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  1. 3061
  2. 3062

    Store‐operated calcium entry controls innate and adaptive immune cell function in inflammatory bowel disease by Marilena Letizia, Yin‐Hu Wang, Ulrike Kaufmann, Lorenz Gerbeth, Annegret Sand, Max Brunkhorst, Patrick Weidner, Jörn Felix Ziegler, Chotima Böttcher, Stephan Schlickeiser, Camila Fernández, Megumi Yamashita, Kenneth Stauderman, Katherine Sun, Désirée Kunkel, Murali Prakriya, IBDome Researchers, Ashley Sanders, Britta Siegmund, Stefan Feske, Carl Weidinger

    Published 2022-08-01
    “…We observed that the pharmacologic inhibition of SOCE attenuated the production of proinflammatory cytokines including IL‐2, IL‐4, IL‐6, IL‐17A, TNF, and IFNγ by human colonic T cells and ILCs, reduced the production of IL‐6 by B cells and the production of IFNγ by myeloid cells, but had no effect on the viability, differentiation, and function of intestinal epithelial cells. T cell‐specific deletion of CRAC channel genes in mice showed that Orai1, Stim1, and Stim2‐deficient T cells have quantitatively distinct defects in SOCE, which correlate with gradually more pronounced impairment of cytokine production by Th1 and Th17 cells and the severity of IBD. …”
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  3. 3063

    GSFM: A genome-scale functional module transformation to represent drug efficacy for in silico drug discovery by Saisai Tian, Xuyang Liao, Wen Cao, Xinyi Wu, Zexi Chen, Jinyuan Lu, Qun Wang, Jinbo Zhang, Luonan Chen, Weidong Zhang

    Published 2025-01-01
    “…Here, we developed a new genome-scale functional module (GSFM) transformation framework to quantitatively evaluate drug efficacy for in silico drug discovery. …”
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    Article
  4. 3064
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    The Functional State of the Myocardium in Patients with Ischemic Heart Disease, Diabetes Mellitus Type 2 and Cardiac Insufficiency by Horb Yu., Strona V., Komir I.

    Published 2020-04-01
    “…Gender analysis showed a significant increase in left ventricular and left atrial dimensions, with a more pronounced decrease in myocardial systolic function in men with type 2 diabetes, obesity, and postinfarction cardiosclerosis compared with women regardless of age. …”
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    Article
  6. 3066

    Utrophin haploinsufficiency does not worsen the functional performance, resistance to eccentric contractions and force production of dystrophic mice. by Antoine Boulanger Piette, Dounia Hamoudi, Laetitia Marcadet, Frédérique Kyomi Labelle, Rares Ovidiu David, Sabrina Bossé, Anteneh Argaw, Jérôme Frenette

    Published 2018-01-01
    “…The functional performances of mdx/utrn+/- mice showed that they are not more affected than mdx/utrn+/+ mice based on downhill treadmill running parameters and subsequent recovery measured by open-field voluntary activity. …”
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  7. 3067

    Global assessment of swallow function (GASF) following VMAT radiotherapy for head and neck squamous cell carcinoma by Kate Toft, Kirsty McLachlan, Mark Winton, Karen Mactier, Nadine Hare, Claire Nugent, Lucie Wincott, Devraj Srinivasan, Joanna Mackenzie, Bill Nailon, David Noble

    Published 2024-12-01
    “…Aim: This study aimed to conduct a global assessment of swallow function (GASF) using a range of swallow outcome tools, in a cohort of patients pre- and post-treatment with image-guided volumetric modulated arc therapy (VMAT) radiotherapy. …”
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    The FAST Ursa Major Supergroup H i Survey (FUMaS): Catalog and H i Mass Function by Haiyang Yu, Ming Zhu, Chuan-Peng Zhang, Peng Jiang, Jin-Long Xu

    Published 2025-01-01
    “…We computed the neutral hydrogen mass function (H i MF) of the UMa supergroup using the 1/ ${V}_{\max }$ method and fitting it with the nonlinear least-squares (NLLS) and modified maximum likelihood (MML) methods. …”
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    Article
  11. 3071

    Precipitation–fire functional interactions control biomass stocks and carbon exchanges across the world's largest savanna by M. Williams, M. Williams, D. T. Milodowski, D. T. Milodowski, T. L. Smallman, T. L. Smallman, K. G. Dexter, G. C. Hegerl, I. M. McNicol, M. O'Sullivan, C. M. Roesch, C. M. Ryan, C. M. Ryan, S. Sitch, A. Valade

