Low‐Intensity Focused Ultrasound‐Responsive Nanobubbles Enhance Thrombus Targeting and Penetration for Highly Effective Thrombolytic Therapy by Wenli Zhang, Maoyuan Sun, Lian Xu, Sijin Chen, Xiyue Rong, Junrui Wang, Jia Liu, Bo Liu, Jie Xu, Ying Luo, Qianying Du, Yi Wang, Yun Liu, Zhigang Wang, Haitao Ran, Dajing Guo

“…Based on the natural targeting and immune escape functions of platelets during thrombosis, spatiotemporally controlled nanobubbles (PAF@M) are developed to specifically target thrombus sites. …”
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Levels of Neurospecific Peptides, Neurotransmitters and Neuroreceptor Markers in the Serum of Children with Various Sensory Disorders, Mild Cognitive Impairments and Other Neuropat... by George A. Karkashadze, Leyla S. Namazova-Baranova, Leonid M. Yatsik, Olga B. Gordeeva, Elena A. Vishneva, Kamilla E. Efendieva, Elena V. Kaytukova, Natella V. Sukhanova, Natalia S. Sergienko, Julia V. Nesterova, Svetlana E. Kondratova, Madina T. Fatakhova, Alexandr V. Pashkov, Irina V. Naumova, Irina V. Zelenkova, Viktor A. Gankovskiy, Svetlana G. Gubanova, Elizaveta V. Leonova, Alina R. Pankova, Anna A. Alexeeva, Daria A. Bushueva, Tinatin Yu. Gogberashvili, Dmitriy S. Kratko, Safarbegim H. Sadilloeva, Natalia E. Sergeeva, Marina A. Kurakina, Tatiana A. Konstantinidi, Inessa A. Povalyaeva, Margarita A. Soloshenko, Mariya I. Slipka, Viktor V. Altunin, Anastasiya I. Rykunova, Tatiana A. Salimgareeva, Pavel A. Prudnikov, Nadezhda A. Ulkina, Alexey I. Firumyantc, Nikita S. Shilko, Julia E. Kazanceva

“…General neuroplasticity processes were activated in all cases of visual deficits but more specific. However, more specific and well-studied processes were activated in mild organic CNS lesions, and neuroplasticity processes did not activate adequately in severe organic CNS lesions probably due to the limited neuronal and synaptic resources.…”
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Carfilzomib modulates tumor microenvironment to potentiate immune checkpoint therapy for cancer by Qian Zhou, Jinxia Liang, Tong Yang, Jin Liu, Bo Li, Yingchang Li, Zhenzhen Fan, Weida Wang, Wensheng Chen, Sujing Yuan, Meng Xu, Qigui Xu, Zhidong Luan, Zhongjun Xia, Penghui Zhou, Yadong Huang, Liang Chen

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Design of a Wearable Exoskeleton Piano Practice Aid Based on Multi-Domain Mapping and Top-Down Process Model by Qiujian Xu, Meihui Li, Guoqiang Chen, Xiubo Ren, Dan Yang, Junrui Li, Xinran Yuan, Siqi Liu, Miaomiao Yang, Mufan Chen, Bo Wang, Peng Zhang, Huiguo Ma

“…Based on five user requirements (P), we calculated the corresponding demand weight (K), making the design more aligned with user needs. The device excels in enhancing motion accuracy, interactivity, and comfort, filling the gap in traditional piano assistance devices in terms of multi-functionality and high adaptability, and offering new ideas for the design and promotion of intelligent assistive devices. …”
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A Polymorphism in Hepatocyte Nuclear Factor 1 Alpha, rs7310409, Is Associated with Left Main Coronary Artery Disease by Rui Liu, Hanning Liu, Haiyong Gu, Xiao Teng, Yu Nie, Zhou Zhou, Yan Zhao, Shengshou Hu, Zhe Zheng

“…In conclusion, the present study provides evidence that the HNF1A rs7310409 G/A functional polymorphism may contribute to the risk of LMCAD.…”
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Bat RNA viruses employ viral RHIMs orchestrating species-specific cell death programs linked to Z-RNA sensing and ZBP1-RIPK3 signaling by Sanchita Mishra, Disha Jain, Ayushi Amin Dey, Sahana Nagaraja, Mansi Srivastava, Oyahida Khatun, Keerthana Balamurugan, Micky Anand, Avinash Karkada Ashok, Shashank Tripathi, Mahipal Ganji, Sannula Kesavardhana

