Treatment responses to Azithromycin and Ciprofloxacin in uncomplicated Salmonella Typhi infection: A comparison of Clinical and Microbiological Data from a Controlled Human Infecti... by Celina Jin, Malick M Gibani, Shaun H Pennington, Xinxue Liu, Alison Ardrey, Ghaith Aljayyoussi, Maria Moore, Brian Angus, Christopher M Parry, Giancarlo A Biagini, Nicholas A Feasey, Andrew J Pollard

“…A prolonged treatment response was observed significantly more frequently in the azithromycin group (28/52 [54.9%]) compared with the ciprofloxacin group (1/29 [3.5%]; p<0.001). …”
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Design of AgI/BiVO4 heterostructures for photocatalytic antibiotic removal and antimicrobial action by Hanh Thi Truong, Tho Truong Pham, Nhi Dinh Bui, Ha Tien Le, Thuan Chi Nguyen

“…This bandgap reduction supports more efficient separation of photogenerated electrons and holes, facilitating the production of reactive radicals such as ·O _2 ^− and ·OH. …”
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Do continuous glucose monitoring (CGM) metrics predict macrovascular and microvascular complications in diabetes? The FACULTY protocol of a retrospective real-world cohort study by Eric Vicaut, Ramzi A Ajjan, J Seufert, Gérard de Pouvourville, Emmanuel Cosson, Laure Carcaillon-Bentata, Tadej Battelino, Patrick Blin, Fleur Levrat-Guillen, Michael Joubert

“…Continuous glucose monitoring (CGM)-derived glucose metrics provide a more comprehensive assessment of glycaemia, but their role in predicting future vascular complications remains unclear. …”
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Parameter optimization for multistage horizontal well fracturing based on multi-cluster perforation for deep coal measure gas: A case study of the Jurassic Baijiahai area in the Ju... by Bo WANG, Chenghong JIN, Jiang LIU, Zhiwei WANG, Shenjian LI, Mao SHENG

“…As a result, existing fracturing experience cannot be directly applied, highlighting the investigation of fracturing parameter optimization tailored for deep CMG production.MethodsFocusing on deep CMG reservoirs in the Baijiahai area within the Junggar Basin, this study constructed a model of multistage horizontal well fracturing based on multi-cluster perforation for a composite geological structure composed of a roof, a floor, gangue, and coals. …”
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Exploring Ethical, Cultural, and Transnational Competence Among International Healthcare Management Students: An Australian Perspective by Howard M, Tan KL, Jayasekara R

“…This exploratory study examined the challenges faced by these students to establish foundational understanding of the competencies needed for effective ethical decision-making, cultural integration, and transnational readiness in diverse healthcare environments.Methods: Using a composite theoretical framework incorporating Cultural Relativism, Ethical Climate Theory, Institutional Theory, and Transnationalism, a 35-item instrument was adapted from three validated sources. …”
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Increasing risk of postlung transplant hospitalizations for infection: An analysis of recent trends by Shi Nan Feng, BSPH, Armaan F. Akbar, BS, Alice L. Zhou, MS, Andrew Kalra, BS, Sean Agbor-Enoh, MD, PhD, Christian A. Merlo, MD, MPH, Errol L. Bush, MD

“…We examined trends in hospitalizations for infection in the first year after LT. Methods: We identified adult LT recipients in the United States (March 1, 2018-March 9, 2023) using the Organ Procurement and Transplantation Network database. …”
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Risk factors, management, and outcomes of amniotic fluid embolism: A multicountry, population-based cohort and nested case-control study. by Kathryn E Fitzpatrick, Thomas van den Akker, Kitty W M Bloemenkamp, Catherine Deneux-Tharaux, Alexandra Kristufkova, Zhuoyang Li, Timme P Schaap, Elizabeth A Sullivan, Derek Tuffnell, Marian Knight

“…Factors associated with poor maternal outcomes (fatality and composite of fatality or permanent neurological injury) amongst women with AFE from each of the countries were investigated using logistic regression or Wilcoxon rank-sum test. …”
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A Review of Multidisciplinary Evidence on the Role of Urban Green Space in Improving the Sleep Quality of the Elderly by Ning KANG, Han XIE, Tao JIANG