    Published 2025-03-01
    “…The current generation of LSMs represents savanna as a single plant functional type, missing important spatial functional variations identified here. …”
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    Article
  12. 3072

    Effects of Du Meridian Electroacupuncture Combined with Treadmill Training on Motor Function of Rats with Spinal Cord Injury by CHENG Mei, TIAN Yu, PENG Jing, YU Shuangqi, ZHANG Xuejun, DING Fan

    Published 2025-04-01
    “…Rats with death or BBB motor function scale score>2 were excluded, and finally eight rats were included in each group. …”
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  13. 3073

    Optimizing shrimp nutrition and health: ginseng saponins as functional additives in low-fishmeal diets on Litopenaeus vannamei by Sihan Lin, Rong Yao, Xin Cui, Yucai Guo, Denghui Hu, Bin Zhou, Zhaobin Zhou, Xuanshu He, Zhihong Liao, Beiping Tan, Jin Niu

    Published 2024-10-01
    “…Caspase3 and p53, along with bcl-2 and bax, were found to be significantly more expressed in shrimp of the GSP0.3 group than in all other groups (P<0.05). …”
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  14. 3074

    Loss of plant functional group mediates microbial community assembly in litter decomposition of alpine fir forest by Qianwei Li, Yamei Chen, Lin Xu, Xinglei Cui, Hongwei Xu, Lixia Wang, Chengming You, Xingjun Tian, Xinhua He, Yang Liu

    Published 2025-04-01
    “…We found that bacterial communities were more sensitive than fungal communities to loss of single plant functional group, with significant changes in the abundance of Alphaproteobacteria. …”
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  15. 3075

    Genotype–phenotype analysis and functional study of three novel LRP6 variants in non-syndromic oligodontia by Yunyun Yuan, Ya Zhao, Lingqiang Meng, Shuyun Zheng, Hui Li, Jiabao Ren, Beibei Li, Chenyun Dou, Yan Hou, Wenjing Chen, Jing Zhang, Jing Zhang, Yulin Ding, Yulin Ding, Wenjing Shen

    Published 2025-06-01
    “…Introduction:Tooth agenesis (TA) is a common craniofacial malformation in humans, characterized by the absence of one or more permanent teeth. Recent studies have identified the low-density lipoprotein receptor-related protein 6 (LRP6) gene as an autosomal dominant contributor to TA. …”
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    Article
  16. 3076

    SOUTH AFRICAN USERS’ FUNCTION AND EXPERIENCE WITH A MAGNETORHEOLOGICAL MICROPROCESSOR KNEE: A MIXED METHODS STUDY by Surona Visagie, Benje Theron

    Published 2025-06-01
    “…OBJECTIVE: To explore and describe South African users’ function and experience with the Rheo XC microprocessor knee (MPK). …”
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    Article
  17. 3077

    Traffic-related diesel pollution particles impair the lysosomal functions of human iPSC-derived microglia by Sohvi Ohtonen, Henna Jäntti, Luca Giudice, Ahmed Mohamed, Anastasia Shakirzyanova, Táňa Závodná, Ilya Belevich, Hong Yan, Angélica María Sabogal-Guáqueta, Liudmila Saveleva, Mari-Anna Väänänen, Ashley Rillo-Albert, Elisa Perciballi, Daniela Ferrari, Minna-Mari Tervo, Mireia Gómez-Budia, Zdeněk Krejčík, Päivi Aakko-Saksa, Jari Koistinaho, Šárka Lehtonen, Katja M. Kanninen, Jan Topinka, Eija Jokitalo, Alejandra Sierra, Martina Schmidt, Amalia M. Dolga, Pasi I. Jalava, Paula Korhonen, Tarja Malm

    Published 2025-05-01
    “…In addition, we show that response to particles is more pronounced in human iMGLs compared to mouse primary microglia.To conclude, particles from older emission technology impair phago-lysosomal functions of iMGLs, but modern alternatives with filtration do not induce drastic changes in the functionality of iMGLs.…”
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  18. 3078

    Cognitive functions in patients suffering from hypertension and hypothyroidism with retrospective evaluation of control over disease compensation. by M. I. Lesiv

    Published 2020-04-01
    “…To assess cognitive functions, Mini Mental State Examination (MMSE) and the Addenbrooke’s cognitive examination (ACE-R) were used. …”
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