Role of Salivary Biomarkers IL-1β and MMP-8 in Early Detection and Staging of Periodontal Disease by Liliana Sachelarie, Corina Laura Stefanescu, Rodica Maria Murineanu, Mircea Grigorian, Agripina Zaharia, Ioana Scrobota, Loredana Liliana Hurjui

Get full text

The association between eight complete blood count-derived inflammatory markers and muscle health by Jingyuan Zhang, Yuqi Wang, Heng Liu, Zhuolin Lei, Shouquan Cheng, Hong Cao

“…SII may be crucial in identifying “hidden sarcopenia” and the early stages of muscle functional decline.…”
Get full text

Cystoscopic Local Application of Mitomycin-C following Internal Urethrotomy for Recurrent Short Urethral Strictures in Children: A Preliminary Experience by Simmi K. Ratan, Nitesh Kumar Sharma, Gaurav Saxena, Sujoy Neogi

“…Iatrogenic and posttraumatic causes in the US are more frequent than the idiopathic, infective, and inflammatory causes. …”
Get full text

VERTICAL DIMENSION OF OCCLUSION CHARACTERISTICS IN PATIENTS WITH DIFFERENT TYPES OF MALOCCLUSIONS BY THE SHIMBASHI INDEX IN THE AGE ASPECT by O.M. Makarova, V.D. Kuroiedova, Y.V. Rud

“… Occlusal vertical dimension is one of the important parameters, which is significantly related to the functional status of the masticatory complex. The finding of the optimal occlusal vertical dimension and the method of its determining is a debatable and topical issue in planning of orthodontic correction and orthopedic rehabilitation. …”
Get full text

A Novel Triptolide Nano-Liposome with Mitochondrial Targeting for Treatment of Hepatocellular Carcinoma by Zhou L, Du Y, Shang Y, Xiang D, Xia X

“…Lili Zhou,1 Yang Du,2 Yating Shang,1 Debiao Xiang,3,* Xinhua Xia1,* 1School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, People’s Republic of China; 2The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, 410208, People’s Republic of China; 3Department of Pharmacy, The Third Hospital of Changsha, Changsha, 410208, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xinhua Xia; Debiao Xiang, Email xiaxinhua001@hnucm.edu.cn; debiao-xiang@cssdsyy.comBackground: Modern pharmacological studies have demonstrated that although triptolide (TP) is effective against hepatocellular carcinoma, it has poor water solubility and more toxic side effects. In this study, we used triptolide (TP), a bioactive constituent in Tripterygium wilfordii Hook F, as a model drug to develop a novel nano-liposome drug delivery system for the treatment of liver tumours.Methods: We constructed a functionally-modified triptolide liposome (FA+TPP-TP-Lips) using the film-dispersion method and investigated its physicochemical properties, mitochondrial targeting of hepatic tumour cells, in vitro and in vivo anti-hepatic tumour activity and its mechanism.Results: The prepared FA+TPP-TP-Lips had a particle size of 99.28 ± 5.7 nm, a PDI of 0.20 ± 0.02, a zeta potential of 1.2 ± 0.08 mV, and an encapsulation rate of 74.37% ± 1.07%.FA+TPP-TP-Lips facilitates the cellular uptake of drug delivery systems and improves their targeted delivery to mitochondria. …”
Get full text

Emerging Healthcare Technologies in Gastrointestinal Endoscopy: 75 Years of Evolution by Irina Florina CHERCIU HARBIYELI, Elena Daniela BURTEA, Vlad IOVANESCU, Dan Nicolae FLORESCU, Ion ROGOVEANU, Dan Ionut GHEONEA, Adrian SAFTOIU

“…Future capsules will feature AI-driven lesion detection and therapeutic functions, higher-resolution imaging, wider fields of view, controllable movement bringing the concept of "swallowing the gastroenterologist" closer to reality. …”
Get full text

