Use of Beta-Blockers as a First-Line Treatment for Primary Hypertension by Maryam Izadi, Shiva Shafabakhsh, Amir Mirnateghi

“…Therefore, this study aimed to clarify beta-blocker efficacy by incorporating the data from all relevant beta-blocker trials, using the composite outcome of major cardiovascular events. <i>Method</i>: A search was conducted on MEDLINE, PubMed, Embase, and the Cochrane Library, restricted to published, peer-reviewed, human, meta-analysis, and controlled clinical trials. …”
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Plant-based scaffolds and osteogenesis: a systematic review by Hashmat Gul, Kunza Naveed Asdaq, Muhammad Kaleem, Muhammad Hashim Malik

“…Conclusions: Plant-based scaffolds promote osteogenesis, but more in vivo research on plant-based studies is needed to label it as suitable scaffolds for bone tissue engineering. …”
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Gas chromatography and mass spectrometry (GC-MS) analysis of supercritical CO₂ extract of flower bud of Chrysanthemum indicum and its antibacterial activity by WANG Chunrong, FANG Chengji, YU Qingqing, JIANG Peng, TIAN Wei

“…The chemical compositions of Jumi essential oil were determined by GC-MS and their inhibitory activities against Staphylococcus aureus and Escherichia coli were analyzed by filter paper tablet bacteriostatic method and minimum inhibitory concentration (MIC).The results showed that the 28 types of components with the similarity of more than 70% were identified in Jumi essential oil by GC-MS analysis, which were mainly terpenes and their derivatives, and the former mainly include monoterpene and sesquiterpene, and the latter was mainly alcohols, for example, the contents of hexamethyl-benzene, 2- (2, 4-hexadiynylidene) -1, 6-dioxaspiro[4, 4] nonane-3-ene and (2 R-Cis) -1, 2, 3, 4, 4a, 5, 6, 7-octahydro-. alpha.,. alpha., 4a, 8-tetramethyl-2-naphthalenemethanol were higher than 9%, respectively. …”
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Interferon Gamma and Tumor Necrosis Factor Alpha Are Inflammatory Biomarkers for Major Adverse Cardiovascular Events in Patients with Peripheral Artery Disease by Ben Li, Eva Lindner, Raghad Abuhalimeh, Farah Shaikh, Houssam Younes, Batool Abuhalimeh, Abdelrahman Zamzam, Rawand Abdin, Mohammad Qadura

“…Incorporating these biomarkers into PAD management may improve systemic cardiovascular outcomes through more personalized and targeted treatment approaches.…”
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Adherence to the ABC (atrial fibrillation better care) pathway and risk of adverse outcomes in patients with chronic kidney disease: a report from the prospective APHRS-AF registry... by Tommaso Bucci, Katarzyna Nabradalik, Krysztof Irlik, Alena Shantsila, Giulio Francesco Romiti, Marco Proietti, Wee-Siong Teo, Hyung-Wook Park, Wataru Shimizu, Hung-Fat Tse, Tze-Fan Chao, Gregory Y.H. Lip, Hung-Fat Tse, Chun-Wah David Siu, Wataru Shimizu, Kenji Yodogawa, Hiroyuki Tsutsui, Yasushi Mukai, Hirofumi Tomita, Daisuke Horiuchi, Joji Hagii, Kazutaka Aonuma, Yasuo Okumura, Masahiko Goya, Kenzo Hirao, Ajioka Masayoshi, Nobuhisa Hagiwara, Atsushi Suzuki, Teiichi Yamane, Takanori Ikeda, Hitomi Yuzawa, Kazuhiro Satomi, Yoshinao Yazaki, Keiichi Fukuda, Yoshinori Kobayashi, Norishige Morita, Toyoaki Murohara, Eiichi Watanabe, Masahide Harada, Satoru Sakagami, Takahiro Saeki, Kengo Kusano, Koji Miyamoto, Shinsuke Miyazaki, Hiroshi Tada, Koichi Inoue, Nobuaki Tanaka, Yukihiro Koretsune, Haruhiko Abe, Yasuki Kihara, Yukiko Nakano, Akihiko Shimizu, Yasuhiro Yoshiga, Tomohiro Sakamoto, Ken Okumura, Naohiko Takahashi, Tetsuji Shinohara, Kyoko Soejima, Masahiko Takagi, Mitsuharu Kawamura, Yumi Munetsugu, Hyung-Wook Park, Jae-Min Shim, Jae Sun Uhm, Sung Il Im, Hyoung-Seob Par, Jun Hyung Kim, Young Keun On, Il-Young Oh, Seung Yong Shin, Jum Suk Ko, Jun Beom Park, Wee-Siong Teo, Kelvin Cheok-Keng Wong, Toon-Wei Lim, David Foo, Shih-Ann Chen, Tze-Fan Chao, YennJiang Lin, Fa-Po Chung, Yu-Feng Hu, Shil-Lin Chang, Ta-Chuan Tuan, Jo-Nan Liao, Cheng-Hung Li, Jin-Long Huang, Yu-Cheng Hsieh, Tsu-Juey Wu, Ying-Chieh Liao, Cheng-Hung Chiang, Hsiang-Chiang Hsiao, Tung-Chen Yeh, Wei-Siang Lin, Wen-Yu Lin, Jen-Yuan Kuo, Chong-Lie Hong, Yih-Je Wu, Ying-Siang Li, Jui-Peng Tsai, Kuo-Tzu Sung, Sheng-Hsiung Chang

