Non-high density lipoprotein cholesterol/high density lipoprotein cholesterol is L-shaped associated with all-cause mortality and U-shaped with cardiovascular mortality in hyperten... by Meiqian Chen, Meiqian Chen, Li Zhang, Qian Liu, Qingxin Gu, Shuhui Yu, Guanzhen Lu, Guanzhen Lu

“…The relationship between the novel composite lipid metric, NHHR, and all-cause and cardiovascular mortality in hypertensive patients remains unknown and warrants further investigation.MethodsWe analyzed data from 5,561 hypertensive participants in the National Health and Nutrition Examination Survey (NHANES) spanning from 1999 to 2018. …”
Get full text

Vitrectomy, subretinal Tissue plasminogen activator and Intravitreal Gas for submacular haemorrhage secondary to Exudative Age-Related macular degeneration (TIGER): study protocol... by Timothy L. Jackson, Catey Bunce, Riti Desai, Jost Hillenkamp, Chan Ning Lee, Noemi Lois, Tunde Peto, Barnaby C. Reeves, David H. Steel, Rhiannon T. Edwards, Jan C. van Meurs, Hatem Wafa, Yanzhong Wang

“…Eligible participants have large, fovea-involving SMH of no more than 15 days duration due to treatment-naïve or previously treated neovascular AMD, including idiopathic polypoidal choroidal vasculopathy and retinal angiomatous proliferation. …”
Get full text

Right Ventricular–Pulmonary Artery Uncoupling and Strain in Acute Heart Failure by Alberto Palazzuoli, Frank Loyd Dini, Nicola Riccardo Pugliese, Gaetano Ruocco, Paolo Severino, Dario Vizza, Rosa Carbonara, Andrea Passantino, Erberto Carluccio

“…The end point was a composite of all‐cause death/HF‐related hospitalizations assessed at 180 days. …”
Get full text

The predictive role of the hs-CRP/HDL-C ratio for long-term mortality in the general population: evidence from a cohort study by Yifeng Wang, Li Wang, Zongquan Zhao, Song Yin, Xuejun Tang, Kerui Zhang

“…A two-piecewise linear regression model indicated that the risk of all-cause mortality increased more prominently when the hs-CRP/HDL-C ratio was less than 1.21. …”
Get full text

Uptake of DU145 and LNCaP prostate cancer cell line derived extracellular vesicles is inversely correlated with blood–brain barrier integrity in vitro by Ana Špilak, Adrián Klepe, Sophia Theresa Kriwanek, Heinz-Peter Friedl, Andreas Brachner, Christa Nöhammer, Winfried Neuhaus

“…This study investigated the interaction and effects of sEVs derived from low (LNCaP) and moderately metastatic (DU145) prostate cancer (PCa) cell lines with the human brain endothelial cell line hCMEC/D3. Methods Systematic optimization of the cell culture membrane insert set-up for sEV transport studies was accomplished with inserts with different pore sizes, varied coating procedures and medium compositions. …”
Get full text

[18F]PSMA-1007 PET for biochemical recurrence of prostate cancer, a comparison with [18F]Fluciclovine by Cato C. Loeff, Willemijn van Gemert, Bastiaan M. Privé, Inge M. van Oort, Rick Hermsen, Diederik M. Somford, James Nagarajah, Linda Heijmen, Marcel J. R. Janssen

“…For lesion confirmation a composite reference score was established using follow-up data. …”
Get full text

Sources of risk communication, knowledge and preventive practices toward Lassa fever in Bauchi State, Nigeria by Benjamin Bukky Ilesanmi, Nathanael Afolabi, Olayinka Badmus, Munkail Titilola, Abdulmajid Ahmad, Usman Inuwa, Matthew Okoh, Hajara Aliyu, Shittu Abdu-Aguye, Foyeke Oyedokun-Adebagbo

“…We analysed data of 1173 respondents aged 18 years and above who have heard of LF. Composite and median statistics were used to compute KPLF and was dichotomized into low and high. …”
Get full text

Prebiotic and panthenol-containing dermocosmetic improves tolerance from artificial daylight photodynamic therapy: A randomized controlled trial in patients with actinic keratosis by Gabriella Fredman, Kevin Jacobsen, Peter A Philipsen, Stine R Wiegell, Merete Haedersdal

“…Objective measurements showed milder erythema in DC-treated areas on Day 2 (p=0.045) and Day 7 (p=0.005). Crusting resolved more effectively in DC-treated areas by Day 7 (40% vs. 20%; p=0.039). …”
Get full text

Exploration of the relationships between the information and communication technology (ICT) and the education system in Morocco by Abdelkarim Taam, Amine Amar, Brahim Hmedna, Khalid Benabbes, El Menzhi Kaoutar, Rachid Daoudi, Adil El Makrani

“…The second part of our methodology is based on the multiple correspondence analysis (MCA) to determine a composite indicator of ICT integration. Our key findings demonstrate that the “Online learning” is more associated with the “age”, the “education level”, the “cycle” and the “area”. …”
Get full text

EXPERIMENTAL STUDY OF THE SAFETY OF INDIRECT CERAMIC RESTORATIONS REMOVAL BY COMPARING THE DYNAMICS OF THERMOMETRIC INDICATORS by O.V. Pavlenko, O.M. Stupnytska, I.H. Chaikovskyi, V.V. Chamata

“…Today, porcelain laminate veneers are mainly used to optimize tooth form and position, close diastema, replace discoloured or unaesthetic composite resin restorations, restore teeth with incisal abrasions or tooth erosion, and mask or reduce tooth discoloration. …”
Get full text