“…The elderly with genetically susceptible gut microbiota may experience distinct sleep improvement effects from green spaces compared to those with more stable gut microbiota compositions. Additionally, culturally-specific lifestyle patterns and attitudes toward nature may lead to variations in sleep improvement outcomes among the elderly from diverse cultural backgrounds when they use green spaces.ConclusionResearch on improving sleep health of the elderly must transcend single-discipline limitations, integrating theories and research methods from multiple fields including geriatrics and gerontology, neuroscience and neurology, psychiatry, psychology, behavioral science, sociology, rehabilitation medicine, exercise science, and environmental science and ecology. …”
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Hypomethylating agents plus venetoclax for high-risk MDS and CMML as bridge therapy to transplant: a GESMD study by Ines Zugasti, Monica Lopez-Guerra, Sandra Castaño-Díez, Daniel Esteban, Alejandro Avendaño, Helena Pomares, Ana Perez, Sara García-Ávila, Irene Padilla Conejo, Cristina de la Fuente Montes, Alexandra Martínez-Roca, Beatriz Merchán, Carlos Jiménez-Vicente, Francesca Guijarro, Jose Ramón Álamo, Albert Cortes-Bullich, Victor Torrecillas, Lucia Mont, Esther Carcelero, Gisela Riu, Lurdes Zamora, Joan Bargay, Ana Triguero, Maria Suarez-Lledó, Maria Queralt Salas, Felix López-Cadenas, Fernando Ramos, Blanca Xicoy, David Valcárcel, Montserrat Arnan, Carmen Martínez, Montserrat Rovira, Francesc Fernández-Avilés, Maria Díez-Campelo, Jordi Esteve, Marina Díaz-Beyá

“…Recent evidence suggests that combining HMA with venetoclax (HMA/VEN) could increase HMA efficacy in HR-MDS but it remains unclear if this combination could bridge more patients to allo-SCT. Methods We retrospectively evaluated HMA/VEN as a bridge to allo-SCT in 30 patients with HR-MDS or CMML eligible for transplant. …”
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Four 2×2 factorial trials of smartphone CBT to reduce subthreshold depression and to prevent new depressive episodes among adults in the community–RESiLIENT trial (Resilience Enhan... by Toshi A Furukawa, Pim Cuijpers, Tatsuo Akechi, Masaru Horikoshi, Yan Luo, Hisashi Noma, Takeo Nakayama, Helen Christensen, Naoki Kondo, Norito Kawakami, Aran Tajika, Ronald C Kessler, Shingo Fukuma, Masatsugu Sakata, Rie Toyomoto, James M S Wason

“…Guided internet cognitive–behavioural therapies (iCBT) appear promising but there is room for improvement because we do not yet know which of various iCBT skills are more efficacious than others, and for whom. In addition, there has been no platform for iCBT that can accommodate ongoing evolution of internet technologies.Methods and analysis Based on our decade-long experiences in developing smartphone CBT apps and examining them in randomised controlled trials, we have developed the Resilience Training App Version 2. …”
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Epilepsy is associated with the accelerated aging of brain activity in sleep by Peter N. Hadar, Mike Westmeijer, Mike Westmeijer, Haoqi Sun, Erik-Jan Meulenbrugge, Jin Jing, Luis Paixao, Ryan A. Tesh, Madalena Da Silva Cardoso, Pierrick Arnal, Rhoda Au, Chol Shin, Chol Shin, Soriul Kim, Robert J. Thomas, Sydney S. Cash, M. Brandon Westover

“…Higher brain age indices are associated with poorer cognition and more severe epilepsy, specifically generalizability and higher seizure burden. …”
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Clinical Features and Outcomes of Primary Sclerosing Cholangitis in the Highly Admixed Brazilian Population by Mateus Jorge Nardelli, Paulo Lisboa Bittencourt, Guilherme Grossi Lopes Cançado, Luciana Costa Faria, Cristiane Alves Villela-Nogueira, Vivian Rotman, Eliabe Silva de Abreu, Fernanda Maria Farage Osório, Andreia Silva Evangelista, Liliana Sampaio Costa Mendes, Daniel Ferraz de Campos Mazo, Elodie Bonfim Hyppolito, Adrielly de Souza Martins, Liana Codes, Izabelle Venturini Signorelli, Geisa Perez Medina Gomide, Luciana Agoglia, Claudia Alexandra Pontes Ivantes, Valéria Ferreira de Almeida e Borges, Gabriela Perdomo Coral, Rosamar Eulira Fontes Rezende, Maria Lucia Gomes Ferraz, Debora Raquel Benedita Terrabuio, Eduardo Luiz Rachid Cançado, Claudia Alves Couto

“…Adverse outcomes were more frequent, probably due to advanced disease at baseline.…”
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Implications of Tricuspid Regurgitation Severity in Patients Undergoing Mitral Transcatheter Edge‐to‐Edge Repair by Alon Shechter, Homa Taheri, Takashi Nagasaka, Aakriti Gupta, Danon Kaewkes, Vivek Patel, Kazuki Suruga, Manvir Dhillon, Keita Koseki, Ofir Koren, Moody Makar, Sabah Skaf, Dhairya Patel, Tarun Chakravarty, Robert J. Siegel, Raj R. Makkar