“…Cox regression estimated hazard ratios (HRs) for a composite outcome of all-cause mortality and major adverse cardiovascular events. …”
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Effects of Sodium Selenite on Accumulations of Selenium and GABA, Phenolic Profiles, and Antioxidant Activity of Foxtail Millet During Germination by Shuaiduo Sun, Jingjing Zhang, Yongji Li, Yunfeng Xu, Runqiang Yang, Lei Luo, Jinle Xiang

“…It was indicated that selenium-enriched germination treatment should be an effective method to produce functional selenium-enriched foxtail millet sprouts with more abundant GABA and polyphenols, thus enhancing the health benefits and added value of foxtail millet.…”
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Accelerated design of eutectic high-entropy alloys using high-throughput phase diagram calculations and machine learning by Mingxu Wu, Bang Guan, Junfeng Wang, Shubin Wang, Chao Yang, Chuan Zhang, Da Shu, Chengbo Xiao, Baode Sun

“…This ML combining HTCs eutectic design method is expected to be extendable to multi-component alloys with even more elements and other alloy systems.…”
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Multi-Disciplinary Investigations on the Best Flying Wing Configuration for Hybrid Unmanned Aerial Vehicles: A New Approach to Design by Janani Priyadharshini Veeraperumal Senthil Nathan, Martin Navamani Chellapandian, Vijayanandh Raja, Parvathy Rajendran, It Ee Lee, Naveen Kumar Kulandaiyappan, Beena Stanislaus Arputharaj, Subhav Singh, Deekshant Varshney

“…The optimization process continues to add more desired modifications to the model, to finalize the best design of flying wing frame for the chosen application and mission profile. …”
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Mechanisms of Chromium Removal from Water and Soil Using Bioleached Nano Zero-Valent Iron-Mediated Biochar via Co-Pyrolysis by Zhiyi Liu, Shuhong Zhou, Yubing Cai, Xuehai Zhang, Muhammad Shaaban, Qi-an Peng, Yajun Cai

“…This enhancement in chromium elimination from soil was evident, as the residual state increased more for nZVI@BC (10.45%) than for BC alone (9.67% and 8.48%). …”
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Effect of New Mesh Fins on the Heat Storage Performance of a Solar Phase Change Heat Accumulator by Zihan Zhao, Jingzhi Jiang, Jingzhou An

“…In view of the problems of slow heat storage process and uneven temperature distribution in the existing phase change heat accumulator, a new type of mesh fin heat accumulator was designed and developed which increased the contact area between the phase change material (PCM) and the fins, enhanced the apparent thermal conductivity of the PCM, improved the heat storage efficiency of the heat accumulator, blocked the PCM, improved the natural convection erosion of the PCM on the upper and lower parts of the heat accumulator, and melted the PCM in each area more evenly. Fluent15.0 was used to numerically simulate the heat storage process of the mesh fins heat accumulator with the finite volume method. …”
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Applicability of the regression approach for histological multi-class grading in clear cell renal cell carcinoma by Mayu Shibata, Akihiro Umezawa, Saki Aoto, Kohji Okamura, Michiyo Nasu, Ryuichi Mizuno, Mototsugu Oya, Kei Yura, Shuji Mikami

“…Using convolutional neural network models (DenseNet-121 and Inception-v3), we found that regression models predict as accurately as classification models, achieving an accuracy of 0.990 at the highest, with fewer prediction errors by two or more grades. Furthermore, we found that the predictions by the regression models qualitatively capture intra-tumor heterogeneity of grades using the composite image patches. …”
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Early detection to improve outcome in people with undiagnosed psoriatic arthritis: the PROMPT research programme including RCT by Neil McHugh, Laura Bojke, Mel Brooke Turfrey, Rachel Charlton, Myka Ransom, Laura C Coates, Howard Collier, Claire Davies, Emma Dures, Philip Helliwell, Jana James, Anya Lissina, Vishnu B Madhok, Alison L Nightingale, Jonathan Packham, Catherine Smith, Eldon Spackman, Cerys Tassinari, William Tillett, Sarah T Brown

