DLL4-targeted CAR-T therapy sensitizes neoadjuvant chemotherapy via eliminating cancer stem cells and reshaping immune microenvironment in HER2+ breast cancer by Tianxing Zhou, Yongjie Xie, Yanfang Yang, Ziyun Liu, Jingrui Yan

“…This led to the exclusion of lymphocyte infiltration, thereby enhancing therapy resistance. What is more, we designed a DLL4-targeted CAR-T to eliminate DLL4+ tumor cells and reverse the resistant status.Conclusions Our study revealed novel functions of DLL4 in cell stemness and immune infiltration, including NET formation and T cell exclusion, which collectively contributed to THP neoadjuvant therapy resistance in HER2+ BC. …”
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The clinical impact of recent amphetamine exposure in aneurysmal subarachnoid hemorrhage patients by Jeffrey R. Vitt, Roger C. Cheng, Jason Chung, Travis Caton, Bo Zhou, Nerissa Ko, Karl Meisel, Edilberto Amorim

“…Further investigations about localized effects in the posterior circulation and impact on long-term functional outcomes are warranted.…”
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Prognostic factors for work disability in patients with chronic widespread pain and fibromyalgia: protocol for a cohort study by Robin Christensen, Marius Henriksen, Eva Ejlersen Wæhrens, Henning Bliddal, Lars Erik Kristensen, Karsten Thielen, Henning Locht, Kirstine Amris, Pernille H Duhn

“…Although research support large interindividual differences in functional outcomes, limited studies are available on the socio-economic consequences of offering stratified treatment based on prognostic factors. …”
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Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer. by Ian P M Tomlinson, Luis G Carvajal-Carmona, Sara E Dobbins, Albert Tenesa, Angela M Jones, Kimberley Howarth, Claire Palles, Peter Broderick, Emma E M Jaeger, Susan Farrington, Annabelle Lewis, James G D Prendergast, Alan M Pittman, Evropi Theodoratou, Bianca Olver, Marion Walker, Steven Penegar, Ella Barclay, Nicola Whiffin, Lynn Martin, Stephane Ballereau, Amy Lloyd, Maggie Gorman, Steven Lubbe, COGENT Consortium, CORGI Collaborators, EPICOLON Consortium, Bryan Howie, Jonathan Marchini, Clara Ruiz-Ponte, Ceres Fernandez-Rozadilla, Antoni Castells, Angel Carracedo, Sergi Castellvi-Bel, David Duggan, David Conti, Jean-Baptiste Cazier, Harry Campbell, Oliver Sieber, Lara Lipton, Peter Gibbs, Nicholas G Martin, Grant W Montgomery, Joanne Young, Paul N Baird, Steven Gallinger, Polly Newcomb, John Hopper, Mark A Jenkins, Lauri A Aaltonen, David J Kerr, Jeremy Cheadle, Paul Pharoah, Graham Casey, Richard S Houlston, Malcolm G Dunlop

“…Our data emphasise that genetic fine-mapping studies can deconvolute associations that have arisen owing to independent correlation of a tagSNP with more than one functional SNP, thus explaining some of the apparently missing heritability of common diseases.…”
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Microstructure, stability and oxidation resistance of ex-situ Alloy 625 + TiC nanocomposites processed by suction casting intended for repair of aerospace components by Łukasz Rakoczy, Małgorzata Grudzień-Rakoczy, Grzegorz Cempura, Tomasz Kargul, Ewa Rząd, Marcin Madej, Tomasz Dudziak, Dawid Kozień, Rafał Cygan, Dušan Galusek

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MATHEMATICAL SUBSTANTIATION OF THE USE OF DIFFERENT TYPES OF CLAMMERS DURING THE RESTORATION OF THE DENTITION WITH DOUBLE-SIDED DISTAL DEFECTS AND THE DEFECT INCLUDED IN THE FRONTA... by R.V. Kozak, D.M. Korol

“…The basic conditions that ensure good functional qualities and durability of prosthetic structures from the point of view of biomechanics, undoubtedly include an optimal way of fixing a partial removable prosthesis, which consists in the correct choice of the clamping system that ensures reliable fixation of the prosthesis in the given position and at the same time causing a minimum of harm supporting teeth, as well as the most rational distribution of occlusal loads transmitted to the supporting tissues, since it is these factors that determine the durability functioning dentures. …”
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Post-operative face-up or face-down positioning after silicone oil tamponade in retinal surgery: results of a retrospective study by Mohammad Idrees Adhi, Mehreen Adhi, Tariq Aldebasi, Mohammed Hazzazi, Mohammed Nabeel Refka, Aamir Omair

“…Migration of silicone oil in the anterior chamber was more common in group A (p=0.470). Pupil block glaucoma was seen in 2(1.9%) eyes in group A only.Silicone oil-related complications, functional outcomes and anatomical outcomes were non-significantly different between the grpups (p>0.05) except a weak significant difference with respect to redetachments after removal of silicone oil (p=0.047). …”
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Unveiling the Antioxidant Power and Secondary Metabolites of <i>Tabebuia chrysantha</i> (Jacq.) Leaves and Flowers from Ecuador by Raluca A. Mihai, Ramiro Fernando Vivanco Gonzaga, Nelson Santiago Cubi Insuaste, Nilo Rigoberto Maza Morocho, Rodica D. Catana

