with ICC.…”
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Anti-corrosive efficiency of salvadora persica plant stick powder on SS 316L orthodontic wire in artificial saliva by H.Mohamed Kasim Sheit, K.S. Mohan, P. Srinivasan, S.Esakki Muthu, A. Dinesh, B. Rajeswari, L. Srimathi Priya, Lalitha Gnanasekaran, Munawar Iqbal

“…Open-circuit potential (OCP) metrics demonstrated that the system incorporating SP presented more negative values relative to the control, reinforcing the inhibitory effect exerted by the constituents of SP. …”
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