An immunocompetent mouse model revealed that congenital Zika virus infection disrupted hippocampal function by activating autophagy by Wei Yang, Zhan-Zhan Bian, Zhe Li, Yi-Teng Zhang, Li-Bo Liu, Jia-Tong Chang, Dan Li, Pei-Gang Wang, Jing An, Wei Wang

“…These findings highlighted that congenital ZIKV infection could interrupt hippocampal function by activating autophagy, thus providing a theoretical basis for the clinical treatment of congenital ZIKV-infected infants.…”
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Functional Outcome of Epidural Steroid Injection in the Treatment of Chronic Low Backache due to Intervertebral Disc Prolapse by R Sahaya Jose, SL Binesh, N Kattu Bava, M Syed Moosa

“…The Chi-squared test will be used to determine the statistical significance of the relationship between the functional outcome of an ESI and qualitative indicators. …”
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Functioning in patients with major depression treated with duloxetine or a selective serotonin reuptake inhibitor in East Asia by Novick D, Montgomery W, Haro JM, Moneta MV, Zhu G, Yue L, Hong J, Duenas H, Brugnoli R

“…Both descriptive and regression analyses confirmed improvement in functioning in both groups during follow-up, but duloxetine-treated patients achieved better functioning. …”
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Effects of an exercise program with augmented reality on functional fitness and physical activity of community-dwelling older adults by Soraia Ferreira, Soraia Ferreira, José Marmeleira, José Marmeleira, Jesus Del Pozo Cruz, Jesus Del Pozo Cruz, Nilton Leite, Nilton Leite, Alexandre Bernardino, Ana Moradell, Ana Moradell, Ana Moradell, Ana Moradell, Armando Raimundo, Armando Raimundo

“…The clinical effect sizes of the interventions were large for balance (ES = 1.19) in EG1 and for upper limb strength (ES = 1.24) in EG2, and medium for cardiorespiratory fitness (ES = 0.74), agility (ES = 0.50), and lower limb flexibility (ES = 0.65) in EG1, and lower limb strength (ES = 0.61) and cardiorespiratory fitness (ES = 0.79) in EG2.ConclusionBoth intervention programs led to improvements in several functional domains. However, the multimodal training combined with augmented reality program showed improvements across more domains, resulting in greater changes. …”
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Clinical trajectories of hand function impairment in systemic sclerosis: an unmet clinical need across disease subsets by Lorraine Green, Ariane L Herrick, Michelle Wilson, Francesco Del Galdo, Enrico De Lorenzis, Philip Helliwell, Benazir Saleem, Emma Derrett-Smith, Begonya Alcacer-Pitarch, Karen Douglas, Vishal Kakkar, Chris Denton, Theresa Barnes, Stefano Di Donato, Muhammad Nisar, Catherine Morley

“…Least absolute shrinkage and selection operator analysis identified male gender, disease subset, Raynaud’s Condition Score, tenosynovitis and pain, as some of the key factors associated with worsening hand involvement.Conclusions Hand function deteriorates over time in more than 50% of SSc patients despite available therapies. …”
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PhyloFunc: phylogeny-informed functional distance as a new ecological metric for metaproteomic data analysis by Luman Wang, Caitlin M. A. Simopoulos, Joeselle M. Serrana, Zhibin Ning, Yutong Li, Boyan Sun, Jinhui Yuan, Daniel Figeys, Leyuan Li

“…A more informative functional distance metric that incorporates evolutionary relatedness is needed to better understand microbiome functional dissimilarities. …”
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Aging, HIV infection, and alcohol exert synergist effects on regional thalamic volumes resulting in functional impairment by Adolf Pfefferbaum, Natalie M. Zahr, Stephanie A. Sassoon, Rosemary Fama, Manojkumar Saranathan, Kilian M. Pohl, Edith V. Sullivan

“…Results: Aging in the control group was best modeled with quadratic functions in the Anterior and Ventral regions and with linear functions in the Medial and Posterior regions. …”
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Posterolateral Tibial Plateau Fractures in Adult Anterior Cruciate Ligament Avulsion Effect on Postoperative Knee Function by Bin Feng, Jian Peng, Weizhi Ren, Zhenghui Hu, Jiawei Ouyang, Wei Xu

“…More extensive PLTPFs were linked to increased fracture collapse and a higher rate of lateral meniscus injuries. …”
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Current situation of pharmacy services in community health centers and the functioning of pharmacists in family doctor teams in Shanghai by Rui LIU, Yu CAO, Aiqun CHU, Huanyun WU

“…Challenges included shortage of pharmacist workforce, need for enhanced professional quality, incomplete community pharmacy drug lists, and need for more applying information technology. Furthermore, community pharmacists are often undervalued, with services focusing narrowly on dispensing, insufficient targeted training on rational drug use, and limited functioning within family doctor teams. …”
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Modern diagnostic potentials of studying structural and functional changes of the retina and the optic nerve in multiple sclerosis patients by A. Zh. Fursova, M. Yu. Zubkova, M. A. Vasilyeva, Yu. A. Gamza, N. A. Malkova, A. I. Prokaeva, F. K. Rabota