Gold(III) Complexes with 2-(1-Ethylbenzyl)pyridine as Promising Antimicrobial and Antitumor Agents by Antonio Zucca, Bruna Canu, Maria I. Pilo, Sergio Stoccoro, Giacomo Senzacqua, Sara Fais, Giuseppina Pichiri, Alessandra Scano

“…Metal ions in biological systems can essentially have two roles: structural or functional. In the former, the metal ion serves to stabilize structures, especially proteins, while in the latter, the metal is involved in bio-site reactivity (essentially in metallo-enzymes). …”
Get full text

Autosomal dominant hypercalciuria in a mouse model due to a mutation of the epithelial calcium channel, TRPV5. by Nellie Y Loh, Liz Bentley, Henrik Dimke, Sjoerd Verkaart, Paolo Tammaro, Caroline M Gorvin, Michael J Stechman, Bushra N Ahmad, Fadil M Hannan, Sian E Piret, Holly Evans, Ilaria Bellantuono, Tertius A Hough, William D Fraser, Joost G J Hoenderop, Frances M Ashcroft, Steve D M Brown, René J M Bindels, Roger D Cox, Rajesh V Thakker

“…Compared to wild-type littermates, heterozygous (Trpv5(682P/+)) and homozygous (Trpv5(682P/682P)) mutant mice had hypercalciuria, polyuria, hyperphosphaturia and a more acidic urine, and ∼10% of males developed tubulointerstitial nephritis. …”
Get full text

Green synthesis of copper oxide nanoparticles using Rosmarinus officinalis leaf extract and evaluation of its antimicrobial activity by Mekides Dinka Moroda, Tolesa Leta Deressa, Ardila Hayu Tiwikrama, Tolesa Fita Chala

“…Due to the development of green technology, researchers are becoming more interested in low-cost, environmental eco-friendly methods for the synthesis of nanoparticles (Nps). …”
Get full text

How do health problems affect the quality and everyday life of patients with endometriomas? by K. Chmaj-Wierzchowska, M. Wojciechowska, I. Parda, K. Plagens-Rotman, P. Rzymski, M. Wilczak

“…Women with endometrial cysts significantly more frequently reported issues related to occupation (Cramer’s V 0.578, p ≤ 0.001), household chores (Cramer’s V 0.597, p ≤ 0.001), social life (Cramer’s V 0.581, p ≤ 0.001), family life (Cramer’s V 0.576, p ≤ 0.001), sexual life (Cramer’s V 0.561; p ≤ 0.001), participation in hobbies (Cramer’s V 0.876, p ≤ 0.001), and holidays (Cramer’s V 0.876; p ≤ 0.001). …”
Get full text

Can patient-reported profiles avoid unnecessary referral to a spine surgeon? An observational study to further develop the Nijmegen Decision Tool for Chronic Low Back Pain. by Miranda L van Hooff, Johanna M van Dongen, Veerle M Coupé, Maarten Spruit, Raymond W J G Ostelo, Marinus de Kleuver

“…The primary outcome was functional ability: 'response' (Oswestry Disability Index [ODI] ≤22) and 'non-response' (ODI ≥41).…”
Get full text

Analyzing special needs reports for children: sociodemographic trends, diagnoses, and support areas over five years (2019–2024) by Semih Canpolat, Mehmet Emin Parlak, Esra Kurt Canpolat, Erdogan Oz

“…Through ongoing analysis and adaptation, these efforts hold the promise of fostering a more inclusive and supportive environment for children with diverse needs.…”
Get full text

Content of CD4⁺T cell subpopulations in predicting the efficacy of biological therapy for psoriasis in children by D. G. Kuptsova, T. V. Radigina, O. V. Kurbatova, A. I. Materikin, R. V. Epishev, L. A. Opryatin, A. A. Khotko, N. N. Murashkin, S. V. Petrichuk

“…The pathophysiology of psoriasis is also associated with a decrease in anti-inflammatory functions of immunosuppressive cells. Recently, there are more cases of development of resistance to ongoing therapy with biologics in children, requiring cancellation of drug or its replacement. …”
Get full text