“…These findings highlight a functional specialization, with leaves synthesizing more flavonoids to mitigate oxidative stress from environmental factors such as UV radiation. …”
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Exploring the impact of myoelectric prosthesis controllers on visuomotor behavior by Kodi Y. Cheng, Heather E. Williams, Ahmed W. Shehata, Patrick M. Pilarski, Craig S. Chapman, Jacqueline S. Hebert

“…Unreliability can arise from the unpredictable control due to variations in electromyography signals that can occur when the arm moves through different limb positions during functional use. More robust position-aware control systems have been explored using deep learning methods, specifically ones that utilize data from different limb positions, that show promising improvements in control characteristics. …”
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Single-cell RNA sequencing reveals the role of GTF2F2 in ovarian cancer oncogenesis and progression by Haiyang Du, Gao Si, Jiqing Si, Xuejie Song, Fuchun Si

“…Drug sensitivity predictions indicated that osimertinib, rapamycin, and dihydrorotenone might have stronger inhibitory effects in the high-risk group, whereas ERK inhibitors were more effective in the low-risk group. Functional assays demonstrated that GTF2F2 knockdown significantly suppressed ovarian cancer cell migration and invasion. …”
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Residuos de Café, Cacao y Cladodio de Tuna: Fuentes Promisorias de Fibra Dietaria by Diego Abarca, Ruth Martínez, Juan José Muñoz, María Paulina Torres, Galo Vargas

“…The parchment of coffee, peel of cocoa, husk of cladode demonstrated to be good sources of FDI and the mucilage and husk of cacao and pulp of cladode demonstrated to be good sources of FDS, also the husk of cocoa and pulp of cladode presented an excellent balance FDI/FDS and for it these could be excellent sources to be added in foods. About its functional properties the residual material with more swelling (SW) was the husk of cladode, the most water retention capacity(WRC) was the pulp and husk of cladode and finally the most fat adsorption capacity (FAC) was the peel  and husk of cocoa. …”
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A 10-Year Follow-Up of an Approach to Restore a Case of Extreme Erosive Tooth Wear by Davide Foschi, Andrea Abate, Francesca Vailati, Ignazio Loi, Cinzia Maspero, Valentina Lanteri

“…At 10-year follow-up, biological, functional, and esthetic success was still confirmed.…”
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Juvenile Idiopathic Arthritis Subtype- and Sex-specific Associations with Genetic Variants in the PSMA6/PSMC6/PSMA3 Gene Cluster by Tatjana Sjakste, Natalia Paramonova, Ingrida Rumba-Rozenfelde, Ilva Trapina, Olga Sugoka, Nikolajs Sjakste

“…Theoretical models of the functional significance of allele substitutions are discussed.…”
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Recent Advances in Antibacterial Strategies Based on TiO₂ Biomimetic Micro/Nano-Structured Surfaces Fabricated Using the Hydrothermal Method by Zilin Guo, Hanpeng Liu, Wuzhi Wang, Zijun Hu, Xiaofang Li, Hao Chen, Kefeng Wang, Zhaoyang Li, Caideng Yuan, Xiang Ge

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Using the optimal seed germination temperature approach to determine the potential distribution of Inga jinicuil in Mexico under climate change scenarios by Salvador Sampayo-Maldonado, Daniel Cabrera-Santos, Patricia Dávila-Aranda, Norma Isela Rodríguez-Arévalo, Alma Orozco-Segovia, Maraeva Gianella, Elizabeth Bell, Michael Way, Robert H. Manson, Gabina S. Quintas, Cesar M. Flores-Ortíz, Tiziana Ulian

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Comparison of the Efficacy of Elastodontic Devices and Aligners in Dentoalveolar Transverse Expansion: A Randomized Open Label Clinical Trial by Eleonora Ortu, Mariano Lacarbonara, Samuele Cova, Elena Gigliozzi, Maria Ausilia D’Angelo, Annalisa Monaco, Davide Pietropaoli

“…Specifically, it is intended to determine which of the two methods is more effective in terms of dentoalveolar expansion in a sample of children with mixed dentition. …”
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Management approach matters: meeting seagrass recovery and carbon mitigation goals by Melissa Ward, Connor Dibble, Maddie Millington-Drake, John Lynch, Karen McGlathery, Richard J. Lilley, Aaron L. Strong, Lisa M. Wedding

“…Abstract Seagrass habitats support biodiversity, improve water quality, protect coastlines, and sequester carbon, among other essential ecosystem functions, yet they are declining worldwide due to human activity. …”
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Incidence and predictive factors of hyperventilation syndrome in patients after COVID 19 pneumonia: a prospective cohort study [version 1; peer review: 2 approved] by Salma Mokaddem, Hela CHERIF, Mohamed Ridha Charfi, Ferdaous Yangui, Slim Kalboussi, Soumaya Debiche

“…Functional limitations (PCFS Grade > 2) were observed in 19.6% of patients. …”
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Rewriting the Treatment Paradigm: Ilizarov Method Achieves High Success in Septic Non-Unions Without Local Antibiotics or Biologic Adjuncts by Filippo Vandenbulcke, Andrea Dorotei, Emiliano Malagoli, Alexander Kirienko

“…Patients who have suffered a more recent trauma or fewer previous surgeries achieved a better outcome. …”
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Use ATCCfinder to identify commercially available American Type Culture Collection strains based on sequence queries by Samuel I. Koehler, Earl A. Middlebrook, Blake T. Hovde, Erik R. Hanschen

“…ATCCfinder efficiently accesses, queries, and summarizes ATCC resources, identifying purchasable strains homologous to historical sequences, functional genes, operons, and other genetic components.…”
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