Sodium-glucose cotransporter 2 inhibitors and cardiovascular events among patients with type 2 diabetes and low-to-normal body mass index: a nationwide cohort study by Yuichiro Mori, Toshiaki Komura, Motohiko Adomi, Ryuichiro Yagi, Shingo Fukuma, Naoki Kondo, Motoko Yanagita, O. Kenrik Duru, Katherine R. Tuttle, Kosuke Inoue

“…The present study aims to investigate the effectiveness of SGLT2 inhibitors for cardiovascular outcomes among patients with type 2 diabetes and low-to-normal BMI, using finer stratification than previous trials. Methods This cohort study with a target trial emulation framework was conducted using insurance claims and health screening records of more than 30 million working-age citizens in Japan acquired from April 1, 2015 to March 31, 2022. 139,783 new users of SGLT2 inhibitors matched to 139,783 users of dipeptidyl protease (DPP) 4 inhibitors with stratification by BMI category (< 20.0, 20.0–22.4, 22.5–24.9, 25.0–29.9, 30.0–34.9, and 35.0 ≤ kg/m2). …”
Get full text

Preliminary evaluation of a mindfulness intervention program in women with long COVID dysautonomia symptoms by Elizabeth Vandenbogaart, Matthew Figueroa, Diana Winston, Steve Cole, Julienne Bower, Jeffrey J. Hsu

“…Nonetheless, the symptom burden in this population is very high, and more attention is needed to provide effective multi-modal clinical therapies to this population.…”
Get full text

The Efficacy and Safety of Ferric Carboxymaltose in Heart Failure with Reduced Ejection Fraction and Iron Deficiency: An Updated Systematic Review and Meta-Analysis of Randomized C... by Inderbir Padda, Sneha Annie Sebastian, Daniel Fabian, Yashendra Sethi, Gurpreet Johal

“…However, while earlier studies showed favorable results, more recent studies have failed to demonstrate significant improvements in outcomes for patients with heart failure with reduced ejection fraction (HFrEF) and ID. …”
Get full text

Expert consensus on the technical specifications of the in vitro skin penetration test of cosmetic product by Franz diffusion cell by Bingwen Liang, Liling Zhou, Chuanbin Wu, Liang Fang, Lisheng Wang, Lihua Peng, Peng Shu, Lifeng Tang, Yu Bei, Xiaodong Cui, Xiaojia Chen, Yuan Gao, Chong Han, Yan Jia, Huaqing Lin, Yifang Li, Ying Liu, Yiguang Li, Zhiwei Li, Zixiu Liu, Shaohua Ren, Jun Shi, Wanyang Sun, Lijuan Tian, Qun Wang, Yuan Wang, Yuehong Xu, Ming Zeng, Quangang Zhu, Shu Zhang, Yifan Zhang, Qi Xiang

“…Cosmetic formulations with different compositions and types may show different release kinetics, and this consensus does not cover all possible situations.…”
Get full text

Truncated Modular Exponentiation Operators: A Strategy for Quantum Factoring by Robert L. Singleton Jr

“…In this way, we fill the circuits for the ME operators with more and more gates, and the correlations between the various composite operators $U^p$ (where $p$ is a power of two) compensate for the missing levels. …”
Get full text

Study on Multiparameter Precursory Information Identification of the Fracture of Yellow Sandstone by Xiao Fukun, Wang Houran, Liu Gang

“…In order to explore the disaster caused by uncontrollable instability of coal and rock mass, a multiparameter fusion system is constructed to predict and predict disasters more accurately by identifying the mechanical and acoustic precursors of coal and rock fracture. …”
Get full text

Kinetics and Isotherm Studies of Copper Removal by Brushite Calcium Phosphate: Linear and Non-Linear Regression Comparison by Adnane El Hamidi, Said Arsalane, Mohamed Halim

Get full text

A Fugue as Art: Between Form and Metamorphoses by Maya I. Shinkareva

“…Diverse and sometimes paradoxical compositional solutions of the fugue provide a ground to supplement the above list of antonymic pairs with one more opposition: “morph vs. metamorphosis” (“morph” is a Greek word for “form”). …”
Get full text

Plasma extracellular vesicle cargo microRNAs are associated with heart failure and cardiovascular death following acute coronary syndrome by Worawan B. Limpitikul, Michael G. Silverman, Nedyalka Valkov, Jeong-Gun Park, Ashish Yeri, Fernando Camacho Garcia, Guoping Li, Priyanka Gokulnath, Marta Garcia-Contreras, Eric Alsop, Elizabeth Hutchins, Michail Spanos, Claire Lin, Kriti Bomb, Anthony Rosenzweig, Raymond Kwong, Kendall van-Keuren Jensen, James L. Januzzi, Jr., Ravi Shah, David A. Morrow, Marc S. Sabatine, Saumya Das

“…Both miR-223-3p and 378c were more enriched in small EVs (sEVs) compared to NVEPs. …”
Get full text

Heart failure with mildly reduced ejection fraction: retrospective study of ejection fraction trajectory risk by Robert J.H. Miller, Majid Nabipoor, Erik Youngson, Gynter Kotrri, Nowell M. Fine, Jonathan G. Howlett, Ian D. Paterson, Justin Ezekowitz, Finlay A. McAlister

“…Patients with HFmrEF‐Decreasing were more likely to experience the composite outcome in unadjusted analyses (unadjusted HR 1.19, 95% CI 1.01–1.40, P = 0.040) but not adjusted analyses (adjusted HR 1.16, 95% CI 0.98–1.37, P = 0.092). …”
Get full text