“…However, Nsp13 viral RHIM is more critical for human cell death than in bat-derived Tb1 Lu cells, suggesting species-specific regulation. …”
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HER3: Unmasking a twist in the tale of a previously unsuccessful therapeutic pursuit targeting a key cancer survival pathway by Omkar Desai, Moeez Rathore, Christina S. Boutros, Michel'le Wright, Elizabeth Bryson, Kimberly Curry, Rui Wang

“…This review offers a comprehensive description of the oncogenic functions of HER3, encompassing its structure and mediating signaling pathways. …”
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48-Hour and 24-Hour Time-lapse Single-nucleus Transcriptomics Reveal Cell-type specific Circadian Rhythms in Arabidopsis by Yuwei Qin, Zhijian Liu, Shiqi Gao, Carlos Martínez-Vasallo, Yanping Long, Xinlong Zhu, Bin Liu, Ya Gao, Xiaodong Xu, Maria A. Nohales, Qiguang Xie, Jixian Zhai

“…Abstract Functional circadian clock is critical to the adaptation and survival of organisms. …”
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A novel strategy for bone defect repair: Stromal cell-derived factor 1α sustained-release acellular fish scale scaffolds combined with injection of bone marrow mesenchymal stem cel... by Shilong Su, Jinwu Bai, Ruideng Wang, Shan Gao, Rubing Zhou, Fang Zhou

“…We first prepared a polydopamine-functionalized acellular fish scale scaffold that can continuously release stromal cell-derived factor 1α (SDF-1α) (termed as SDF-1α/PAFS) in vivo for at least 10 days. …”
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Starrydata: from published plots to shared materials data by Yukari Katsura, Masaya Kumagai, Tomoya Mato, Yu Takada, Yuki Ando, Erina Fujita, Fumikazu Hosono, Eiji Koyama, Farhan Mudasar, Ton Nu Thanh Phuong, Naoto Saito, Yoshihiro Sakamoto, Atsumi Tanaka, Dewi Yana, Kaoru Kimura, Koji Tsuda, Masahiko Demura

“…Currently, Starrydata encompasses over 194,000 curves extracted from more than 82,000 physical samples, as reported in over 13,000 publications on functional inorganic materials, including thermoelectric and magnetic materials. …”
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The MEK inhibitor trametinib is effective in inhibiting the growth of canine oral squamous cell carcinoma by William P. Katt, Cheryl E. Balkman, Scott D. Butler, Michael Byron, Patrick C. Carney, Amy B. Todd-Donato, Matthew E. Drozd, Gerald E. Duhamel, Jacquelyn M. Evans, Nadine Fiani, Jordan C. Ford, Jennifer K. Grenier, Jessica J. Hayward, Kristiina Heikinheimo, Kelly R. Hume, Elizabeth S. Moore, Rishi Puri, Skylar R. Sylvester, Sydney L. Warshaw, Suzin M. Webb, Andrew C. White, Alexandra L. Wright, Richard A. Cerione, Santiago Peralta

“…Given the limited treatment options available and the number of dogs for which standard of care is not acceptable, these preliminary findings provide new hope that more suitable treatment options may soon enter the veterinary clinic.…”
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Whole exome sequencing reveals an FCGBP variant associated with spontaneous intraabdominal hemorrhage in severe acute pancreatitis by Qiu‐Yi Tang, Yue‐Peng Hu, Qi Yang, Jing Zhou, Jing‐Zhu Zhang, Jie Yang, Hai‐Bin Hao, Gang Li, Bai‐Qiang Li, Lu Ke, Zhi‐Hui Tong, Yu‐Xiu Liu, Evan Yi‐Wen Yu, Wei‐Qin Li

“…Abstract This study investigated the genetic basis of spontaneous intraabdominal hemorrhage (SIH) in severe acute pancreatitis (SAP) to facilitate the development of more effective treatments for this life‐threatening complication. …”
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Balancing on carbon storage and ecological security in urban areas: The case of Dongguan city, China by Xinyi Wang, Fenzhen Su, Fengqin Yan, Vincent Lyne, Yikun Cui, Bin He, Rong Fan

“…Current and future national urban policies must therefore enhance carbon sink functions of ecosystems while maintaining spatial ecological structure networks. …”
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A Conformationally Driven Mechanism in n‐Type Doping of Naphthalene Diimide‐Bithiophene Copolymer by 1H‐Benzimidazoles by Simone Cimò, Ilaria Denti, Lorenzo Rossi, Marco Cassinelli, Martina Rossi, Rossella Castagna, Garrett LeCroy, Alberto Salleo, Mario Caironi, Antonino Famulari, Chiara Castiglioni, Chiara Bertarelli