Comprehensive sieve analysis of breakthrough HIV-1 sequences in the RV144 vaccine efficacy trial. by Paul T Edlefsen, Morgane Rolland, Tomer Hertz, Sodsai Tovanabutra, Andrew J Gartland, Allan C deCamp, Craig A Magaret, Hasan Ahmed, Raphael Gottardo, Michal Juraska, Connor McCoy, Brendan B Larsen, Eric Sanders-Buell, Chris Carrico, Sergey Menis, Gustavo H Kijak, Meera Bose, RV144 Sequencing Team, Miguel A Arroyo, Robert J O'Connell, Sorachai Nitayaphan, Punnee Pitisuttithum, Jaranit Kaewkungwal, Supachai Rerks-Ngarm, Merlin L Robb, Tatsiana Kirys, Ivelin S Georgiev, Peter D Kwong, Konrad Scheffler, Sergei L Kosakovsky Pond, Jonathan M Carlson, Nelson L Michael, William R Schief, James I Mullins, Jerome H Kim, Peter B Gilbert

“…The identified signature sites significantly covaried with other sites across the genome (mean = 32.1) more than did non-signature sites (mean = 0.9) (p < 0.0001), suggesting functional and/or structural relevance of the signature sites. …”
Get full text

When do the symptoms of autonomic nervous system malfunction appear in patients with Parkinson’s disease? by De Luka Silvio R., Svetel Marina, Pekmezović Tatjana, Milovanović Branislav, Kostić Vladimir S.

“…The patients who developed complete autonomic neuropathy (both sympathetic and parasympathetic) were individuals with considerable level of functional failure, more severe clinical presentation and the existing anxiety and depression. …”
Get full text

The impact of urbanization on land use land cover change using geographic information system and remote sensing: a case of Mizan Aman City Southwest Ethiopia by Addis Bikis, Muluye Engdaw, Digvijay Pandey, Binay Kumar Pandey

“…Deforestation for urban functions, including timber production, construction materials, and firewood, adversely affects the environment. …”
Get full text

Vasoreactive testing prevalence and characteristics in patients with idiopathic pulmonary arterial hypertension by Goncharova Natalia, Kirill Lapshin, Aelita Berezina, Irina Zlobina, Anton Ryzhkov, Zhaneta Matakaeva, Elizaveta Andreeva, Olga Moiseeva

“…INTRODUCTION: The choice of treatment strategy in patients with idiopathic pulmonary arterial hypertension (IPAH)/HPAH/DPAH (Hereditary pulmonary arterial hypertension/ Drug-induced pulmonary arterial hypertension) II-III functional class (FC) (WHO) based on an acute vasoreactive testing result (VRT). …”
Get full text

Quality Evaluation of Muffins Enriched With Blueberry and Cranberry Powders by Njomza Gashi, Endrit Hasani, Salih Salihu

“…This factor is crucial to fulfill consumers’ requests for more attractive attributes of such products not only in taste but also in their physical appearance. …”
Get full text

Biologically targeted dual adaptive and innate nano-Immunotherapy for clear cell renal cell carcinoma treatment by Kin Man Au, Siqing Li, Tian Zhang, Andrew Z. Wang

“…The anticancer activity of MINPs in mice humanized with hPBMCs from older donors was slightly weaker than in those humanized with younger donors. More importantly, the MINP formulation effectively prevented the hepatotoxicity associated with the systemic administration of immune checkpoint agonistic antibodies. …”
Get full text

Healthcare providers' insights on pediatric care quality in Gaza hospitals: integrating evidence-based practices and illness management, health information systems, and referral ef... by Saeed Y. Eleyyan, Bothyna B. ELssyed Etewa, Fatma Al’Haj Ahmad, Abdel Hamid El Bilbeisi, Abdel Hamid El Bilbeisi

“…A significant portion (64.6%) held a bachelor's degree, and a majority (83.3%) had not pursued specialized studies in pediatric care. However, more than half (58.3%) had attended pediatric care training courses, and 23.2% had less than five years of experience. …”
Get full text