“…We aimed to explore the prevalence, correlates, and consequences of TR grades and postprocedural trends in this setting. Methods and Results A single‐center registry of isolated, first‐time interventions was retrospectively assessed for pre‐, intra‐, and postprocedural aspects up to 1 year, of them the primary composite outcome of all‐cause deaths or heart failure (HF) hospitalizations, all according to TR severity at baseline and at 1 month following mitral transcatheter edge‐to‐edge repair. …”
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SGLT2-inhibitors in diabetic patients with severe aortic stenosis and cardiac damage undergoing transcatheter aortic valve implantation (TAVI) by Pasquale Paolisso, Marta Belmonte, Emanuele Gallinoro, Roberto Scarsini, Luca Bergamaschi, Leonardo Portolan, Matteo Armillotta, Giuseppe Esposito, Elisabetta Moscarella, Giovanni Benfari, Claudio Montalto, Monika Shumkova, Elayne Kelen de Oliveira, Francesco Angeli, Mateusz Orzalkiewicz, Margherita Fabroni, Nurcan Baydaroglu, Andrea Raffaele Munafò, Daniele Oreste D’Atri, Matteo Casenghi, Lucia Scisciola, Michelangela Barbieri, Raffaele Marfella, Felice Gragnano, Edoardo Conte, Dario Pellegrini, Alfonso Ielasi, Daniele Andreini, Martin Penicka, Jacopo Andrea Oreglia, Paolo Calabrò, Antonio Bartorelli, Carmine Pizzi, Tullio Palmerini, Marc Vanderheyden, Francesco Saia, Flavio Ribichini, Emanuele Barbato

“…Patients not treated with SGLT2i were more likely to progress to a worse EVCD stage over time (p = 0.018). …”
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Low-Density Lipoprotein Cholesterol Level, the Lower the Better? Analysis of Korean Patients in the Treat Stroke to Target Trial by Hanim Kwon, Jae-Chan Ryu, Jae-Kwan Cha, Sang Min Sung, Tae-Jin Song, Kyung Bok Lee, Eung-Gyu Kim, Yong-Won Kim, Ji Hoe Heo, Man Seok Park, Kyusik Kang, Byung-Chul Lee, Keun-Sik Hong, Oh Young Bang, Jei Kim, Jong S. Kim

“…The primary endpoint was a composite of ischemic stroke, myocardial infarction, coronary or cerebral revascularization, and cardiovascular death. …”
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Very low urinary marinobufagenin excretion reflects a high risk of disease progression in non-advanced CKD by Davide Bolignano, Davide Bolignano, Marta Greco, Marta Greco, Loredana Tripodi, Mario D’Agostino, Paola Cianfrone, Roberta Misiti, Roberta Misiti, Sara Pugliese, Mariateresa Zicarelli, Michela Musolino, Michela Musolino, Daniela Patrizia Foti, Daniela Patrizia Foti, Michele Andreucci, Michele Andreucci, Giuseppe Coppolino, Giuseppe Coppolino

“…This trend remained unaffected by adjustment for age, baseline eGFR, and 24 h-proteinuria.ConclusionIn individuals with non-advanced CKD, very low urinary excretion of MBG reflects a more sustained risk of CKD progression over time. …”
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Sunlight-Induced Photocatalytic Removal of Paracetamol Using Au-TiO₂ Nanoparticles by Lamine Aoudjit, Joana M. Queirós, A. S. Castro, Djamila Zioui, Noelia González-Ballesteros, S. Lanceros-Mendez, Pedro M. Martins

“…Under these conditions, paracetamol in 1 g/L of Au-TiO₂ nanocomposites can be degraded by more than 99.17% under solar irradiation. As a result of the Au-TiO₂ composite’s ability to successfully serve as a photocatalyst using sun radiation, water purification processes can be more widespread, cost-effective, and environmentally friendly.…”
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Comparison of right ventricular function and clinical outcomes in type 2 diabetes patients with and without obstructive coronary artery disease: insights from a CMR study by Jin Wang, Wei-Feng Yan, Ke Shi, Hua-Yan Xu, Shi-Qin Yu, Ying-Kun Guo, Li Jiang, Yue Gao, Yu-Jiang, Xue-Ming Li, Yuan Li, Zhi-Gang Yang

“…The endpoints, which included all-cause mortality, heart failure hospitalization, and overall composite outcome, were evaluated over a median follow-up period of 5.7 (3.1, 6.7) years. …”
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The relationship of sex and aortic diameter at the time of acute type A aortic dissectionCentral MessagePerspective by Lamia Harik, MD, Mario Gaudino, MD, PhD, Mohammed Rahouma, MD, Arnaldo Dimagli, MD, Roberto Perezgrovas-Olaria, MD, Kevin R. An, MD, Talal Alzghari, MD, Giovanni Soletti, Jr., MD, Jordan Leith, BS, Gianmarco Cancelli, MD, Charles Mack, MD, Leonard N. Girardi, MD, Christopher Lau, MD

“…Objective: Evaluate sex differences in patients undergoing repair of acute type A aortic dissection (ATAAD). Methods: Sex-stratified, single-center cohort study of patients undergoing ATAAD repair from 1997 to 2022. …”
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Modeling and Reconstruction of Mixed Functional and Molecular Patterns by Yue Wang, Jianhua Xuan, Rujirutana Srikanchana, Peter L. Choyke

“…Recent research aims to dissect the distribution or expression of multiple biomarkers associated with disease progression or response, where the signals often represent a composite of more than one distinct source independent of spatial resolution. …”
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