“…A pain visual analogue scale (VAS) and Functional Assessment of Chronic Illness Therapy-Fatigue instrument (chosen from PROMS) were added as modifications to the Composite Psoriatic Disease Activity Index (CPDAI) and the GRAppa Composite Exercise (GRACE) composite measures. …”
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Easy Direct Functionalization of 2D MoS2 Applied in Covalent Hybrids with PANI as Dual Blend Supercapacitive Materials by Matteo Crisci, Felix Boll, Sara Domenici, Jaime Gallego, Bernd Smarsly, Mengjiao Wang, Francesco Lamberti, Andrea Rubino, Teresa Gatti

“…Abstract The pressing demand for more sustainable energy provision and the ongoing transition toward renewable resources underline the critical need for effective energy storage solutions. …”
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Utilizing Freeze-Thaw-Ultrasonication to Prepare Mesoporous Silica-Encapsulated Colloidal Silver Nanoaggregates with Long-Term Surface-Enhanced Raman Spectroscopy Activity by Shuoyang Yan, Ling Chen, Zhiyang Zhang

“…Herein, we demonstrate mesoporous silica-encapsulated colloidal Ag nanoaggregates (AgNAs@m-SiO₂) by combining a freeze-thaw-ultrasonication method and a cetyltrimethylammonium bromide (CTAB)-assisted silanization reaction, achieving long-term SERS stability of more than two months. …”
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Antibacterial activity of reduced graphene-silver oxide nanocomposite against gram-negative bacteria by Rashi Chaudhary, N.B. Singh, Garima Nagpal, Fredrick K. Saah

“…The reduced agglomeration of silver nanoparticles in the composite also led to a more sustained release of antibacterial silver ions. …”
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Comprehensive N-glycosylation profiling of recombinant spike S1 protein from the wild-type SARS-CoV-2 and its variants by Yao Peng, Yao Peng, Yao Peng, Tian-Tian Tong, Qiu-Yu Deng, Lee-Fong Yau, Jia-Qi Qiu, Qing Zhao, Jia-Qi Wu, Zhi-Qiang Xin, Man-Ci Guan, Yue Li, Zhi-Hong Jiang, Hu-Dan Pan, Hu-Dan Pan, Liang Liu, Liang Liu, Liang Liu, Jing-Rong Wang, Jing-Rong Wang

“…The Spike protein forms trimers that bind to the ACE2 receptor on host cells, with the S1 subunit being a primary target for vaccines and antiviral treatments.MethodsHerein, we performed an in-depth analysis of the N-glycosylation of the recombinant Spike S1 protein (S1 protein) across the wild-type (WT) virus and its 5 variants, including Alpha, Beta, Gamma, Delta, and Lambda, by integrating ultrahigh-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UHPLC-Q-TOF MS) and unique TiO₂-PGC chip-based LC/MS techniques.ResultsA total of 332 glycan structures arising from 180 compositions on the S1 and RBD regions were identified, revealing remarkable glycosylation diversity of the S1 protein. …”
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Zirconium–Polycarboxylato Gel Systems as Substrates to Develop Advanced Fluorescence Sensing Devices by Jon Pascual-Colino, Garikoitz Beobide, Oscar Castillo, Javier Cepeda, Mónica Lanchas, Antonio Luque, Sonia Pérez-Yáñez

“…Therefore, to increase their mechanical stability during manipulation, a composite material was developed by combining the MOGs with quartz microcrystals, which proved to be a more reliable fluorescent system. …”
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Study on the crack self-healing performance of nano-micro silica modified hydrogel by MA Mengyang, LI Ting, WANG Tie, LONG Yong, SU Ying, YANG Jin

“…This study used nano-micro silica fume to compositely modify hydrogels to enhance their crack self-healing ability. …”
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PERAMALAN INDEKS HARGA SAHAM GABUNGAN (IHSG) DENGAN METODE FUZZY TIME SERIES MARKOV CHAIN by Y Aristyani, E Sugiharti

“…Because the MSE values obtained was smaller then the method of Markov Chain Fuzzy Time Series is more accurate and has better performance for forecasting. …”
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Outcomes for older people with screening-detected versus existing chronic kidney disease: a cohort study with data linkage by Anna K Forbes, José M Ordóñez-Mena, Winnie Mei, Clare J Taylor, Nicholas Jones, Jennifer A Hirst, FD Richard Hobbs

“…Design & setting: Prospective cohort study of 892 primary care patients aged ≥60 years with CKD (existing and screening detected) in Oxfordshire, with data linkage to civil death registry and secondary care. Method: Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazard models to compare the risk of all-cause mortality, hospitalisation, CVD, ESKD separately, and as a composite between CKD groups, as well as to identify factors associated with mortality. …”
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