“…The study interestingly demonstrates that a relevant change in conductivity, with an increase of more than three orders of magnitude with respect to pristine P(NDI2OD‐T2), occurs before the annealing process takes place, thus revealing that benzimidazole‐derived dopants are already active at room temperature. …”
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Unveiling the Causes of Acute and Non-Acute Myocardial Ischemic Syndromes: The Role of Optical Coherence Tomography by Angela Buonpane, Alberto Ranieri De Caterina, Giancarlo Trimarchi, Francesca Maria Di Muro, Domenico Galante, Samuela Zella, Fausto Pizzino, Marco Ciardetti, Umberto Paradossi, Giovanni Concistrè, Sergio Berti, Antonio Maria Leone, Filippo Crea, Carlo Trani, Francesco Burzotta

“…In Non-Acute Myocardial Ischemic Syndromes, OCT assists in evaluating stenosis severity, plaque morphology, vulnerability, and healing, and may contribute to the diagnosis of Ischemia with Non-Obstructive Coronary Arteries, identifying myocardial bridge and epicardial spasm alongside conventional functional assessment of intermediate stenoses. This narrative review outlines the expanding clinical applications of OCT across the full spectrum of ischemic syndromes, emphasizing its role in bridging obstructive and non-obstructive pathophysiology and supporting a more comprehensive diagnostic approach to ischemic heart disease.…”
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CircYAP1 inhibits osteosarcoma progression through the miR-135b-5p/FRK axis by Mingrui Du, Xuesan Zhang, Menglin Cong, Chengkui Cai, Qingxiang Zhang, Haixia Xin, Lanbo Yang, Qingqing Geng, Mingfu Shang, Zheng Zhang, Le Shen, Shusen Tan, Kang Han

“…In vitro functional assays demonstrated the inhibitory effects of circYAP1 on osteosarcoma cell proliferation, invasion, and migration. …”
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Environmental Heterogeneity Drives Secondary Metabolite Diversity from Mesquite Pods in Semiarid Regions by Alfredo Esparza-Orozco, Liliana Carranza-Becerra, Lucía Delgadillo-Ruiz, Juan José Bollaín y Goytia, Norma Angélica Gaytán-Saldaña, Cruz Daniel Mandujano-García, Eladio Delgadillo-Ruiz, Claudia Yared Michel-López, Josefina Huerta-García, Benjamín Valladares-Carranza, Héctor Emmanuel Valtierra-Marín

“…Advancements in remote sensing have enhanced the ability to assess plant functional traits more affordably and comprehensively by integrating spectral reflectance data with detailed plant metabolomics. …”
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Lipedema: diagnosis, treatment and the vicious cycle - a review of the literature by Justyna Głowacka, Natalia Tekiela, Natalie Papachristoforou, Daria Michałka, Zuzanna Gałuszka, Monika Makar, Tomasz Bartuś, Emilia Bąk, Aleksandra Kocjan, Radosław Chmiel

“…However, knowledge about this disease is becoming more publicised, through media, among other means, and research is being conducted at a larger scale. …”
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Islet Transplantation Attenuating Testicular Injury in Type 1 Diabetic Rats Is Associated with Suppression of Oxidative Stress and Inflammation via Nrf-2/HO-1 and NF-κB Pathways by Xiandong Zhu, Feixia Guo, Hengjie Tang, Chongchu Huang, Gangyin Xie, Tingting Huang, Yonglin Li, Chengyang Liu, Hongwei Wang, Bicheng Chen

“…Testicular structural and functional impairment is a serious complication in male diabetes mellitus (DM) patients that leads to impaired fertility in adulthood. …”
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Anisotropic Spin Fluctuations Induced by Spin‐Orbit Coupling in a Misfit Layer Compound (LaSe)1.14(NbSe2) by Min Shan, Shunjiao Li, Ye Yang, Dan Zhao, Jian Li, Linpeng Nie, Zhimian Wu, Yanbing Zhou, Lixuan Zheng, Baolei Kang, Tao Wu, Xianhui Chen

“…More importantly, the significant SOC induces both a weak antilocalization (WAL) effect and anisotropic spin fluctuations in noncentrosymmetric NbSe2 layers. …”
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