“…Purpose: to study significant functional and structural changes in the retina and the intraocular section of the optic nerve in multiple sclerosis (MS) patients and analyze how they are interrelated with electrophysiological changes in the visual analyzer.Materials and methods. …”
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Interferon-γ Signaling in Eosinophilic Esophagitis Affects Epithelial Barrier Function and Programmed Cell DeathSummary by Megha Lal, Caitlin M. Burk, Ravi Gautam, Zoe Mrozek, Karina E. Canziani, Tina Trachsel, Jarad Beers, Margaret C. Carroll, Duncan M. Morgan, Amanda B. Muir, Wayne G. Shreffler, Melanie A. Ruffner

“…The functional impact of IFN-α and IFN-γ on epithelial cells was investigated using organoid models. …”
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Optimizing one-leg standing test duration for screening functional decline in community-dwelling older adults by Akira Iwata, Izumi Arihara, Keita Sasada, Atsuki Kanayama, Kenichiro Tsubokura, Gaito Kitada, Ryoga Ueba, Shuji Okuno, Toshimitsu Ohmine, Saki Yamamoto

“…A shorter duration (10 s) effectively detected severe impairments, whereas a longer duration (60 s) was more sensitive for identifying early declines. The choice of test duration should be guided by the specific functional deficits being assessed.…”
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The dose of febuxostat required to achieve the target level of uric acid in patients with normal and impaired renal function by M. S. Eliseev, M. N. Chikina, O. V. Zhelyabina, Ya. I. Kuzmina

“…The efficacy of FS does not decline in patients with gout and moderate decline in renal function. In more than 80% of cases it is possible to achieve the target level of UA in these patients, but it is associated with the need to use the maximum daily doses of the drug.…”
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Functional ultrasound imaging and prewhitening analysis reveal MK-801-induced disruption of brain network connectivity by Erik Hakopian, Argishti E. Stepanian, Shan Zhong, Shan Zhong, Kofi A. Agyeman, Kofi A. Agyeman, Nancy Zepeda, Kevin Wu, Charles Liu, Charles Liu, Charles Liu, Charles Liu, Darrin J. Lee, Darrin J. Lee, Darrin J. Lee, Darrin J. Lee, Vassilios Christopoulos, Vassilios Christopoulos, Vassilios Christopoulos, Vassilios Christopoulos

“…To account for the nonstationarity and autocorrelation inherent in fUSI time series, an AutoRegressive Integrated Moving Average (ARIMA) model was applied to stabilize the mean and remove autocorrelation, ensuring more reliable signal analysis.ResultsOur analysis revealed that MK-801 significantly disrupts functional connectivity (FC) across key brain regions, including the hippocampus, mPFC, and striatum. …”
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Bone mineral density in comparison to anthropometric parameters and level of gross motor function in children with cerebral palsy by Zvekić-Svorcan Jelena, Stojšić Mirjana, Krasnik Rastislava, Nenadov Nataša, Demeši-Drljan Čila, Mikov Aleksandra, Radovanov Maja

“…The aim of this work was to estimate bone mineral density in relation to the anthropometric parameters and the level of gross motor function in the children with cerebral palsy. Methods. …”
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Imaging the impact of sex and age on OATP function in humans: Consequences for whole-body pharmacokinetics and liver exposure by Solène Marie, Anne-Lise Lecoq, Louise Breuil, Fabien Caillé, Vincent Lebon, Claude Comtat, Sébastien Goutal, Laurent Becquemont, Michel Bottlaender, Céline Verstuyft, Nicolas Tournier

“…In males, neither liver exposure, blood exposure, nor kuptake were affected by aging (P < 0.05). kuptake was positively and negatively correlated with liver (P < 0.01, R2 = 0.78) and blood (P < 0.01, R2 = 0.40) exposures respectively. The impact of OATP function (kuptake) on liver exposure was 4-fold more pronounced than on blood exposure. …”
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Impacts of plant root traits and microbial functional attributes on soil respiration components in the desert-oasis ecotone by Jinlong Wang, Jinlong Wang, Jinlong Wang, Guanghui Lv, Guanghui Lv, Guanghui Lv, Jianjun Yang, Jianjun Yang, Jianjun Yang, Xuemin He, Xuemin He, Xuemin He, Hengfang Wang, Hengfang Wang, Hengfang Wang, Wenjing Li, Wenjing Li, Wenjing Li

“…., taxonomic composition) and functional attributes (specifically, functional genes implicated in microbial carbon metabolism). …”
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Melatonin Improves Salt Tolerance in Tomato Seedlings by Enhancing Photosystem II Functionality and Calvin Cycle Activity by Xianjun Chen, Bi Chen, Yao Jiang, Jianwei Zhang, Mingjie Liu, Qin Yang, Huiying Liu

“…These changes suggest improved PSII functional stability and reduced excess thermal energy dissipation. …”
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Role of bitter contributors and bitter taste receptors: a comprehensive review of their sources, functions and future development by Xinyue Zhou, Han Wang, Ming Huang, Jin Chen, Jianle Chen, Huan Cheng, Xingqian Ye, Wenjun Wang, Donghong Liu

“…This review provided a new perspective on exploring and explaining the nutrition of bitter foods, revealing the relationship between the functions of bitter contributors from food and T2Rs. …”
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THE OUTCOMES OF FUNCTIONING OF THE UNIFIED SYSTEM OF INDIVIDUAL DOSE CONTROL OF THE RUSSIAN FEDERATION CITIZENS BASED ON THE 2015 DATA by A. N. Barkovsky, R. R. Akhmatdinov, N. K. Baryshkov, A. A. Bratilova, T. A. Kormanovskaya, S. I. Kuvshinnikov, L. V. Repin, I. P. Stamat, O. E. Tutelyan

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